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UpToDate’s Value Proposition UpToDate synthesizes the most recent medical information into evidence-based, practical recommendations clinicians trust to make the right point-of-care decisions. Easy to Use Relevant Content World-renowned Authors UpToDate Facts-at-a-Glance • 9,000+ topics in 18 specialties • Additional 5,000+ unique drug entries • 700+ patient information topics • 4,800+ physician authors, editors and peer reviewers • 7,700+ graded recommendations • 450,000+ users in 149 countries Specialties Covered in UpToDate Adult and Pediatric Emergency Medicine Infectious Diseases Adult Primary Care and Internal Medicine Nephrology and Hypertension Allergy and Immunology Neurology Cardiovascular Medicine Obstetrics, Gynecology and Women’s Health Dermatology* Oncology Endocrinology and Diabetes Pediatrics Family Medicine Psychiatry* Gastroenterology and Hepatology Pulmonary, Critical Care and Sleep Medicine Geriatrics Rheumatology Hematology Surgery* Hospital Medicine *In development UpToDate Is Trusted Worldwide UpToDate has users in 149 countries UpToDate’s Editorial Process • Authored and edited by leading physicians • World-renowned expertise • Hand-searching of 460+ journals • Three-tiered peer review process UpToDate’s Editorial Process Our authors collaborate with multiple specialty editors to create or update the topic. New clinical studies are released that impact care. Topic is available to clinicians worldwide via UpToDate. The topic is peer-reviewed. UpToDate Editorial Process Final topic content consensus is reached. A grading editor reviews the graded recommendations. Graded Recommendations Grades denote strength of recommendation and quality of evidence • Strong recommendation = Grade 1 • Weak recommendation = Grade 2 • Evidence = Grade A, B or C [ “We recommend” ] [ “We suggest” ] [ High, moderate or low quality ] Graded Recommendations Hierarchy of Evidence High - Quality Meta-analyses of randomized trials of high methodological quality Randomized trials with methodological limitations Low - Quality Observational studies Unsystematic clinical observations Users Say UpToDate Improves Care 94% improves quality of care 89% changed management 81% changed diagnostic testing 0% Source: UpToDate Subscriber Survey, 2010 20% 40% 60% 80% 100% Medical Professionals Endorse UpToDate UpToDate “changes the way you practice medicine — really.” Pam Wetzel, MD Chief Medical Information Officer Swedish American Hospital, Rockford, IL Medical Professionals Endorse UpToDate UpToDate “applicability to patients is in evidence every day.” Marc Greenwald, MD Chief of Medicine Signature Healthcare-Brockton Hospital, Brockton, MA Medical Professionals Endorse UpToDate “UpToDate is …a new way of practicing medicine … for day-to-day practice there is no other product.” R.M. Valentijn, MDMDHAGA Hospital, the Hague, the Netherlands