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Transcript 
CELLULAR RESPIRATION
Walsh Ingraham battle iron man
http://www.youtube.com/watch?v=MTn1v5TGK_w
Glycolysis
http://highered.mcgrawhill.com/sites/00725074
70/student_view0/chapt
er25/animation__how_gl
ycolysis_works.html
CELLULAR RESPIRATION AS A
REDOX REACTION
loses e-
gains e-
+
oxidized
+
oxidation
reduced
+
–
H
reduction
H
C6H12O6 +
6O2
 6CO2 + 6H2O + ATP
Cellular Respiration
ANAEROBIC
A. Glycolysis:
AEROBIC
B. Pyruvate Oxidation & Citric Acid Cycle (Kreb Cycle)
C. Oxidative Phosphorylation
Cellular Respiration
Stage 1:
Glycolysis
2007-2008
CH2OH
O
Glucose
1
hexokinase
ATP
ADP
CH2
O
O
P
Glucose 6-phosphate
2
phosphoglucose
isomerase
CH2 O
O
P
CH2
CH2
CH2OH
Fructose 6-phosphate
3
phosphofructokinase
ATP
P O
ADP
O
Fructose 1,6-bisphosphate
P
aldolase
4,5
isomerase
O CH2
C
O
CH2OH
1st
NAD+
Dihydroxyacetone
phosphate
H
C
Glyceraldehyde 3
-phosphate (G3P)
Pi
CHOH
CH2 O
NAD+
Glucose Priming
NADH
Pi
6
glyceraldehyde
3-phosphate
dehydrogenase
1,3-Bisphosphoglycerate
(BPG)
NADH
1,3-Bisphosphoglycerate
(BPG)
O
P
O
P
O
CHOH
CH2 O
P
O
P
2nd Cleavage
P O
CH2
ADP
CH2
O
4,5
Fructose 1,6-bisphosphate
aldolase
H
P
O CH2
isomerase
C
C
O Dihydroxyacetone
phosphate
Glyceraldehyde 3
-phosphate (G3P)
O
CHOH
CH2OH
CH2 O
NAD+
Pi
6
Pi
NAD+
P
O
P
Energy Harvest (5 reactions)
G3P
C-C-C-P
NAD+
Pi
Pi
6
NAD+
NADH
NADH
7
phosphoglycerate
kinase
ADP
ATP
ADP
ATP
3-Phosphoglycerate
(3PG)
3-Phosphoglycerate
(3PG)
8
phosphoglyceromutase
2-Phosphoglycerate
(2PG)
Phosphoenolpyruvate
(PEP)
ADP
Payola!
Finally some
ATP!
O P
C O
H C O
CH2OH
P
OH2O
Phosphoenolpyruvate
(PEP)
10
pyruvate kinase
ADP
ATP
Pyruvate
C
C
O
O
CH2
OC
ATP
Pyruvate
CHOH
CH2
O-
2-Phosphoglycerate
(2PG)
9
enolase
H2O
OC
O
C O
CH3
P
Glycolysis summary
ENERGY INVESTMENT
-2 ATP
ENERGY PAYOFF
G3P
C-C-C-P
4 ATP
like $$
in the
bank
NET YIELD
Energy Transformations in
Glycolysis
Glycolysis
• Breaking down glucose
glucose      pyruvate
2x 3C
6C
That’s not enough
ATP for me!
In the
cytosol?
Why does
that make
evolutionary
sense?
Evolutionary perspective
• Prokaryotes
• Anaerobic atmosphere
• Prokaryotes that evolved glycolysis are ancestors
of all modern life
– ALL cells still utilize glycolysis
You mean
we’re related?
Do I have to invite
them over for
the holidays?
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