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Synthesis and Characterization of a Magnetically
Responsive Polymeric Drug Delivery System
S. Yu and G. M. Chow
Abstract—A magnetic target drug delivery system consisting
of biodegradable polymeric microspheres (poly D, L-lactic
acid) loaded with magnetite nanoparticles (10-100 nm) and
anticancer drug (paclitaxel) was studied. The magnetite
nanoparticles were synthesized by chemical precipitation.
The
as-synthesized
magnetite
nanoparticles
were
subsequently introduced into a mixture of polymer magnetic
polymeric composite particles were investigated and further
correlated with the reaction parameters. It was found that
the size and characteristics of the polymeric composite
particles depended on the viscosity of the polymer solution.
Preliminary drug release experiments showed that the
loaded drug was released with the degradation of the
polymer. The release rates could be enhanced by an
oscillating external magnetic field.
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