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Transcript 
Immunoglobulins.
Immunoglobulins.
-globulins
not globins
Immunoglobulins.
-globulins:
any of a class of simple
proteins that are insoluble in pure water but
are soluble in dilute salt solutions…
not globins:
a colorless protein derived
by removal of a heme from a conjugated
protein
ABSTRACT antibody
Early history…
The molecule:
The molecule:
Put proteins in space…
Put immunoglobulins in space
Put immunoglobulins in two dimensions
Put immunoglobulins in space
Put immunoglobulins in space
Ribbon model…
Put immunoglobulins in space
Space filling model…
Put immunoglobulins in space
Domain model…
Amino acid composition of CDR’s
Put immunoglobulins in space
A bread and butter sandwich held together with a toothpick
Wu-Kabat plot:
Wu-Kabat plot:
Examples:
The lowest ratio:
Wu-Kabat index =
1 =
The highest ratio:
Wu-Kabat index =
400 = 20/0.05
A characteristic ratio for a CDR:
Wu-Kabat index =
=
50 = 10/0.2
80 = 12/0.15
1/1
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