Download Drug delivery: Engineering new methods for disease

Biomaterials, Drug Delivery, and Tissue
Engineering
W. Mark Saltzman
Yale University
[email protected]
http://saltzman.eng.yale.edu/research.html
Cumulative Drug Released
Biomaterials for Controlled Release of Drugs
0.8
0.6
0.4
PLGA nanoparticles loaded with
camptothecin (CPT). Scale bar: 500
nm.
0.2
0
0
4
8
12
16
Time (day)
Brem, Colvin, Langer, Saltzman,
and Guilford Pharmaceuticals
Sawyer, Saucier-Sawyer, Booth, Liu, Patel, Piepmeier, Saltzman (2011)
(1990-2006): Gliadel ® approved
for
Sawyer, Saucier-Sawyer, Booth, Liu, Patel, Piepmeier,
glioblastoma multiforme (1996)
Saltzman (2011)
Nanoparticles Loaded with Genetic Material
DNA:
Pharm Res 16:1300, 1999;
J Cont Rel 129:66, 2008;
Nanomedicine 6:334, 2010;
Nature Materials 11:82, 2012
siRNA:
Nature Materials 8:526, 2009;
Biomaterials 32:6194, 2011;
Biomaterials 33:583, 2012
Peptide Nucleic Acids:
Molecular Therapy 19:172, 2011
Molecular Pharmaceutics
9:1481, 2012
Zhou, Patel, Fu, Bertram, and Saltzman (2012)
Tissue Engineering: Transplantable
materials that turn into vascularized tissues
With Jordan Pober,
Immunobiology
Human endothelial
cells
Suspend in a
Collagen Gel
Polymer microparticles
loaded with proteins that
stimulate blood vessel
growth
Implant into a
location in the
body where
new blood
vessels are
needed