Download Analyst Toolkit Team

An Introduction to
Derwent World Drug
Index
Richard Lambert
Pharmaceutical Product Manager
World Drug Index - Background
• World Drug Index launched in 1994
• Originated from Standard Drug File
(SDF)
• Coverage back to 1964
• Contains only named compounds,
including Trial Preparation Codes
• Released on a quarterly cumulative
basis
World Drug Index - What is it?
• Integrated drug database containing
– marketed drugs
– drugs in development
– new chemical entities (NCE’s) from scientific
literature or reported at conferences
• Text and structure searchable
• 20 searchable fields with controlled
keywords
• Standard conventions for selection
and structure input
World Drug Index Coverage/Selection Guidelines
• Source Materials
– Literature articles from over 1,200 journals
– Conference proceedings (approx. 20 per year)
– Pharmacopoeias and Approved Name Lists
• Selection Criteria
– All named compounds from the Derwent Drug File
– All named compounds from Conference Fast-Track
– Named compounds from pharmacopoeias and
approved name lists (e.g. USAN and INN)
World Drug Index - Statistics
• Over 64,000 drug records
• 4000 new records per annum
• 16,000 updates to existing records
per annum
• Over 203,000 synonyms
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12,000 Approved Names
34,000 Trial Preparation Codes
144,000 Trade Names/Trivial Names
13,000 Combination Names
• Over 20,000 source references (added
since 1994)
World Drug Index - Data fields
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Derwent Drug Name
Structure
Derwent Registry Name
Pharmacological Activity /
Mechanism of Action
Reference
Chemical Substructure keywords
Synonyms
Biomedical Data
World Drug Index - Features/Uses
• Structure/sub-structure activity
relationships
• Archive reference file for marketed
and development drugs
• Information on drug manufacturers
and countries of origin/sale
• Trade name and synonym searching
World Drug Index - Daylight’s
Implementation
• Full Version
• Lite Version
– Includes:
• Structural data
• Synonyms
• Activity
– Excludes:
• Mechanism of Action
• Biomedical Information
World Drug Index - HTML Version
• Simple intuitive interface
• Text fields
– Names
– CAS numbers
– Smiles
• Structure searchable using GRINS
– Exact
– Substructure
– Superstructure