Survey
* Your assessment is very important for improving the work of artificial intelligence, which forms the content of this project
Download Thesis Figures For Review
Document related concepts
no text concepts found
Transcript
Figure S1: Adipose Chart 1 Percentage of Reactions Retained by Subsystem in Adipose Tissue - 1 Butanoate Metabolism Transport, Lysosomal100 C5-Branched Hyaluronan Metabolism Carnitinedibasic shuttleacid metabolism Glutathione Metabolism Citric Acid Cycle 90 Transport, Mitochondrial CoA Biosynthesis 80 Tryptophan metabolism Cysteine Metabolism 70 Fatty acid elongation Arginine and Proline Metabolism Propanoate Metabolism Pentose Phosphate Pathway Nucleotides 60 50 40 30 20 10 0 Glycerophospholipid Metabolism Miscellaneous Glycolysis/Gluconeogenesis N-Glycan Degradation Glutamate metabolism Steroid Metabolism Cholesterol Metabolism Aminosugargroup Metabolism Urea cycle/amino metabolism Eicosanoid Metabolism Fatty Acid Metabolism Fatty acid oxidation Heme Biosynthesis Heme Degradation IMP Biosynthesis Keratan sulfate degradation Oxidative Phosphorylation Purine Catabolism Pyrimidine Biosynthesis ROS Detoxification Transport, Endoplasmic Reticular Leucine, and Isoleucine… FattyValine, acid activation Figure S2: Adipose Chart 2 Percentage of Reactions Retained by Subsystem in Adipose Tissue - 2 Triacylglycerol Synthesis Tyr, Phe,Metabolism Trp Biosynthesis 80 Transport, Endoplasmic Reticular Histidine Pyruvate Metabolism CYP Metabolism Galactose metabolism 70 Lysine Metabolism Pyrimidine Catabolism 60 Biotin Metabolism Transport, Extracellular 50 Taurine and hypotaurine metabolism Folate Metabolism Fatty acid oxidation, peroxisome Inositol Phosphate Metabolism Glyoxylate and Dicarboxylate… Vitamin D Tyrosine metabolism Riboflavin Metabolism beta-Alanine metabolism NAD Metabolism 40 30 20 10 0 Bile Acid Biosynthesis Methionine Metabolism Exchanges Glycine, Serine, and Threonine… Pentose and Glucuronate… Transport, Peroxisomal Vitamin A Metabolism Alanine and Aspartate Metabolism R Group Synthesis Fructose and Mannose Metabolism N-Glycan Biosynthesis Ascorbate and Aldarate Metabolism Thiamine Metabolism Salvage Pathway Transport, Sphingolipid Metabolism Starch and SucroseNuclear Metabolism Tetrahydrobiopterin Vitamin B6 Metabolism Figure S3: Liver Chart 1 Percentage of Reactions Retained by Subsystem in Liver Tissue - 1 Ascorbate and Aldarate Metabolism Hyaluronan Metabolism100 C5-Branched dibasic acid metabolism Glutathione Metabolism Carnitine shuttle Alanine and Aspartate Metabolism Cysteine Metabolism 90 Nucleotides Fatty acid oxidation 80 Transport, Extracellular Fructose and Mannose Metabolism 70 Cholesterol Metabolism Pyruvate Metabolism Pyrimidine Biosynthesis Propanoate Metabolism Aminosugar Metabolism 60 50 40 30 20 10 0 Urea cycle/amino group metabolism Fatty acid activation Fatty Acid Metabolism Biotin Metabolism Steroid Metabolism Valine, Leucine, and Isoleucine… Glycolysis/Gluconeogenesis Citric Acid Glycine, Serine, and Cycle Threonine… Galactose metabolism Glutamate metabolism Heme Biosynthesis Heme Degradation IMP Biosynthesis Keratan sulfate degradation Lysine Metabolism Methionine Metabolism Oxidative Phosphorylation Purine Catabolism ROS Detoxification Transport, Endoplasmic