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Contents
Chapter 1:
General introduction
Chapter 2:
Genetic polymorphism of glutathione S-transferases associated
with idiosyncratic adverse drug events
49
Chapter 3:
Role of human glutathione S-transferases in the inactivation
of reactive metabolites of clozapine
97
Chapter 4:
The effect of glutathione S-transferases on the formation
of glutathione conjugates of diclofenac
119
Chapter 5:
Effect of human glutathione S-transferase hGSTP1-1
polymorphism in the detoxification of reactive metabolites of drugs
141
Chapter 6:
Role of residue 87 in the activity and regioselectivity
of clozapine metabolism by drug-metabolizing
CYP102A1 M11H: application for structural characterization
of clozapine GSH conjugates.
161
Chapter 7:
Characterization of human cytochrome P450s involved in
the bioactivation of clozapine.
185
Chapter 8:
Interindividual variability in clozapine metabolites in patient
urine and precision-cut human liver slices: Identification of
GSH-related metabolites and role of genetic polymorphism
of human glutathione S-transferase
207
Chapter 9:
Summary, conclusions and perspectives
231
Appendices:
Nederlandse samenvatting
List of abbreviations
List of publications
Curriculum Vitae
Dankwoord
9
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