Download visualization in biology

VISUALIZATION IN BIOLOGY
Rama Viswanathan
Professor of Chemistry and Computer Science
(At Beloit College since 1983)
• CHEMISTRY: StructureFunction
• BIOLOGY:
Structure FunctionSequenceCell
CACHE (FUJITSU)
COMPUTATIONAL CHEMISTRY PACKAGE
(a) Molecule Structure Editor
(b) 3-D Visualization
(c) “Computation” of best/equilibrium structures
(d) Applications in Biology
• Mycobacterium tubercolosis nucleoside
phosphorylase (TB-PNP) COMPLEXED
with transition state analague Immucillin-H
(ImmH) and phosphate
• Q) Why study?
• A) Rational drug designSelective
Inhibitor
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Import and view structure from PDB
“Clean up”
Analyze protein-ligand interactions
Import,modify, screen potential ligands
“Dock” ligands into the protein active site
Structure-Activity analysis
GRAPHICAL VISUALIZATION
IN
SYSTEMS BIOLOGY
• Metabolic and Regulatory Pathways
• CONNECTIVITY
• EXCEL FRONT END to sophisticated
software for graphical layout: TOM
SAWYER