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Transcript 
Electron Microscopy - Osler Institute Pathology Board Review
Primer of Organelles
Cytoplasm
Annulate lamellae
Cellular immaturity
Electron Microscopy - Osler Institute Pathology Board Review
Primer of Organelles
Cytoplasm
Cylindric confronting
cisternae
Ring shaped and tubular
forms in HIV infection
Electron Microscopy - Osler Institute Pathology Board Review
Primer of Organelles
Cytoplasm
Microtubules
Cell processes of neuroblastoma
Intracisternal microtubules
Melanoma
Extraskeletal
chondrosarcoma
Electron Microscopy - Osler Institute Pathology Board Review
Primer of Organelles
Cytoplasm
Myosin and Actin
Myosin - 15 nm
Actin – 6 -8 nm
Electron Microscopy - Osler Institute Pathology Board Review
Primer of Organelles
Cytoplasm
Cytokeratin filaments
Squamous cell carcinomas
Electron Microscopy - Osler Institute Pathology Board Review
Primer of Organelles
Cytoplasm
Vimentin filaments
Mesenchymal cells,
endothelial cells, tumors
Abundant in rhabdoid
tumors of the kidney
Carcinoid tumor with
intracytoplasmic vimentin
filaments
Electron Microscopy - Osler Institute Pathology Board Review
Primer of Organelles
Cytoplasm
Intermediate filaments
Aggregates of smooth muscle actin
Infantile digital fibromatosis
Electron Microscopy - Osler Institute Pathology Board Review
Primer of Organelles
Cytoplasm
Glial filaments
51 – 52 KD glial fibrilllary acidic
protein
Astrocytic tumors
Plaques of multiple sclerosis
Rosenthal fibers – pilocytic
astrocytoma
Electron Microscopy - Osler Institute Pathology Board Review
Primer of Organelles
Endoplasmic reticulum
Rough endoplasmic
reticulum
Abundant RER in:
• Plasma cells
• Acinar cell neoplasms
Electron Microscopy - Osler Institute Pathology Board Review
Primer of Organelles
Cytoplasm
Smooth Endoplasmic
reticulum
Ovarian sex cord tumors
Lipid cell tumors
Hilus cell tumor of ovary
Luteomas
Sertoli adenoma of testis
Adrenal cortical tumors
Sebaceous gland neoplasms
Electron Microscopy - Osler Institute Pathology Board Review
Primer of Organelles
Cytoplasm
Intercellular junctions
Junctional complexes – cytoplasmic lumina
Desmosomes - carcinomas
Primitive junctions – sarcomas, carcinomas
Electron Microscopy - Osler Institute Pathology Board Review
Primer of Organelles
Cytoplasm
Lamellar cytoplasmic
inclusions
Myelinosomes
Bronchioloalveolar cell
carcinoma
Type II pneumocyte
Electron Microscopy - Osler Institute Pathology Board Review
Primer of Organelles
Cytoplasm
Langerhan’s cell (Birbeck)
granules
Eosinophilic granuloma
Electron Microscopy - Osler Institute Pathology Board Review
Primer of Organelles
Cytoplasm
Lipid
Hibernomas
Steroid secreting cells
Clear cell carcinoma of kidney
Malignant fibrous histiocytoma
Electron Microscopy - Osler Institute Pathology Board Review
Primer of Organelles
Cytoplasm
Lysosomes
Secondary lysosomes
Granular cell tumors
Myelomonocytic leukemia
Malignant histiocytosis
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