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PROTEASE/ANTI-PROTEASE
IMBALANCE
INFLAMMATION
macrophages
phosphatidylserine receptor
1
MMPs / TIMPs
impaired clearance
of apoptotic cells
NE / 1-AT
neutrophils
4
NE
Activation of FasL
degradation of BM
CD8+ T-cells
2
perforins
granzyme B
APOPTOSIS
VEGF
epithelial cell injury
5
OXIDATIVE STRESS
Figure 3.
3
survival signals
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