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Information on PAROXETINE for Service Users and their Families This leaflet provides general information about your medication. Manufacturer patient information leaflets are also provided with all medicines. If you require further information, speak to your doctor, pharmacist or nurse. Paroxetine is also known as Seroxat or just paroxetine. It comes as tablets or liquid. Paroxetine is pronounced Par-ox-eh-teen Reviewed by: DTC On: January 2014 Next Review: January 2017 The Mersey Care Medicines Information Service1 regularly updates this information sheet. 1 Medicines Information, Pharmacy, Mossley Hill Hospital, Park Avenue, Liverpool L18 8BU What is Paroxetine for? Paroxetine is part of a group of medicines called SSRI antidepressants which are used to treat depression. Symptoms of depression may include low mood, poor sleep appetite changes, a loss of interest in everyday activities, and feelings of guilt. Paroxetine is also used to treat other disorders such as panic attacks, anxiety states, and obsessive disorders. How should I take Paroxetine? Before taking any paroxetine, tell your doctor if: you are allergic to paroxetine and any of its ingredients you suffer from heart, kidney or liver problems, epilepsy/fits, diabetes, glaucoma, stomach ulcer, or elated mood/mania. you bruise or bleed easily you are taking ANY other medicines including those you have bought yourself, especially other antidepressants, St John’s Wort, antipsychotics, painkillers, antibiotics, migraine treatments you are pregnant, planning a pregnancy or breast-feeding Your doctor will advise you on the daily dose you should take. Paroxetine are usually taken in the morning, swallowed whole with a glass of water, after food. If you are taking the liquid, you will be supplied with the right measure. Never take more than the prescribed dose. Ask your pharmacist or nurse if you are not sure of anything. Can I stop taking Paroxetine if I feel better? It is better to discuss with your doctor how long you will need to be on medication. Antidepressant medication tends to be taken long term. If you want to stop your medication it is better to do it in discussion with your doctor, and slowly so that you can be monitored for any unpleasant withdrawal effects. What if I forget a dose of Paroxetine? Take the missed dose as soon as possible. However, if it is almost time for the next dose, skip the missed dose and take the next dose at the usual time then continue your course as prescribed. Do not double the dose or take extra doses to make up for the missed dose. When will Paroxetine start to work? You may notice a little improvement and may feel worse in the first few weeks of treatment with paroxetine. It may take a couple of weeks or longer for the benefits of treatment to become noticeable. Are there any side effects? Paroxetine can cause side effects in some people, but they may vary from person to person. Many side effects wear off over time. Known side effects include: feeling or being sick restlessness stomach problems sweating constipation or diarrhoea nervousness and anxiety appetite/weight changes drowsiness feeling thirsty dizziness tiredness or weakness shakiness or tremor yawning, dry mouth difficulty sleeping headache sexual problems Occasionally more serious side effects can occur. These include: allergy - such as difficulty breathing, itchy rash, and swelling confusion fast or slow heart beat eyesight problems difficulty passing urine fits unusual bleeding or bruising liver problems distressing thoughts of harming or killing yourself bone fractures especially in people 50 years old and over serotonin syndrome (restlessness, high temperature sweating, tremor, shivering, confusion, muscle twitching, fits) If you are concerned about any side effects, talk to your doctor nurse or pharmacist. If you think a medicine has caused you an unwanted side effect, please report the problem either on a Yellow Card form available from your doctor, nurse or pharmacist OR online at this website http://yellowcard.mhra.gov.uk/. Can I take other medicines? Other medicines may interact with paroxetine causing undesirable effects. Medicines you can buy over the counter without a prescription may interact with prescribed medicines. Always ask your doctor or pharmacist before taking any other medicines. Can I drive? Paroxetine can make you feel drowsy and affect your concentration and alertness. If you are affected in this way, do not drive or work with heavy machinery. Can I drink alcohol? Avoid drinking alcohol while taking paroxetine. The combined effects of paroxetine and alcohol can make you feel more drowsy increasing the risk of falls and accidents. Alcohol can make depression and anxiety worse. Can I get pregnant or breast feed? Medicines can have harmful effects at any time during pregnancy. Some babies whose mothers took paroxetine during the first few months of pregnancy have shown an increased risk of heart defects. If you are pregnant, or are planning to get pregnant, you should get advice from your doctor. You and your doctor or specialist will decide if the potential benefits of treatment outweigh the potential risks to the baby. Paroxetine can be passed into breast milk. If you are breastfeeding, you should get your doctors advice. What alternative treatments are there? Paroxetine is an antidepressant known as a SSRI. Other SSRIs include citalopram, sertraline and fluoxetine. A different group of antidepressant known as the ‘tricyclic’ antidepressants like amitriptyline and lofepramine are an alternative medication. Other medications such as duloxetine, mirtazapine and venlafaxine may be used to treat depression. Talking therapies may also be an option. Your doctor or pharmacist will be able to provide you with further information about these medications. IMPORTANT Remember to keep medicines where children cannot see or reach them. Never share medicines with others even if their symptoms appear the same as yours. NEVER EXCEED THE STATED DOSE OF YOUR MEDICINE