Download Sean McDonnell (Informa Healthcare)

SLA Spring Meeting – 8th April 2008
St Petersburg, Florida
Sean McDonnell
[email protected]
212-520-2786
Introduction
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Global R&D pipeline database in development since 1980
41,000+ full drug profiles (9144 active)
3100+ private and public company profiles
218 detailed therapy profiles
1645 Searchable targets and target families
16,000+ complete chemical structures
34 Full-time Pharmaprojects scientific editors (based in Europe,
US and India)
Over 200 contributing editors
Information Sources
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News feeds and Press Releases
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Company Web sites, fact sheets & Annual reports
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Meetings abstracts (covered 140+ medical & investor meetings in 2007)
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Editorial contacts within companies - 6039 drugs (15%) have direct
communication data in profile
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Other Informa products – Scrip, TrialTrove, Clinica, Datamonitor
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Online resources – EntrezGene, PubMed, Espacenet, FDA
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Peer reviewed journals
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FDA and SEC filings
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Published Trials Results
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Public trials registries (clinicaltrials.gov, cancer.gov)
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Company Conference calls with analysts
Unique Features
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Functionality and specificity
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Established reputation for high quality information
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75 fields of searchable and exportable data
28 years of R&D data collection
Innovative and original content
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Trend Analysis – Annual data from 1995 to 2008, which can be
searched to see how R&D patterns are shifting.
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Pharmaprojects Rating system –Internal benchmarking program
Target Families - Grouping together protein targets by activity
More than just a database…
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Fully customised and consultative training programme
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Complete access to all Pharmaprojects scientific editors
75 fields…
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Generic Name, Synonyms, Active Ceased or Fully Launched, Accession Number,
Detailed Information, Clinical Information, Clinical References, World Status, Originator,
Originator Country, Originator Status, Licensee, Licensee Country, Licensee Status,
Primary Therapy Code, Primary Therapy Description, Primary Therapy Status, Any
Therapy Code, Any Therapy Description, Any Therapy Status, Link Pharmacology Code,
Primary Pharmacology Code, Primary Pharmacology Description, Any Pharmacology
Code, Any Pharmacology Description, Link Therapy Code, Primary Indication, Primary
Indication Status, Any Indication, Any Indication Status, Primary ROA Code, Primary
ROA Description, Any ROA Code, Any ROA Description, Target
Family>Group>Subgroup, EC Number(s), Primary Target Name, Primary
LocusLink/Entrez Gene ID, Any Target Name, Any LocusLink/ Entrez Gene ID, Origin of
Material Code, Origin of Material Description, CAS Number, Rotatable Bonds,
Hydrogen Bond Acceptors, Hydrogen Bond Donors, AlogP, Molecular Weight, Chemical
Name, Chemical Structure, New Chemical Entity, Patent Country, Patent Number,
Patent Priority Country, Patent Priority Date, Country Status, Country Name, Licensing
Opportunity, Novelty Rating, Novelty Rating Description, Market Size Rating, Market
Size Rating Description, Speed Rating, Speed Rating Description, Total Rating, Major
Event, Major Event Details, Major Event Date, Act/Est, Last Updated On, Updated By,
Latest Change
Powerful analytical Interface
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Searching
 Ability to create both simple and complex Boolean logic
searches
 Access to previously saved searches
 Wildcard, proximity and free text searching
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Exporting:
 Fully customized report tables (HTML, Excel, BizInt, SDF)
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Full drug, company and therapy profiles (MS Word, Rich text, HTML)
Graphs and charts
Import/export chemical structures for exact, sub-structure &
‘similarity’ searching (Chemdraw, CAS,CXF, ISIS, MDL, SMD, SMILES)
Innovative and Original Content
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Trend Analysis
 Annual snapshot of Pharmaprojects data, inc; company
pipelines, therapies, country status & mechanism of action
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Pharmaprojects Ratings system
 Internal ratings system designed to predict blockbuster
compounds of the future, using 3 key criteria:
• Market -based on the reported worldwide sales (in US$ million) for its
primary therapeutic category.
• Novelty -uses Pharmaprojects' pharmacological classification system
in combination with the therapeutic classification to identify which new
drug development strategies are the most advanced.
• Speed – Uses calculated averages to benchmark the speed in which a
compound moves through the development stages and determine it’s
progress.
