Survey
* Your assessment is very important for improving the work of artificial intelligence, which forms the content of this project
Download Chapter 16 Cholinesterase Inhibitors
Document related concepts
no text concepts found
Transcript
Chapter 98 Antiprotozoal Drugs II: Miscellaneous Agents Elsevier Inc. items and derived items © 2010 by Saunders, an imprint of Elsevier Inc. Protozoal Infections Increasing world travel by Americans Increased immigration from regions of high infection rates Increase of protozoal infections in the U.S. Most frequent Entamoeba histolytica Trichomonas vaginalis Giardia lamblia Elsevier Inc. items and derived items © 2010 by Saunders, an imprint of Elsevier Inc. 2 Elsevier Inc. items and derived items © 2010 by Saunders, an imprint of Elsevier Inc. 3 Protozoal Infections Amebiasis Giardiasis Leishmaniasis Pneumocystis carinii pneumonia Toxoplasmosis Trichomoniasis American trypanosomiasis (Chagas’ disease) African trypanosomiasis (sleeping sickness) Elsevier Inc. items and derived items © 2010 by Saunders, an imprint of Elsevier Inc. 4 Principal Protozoal Infections in the United States Trichomoniasis Giardiasis Metronidazole drug of choice Metronidazole drug of choice Amebiasis Symptomatic or asymptomatic – metronidazole is drug of choice Elsevier Inc. items and derived items © 2010 by Saunders, an imprint of Elsevier Inc. 5 Drugs of Choice for Protozoal Infections Iodoquinol Metronidazole Tinidazole Benznidazole Nitazoxanide Pentamidine Elsevier Inc. items and derived items © 2010 by Saunders, an imprint of Elsevier Inc. 6 Drugs of Choice for Protozoal Infections Suramin Melarsoprol Eflornithine Pyrimethamine Sodium stibogluconate Miltefosine Nifurtimox Elsevier Inc. items and derived items © 2010 by Saunders, an imprint of Elsevier Inc. 7 Drugs of Choice for Protozoal Infections Metronidazole (Flagyl, Protostat) Active against several species Drug of choice for symptomatic intestinal amebiasis and systemic amebiasis Adverse effects • Nausea, headache, dry mouth, unpleasant metallic taste, and harmless darkening of urine • If combined with alcohol, may have disulfiram-like actions Elsevier Inc. items and derived items © 2010 by Saunders, an imprint of Elsevier Inc. 8 Drugs of Choice for Protozoal Infections Suramin Adverse effects • GI effects • Itching, rash • Photophobia Melarsoprol Adverse effects • Toxic • Hypertension • Neuropathy • Myocardial damage Elsevier Inc. items and derived items © 2010 by Saunders, an imprint of Elsevier Inc. 9
Related documents