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Prodigiosin Synthesis UV-induced “Colorless” Mutants of Serratia marcescens The Normal Pathway to Prodigiosin alanine amino acids proline enzyme x MAP(g) Prodigiosin enzyme z enzyme y O MBC(ws) N H N H N Serratia marcescens D1 (wild type) (DNA is not mutated for any of the genes) ALA amino acids PRO enzyme x MAP(g) enzyme z enzyme y MBC(ws) Prodigiosin Serratia marcescens D1 (wild type) (DNA is not mutated for any of the genes) ala amino acids pro enzyme x MAP(g) enzyme z enzyme y MBC(ws) Prodigiosin Serratia marcescens D1 (wild type) (DNA is not mutated for any of the genes) ala amino acids pro enzyme x MAP(g) enzyme z enzyme y MBC(ws) Prodigiosin Serratia marcescens ( ) (DNA is mutated in enzyme x gene) ala amino acids pro enzyme x MAP(g) enzyme z enzyme y MBC(ws) Prodigiosin Serratia marcescens ( ) (DNA is mutated in enzyme x gene) ALA amino acids PRO enzyme x MAP(g) enzyme z enzyme y MBC(ws) Prodigiosin Serratia marcescens ( ) (DNA is mutated in enzyme x gene) ALA amino acids pro enzyme x MAP(g) enzyme z enzyme y MBC(ws) Prodigiosin Serratia marcescens ( ) (DNA is mutated in enzyme x gene) ALA amino acids pro ala amino acids pro enzyme x MAP(g) enzyme z enzyme y enzyme x MBC(ws) MAP(g) enzyme z enzyme y Prodigiosin Prodigiosin MBC(ws) Serratia marcescens ( (DNA is mutated in enzyme y gene) ) Serratia marcescens ( ) (DNA is mutated in enzyme x gene) ALA amino acids pro ALA amino acids PRO enzyme x MAP(g) enzyme z enzyme y enzyme x MBC(ws) MAP(g) enzyme z enzyme y Prodigiosin Prodigiosin MBC(ws) Serratia marcescens ( (DNA is mutated in enzyme y gene) ) Serratia marcescens ( ) (DNA is mutated in enzyme x gene) ALA amino acids pro ala amino acids PRO enzyme x MAP(g) enzyme z enzyme y MBC(ws) enzyme x MAP(g) enzyme z enzyme y Prodigiosin Prodigiosin MBC(ws) Serratia marcescens ( (DNA is mutated in enzyme y gene) ) Serratia marcescens ( ) (DNA is mutated in enzyme x gene) ALA amino acids pro ala amino acids PRO enzyme x MAP(g) enzyme z enzyme y MBC(ws) enzyme x MAP(g) 933 enzyme z enzyme y Prodigiosin WCF Prodigiosin MBC(ws) Serratia marcescens ( (DNA is mutated in enzyme y gene) ) Serratia marcescens (933) (DNA is mutated in enzyme x gene) ALA amino acids pro ala amino acids PRO enzyme x MAP MAP(g)(g) enzyme z enzyme y MBC(ws) enzyme x MAP(g) Prodigiosin Prodigiosin 933 MAP(g) enzyme z enzyme y WCF Prodigiosin MBC(ws) Serratia marcescens (WCF) (DNA is mutated in enzyme y gene) Serratia marcescens (933) (DNA is mutated in enzyme x gene) ALA amino acids pro enzyme x MAP(g) Prodigiosin enzyme z enzyme y MBC(ws) 933 WCF MBC(ws) ala amino acids PRO enzyme x MAP(g) enzyme z enzyme y Prodigiosin Prodigiosin MBC(ws)(ws) MBC Serratia marcescens (WCF) (DNA is mutated in enzyme y gene) Serratia marcescens D1 (wild type) (DNA is not mutated for any of the genes) ala MAP(g) enzyme x amino Prodigiosin enzyme z acids MBC(ws) pro enzyme y Why is D1 (so capable!) such a poor donor to either mutant… D1 933 D1 WCF MAP(g) MBC(ws) 933 WCF MAP(g) MBC(ws) …compared to cross-feeding from either mutant?
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