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April 7, 2006 The Lactic Acid System and Aerobic Systems for Energy Production During Exercise David L. Gee, PhD www.cwu.edu/~geed Lactic Acid System Anaerobic Uses glycolysis muscle glycogen, blood glucose, liver glycogen as substrates (not FAT or PRO) High rate of ATP energy production Primary fuel in sprint-type activities (a few seconds - few minutes) Lactic Acid System Important when: Activity longer than a few seconds • creatine-P depleted/limited Activity too intense for aerobic metabolism • oxygen delivery limited – limited rate of O2 : • uptake in lung • transport and delivery to muscle cell • transport and delivery to mitochondria Lactic Acid System Lactic acid is the end product Low total energy capacity • lactic acidosis • Inhibits glycolytic enzymes Training effects • improved aerobic capacity reducing lactate production • improved removal of lactate Ergogenic aids • bicarbonate loading Oxygen Energy System Oxygen Energy Systems Aerobic carbohydrate metabolism • glycolysis, Krebs cycle, electron transport system lower rate of ATP energy production high total energy capacity primary source of energy for higher intensity endurance events (~< 30 min) 09.06 Aerobic Respiration Overview Slide number: 2 Glucose Plasma membrane Mitochondrion Cytoplasm Extracellular fluid Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. 09.06 Aerobic Respiration Overview Slide number: 4 Glucose Glycolysis Pyruvate ATP NADH Acetyl-CoA NADH Plasma membrane Mitochondrion Cytoplasm Extracellular fluid Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. 09.06 Aerobic Respiration Overview Slide number: 6 Glucose Glycolysis Pyruvate ATP NADH Acetyl-CoA Krebs cycle NADH H2O ATP NADH Plasma membrane Mitochondrion Cytoplasm ATP Extracellular fluid CO2 Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. O2 Oxygen Energy Systems Fat oxidation • Beta-oxidation, Krebs cycle, Electron transport system Lowest rate of ATP-energy production Highest total energy capacity Primary source of energy during lower intensity endurance events (~>30 min) Oxygen Energy Systems Protein oxidation • Amino acid oxidation, Krebs cycle, Electron transport system Low rate of ATP-energy production Limited total energy capacity significant source of energy during long endurance events % Contribution of Aerobic and Anaerobic Energy Sources