Download Day 2 - P3 DebugIT overview-Colaert-Lovis

Dr Dirk Colaert, MD - Prof Christian Lovis, MD MPH
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EHR Stakeholder workshop - EU - March 10th & 11th 2008 - Bruxelles
Detecting and Eliminating Bacteria
UsinG Information Technology
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EHR Stakeholder workshop - EU - March 10th & 11th 2008 - Bruxelles
The Project in short
FP7 funded project (Framework Program 7)
This is a research initiative from the European Union
The DebugIT project proposal was ranked first
Start date:
End date:
Jan 1st, 2008
December 31st, 2011
11 Partners
11 Work packages
Total EU funding of the project 7M€
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EHR Stakeholder workshop - EU - March 10th & 11th 2008 - Bruxelles
The Partners
1 Agfa
2 HUG
3 UNIGE
4 LIU
5 EMP
6 UCL
7 INSERM
8 UKLFR
9 TEILAM
10 IZIP
11 GAMA
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Agfa HealthCare N.V.
Les Hôpitaux universitaires de Genève
Université De Genève
LINKÖPINGS UNIVERSITET
Empirica
University College London
Institut National de la Santé et de la Recherche Médicale
Universitätsklinikum Freiburg
TECHNOLOGIKO EKPEDEFTIKO IDRIMA LAMIAS
IZIP A.S.
Gama/Sofia Ltd.
EHR Stakeholder workshop - EU - March 10th & 11th 2008 - Bruxelles
clinical context
Antibiotic resistance is a consequence
of evolution via natural selection
antibiotic action is an environmental pressure
• patterns of antibiotic usage greatly affect the number of resistant
organisms which develop.
• overuse of broad-spectrum antibiotics
• incorrect diagnosis
• unnecessary prescriptions
• improper use of antibiotics
• use of antibiotics as livestock food additives for growth promotion
• counterfeited drugs
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EHR Stakeholder workshop - EU - March 10th & 11th 2008 - Bruxelles
clinical context
antibiotic resistance in Salmonella typhimurium DT104, England and
Wales, 1984-1995
WHO Weekly Epidemiological Record,
Vol 71, No 18, 1996
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EHR Stakeholder workshop - EU - March 10th & 11th 2008 - Bruxelles
clinical context
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EHR Stakeholder workshop - EU - March 10th & 11th 2008 - Bruxelles
clinical context
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http://www.rivm.nl/earss
EHR Stakeholder workshop - EU - March 10th & 11th 2008 - Bruxelles
…
a race against evolution can only be lost
new solutions must be found
This has become a new war !
New Antibiotics can not keep
up with the bacterial resistance
If this is a war: we need a new weapon
ITbiotics to help the Antibiotics
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EHR Stakeholder workshop - EU - March 10th & 11th 2008 - Bruxelles
The DebugIT project
Clinical Care
Medical research
1-Collect
Data
clinical data
Clinical
Data
Repository
clinical data
(aggregated,
distributed)
4-Apply
Clinical
Activity
Reasoning
engine
Analysis
2-Learn
Activities
Knowledge
Repositories
Knowledge
(aggregated,
distributed)
Knowledge
3-Store
Knowledge
Repositories
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EHR Stakeholder workshop - EU - March 10th & 11th 2008 - Bruxelles
The Translational Framework
Clinical Care
Medical research
1-Collect
Data
clinical data
Clinical
Data
Repository
clinical data
(aggregated,
distributed)
4-Apply
Clinical
Activity
Reasoning
engine
Analysis
2-Learn
Activities
Knowledge
Repositories
Knowledge
(aggregated,
distributed)
Knowledge
3-Store
Knowledge
Repositories
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EHR Stakeholder workshop - EU - March 10th & 11th 2008 - Bruxelles
Focus points, challenges
• Technological
– Interoperability
– Clinical Data Repository Formalism
– Federated Data Mining
• Collect everything and mine afterwards or mine on distributed data ?
– Multimodal Data Mining
• Structured, unstructured, images, …
– Data Mining steered by knowledge/reasoning
– Federated Knowledge Repository
• Multi format, multi source
– Reasoning
• Statistical + logical
• Performance
• Formalism and decidability
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EHR Stakeholder workshop - EU - March 10th & 11th 2008 - Bruxelles
Focus points, challenges
• Functional
–
–
–
–
Representation of Knowledge
Integration in Clinical Systems
Usability
Proof of concept and example of translational medicine
• Clinical Care
– Decision support
– Patient safety + Efficiency
• Medical Research
– Pharmaco-vigilance
– Strict clinical trials versus ‘real data’ mining
• a “nice picture of a dirty world”
• applicability and usefulness of results
• the “context” problem
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EHR Stakeholder workshop - EU - March 10th & 11th 2008 - Bruxelles
Conclusion
• DebugIT will make a proof of concept of a generic
translational framework focused on a specific clinical
problem
• By it’s very nature the system will be scalable and fractal,
such that it can be used from very low local levels to high
strategic global levels
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EHR Stakeholder workshop - EU - March 10th & 11th 2008 - Bruxelles
…
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EHR Stakeholder workshop - EU - March 10th & 11th 2008 - Bruxelles