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1 Stewart J. Tepper, MD Curriculum Vitae Phone: 914-469-1658 Land line: 508-432-7121 Email: [email protected] Professional information Accepted position, Dartmouth Medical College/Dartmouth Hitchcock Medical Center Department of Neurology Headache Center Staff with Professorship 2015 Cleveland Clinic Headache Center Staff Education: 2008-2015 Bachelor of Arts, Cum Laude, Honors in Psychobiology, Yale College, 1975 MD, Cornell University Medical College, 1979 Career: 1979-1980, Intern, Internal Medicine, Boston University Hospital, Boston City Hospital, Boston, MA 1980-1981 Junior Residency, Internal Medicine, University of Washington School of Medicine, Seattle, WA 1981-1984 Neurology Residency, Longwood Area Neurology Training Program, Harvard Medical School, Boston, MA University positions: Current: Professor of Medicine (Neurology) Cleveland Clinic Lerner College of Medicine Case Western University Cleveland, OH, 2009- 2015 2 Associate Clinical Professor of Neurology Yale University School of Medicine Department of Neurology, New Haven, CT 2006-2008 Assistant Clinical Professor of Neurology Yale University School of Medicine Department of Neurology, New Haven, CT 2001-2006 Clinical Assistant Professor of Neurology University of Washington Department of Neurology, Seattle, Washington 1988- 2000 Other positions: Co-Director of Research Center for Neurological Restoration Neurological Institute Cleveland Clinic, 2008- 2015 Director of Resident Research Department of Neurology Neurological Institute Cleveland Clinic, 2009- 2015 Board Certification: Neurology and Psychiatry, 1986, American Board of Neurology and Psychiatry Headache Medicine, United Council for Neurologic Subspecialties, 2006 Professional Service: Editor-in Chief, Headache Currents, second journal of the American Headache Society (AHS), 2012- present Associate Editor, Headache, journal of the American Headache Society (AHS), 2008- present President, North Central Headache Society (formerly the Ohio Headache Association), 2014- 2015 Board of Directors, North Central Headache Society (Ohio Headache Association), 2008- 2015 Scientific Advisory Board, Association of Migraine Disorders, 2014present 3 Course Co-Director, Scottsdale Headache Symposium of the American Headache Society, 2008- present Education Committee, American Headache Society, 2007- present Vice President, New York State Neurologic Society, 2006-2007 Executive Board of Directors, Headache Cooperative of New England, 2001- 2008 Headache Care for Practicing Clinicians, 2002present American Council of Headache Education, 20042006 North Central Headache Society (formerly Ohio Headache Association), 2009- present President, Puget Sound Neurological Society, 1989-1990 Course Director, Headache Therapy, American Academy of Neurology, 2009-2011 Course Co-Director, Winter Meeting of the American Headache Society, 2002, 2005- 2007 Abstracts Editor, Headache, journal of the American Headache Society (AHS), 2002- 2008 Education and Membership Committee, International Headache Society 1998- 2003 Editor, North America, Headache Care, journal of Headache Care for Practising Clinicians (HCPC), 2003- 2009 Clinical Science Contributing Editor, Headache Currents, 2006- 2009 Journal Editorial Board member: Headache, 2002- present Headache Care, 2004- 2007 Current Drug Safety, 2005- present US Neurology, 2010-2011 Frontiers in Headache Medicine and Facial Pain, 2010- 2011 Neurology and Therapy, 2014- present 4 Director: The New England Center for Headache, Stamford, CT 19992007 Director: The New England Research Institute, Stamford, CT 1999-2007 Abstracts Reviewer, American Academy of Neurology, 2001-2004 Scientific Abstracts and Poster Reviewer, Headache Care for Practicing Physicians and World Headache 2000, Scientific Abstract reviewer, 2000 Quality Assurance Improvement Committee, Providence Medical Center, Seattle, WA, 1987-1997 American Health Care Policy and Research (AHCPR) Group on Headache 1995-1997 Society memberships: Fellow, American Headache Society; International Headache Society, North