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Hairy T-cell 1665 – Robert Hooke Used a simple microscope Observed cells in cork. Coined the term "cells”. He thought cells only existed in plants and Fungi Anton van Leuwenhoek • 1673- Used a handmade microscope to observe pond scum & discovered single-celled organisms • He called them “animalcules” • He also observed blood cells from fish, birds, frogs, dogs, and humans • Therefore, it was known that cells are found in animals as well as plants Cells are Diverse… both in size, shape, and internal organization. How big are cells? Most are microscopic!!! • Largest cell on the human body = ovum • Size= • 1000 µm in diameter (1 mm) How big are cells? • Largest cell = yolk of an ostrich egg Common features of all cells 1. Cell Membrane – selectively/differentially permeable (lets some things in and out) Common features of all cells 2. Cytoplasm – semi-fluid material in which cell organelles float Common features of all cells 3. Nucleic acid containing genetic code : DNA Common features of all cells 4. Ribosomes – make proteins Important events in the discovery of the cell and the development of the cell theory….. 150-200 Year Gap??? • Between the Hooke/Leuwenhoek discoveries and the mid 19th century, very little cell advancements were made. • This is probably due to the widely accepted, traditional belief in Spontaneous Generation. • Examples: -Mice from dirty clothes/corn husks -Maggots from rotting meat Principle 1 •All living things are made up of Cells 1838 - Matthias Schleiden A botanist who concluded that all plants are made of cells. Typical Plant Cell 1839 - Theodor Schwann A zoologist who concluded that all animals are made of cells. Nerve Cells Principle 2 Development of Cell Theory , Matthias Schleiden and Theodor Schwann, are given credit for this part of the cell theory as well. The most basic unit of structure in all living things are cells. They have specific functions and structures within in living organisms.(plants and animals) All cells are basically the same in chemical composition and metabolic activities. Principle 3 All Cells come from existing cells. 1855 - Rudolph Virchow Much doubt existed around Spontaneous Generation A physician who did research on cancer cells and concluded “Omnis cellula e cellula”. “All cells are from other pre-existing cells.” Cells reproduce to make new cells The Cell Theory 1. All living things are composed of one or more cells. 2. Cells are the basic units of structure and function in an organism. 3. Cells come only from existing cells.