Reticular Tyr,B6 Phe, Trp Biosynthesis Vitamin Metabolism Figure S4: Liver Chart 2 Percentage of Reactions Retained by Subsystem in Liver Tissue - 2 Miscellaneous Riboflavin Metabolism 80 Pentose Phosphate Pathway CoA Biosynthesis Thiamine Metabolism Taurine and hypotaurine metabolism Bile Acid Biosynthesis 70 CYP Metabolism Vitamin A Metabolism 60 Inositol Phosphate Metabolism Exchanges 50 Fatty acid oxidation, peroxisome Transport, Endoplasmic Reticular Transport, Lysosomal N-Glycan Biosynthesis Vitamin D Eicosanoid Metabolism Transport, Nuclear N-Glycan Degradation Folate Metabolism Triacylglycerol Synthesis 40 30 20 10 0 Pentose and Glucuronate… Transport, Peroxisomal Transport, Mitochondrial Tryptophan metabolism Glycerophospholipid Metabolism Salvage Pathway Tetrahydrobiopterin Starch and Sucrose Metabolism R Group Synthesis Fatty acid elongation Histidine Metabolism Glyoxylate and Dicarboxylate… Butanoate Metabolism NAD Metabolism beta-Alanine metabolism Sphingolipid Metabolism Arginine and Proline Metabolism Tyrosine metabolism Pyrimidine Catabolism Figure S5: Skeletal Muscle Chart 1 Percentage of Reactions Retained by Subsystem in Skeletal Muscle Tissue - 1 Ascorbate and Aldarate Metabolism Glycerophospholipid Metabolism Butanoate Metabolism 100 Folate Metabolism C5-Branched dibasic acid metabolism Glyoxylate and Dicarboxylate… Carnitine shuttle 90 Cholesterol Metabolism Heme Biosynthesis 80 Transport, Mitochondrial Heme Degradation 70 60 Tetrahydrobiopterin IMP Biosynthesis 50 Pyrimidine Catabolism Keratan sulfate degradation 40 30 Vitamin A Metabolism Oxidative Phosphorylation 20 Glutathione Metabolism Purine Catabolism 10 0 Exchanges Fatty acid activation Propanoate Metabolism Transport, Extracellular Galactose metabolism Urea cycle/amino group metabolism Triacylglycerol Synthesis Thiamine Metabolism Miscellaneous Glycolysis/Gluconeogenesis Fructose and Mannose Metabolism Biotin Metabolism Fatty Acid Metabolism Glutamate metabolism Fatty acid oxidation Vitamin B6 Metabolism Citric Acid Cycle Valine, Leucine, and Isoleucine… Pyruvate Metabolism Nucleotides Figure S6: Skeletal Muscle Chart 2 Percentage of Reactions Retained by Subsystem in Skeletal Muscle Tissue - 2 Pentose Phosphate Pathway Tyr, Phe, Trp Biosynthesis Transport, Peroxisomal 60 Transport, Endoplasmic Reticular Cysteine Metabolism Salvage Pathway R Group Synthesis N-Glycan Degradation Pentose and Glucuronate… 50 N-Glycan Biosynthesis Transport, Nuclear 40 Methionine Metabolism Arginine and Proline Metabolism 30 Hyaluronan Metabolism Lysine Metabolism Histidine Metabolism 20 CYP Metabolism 10 CoA Biosynthesis 0 Eicosanoid Metabolism Fatty acid oxidation, peroxisome Pyrimidine Biosynthesis Riboflavin Metabolism ROS Detoxification Transport, Endoplasmic Reticular Aminosugar Metabolism Glycine, Serine, and Threonine… Alanine and Aspartate Metabolism Transport, Lysosomal Fatty acid elongation Bile Acid Biosynthesis Steroid Metabolism Taurine and hypotaurine metabolism Vitamin D Tryptophan metabolism Tyrosine metabolism Sphingolipid NAD Metabolism Inositol Phosphate Metabolism Metabolism Starch and Sucrose Metabolism beta-Alanine metabolism 0% Oxidative Phosphorylation Fatty acid oxidation Glutathione Metabolism ROS Detoxification