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Electrical Geodesics Inc & Neuroinformatics Center, UO, 15 Nov. 2013 Ensemble Synchronization in Schizophrenia Kaushik Majumdar, ISI Bangalore Joint work with Pradeep D. Prasad (ISI), John P John (NIMHANS), H. N. Harsha (Nitte University) https://sites.google.com/site/isicng/ (Computational Neuroscience Group) Video Synchronization: Snapshot Prasad et al. Clin. EEG Neurosci. 44(1): 16 – 24, 2013 Pairwise Hilbert Phase Synchronization Hilbert Transformation and Instantaneous Phase s( ) H ( s(t )) d t 1 H ( s)) (t ) arctan s(t ) Phase Synchronization Prasad et al. 2012 Cross Modal Task Videos Healthy control subject http://youtu.be/4aFMQFhiRHw Patient with schizophrenia http://youtu.be/-TECG5XQhB4 Multi-channel synchronization Single Trial Ensemble Synchronization Trial Averaged Ensemble Synchronization ERSP & ITC Trial Selection Classification by Logistic Regression 3 dimensional feature space: 1. Ensemble right hemispheric synchronization. 2. Ensemble left hemispheric synchronization. 3. Response latency. 2 Dimensional Projection of 3 Dimensional Feature Space Incongruent stimulus Cross is patient with schizophrenia square is healthy control subject 2 Dimensional Projection of 3 Dimensional Feature Space Congruent stimulus Plus is patient with schizophrenia circle is healthy control subject 2 Dimensional Projection of 3 Dimensional Feature Space Neutral stimulus Star is patient with schizophrenia diamond is healthy control subject Average Accuracy Probabilistic Score Reference P. D. Prasad, H. N. Halahalli, J. P. John and K. Majumdar, “Single-trial EEG classification using logistic regression based on ensemble synchronization,” accepted in IEEE Journal on Biomedical and Health Informatics.