Central Headache Society (formerly Ohio Headache Association), American Neurological Association, North American Neuromodulation Society Advisory Boards and Consultant, 2006-2015 Acorda, Allergan, Amgen, AstraZeneca, Autonomic Technologies, Inc, Avanir/Otsuka, Axon Advisors, BristolMeyerSquibb, Coherex, DepoMed, Dr. Reddy’s, Elan, Endo, Forrest, GersonLehmanGroup, GSK, Guidepoint Global, Helsinn, Impax, Isis, Labrys, MAP, Medpointe, Merck, NMT, Nautilus, NuPathe, OrthoMcNeil, Optinose, Pharmacia, Pfizer, ScionNeurostim, Teva, UCB, USWorldMeds, Vernalis, Winston, Xcel, Zogenix, Zosana Cleveland Clinic Committees Neurological Institute Residency Research Trainee Project Committee 2008- 2015 Neurosciences Specialty Panel (Pharmacy and Therapeutics), 2009- 2015 Neurological Institute Research Council, 2013- 2015 Neurological Institute Steering Committee for Cleveland Clinic Numoda Joint Venture, 2010-2011 Neurological Institute Research Committee, 2008-2012 5 Professional Honors or Recognition: Visiting Professor, Canadian Headache Society, 2015 International Headache Society Visiting Professor, Mumbai, India, 2013 Elected Fellow of the American Headache Society, 2012 Elected to American Neurological Association, 2011 Best Doctors 2009-2014, Cleveland Magazine Best Doctors (national), 2011-2013 Cleveland SuperDoctors, 2012 Best of the Best Award for abstract, American Academy of Neurology, 2001 Outstanding Teaching Awards: American Academy of Family Physicians, Seattle Providence Medical Center 1988 Seattle Swedish Medical Center 1988-1993 American Headache Society Neurology Ambassador Program Core Faculty, 2000-2004 Examiner, American Board of Neurology and Psychiatry, 1996 Moderator Scientific Sessions, American Academy of Neurology, 2001, 2002, 2003 American Association for the Study of Headache 1995, 1996, 1997, 1999 6 American Headache Society meetings 20052015 National Headache Foundation, 1st Annual Research Symposium, 2004 American Headache Society, Scottsdale, 2004, 2013-2015 Cambridge Who’s Who, 2010;Best Doctors in America, 2007-; Best Doctors in Connecticut/America, 2002, 2003, 2005, 2006; Strathmore’s National Who’s Who, 1999-; Strathmore’s Worldwide Who’s Who 2009-; Marquis Who’s Who in America, 1997-2008; Marquis Who’s Who in Science and Engineering 2006-9; Who’s Who in Medicine and Healthcare 2006-7; Who’s Who in the World 2006; Who’s Who in the 21st Century, 2001; Outstanding 2000 Intellectuals of the 21st Century, 2001, both Cambridge, UK: International Biographical Centre; Cambridge Who’s Who Among Professionals in Research Medicine and Healthcare, 2006; Top Doctors for Women, Connecticut Magazine, 2002, America’s Registry of Outstanding Professionals, 2003-4, Metropolitan Professional Registry, 2004 Consultant Reviewer: King County Medical Regence Blue Shield 1993-1999 PRO-West, Professional Review Organization for Medicare 1991-1999 Faculty: Physician Teleconference Network 1996-2001. E-scape migraine, Snyder Communications, 1999. Primary Care Network, 1999-2009 Featured Guest, “Migraine” The Infinite Mind, National Public Radio, 2/14/01, available at www.lichtensteincreativemedia.com Lecturer and Facilitator, Primary Care Network, 2001- 2009 NPACE Nurse Practitioner national CME, 2003-2009 Primed, 1999, 2008-2009 7 Medical Licensure: Ohio 2008- present Connecticut State 1999-2008 New York State 1999- 2008 Washington State 1984- 2008 Peer Journal Participation: Reviewer for the following journals: 1. Cephalalgia 2. Clinical Drug Investigation 3. CNS Drugs 4. Drug Evaluation 5. European Journal of Neurology 6. Expert Opinion on Investigational Drugs 7. Expert Review of Neurotherapeutics 8. Future Drugs 9. Headache 10. Headache Care 11. Journal of Headache and Pain 12. The Lancet Neurology 13. Medical Science Monitor 14. Neurology 15. Neuroscience 16. Pharmacogenomics 17. Primary Care Consultant 18. Women’s Health in Primary Care 19. American Journal of Managed Care 20. Neurology India 21. Expert Opinion on Pharmacotherapy 22. Journal of Neurology, Neurosurgery and Psychiatry 23. American Journal of Cardiology 24. Journal of Women’s