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RNA interference
dsDNA
nucleus
mRNA
+
Antisense RNA
dsRNA (viral)
dicer
(protective function)
siRNAs (short interfering RNAs or
silencing RNAs, 20-25 NT)
dsRNA
No translation
20-25 NT fragments
RISC
Complex
(RNA-induced
silencing complex)
mRNA
mRNA
cleavage (protective if viral mRNA)
After Schmidt, C. Modern Drug Discovery, pg 38 (July 2003)
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