Download Influence of Lactose Concentration on the Release of Diclofenac

ABSTRACT
Influence of Lactose Concentration on the Release of Diclofenac
Sodium Formulated in Sustained Release Tablet with
Ethylcellulose 10 cps as a Matrix
Oki Yudiswara
The purpose ofthis research was to determine concentration of lactose that
can produce sustained release tablet of diclofenac sodium with ethylcellulose 10
cps as a matrix, with physical quality that appropriate to the regulations, with drug
release condition of sustained release, with higher total release and achieve a zero
order release.
Ethylcellulose matrix tablet of diclofenac sodium using lactose as a
channeling agent were prepared by wet granulation process. The paddle method
was selected to perform the dissolution profiles carried out in 900 ml phosphate
buffer pH 6.8.
There was significant difference in drug release diclofenac sodium from
matrix tablet when lactose concentration was modified from 20% to 25% and
30%. But there was no significant difference in drug release diclofenac sodium
from matrix tablet when lactose concentration was modified from 25% to 30%.
Release of diclofenac sodium from the matrix that contain lactose as a channeling
agent was increase because lactose was easily dissolve that can increase porosity
of matrix resulting in higher release of drug.
The best-fit release kinetic was achieved with Higuchi's model in all
formula. The release mechanism for formula 2, 3 and 4 was achieve with diffusion
non-Fickian.
Keywords: Channeling agent, diclofenac sodium, ethylcellulose 10 cps, lactose,
sustained release