Health 25. Pain Practice 26. Clinical Medicine: Therapeutics 27. International Journal of Vascular Medicine Medical Societies American Neurological Association American Headache Society/American Association for the Study of Headache International Headache Society National Headache Foundation 8 American Council for Headache Education American Academy of Neurology North Pacific Society of Neurology and Psychiatry Puget Sound Neurological Society Washington State Medical Association King County Medical Society Fairfield County Medical Society Connecticut Medical Society Ohio Headache Society/North Central Headache Society Lectures, Courses: Prevention of Headache Recurrence, Migraine Symposium, Scientific Session, American Academy of Neurology, Boston, Mass, April, 1994. Original Syllabus contribution. Pathophysiology and Pharmacology of Migraine. XVI Annual US Army Medical Department Neurology Conference (AMEDD). Madigan Army Medical Center, Tacoma, WA, Nov 21, 1996. Original Syllabus contribution. When should we use 5HT agonists and when might they be used in preference to other treatments such as ergotamines and combination therapies, in New Horizons in Migraine symposium, XVIth World Congress of Neurology, Buenos Aires, Argentina, September 13, 1997. Pharmacologic Treatment of Primary Headache Disorders: Acute Strategies, in Headache: Management and Therapy, Full-day Course on Headache, XVIth World Congress of Neurology, Buenos Aires, Argentina, September 14, 1997. Original Syllabus contribution. Zolmitriptan in clinical practice - establishing the role of 5HT1B/1D receptor agonists in migraine, symposium at the XVIth World Congress of Neurology 15 September 1997, Buenos Aires, Argentina. Ergots and Migraine, Treatment of Migraine, International Symposium, St John’s College, Cambridge University, Cambridge, England, April 1998. Epidemiology of Migraine and the Burden of Disease, The Causes of Migraine- Pathophysiology and the Triptans, International Media Symposium, Warren House, London, England, April 1998 Maximizing Treatment Response to Acute Migraine Therapy. American Association for the Study of Headache, San Francisco, Cal. June 1998. 9 Patient Reported Tablet Utilization of Zolmitriptan and Sumatriptan. Platform presentation, American Association for the Study of Headache, San Francisco, Cal. June 1998. Tolerability of Sumatriptan Nasal Spray in the Acute Treatment of Migraine: A Review of Data from Clinical Trials. Platform presentation, American Association for the Study of Headache, San Francisco, Cal. June 1998. Clinical Use of Zolmitriptan, ADITUS Medical Media Workshop II- New Migraine Treatments and Management Strategies, NY Academy of Medicine, NY, NY June 1998. Rational Migraine Management - Optimising Treatment with Zolmitriptan: What do Physicians Want? 3rd European Federation of Neurologic Societies, Seville, Spain, September 21st, 1998. ADITUS Medical Media Workshop III- New Migraine Treatments and Strategies, 3rd European Federation of Neurologic Societies, Seville, Spain, Sept 22, 1998. The new triptans (5-HT 1B/1D agonists) for acute treatment of migraine: a clinical review using number needed to treat (NNT) analysis. Platform presentation, 3rd European Federation of Neurological Societies, Seville, Spain, Sept 21, 1998. Benchmarks for Patient Satisfaction, Evaluating Triptans, Rome, April 3, 1999. Managing Migraine, Paris, March 20, 1999; April 10, 1999. Ergots or Triptans? XIII International Congress of the Brazilian Headache Society, Salvador, Brazil, May 15, 1999 Migraine Research- Today and in the Future, and The Triptans- 1999 Comparative Review, at Changing the Face of Migraine, St John’s College, Cambridge University, Cambridge, England, May 16-19, 1999. Moderator: American Association for the Study of Headache 1995-1999: Prepared questions and led platform discussion. Scientific Basis of Migraine, in Scientific Basis of Neurology I course, American Academy of Neurology, San Diego, CA, Apr 30, 2000. Original Syllabus contribution. 