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The DNA-binding helix-turn-helix motif. The motif is shown in (A), where each white circle denotes the central carbon of an amino acid. The carboxyl-terminal a helix (red) is called the recognition helix because it participates in sequence-specific recognition of DNA. As shown in (B), this helix fits into the major groove of DNA, where it contacts the edges of the base pairs. From Molecular Biology of the Cell. 3rd ed. Alberts, Bruce; Bray, Dennis; Lewis, Julian; Raff, Martin; Roberts, Keith; Watson, James D. New York and London: Garland Publishing; c1994. From http://www.biologie.uni-hamburg.de/lehre/mikro/mikro402/mi4_711i.jpg Homeodomain-DNA Complex