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Download Signal Pathways in Eukaryotic Cells
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Signal Pathways in Eukaryotic Cells Overview Lipid Soluble Hormones Nuclear Receptors For Lipid Soluble Hormones Hsp90 Nuclear Receptors Receptors for Extra Cellular Signaling Molecules (Water Soluble or Peptide) More Trans-Membrane Receptors Signal Transduction Systems A Seven-Spanning G-Protein Linked Receptor Activation of a heterotrimeric G-protein Liganded receptor promotes exchange of GDP for GTP in G alpha G alpha dissociates from G beta gamma (both are activated) Activation of Effector Protein(s) Inactivation of G-Protein G-Proteins Can Activate Genes Gs Alpha Activates Adenyl Cyclase Protein Kinase A Phosphorylates CREB Enzyme Linked Receptors:Tyrosine Kinases * * * * * * Liganded Tyrosine Kinase Receptors Dimerize and Auto- Phosphorylate Activated TK Receptors Bind Adapter Proteins Which Regulate GTP Binding Proteins Kinase Cascades Activate Genes & Regulate Proteins The Protein Kinases are Evolutionarily Conserved
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