10 Reducing the cost of impairment of Normal Activities due to Migraine: A Stratified-Care Approach. Platform presentation, American Headache Society, Montreal, Canada. June, 2000. Pathophysiology of Migraine, Yale University School of Medicine Department of Neurology Grand Rounds, June, 2000. Migraine and Tension Type Headache, Vanderbilt University Medical School, Nashville, TN, Department of Neurology Grand Rounds, 2000. Understanding Patient Preference, in Rizatriptan: Meeting the Needs of More Migraine Patients Symposium, Headache World 2000, London, UK. Sept 5, 2000. What do patients want in acute migraine treatment? Symposium, European Federation of Neurological Societies, Copenhagen, Denmark, October 2000. Clinical Headache Update Symposium, “Rizatriptan Update”, Mexican Academy of Neurology Congress, Acapulco, Mexico November 16, 2000. Pathophysiology of Migraine. Grand Rounds, Indiana University School of Medicine, Department of Neurology, Feb 8, 2001. Triptan Clinical Efficacy, Clinical Endpoints, and Disability, in Addressing the Burdens of Migraine: Clinical and Treatment Strategies, Mallorca, Spain, March 10, 2001, also with two workshops in Barcelona, Spain March 24, 2001. Optimizing Acute Therapy- A Case for Early Intervention in Treatment of Headache and Facial Pain course with the NY Headache Foundation, NY, NY April 29, 2001. Acute Treatment of Migraine, in Headache Therapy course, American Academy of Neurology, Philadelphia, PA, May 10, 2001. Original Syllabus contribution. Headache Diagnosis and Testing in Headache in Adults I course, American Academy of Neurology, Philadelphia, PA, May 11, 2001. Original Syllabus contribution. How Pathophysiology Explains the Clinical Features of Migraine, Dealing with Headaches in the Real World course, Beth Israel Medical Center and St. Luke’s-Roosevelt Hospital Center, NY, NY June 1, 2001. Original Syllabus contribution. 11 The Triptans: New Clinical Endpoints in Evaluating differences in Triptans for Patient Care. The 15th Italian Society for the Study of Headache, Florence, Italy, June 11, 2001. Original Syllabus contribution. Acute Treatment of Migraine: Issues of Disability and Early Intervention. The 15th Italian Society for the Study of Headache, Florence, Italy, June 12, 2001. Original Syllabus contribution. HIT-6 Scores Discriminate Among Headache Sufferers Differing in Headache-Associated Workplace Productivity Loss. Platform presentation, World Congress of Neurology, London, UK, June 18, 2001. Migraine- A Summary. For Japanese General Neurologists at World Congress of Neurology, London, UK, June 19, 2001. HIT-6 Reliably Measures the Impact of Headache. Platform presentation, World Congress of Neurology, London, UK, June 19, 2001. Impact of Migraine Relative to Other Headache Types. Platform presentation, International Headache Congress, NY, NY, June 27- July 1, 2001. Co-prescription of triptans with other medications: a cohort study involving 240,268 patients. Poster Platform Discussion, International Headache Research Symposium, Copenhagen, Denmark, Nov 30- Dec 1, 2001 Tension Headache and Migraine, Symposium, Winter course, American Headache Society Symposium, Bal Harbour, Fla, Jan 2002. Original Syllabus contribution. Acute Treatment Options, Migraine Symposium, Winter course, American Headache Society, Bal Harbour, Fla, Jan 2002. Original Syllabus contribution. Neurologic Examination of the Headache Patient. Headache Cooperative of New England winter course. Stowe, VT, March 2002. Analgesics and Other Frequently Used Medications are a Cause, Not a Consequence of Chronic Daily Headache, Debate, Winter course, American Headache Society, Bal Harbour, Fla, Jan 2002. Original Syllabus contribution and subsequent invited article in Headache. Efficacy of Oral Zolmitriptan 2.5 mg in Mild, Moderate, and Severe Migraine: Results of Treating More than 20,000 Attacks. Platform 12 presentation, American Academy of Neurology, Denver, Colorado, Apr 18, 2002. Sensitivity of Headache Impact Test (HIT) in Distinguishing Headache Impact among Headache Sufferers Receiving Pharmacological Treatment. Platform presentation, American Academy of Neurology, Denver, Colorado, Apr 18, 2002. New