Download MICROSPHERES AS A NOVEL DRUG DELIVERY SYSTEM

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MICROSPHERES AS A NOVEL
DRUG DELIVERY SYSTEM
Omkar. T, Vikas College of
Pharmacy, Vissannapet,
Andhrapradesh
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Introduction
Microspheres
Synthetic polymers
Non-bio degradable
Polymethyl methacrylate,
Acrolein ,
Epoxy polymers…
Bio – degradable
Lactides ,
Polyanhydrides,
Polyalkyl cyno acrylates..
Natural polymers
Proteins,
Carbohydrates,
Chemcally modified
Carbohydrates…..
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Methods of Preparation
• Single emulsion technique
• Double emulsion technique
• Polymerization technique
• Spray drying technique
• Solvent extraction
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Applications
Synthetic polymers: Parenteral
preparations-- Poly
alkyl cyanoacrylates
 Narcotic antagonists,
cancer drugs-- Poly
lactic acid—sustained
release
 ocular delivery-- Poly
anhydrate microspheres
Natural polymers
 Albumin – Targeted
drug delivery to Tumor
cells.
 Gelatin microspheres –
interferon, phagocytes.
 Starch – more -OH
groups, so all drugs
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In vaccine therapy
Monoclonal antibody therapy
Chemo embolisation
In radiology treatment for cancer
In cosmetic technologies
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Future: Atrigel Drug Delivery System
• The Atrigel® drug delivery system consists of
biodegradable polymers dissolved in biocompatible
carriers. Pharmaceuticals may be blended into this
liquid delivery system at the time of manufacturing
or, depending upon the product, may be added later
by the physician at the time of use. When the liquid
product is injected into the subcutaneous space
through a small gauge needle or placed into
accessible tissue sites through a cannula, water in the
tissue fluids causes the polymer to precipitate and
trap the drug in a solid implant. The drug
encapsulated within the implant is then released in a
controlled manner as the polymer matrix
biodegrades with time.
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