Triacylglycerol Synthesis Fatty acid oxidation, peroxisome Salvage Pathway Heme Degradation Lysine Metabolism Bile Acid Biosynthesis Methionine Metabolism Taurine and hypotaurine metabolism CoA Biosynthesis Carnitine shuttle Fatty acid elongation IMP Biosynthesis Fatty acid activation Tryptophan metabolism Vitamin B6 Metabolism Valine, Leucine, and Isoleucine… Heme Biosynthesis NAD Metabolism Nucleotides Pyrimidine Biosynthesis Steroid Metabolism Citric Acid Cycle Fatty Acid Metabolism Thiamine Metabolism Pentose Phosphate Pathway Cysteine Metabolism R Group Synthesis Glycine, Serine, and Threonine… Fructose and Mannose Metabolism Propanoate Metabolism Pyrimidine Catabolism Miscellaneous Glycolysis/Gluconeogenesis Purine Catabolism Figure S7: Adipose Fold Change 1 Fold Change Analysis in Adipose Tissue - 1 100% 90% 80% 70% 60% 50% 40% 30% 20% 10% Unchanged % Up % Down % 0% Arginine and Proline Metabolism Transport, Peroxisomal Sphingolipid Metabolism Eicosanoid Metabolism Tyrosine metabolism Butanoate Metabolism Glyoxylate and Dicarboxylate… Inositol Phosphate Metabolism Glycerophospholipid Metabolism Transport, Endoplasmic Reticular Urea cycle/amino group metabolism Transport, Mitochondrial Glutamate metabolism beta-Alanine metabolism Vitamin A Metabolism Transport, Lysosomal Pyruvate Metabolism Transport, Nuclear Pentose and Glucuronate… Ascorbate and Aldarate Metabolism Exchanges Transport, Extracellular Alanine and Aspartate Metabolism Cholesterol Metabolism Starch and Sucrose Metabolism Tetrahydrobiopterin Hyaluronan Metabolism Transport, Endoplasmic Reticular Vitamin D N-Glycan Degradation Aminosugar Metabolism Folate Metabolism Galactose metabolism C5-Branched dibasic acid… Biotin Metabolism CYP Metabolism N-Glycan Biosynthesis Riboflavin Metabolism Keratan sulfate degradation Figure S8: Adipose Fold Change 2 Fold Change Analysis in Adipose Tissue - 2 100% 90% 80% 70% 60% 50% 40% 30% 20% 10% Unchanged % Up % Down % 0% Triacylglycerol Synthesis Histidine Metabolism Heme Degradation Bile Acid Biosynthesis N-Glycan Biosynthesis Taurine and hypotaurine metabolism Lysine Metabolism Biotin Metabolism IMP Biosynthesis Cholesterol Metabolism Oxidative Phosphorylation Heme Biosynthesis Eicosanoid Metabolism Salvage Pathway Methionine Metabolism Nucleotides Valine, Leucine, and Isoleucine… Cysteine Metabolism Glycerophospholipid Metabolism Transport, Peroxisomal Inositol Phosphate Metabolism Miscellaneous ROS Detoxification Pentose Phosphate Pathway Transport, Endoplasmic Reticular Glycine, Serine, and Threonine… Transport, Nuclear Steroid Metabolism Fructose and Mannose Metabolism Glycolysis/Gluconeogenesis NAD Metabolism Arginine and Proline Metabolism Sphingolipid Metabolism Alanine and Aspartate Metabolism Glutathione Metabolism Thiamine Metabolism Hyaluronan Metabolism Exchanges Figure S9: Liver Fold Change 1 Fold Change Analysis in Liver Tissue - 1 100% 90% 80% 70% 60% 50% 40% 30% 20% 10% Unchanged % Up % Down % 0% Aminosugar Metabolism Transport, Mitochondrial Tryptophan metabolism Urea cycle/amino group metabolism Ascorbate and Aldarate Metabolism Propanoate Metabolism Galactose metabolism Starch and Sucrose Metabolism Fatty Acid Metabolism Purine Catabolism Tyrosine metabolism Glutamate metabolism Vitamin A