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Compounds are then rated 1-15 based on this information
Target Searching
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There are 1645 unique protein targets (1514 human)
719 correspond directly to pharmacologies
44% of all PP records have ‘real’ targets (i.e. not unspecified/NA etc)
Full links from all drug records to Entrez Gene database
Links to Entrez Gene
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Drug target database developed by NCBI
Collates data on genes and proteins from many reputable sources,
including GenBank, SwissProt, Unigene, OMIM and PubMed
These profiles describe target properties and contain a large number
of useful links, including sequence links, OMIM for detailed
background information, PubMed references, Gene Ontology
classes and KEGG pathways
Target Families
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Classified all drug protein targets into 6 main categories, based on
general activity.
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Cytokine/Growth factor
Enzyme
Ion channel
Peptide hormone
Receptor
Transporter
It is then possible to ‘drill down’ by a further 3 levels of specific target activity.
Example:
(Parent) Receptor
> (Child) GPCR
> (Grandchild) Angiotensin
> (Target) angiotensin II receptor, type 1
> (Target) angiotensin II receptor, type 2
Links to Scrip
Scrip World Pharmaceutical News is a news service, which
delivers an unrivalled range of pharma market intelligence.
• Pharmaprojects analysts access Scrip Daily News Online stories on a daily basis in
order to update information appearing in Pharmaprojects drug profiles.
• For all articles published since January 2001, Pharmaprojects provides links from the
Scrip Daily Online references given in the Pharmaprojects drug profile to the full news
story from Scrip Pharmaceutical News – completely free of charge.
• In clicking the Scrip hyperlink, the full
text article will be displayed.
Links to Pubmed
PubMed is a service of the U.S. National Library of Medicine that includes over 17 million
citations from MEDLINE and other life science journals for biomedical articles back to the
1950s. PubMed includes links to full text articles and other related resources.
• Our editors review new PubMed citations
on a daily basis and with each item of data
sourced, we provide a hyperlink to the
relevant article.
• In PubMed you can access more
bibliographic information by using the list
of further links to related articles, and
access a range of background
information.
•We have added more than 1,000
PubMed links to Pharmaprojects already,
and are increasing this number weekly.
More than just a database...
Pharmaprojects is more than just a database - we provide a research service, offering
immediate access to our team of scientific analysts in both the UK and the US to
schedule bespoke training and offer research and search assistance as required.
• The background and contact
details of each of our scientific
analysts can be found on our
website’s meet the team page.
• Clients can simply call or email
our editors at any time to get
search assistance or to schedule
training.
• We offer both introductory and
ongoing training with editors in
London or New York, to suit our
client’s time zone’s.
• Clients can also contact the editor
responsible for a specific update by
clicking the hyperlink to the editor’s
initials, located in every drug profile.
Pharmaprojects Website
Pharmaprojects launches new web site with free
news and analysis for the pharmaceutical industry
• excellent portal for both subscribers and nonsubscribers, offering access to detailed company
and therapy analyses and pharmaceutical news
articles, written frequently by our team of
scientific analysts.
• Read reports from various
scientific and partnering
conferences around the world.
 Offers a quick and easy way to
access search tips, technical
support, or to arrange training with
one of our scientific analysts.
To keep visitors up-to-date with the
latest cutting-edge research, there
are also short articles on the most
recently-identified drug protein
targets and emerging start-up
pharma companies.
TrialTrove
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Informa Healthcare purchased the
Citeline business in November 2006.
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TrialTrove is Citeline’s flagship
product and is the leading source for
real-time clinical trials intelligence.
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Enterprise-wide system
Over 70,000 trial records
Real time updates
Watch lists
Analyst research requests
TrialTrove’s Additional Sources
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Information not from obvious sources that gives you
an edge:
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Patient Recruitment Channels
• research center and community hospital
web sites
Clinical Research Administration
• University protocol/IRB approval lists and
grant awards lists
• Investigator CV’s
• CRO project listings
Primary Research
13,000+ unique cited Web sources in TrialTrove today!
Trialtrove &Pharmaprojects
collaboration
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Shared editorial practices, sources and company contacts.
Synchronized databases to fill in data gaps and add missing drugs
Standardised field definitions and mechanism of action descriptions.
And the initial impact of this on Pharmaprojects?...
 More efficient and timely editorial updates
 A 20% increase in the number of active products since 2007
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9021
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6830
7193
7181
7322
7684
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0
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2005
2006
2007
2008
No of active drugs
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And the development of our new product - Pipeline…
Pipeline
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This new service launched in January 2008
Enterprise wide access
Pharmaprojects data combined with the functionality,
ease of use and unlimited client service enjoyed by
TrialTrove customers
Over the coming months we will be in contact with our
customers to present this service in detail
For further information…
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[email protected] 212-520-2786