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Transcript 
PROTEIN PHYSICS
LECTURE 10
Protein chain:
gene-encoded
sequence of side-chains,
regular main-chain
Gly
symmetric
ALL THE OTHER: ASYMMETRIC BACKBONE
Ala _L_
Ala -D-
Two amino acids have asymmetric side chains:
THR
ILE
Chemical S-S bond
of two CYS side chains:
non-polar: core
polar: surface
non_polar: in the core
polar: at the surface
no Cb: coil
Сb, 1 : , b, coil
Сb, 2 : b
imino: coil, turn
Pro
imino: coil, turn
1,2,3 rot.
no Сb: coil
Сb, 1 : , b, coil
Сb, 2 : b
charged : coil,
_N
charged +: coil,
_C
Half-charged:
active sites
Pcharged + Puncharged = 1
Pcharged / Puncharged
Pcharged / Puncharged
= 10(pKa – pH)
= 10+(pKa – pH)
Acids (charge )
Bases (charge +)
pKa
pKa
|
|
|
|
|
|

Half-charged: active sites
charged : coil, _N
charged +: coil, _C

Half-charged: active sites
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