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Transcript 
Environmental signal integration
by a modular AND gate
J Christopher Anderson, Christopher A Voigt and Adam P Arkin
Molecular Systems Biology (2007) 3:133
AND gate
INPUT
OUTPUT
A
B
A AND B
0
0
0
0
1
0
1
0
0
1
1
1
Amber stop codon
Nonsense mutation = point mutation in DNA
sequence resulting in premature stop
codon or nonsense codon in transcribed
mRNA -> truncated/non-functional protein
product.
Supressor = tRNA that can “read” nonsense
codon and cause appropriate amino acid
to be incorporated into peptide sequence.
Functionality
Mathematical model
Modularity
Concluding remarks
Independent promoters detecting different
aspects of the environment (O2, pH, cell
density, lactate, glucose) could be integrated
to sense a specific environment.
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