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Old Title vs NIH Guidelines for Research Involving Recombinant DNA Molecules New Title NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules Implement by 3/3/13 Is chemical synthesis covered? synthesizer Not until in a … III-F Registrations Nothing exempt in Boston BPHC adopts updated Guidelines unless… Using nonhazardous plasmids (pBR) to clone gene of interest into host (nonpathogenic E.coli) Often the first step in creating a transgenic animal New exemptions for synthetic NA No origin of replication, no integration… NIH Guidelines: Definition of rNA Molecules constructed by joining nucleic acids & can replicate in a living cell NIH Guidelines: synthetic Nucleic acids that can base pr w naturally occurring nucleic acids NIH Definitions Continued Molecules resulting from replication of rNA or synthetic nucleic acids in past two slides Other Changes Fewer AAV serotypes need review Transfer of drug resistance traits Human Gene Transfer w nucleic acids Risk Assessment & Synthetics % of genome from each parent Fn/purpose of each sequence Assume same fn as original host? Synergism between sequences & transgenes What Next? - XNA ~6 sugars can form NA bbone Store & retrieve genetic info Medical benefit? Slower breakdown in stomach & bloodstream Real World Examples iGEM 2006 Jay Keasling
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