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Long-term potentiation in the anterior cingulate cortex and chronic pain by Min Zhuo Philosophical Transactions B Volume 369(1633):20130146 January 5, 2014 ©2014 by The Royal Society Long-term potentiation and chronic pain. Min Zhuo Phil. Trans. R. Soc. B 2014;369:20130146 ©2014 by The Royal Society Synaptic potentiation as a cellular model for behavioural hyperalgesia and allodynia in chronic pain. Min Zhuo Phil. Trans. R. Soc. B 2014;369:20130146 ©2014 by The Royal Society A synaptic model for LTP in the ACC. Activation of glutamate NMDA receptors leads to an increase in postsynaptic Ca2+ in dendritic spines. Min Zhuo Phil. Trans. R. Soc. B 2014;369:20130146 ©2014 by The Royal Society Postsynaptic and presynaptic mechanisms of chronic pain in the cortex. Min Zhuo Phil. Trans. R. Soc. B 2014;369:20130146 ©2014 by The Royal Society Translational investigation of novel drug targets those are required for pain plasticity in chronic pain. Min Zhuo Phil. Trans. R. Soc. B 2014;369:20130146 ©2014 by The Royal Society