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CHAPTER 15
Mutation, Repair, and
Recombination
Copyright 2008 © W H Freeman and Company
CHAPTER OUTLINE
15.1 The phenotypic consequences of DNA mutations
15.2 The molecular basis of spontaneous mutations
15.3 The molecular basis of induced mutations
15.6 Cancer: an important phenotypic consequence of
mutation
Consequences of point mutations within genes
Figure 15-2
Consequences of point mutations within genes
Figure 15-2 part 1
Consequences of point mutations within genes
Figure 15-2 part 2
Consequences of point mutations within genes
Figure 15-2 part 3
Unnumbered figure pg 515
Point mutations can alter mRNA splicing
Figure 15-3
Consequences of point mutations on gene products
Figure 15-4
“Fluctuation test” hypotheses
Figure 15-5
Replica plating
Figure 15-6
Replica plating demonstrates the presence of mutants before selection
Figure 15-7
Bases may take on rare tautomeric forms prone to mismatch
Figure 15-8a
Bases may take on rare tautomeric forms prone to mismatch
Figure 15-8b
Tautomeric shifts in DNA bases may cause mutations
Figure 15-9
Indel mutations result in frameshifts
Figure 15-10
Unnumbered figure pg 522
Unnumbered figure pg 523
Oxygen radicals can damage DNA
Figure 15-11
Trinucleotide repeats in the FMR-1 gene hinder transcription
Figure 15-12
Slipped mispairing causes repeat expansion
Figure 15-13
Alternative pairings for 5-bromouracil (5-BU)
Figure 15-14
Alternative pairings for 2-aminopurine
Figure 15-15
Unnumbered figure pg 527
Alkylation-induced specific mispairings
Figure 15-16
Intercalating agents
Figure 15-17
Intercalating agents
Figure 15-17a
Intercalating agents
Figure 15-17b
UV-light-generated photoproducts
Figure 15-18
Aflatoxin B1 forms a bulky addition product
Figure 15-19
The Ames test reveals mutagenic compounds
Figure 15-20
Ames test of aflatoxin B1 mutagenicity
Figure 15-21
Normal cells and cells transformed by an oncogene
Figure 15-35
The ras oncogene is continuously active
Figure 15-36
The ras oncogene is continuously active
Figure 15-36a
The ras oncogene is continuously active
Figure 15-36b
Table 15-1