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Formation and Destruction of Red Blood Cells Process Diagrams Step-by-Step Copyright © 2007 by John Wiley & Sons, Inc. 1 Red blood cell death and phagocytosis Macrophage in spleen, liver, or red bone marrow Key: in blood in bile Globin 2 Heme 1 Red blood cell death and phagocytosis Macrophage in spleen, liver, or red bone marrow Key: in blood in bile 3 Globin Amino acids Reused for protein synthesis 2 Heme 1 Red blood cell death and phagocytosis Macrophage in spleen, liver, or red bone marrow Key: in blood in bile 3 Globin Amino acids Reused for protein synthesis 4 Fe3+ 2 Heme Transferrin 1 Red blood cell death and phagocytosis Macrophage in spleen, liver, or red bone marrow Key: in blood in bile 3 Globin Amino acids Reused for protein synthesis 4 Fe3+ 2 Heme 5 Ferritin Transferrin 1 Red blood cell Liver death and phagocytosis Macrophage in spleen, liver, or red bone marrow Key: in blood in bile 3 Globin Amino acids Reused for protein synthesis 4 Fe3+ 2 Heme 5 Fe3+ Transferrin 6 Ferritin Transferrin 1 Red blood cell Liver death and phagocytosis Macrophage in spleen, liver, or red bone marrow Key: in blood in bile 7 3 Globin Amino acids Reused for protein synthesis 4 Fe3+ 2 Heme 5 Fe3+ Transferrin 6 Fe3+ Ferritin Transferrin 1 Red blood cell death and phagocytosis Macrophage in spleen, liver, or red bone marrow Liver + Globin + Vitamin B12 + Erythopoietin Key: in blood in bile Circulation for about 120 days 7 3 Globin Amino acids Reused for protein synthesis 4 Fe3+ 2 Heme 5 Fe3+ Transferrin 6 Fe3+ Ferritin Transferrin 1 Red blood cell death and phagocytosis Liver + Globin + Vitamin B12 + Erythopoietin 8 Erythropoiesis in red bone marrow Macrophage in spleen, liver, or red bone marrow Key: in blood in bile Circulation for about 120 days 7 3 Amino acids Globin Reused for protein synthesis 4 Fe3+ 2 Heme 5 Fe3+ Transferrin 6 Fe3+ Ferritin Transferrin 9 1 Red blood cell Biliverdin death and phagocytosis Bilirubin Liver + Globin + Vitamin B12 + Erythopoietin 8 Erythropoiesis in red bone marrow Macrophage in spleen, liver, or red bone marrow Key: in blood in bile Circulation for about 120 days 7 3 Amino acids Globin Reused for protein synthesis 4 Fe3+ 2 Heme 5 Fe3+ Transferrin 6 Fe3+ Ferritin Transferrin Bilirubin 9 1 Red blood cell Biliverdin death and phagocytosis Liver Bilirubin 10 + Globin + Vitamin B12 + Erythopoietin 8 Erythropoiesis in red bone marrow Macrophage in spleen, liver, or red bone marrow Key: in blood in bile Circulation for about 120 days 7 3 Amino acids Globin Reused for protein synthesis 4 6 5 Fe3+ Fe3+ Transferrin 2 Heme Fe3+ Ferritin Transferrin Bilirubin 9 1 Red blood cell Biliverdin Bilirubin 11 10 death and phagocytosis Small intestine 12 Macrophage in spleen, liver, or red bone marrow Liver Bilirubin Urobilinogen Stercobilin + Globin + Vitamin B12 + Erythopoietin 8 Erythropoiesis in red bone marrow Bacteria Key: in blood in bile Feces Circulation for about 120 days 7 3 Reused for protein synthesis Amino acids Globin 4 6 5 Fe3+ Fe3+ Transferrin 2 Heme Fe3+ Ferritin Transferrin Bilirubin 9 1 Red blood cell Biliverdin Bilirubin 11 10 death and phagocytosis Small intestine Kidney 13 12 Urobilin Macrophage in spleen, liver, or red bone marrow Liver Bilirubin Urobilinogen Stercobilin + Globin + Vitamin B12 + Erythopoietin 8 Erythropoiesis in red bone marrow Bacteria Key: in blood in bile Urine Feces Circulation for about 120 days 7 3 Reused for protein synthesis Amino acids Globin 4 6 5 Fe3+ Fe3+ Transferrin 2 Heme Fe3+ Ferritin Transferrin Bilirubin 9 1 Red blood cell Biliverdin Bilirubin 11 10 death and phagocytosis Small intestine Kidney 13 12 Urobilin Macrophage in spleen, liver, or red bone marrow Bilirubin Urobilinogen Stercobilin Urine Liver Feces + Globin + Vitamin B12 + Erythopoietin 8 Erythropoiesis in red bone marrow Bacteria Key: in blood Large 14 intestine in bile
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