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A B CMV ? CMV CMV CMV Chronic virus stimulation TLR7/9 SMC/ fibroblast B cell + PDC CD4+ T cell CMV Generation of CD4+CD28null T cells Humoral autoimmune phenomena CMV cox-2 5-LO IL-6, TNF-a RANTES,MIF MIP-1a, MIP-1b + Viral mimicry C Myeloid APC + IFN-a, IL-6 TNF-a, IL-10 Th1 cytokines granzyme PGE2, LTB4 Amplification of inflammation D CMV CMV ? VCAM-1 E-selectin Endothelial cell Platelet adhesion/ aggregation SMC US28 PDGF IL-1b, IL-8, fractalkine - - Myeloid APCs Inhibition of APC differentiation Thrombosis Increased angiogenesis IL-10 Inflammation, leukocyte recruitment and adhesion SMC migration and proliferation Vascular damage and vessel narrowing Inhibition of APC maturation, cytokine secretion and cell migration T cells Inhibition of T cell proliferation/ responses Inhibition of myelopoiesis Inhibition of NK activity Immunosuppression
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