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ITMO Genetics, genomics & bioinformatics The impact of genetics, genomics & bioinformatics on personalized medicine Thierry Grange, CNRS ARIIS CIRAD EFS ARIIS CIRAD EFS CEA CHRU CNRS FONDATION MERIEUX CEA CHRU CNRS FONDATION MERIEUX CPU INRA INRIA INSERM INSTITUT PASTEUR INERIS INSTITUT CURIE INSTITUT MINES-TELECOM CPU INRA INRIA INSERM INSTITUT PASTEUR INERIS INSTITUT CURIE INSTITUT MINES-TELECOM IRD IRBA IRD IRBA IRSN UNICANCER IRSN UNICANCER 1 ITMO Genetics, genomics & bioinformatics Coordination of the action of the French research institutions in Genetics, Genomics & Bioinformatics ARIIS CIRAD EFS ARIIS CIRAD EFS CEA CHRU CNRS FONDATION MERIEUX CEA CHRU CNRS FONDATION MERIEUX CPU INRA INRIA INSERM INSTITUT PASTEUR INERIS INSTITUT CURIE INSTITUT MINES-TELECOM CPU INRA INRIA INSERM INSTITUT PASTEUR INERIS INSTITUT CURIE INSTITUT MINES-TELECOM IRD IRBA IRD IRBA IRSN UNICANCER IRSN UNICANCER 2 Major strategic priorities • Next Generation Sequencing & Bioinformatics: Integrating Big Data with Modeling • Epigenetics & Regulation of Gene Expression: Interactions between genomes and environment • Evolution of genomes and populations • Individual genomes and personalized medicine ARIIS CIRAD EFS CEA CHRU CNRS FONDATION MERIEUX CPU INRA INRIA INSERM INSTITUT PASTEUR INERIS INSTITUT CURIE INSTITUT MINES-TELECOM IRD IRBA IRSN UNICANCER 3 Key transversal question • Understanding the relationship between genotype and phenotype ARIIS CIRAD EFS CEA CHRU CNRS FONDATION MERIEUX CPU INRA INRIA INSERM INSTITUT PASTEUR INERIS INSTITUT CURIE INSTITUT MINES-TELECOM IRD IRBA IRSN UNICANCER 4 ITMO Genetics, genomics & bioinformatics How genetics, genomics and bioinformatics can contribute to personalized medicine? ARIIS CIRAD EFS ARIIS CIRAD EFS CEA CHRU CNRS FONDATION MERIEUX CEA CHRU CNRS FONDATION MERIEUX CPU INRA INRIA INSERM INSTITUT PASTEUR INERIS INSTITUT CURIE INSTITUT MINES-TELECOM CPU INRA INRIA INSERM INSTITUT PASTEUR INERIS INSTITUT CURIE INSTITUT MINES-TELECOM IRD IRBA IRD IRBA IRSN UNICANCER IRSN UNICANCER 5 Interpreting personal genomes • Sequencing personal genomes is becoming technically and financially within reach • How can this information be used to adapt treatments to the individual genetic make-up? • There is a need to better understand the relationship between genome sequences and personal/population phenotypes ARIIS CIRAD EFS CEA CHRU CNRS FONDATION MERIEUX CPU INRA INRIA INSERM INSTITUT PASTEUR INERIS INSTITUT CURIE INSTITUT MINES-TELECOM IRD IRBA IRSN UNICANCER 6 Today’s speakers Thierry Frebourg, Inserm CHU Rouen ARIIS CIRAD EFS CEA CHRU CNRS FONDATION MERIEUX Lluis Quintana-Murci, CNRS Institut Pasteur CPU INRA INRIA INSERM INSTITUT PASTEUR INERIS INSTITUT CURIE INSTITUT MINES-TELECOM IRD IRBA IRSN UNICANCER 7
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