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BCH 443 Biochemistry of Specialized Tissues 8. Liver & Integration of Metabolism Well-Fed Conditions Glycolysis Glycogenesis Well-Fed Liver Pentose Shunt Cholesterol Synthesis Triglyceride Synthesis Fatty Acid Synthesis Glycolysis Pentose Shunt Cholesterol Synthesis Triglyceride Synthesis Well-Fed Adipose Fatty Acid Synthesis Glycogenesis Well-Fed Muscle Well-Fed State Brain Pancreas Gut Insulin Glycogen Glucose aa Portal Vein CO2 + H2O Glucose aa Liver Urea Adipose CO2 + H2O Protein Chylomicrons Pyruvate TG TG Lymphatics VLDL CO2 + H2O Lactate Glycogen Muscle Lactate RBC Fasting Conditions Fasting Liver Gluconeogenesis Glycogenolysis Ketone Body Synthesis Fatty Acid Oxidation No Uptake Fasting Adipose Triglyceride Breakdown Fatty Acid Oxidation No Uptake Fasting Muscle Ketone Body Utilization Fatty Acid Oxidation Early Fasting State Brain Pancreas Gut Glucagon Glycogen Portal Vein CO2 + H2O Glucose Adipose Liver FA Pyruvate FA CO2 + H2O CO2 + H2O Lymphatics Lactate Muscle Lactate RBC Extended Fasting State Brain Pancreas Gut Glucagon CO2 + H2O Glucose Portal Vein KB Urea Glycerol FA Liver Pyruvate Adipose FA CO2 + H2O CO2 + H2O Lymphatics aa Protein Lactate Cortisol RBC Muscle Well-Fed State Brain Pancreas Gut Insulin Glycogen Glucose aa Portal Vein CO2 + H2O Glucose aa Liver Urea Adipose CO2 + H2O Protein Chylomicrons Pyruvate TG TG Lymphatics VLDL CO2 + H2O Lactate Glycogen Muscle Lactate RBC Extended Fasting State Brain Pancreas Gut Glucagon CO2 + H2O Glucose Portal Vein KB Urea Glycerol FA Liver Pyruvate Adipose FA CO2 + H2O CO2 + H2O Lymphatics aa Protein Lactate Cortisol RBC Muscle Useful Endocrine & Metabolism Link http://arbl.cvmbs.colostate.edu/hbooks
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