Metabolism Fatty acid oxidation Transport, Extracellular Carnitine shuttle Folate Metabolism Fatty acid oxidation, peroxisome Transport, Endoplasmic Reticular Vitamin D N-Glycan Degradation Fatty acid elongation Fatty acid activation R Group Synthesis Glyoxylate and Dicarboxylate… Pentose and Glucuronate… Pyrimidine Catabolism Transport, Lysosomal CYP Metabolism Pyruvate Metabolism Pyrimidine Biosynthesis Vitamin B6 Metabolism Citric Acid Cycle C5-Branched dibasic acid… Butanoate Metabolism Tetrahydrobiopterin Tyr, Phe, Trp Biosynthesis beta-Alanine metabolism Keratan sulfate degradation Figure S10: Liver Fold Change 2 Fold Change Analysis in Liver Tissue - 2 100% 90% 80% 70% 60% 50% 40% 30% 20% 10% Unchanged % Up % Down % 0% Biotin Metabolism beta-Alanine metabolism Steroid Metabolism Glycine, Serine, and Threonine… Glycolysis/Gluconeogenesis Butanoate Metabolism Transport, Endoplasmic Reticular Glycerophospholipid Metabolism Inositol Phosphate Metabolism Pentose Phosphate Pathway Glutathione Metabolism Tryptophan metabolism Transport, Peroxisomal Miscellaneous Nucleotides R Group Synthesis Valine, Leucine, and Isoleucine… Citric Acid Cycle Heme Biosynthesis Fatty acid activation Lysine Metabolism Fatty acid elongation IMP Biosynthesis Carnitine shuttle Taurine and hypotaurine metabolism Bile Acid Biosynthesis Heme Degradation Fatty acid oxidation, peroxisome Pyrimidine Biosynthesis Cholesterol Metabolism Triacylglycerol Synthesis ROS Detoxification Fatty acid oxidation Oxidative Phosphorylation Figure S11: Skeletal Muscle Fold Change 1 Fold Change Analysis in Skeletal Muscle Tissue - 1 100% 90% 80% 70% 60% 50% 40% 30% 20% 10% Unchanged % Up % Down % 0% Glutamate metabolism Cysteine Metabolism Tyrosine metabolism Fructose and Mannose Metabolism Purine Catabolism Sphingolipid Metabolism Ascorbate and Aldarate Metabolism Propanoate Metabolism Urea cycle/amino group metabolism Transport, Nuclear Fatty Acid Metabolism Transport, Mitochondrial Pyrimidine Catabolism Pyruvate Metabolism Exchanges NAD Metabolism Pentose and Glucuronate… Starch and Sucrose Metabolism Transport, Extracellular Aminosugar Metabolism Arginine and Proline Metabolism Folate Metabolism Vitamin A Metabolism Vitamin D Riboflavin Metabolism Thiamine Metabolism Glyoxylate and Dicarboxylate… Alanine and Aspartate Metabolism Galactose metabolism C5-Branched dibasic acid… Vitamin B6 Metabolism Eicosanoid Metabolism Tetrahydrobiopterin Transport, Lysosomal Keratan sulfate degradation Figure S12: Skeletal Muscle Fold Change 2 Skeletal Fold Change Analysis in Muscle Tissue - 2 100% 90% 80% 70% 60% 50% 40% 30% 20% 10% Unchanged % Up % Down % Figure S13: OMIM Gene Deletion Analysis 1 MCL Multi-tissue Model 0.9 Multi-Recon1 Recon1 0.8 Random Selector True Positive Rate 0.7 0.6 0.5 0.4 0.3 0.2 0.1 0 0 0.1 0.2 0.3 0.4 0.5 0.6 False Positive Rate 0.7 0.8 0.9 1 Figure S14: OMIM Gene Deletion Analysis - Closeup 1 MCL Multi-tissue Model 0.9 Multi-Recon1 Recon1 0.8 Random Selector True Positive Rate 0.7 0.6 0.5 0.4 0.3 0.2 0.1 0 0 0.01 0.02 0.03 False Positive Rate 0.04 0.05 Figure S15: Robustness Analysis Model Metabolites Reactions Replicate 1 2800 4559 Replicate 2 2829 4540 Replicate 3 2894 4693 Replicate 4 2805 4531 Replicate 5 2722 4481
Related documents