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Fig. 26.1 Predicted permeation pore helix and selectivity filter of human TRPV subfamily. Left panel shows a partial alignment of the
primary structure of members of the TRPV family including the permeation zone, selectivity filter (light green) and P-loop (orange),
transmembrane domain 6 (TM6) (light red). Right. Molecular model of the human TRPV1 pore domain ([91]; coordinates drawn using
PyMol molecular graphics program). The different regions are colored to match the color code used in the left panel. The selectivity filter
residues (TIGMGD) are highlighted in sticks representation
Transient Receptor Potential Channels, Md. Shahidul Islam (Ed.)
ISBN: 978-94-007-0264-6, Springer
Fig. 26.2 Energy barrier profile
Transient Receptor Potential Channels, Md. Shahidul Islam (Ed.)
ISBN: 978-94-007-0264-6, Springer
Fig. 26.3 Structural components involved in temperature activation of TRPV1. This molecular model shows the external aspect of the
TRPV1 pore, highlighting the turret and the amino acids residues that have been implicated in temperature detection
Transient Receptor Potential Channels, Md. Shahidul Islam (Ed.)
ISBN: 978-94-007-0264-6, Springer
Fig. 26.4. The basic residues present in TM4 and in the TM4-TM5 linker in thermo-TRPs
Transient Receptor Potential Channels, Md. Shahidul Islam (Ed.)
ISBN: 978-94-007-0264-6, Springer
Fig. 26.5 Sequential and allosteric kinetic models. (a) A five state sequential model with four closed states, C0, C1, C2 and C3, and a single
open state O. (b) Monod-Wyman-Changeaux (MWC) model after Voets et al. [4], used to explain channel activation by agonists. (c)
Allosteric model of TRP channel activation by voltage and temperature. (d) A general gating mechanism includes an allosteric interaction
between channel opening (described by the equilibrium constant L), voltage sensor activation (described by the voltage-dependent
equilibrium constant J), temperature sensor activation (described by the temperature-dependent equilibrium constant K) and agonist
activation (described by the equilibrium constant Q)
Transient Receptor Potential Channels, Md. Shahidul Islam (Ed.)
ISBN: 978-94-007-0264-6, Springer