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Section Objectives • Sequence the events of the cell cycle. • Relate the function of a cell to its organization in tissues, organs, and organ systems. Cell Size Limitations • The cells that make up a multicellular organism come in a wide variety of sizes and shapes. • Considering this wide range of cells sizes, why then can’t most organisms be just one giant cell? Diffusion limits cell size • Although diffusion is a fast and efficient process over short distances, ____________________________________ ____________________________________ ___________________________________. • Because of the slow rate of diffusion, organisms can’t be just ________________. DNA limits cell size • The cell cannot survive unless there is ___________________________________ of the cell. • In many large cells, _________________ _____________________is present. • ____________________________________ ensure that cell activities are carried out quickly and efficiently. Surface area-to-volume ratio 4 mm 1 mm 2 mm 1 mm 1 mm mm2 Surface area = 6 Volume = 1 mm3 4 mm 2 mm 2 mm 4 mm Surface area = 24 mm2 Volume = 8 mm3 • As a __________increases, its ______________increases much faster than its surface area. Surface area-to-volume ratio 4 mm 1 mm 2 mm 1 mm 1 mm mm2 Surface area = 6 Volume = 1 mm3 4 mm 2 mm 2 mm 4 mm Surface area = 24 mm2 Volume = 8 mm3 • If cell size________, the cell would require ____times more _________and would have ____ times more ____________ to excrete. Surface area-to-volume ratio 4 mm 1 mm 2 mm 1 mm 1 mm mm2 Surface area = 6 Volume = 1 mm3 4 mm 2 mm 2 mm 4 mm Surface area = 24 mm2 Volume = 8 mm3 • The___________________, however, would increase by a factor of only_________. Surface area-to-volume ratio 4 mm 1 mm 2 mm 1 mm 1 mm mm2 Surface area = 6 Volume = 1 mm3 4 mm 2 mm 2 mm 4 mm Surface area = 24 mm2 Volume = 8 mm3 • The cell would either ______________or be ___________________from the buildup of waste products. Cell Reproduction • Cell division is the process by which ____________________________________ ___________________________________. • Cell division results in _________________ ____________________________________ ___________________________________. The discovery of chromosomes • Structures, which_____________________ • ___________________________________, are called chromosomes. • Chromosomes are the _________________ • ____________________________________ ___________________________________. • Accurate transmission of chromosomes during cell division is__________________. The structure of eukaryotic chromosomes Centromere Sister chromatids Supercoil within chromosome Chromosome Continued coiling within supercoil Histone H1 Nucleosome DNA The Cell Cycle • The cell cycle is ______________________ • ___________________________________. • The __________ of a cell’s life is spent in the _______________ period known as ______________. Interphase The Cell Cycle • Following interphase, a cell enters its period of ______________________called mitosis. • Following mitosis,______ _____________ ____________, separating the two daughter Mitosis cells. Interphase: A Busy Time • Interphase, the busiest phase of the cell cycle, is_____________________________. Interphase DNA synthesis and replication Rapid growth and metabolic activity Centrioles replicate; cell prepares for division Interphase: A Busy Time • During the first part, the________________ ___________________________________. Interphase Rapid growth and metabolic activity Interphase: A Busy Time • In the next part of interphase,____________ ___________________________________. Interphase DNA synthesis and replication Interphase: A Busy Time • After the chromosomes have been duplicated, the cell enters another shorter growth period in which_________________ ____________________________________ ____________________________________ ___________________________________. Interphase Centrioles replicate; cell prepares for division The Phases of Mitosis • The four phases of mitosis are: • __________________________ • __________________________ • __________________________ • __________________________ Prophase: The first phase of mitosis • During prophase,______________________ ___________________________________. Spindle fibers Disappearing nuclear envelope Doubled chromosome Prophase: The first phase of mitosis • The ______________________________ • ____________are called sister chromatids. Sister chromatids Prophase: The first phase of mitosis • Sister chromatids are ______________by a structure called a centromere, which plays a role in chromosome ___________ during mitosis. Centromere Metaphase: The second stage of mitosis • During metaphase, the chromosomes______ ____________________________________ ___________________________________. Centromere Sister chromatids Anaphase: The third phase of mitosis • During anaphase, the ________________and the sister chromatids are ______________to opposite poles of the cell. Telophase: The fourth phase of mitosis • During telophase, ___________________are formed. The cells _______________as the cell cycle proceeds into the next interphase. Nuclear envelope reappears Two daughter cells are formed Cytokinesis • Following telophase, the ______________ ___________in a process called cytokinesis. • Cytokinesis differs between plants and animals. • Toward the end of telophase in__________, the plasma membrane ________________in along the equator. Cytokinesis • Plant cells have a rigid cell wall, so the plasma membrane ___________________in. • A structure known as the ______________is laid down across the cell’s equator. • A ____________________around each cell, and new cell walls form on each side of the _____________until separation is complete. Results of Mitosis • When mitosis is complete, _________ • _______________remain as ________ cells. • In multicellular organisms, cell growth and reproduction result in _________________ ____________________________________ to perform a specific function. Results of Mitosis • Tissues organize in various combinations to form organs that _________________ __________________________within the organism. • ____________________________that work together form an organ system.