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Case Study 1
Gleevec
Imatinib, Gleevec ™
• ABL1 is the tyrosine kinase that is “locked” in
active state causing replication
• Gleevec binds to its active site
• Makes the cell stop proliferating
http://en.wikipedia.org/wiki/File:Mechanism_i
matinib.svg
Gleevec Structure
http://en.wikipedia.org/wiki/File:Imatinib.svg
ABL1 structure
• http://www.rcsb.org/pdb/explore/explore.do?
structureId=1opl
• http://www.ncbi.nlm.nih.gov/Structure/cdd/c
ddsrv.cgi?uid=173633
Which amino acids are in the active
site?
The active site
Goal: Put Gleevec in the active site and draw the bonds
it makes
Gleevec in Binding Site
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