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Filtration capillaries Barrier Fenestrated Permeable (capillaries to substances < 100 nm with windows) nucleus endothelial cell fenestration basal lamina [email protected] podocyte slit pore mesangial cells [email protected] [email protected] Water Limited Permeable permeability Not Freely permeable permeable to to to albumin molecules large small molecules molecules 60000 Da between 7000 >Da 70000 Da mwt mwt >>70000 <mwt 7000 Da completely - 4diameter nm > diameter diameter ><84nm nm>-8-nm excluded… because of –ve charge endothelial cell fenestration basal lamina (basement membrane) -podocyte slit pore - - - + acids glucose amino Na [email protected] [email protected] Bowman’s Capsule Bowman’s Space Proximal Tubule [email protected]
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