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Contents
11
CHAPTER 1
Introduction
23
CHAPTER 2
Reliable New High-Performance Liquid Chromatographic Method
for the Determination of Ciprofloxacin in Human Serum
Ther Drug Monit 2006; 28(2): 278-281
29
CHAPTER 3
Ciprofloxacin pharmacokinetics in critically ill patients:
a prospective cohort study
Accepted for publication J Crit Care 2008
45
CHAPTER 4
Pharmacokinetics of cefotaxime during continuous and intermittent
infusion in critically ill patients
Submitted for publication
59
CHAPTER 5
Continuous versus intermittent administration of cefotaxim in patients
with chronic obstructive pulmonary disease and respiratory tract infections: Pharmacokinetics, bacterial susceptibility and clinical efficacy
Br J Clin Pharm 2007; 63(1): 100-109
75
CHAPTER 6
Importance of non-drug costs of intravenous antibiotic therapy
Crit Care 2003; 7(6):R184-R190
9
Infectious complications in critically ill patients
87
CHAPTER 7
Hospital-acquired sinusitis is a common cause of fever of unknown
origin in orotracheally intubated critically ill patients
Crit Care 2005; 5;(9):R583-590
99
CHAPTER 8
Rational use of antibiotics in the ICU: Optimum efficacy
for the lowest costs
In: Yearbook of Intensive Care and Emergency Medicine 2005,
Springer-Verlag, Berlin, Ed. J.L. Vincent. pp: 337-348
113
CHAPTER 9
Addendum :
Organisational Aspects of Intensive Care in the Netherlands
ICU Management 2005; 3:60-61
119
CHAPTER 10
Summary, general conclusions and future perspectives
127
CHAPTER 11
Samenvatting, algemene conclusies en toekomst (synopsis in Dutch)
137
CHAPTER 12
Dankwoord (epilogue in Dutch)
143
CHAPTER 13
Curriculum vitae (in Dutch)
145
CHAPTER 14
List of publications
153
CHAPTER 15
List of abbreviations
10