Download RCM_4810_sm_SuppInfo

S S
Pd NP
S1
Pd (0) + HS
S
S
S
S
S
S
S
S
D
S2
Gramicidin D consists of 15 alternating D- and L-amino acid
residues and blocked at both ends with formyl and ethanolamine
groups. The structure of gramicidin is: formyl-L-Val-Gly-L-Ala-DLeu-L-Ala-D-Val-L-Val-D-Val-L-Trp-D-Leu-L-Xxx-D-Leu-L-TrpD-Leu-L-Trp-ethanolamine, where Xxx is Trp in Gramicidin A,
Phe in Gramicidin B, Tyr in Gramicidin C. Gramicidin is
composed of three components: GrA, GrB, and GrC for 80%,
5%, and 15%, respectively. Most of the amino acids in gramicidin
are hydrophobic and the alternative arrangement of D- and
L- amino acids forming a helical dimmer (channel) with hydrophobic ext
interior in lipid bilayers.
pH effect on protein enrichment
250
Intensity
200
150
100
50
0
0
2
4
6
8
pH
S3
10
12
14