Advances and Understandings in the Diagnosis and Care of Migraine Patients, Presentations of Migraine. Symposium, American Headache Society meeting, Seattle, WA June 21, 2002. Advancing the Knowledge of Migraine Therapy, Prevalence of Migraine in General Practice. Chairman and lecture, Symposium, European Headache Federation, Istanbul, Turkey, June 27, 2002. Co-prescription of triptans with other medications: a cohort study involving 240,268 patients. Platform presentation at the American Headache Society meeting, Seattle, WA, June 21, 2002 Co-prescription of triptans with other medications: a cohort study involving 240,268 patients. Platform presentation 6th Congress of the European Headache Federation, Istanbul, Turkey, June 28, 2002. Value of Delivering Health Status Assessment Via the Internet. Platform presentation at the 6th Congress of the European Headache Federation, Istanbul, Turkey, June 29, 2002. Broadening the Spectrum of Efficacy. Symposium, Tokyo, Japan, Sept 14, 2002. Advancing the Diagnosis and Treatment of Migraine, Prevalence and Diagnosis of Migraine in General Practice. Chairman and lecture, Symposium, for the 14th Migraine Trust International Symposium, London, UK, Sept 24, 2002. Expert Panel Review of Patient Diary Data Using IHS Classification. 14th Migraine Trust International Symposium, Poster Platform presentation, London, UK, Sept 25, 2002. Prevalence and Diagnosis of Migraine in a Primary Care Setting- Data from the Landmark Study. Platform Presentation, European Federation of Neurologic Societies meeting, Vienna, Austria, Oct 29, 2002. 13 Association of Headache Impact Test (HIT-6) and IHS Migraine Diagnosis in the Primary Care Setting. European Federation of Neurologic Societies, Vienna, Austria, Oct 28-30, 2002. Reduced Headache Impact with Sumatriptan in the Primary Care Setting. Platform Presentaion, European Federation of Neurologic Societies meeting, Vienna, Austria, Oct 29, 2002. Meta-analyses: Are they useful in clinical decision making? Con. Debate, American Headache Society Headache Symposium, Scottsdale, AZ. Nov 16, 2002. Meet the Professor Breakfast Symposium, Headaches. American College of Allergy, Asthma, and Immunology. San Antonio, TX. Nov 17, 2002. New Thoughts on “Sinus Headaches”. Plenary Session: Controversies in Sinusitis. American College of Allergy, Asthma, and Immunology. San Antonio, TX. Nov 17, 2002. Thoughts on Clinical Management of Chronic Daily Headache and Rebound Headache in the Office. Headache Cooperative of New England, winter course. Stowe, VT, March 1, 2003. Original Syllabus contribution. Tepper SJ, Bigal ME, Sheftell FD, Rapoport AM. Botulinum Toxin in the Preventive Treatment of Refractory Headaches. Platform Poster presentation, International Headache Research Seminars, Copenhagen, Denmark March 2003. Future Therapeutic Targets: Beyond Triptans, for Headache In Adults I, course at American Academy of Neurology, Apr 4, 2003. Original Syllabus contribution. Role of Analgesics in Intractable and Chronic Daily Headache, for Intractable Headaches, course at American Academy of Neurology, Apr 4, 2003. Original Syllabus contribution. Botulinum Toxin in the Preventive Treatment of Refractory Headaches. Platform presentation, American Academy of Neurology, Honolulu, Hawaii, April 2003. Naratriptan in the Preventive Treatment of Refractory Chronic Migraine. Platform Presentation, American Academy of Neurology, Honolulu, Hawaii, April 2003. “Sinus Headaches” and Migraine- Diagnostic Issues. Eastern Allergy Society, Palm Beach, Fl, May, 2003. Original Syllabus contribution. 14 New Thoughts on “Sinus Headache”. New England Allergy Society meeting, Portsmouth, NH, Oct, 2003. Original Syllabus contribution. Understanding the New IHS Criteria. in The New IHS Criteria and Emerging Uses of Long-acting Triptans, CME symposium American Headache Society meeting, Scottsdale, AZ, Nov 15, 2003. How to Identify Migraine in a Primary Care Setting, Osaka, Japan and Tokyo, Japan, Nov 20 and Nov 27, 2003. Moderator: Scientific Sessions, American Academy of Neurology, 2001, 2002, 2003: Prepared questions and led platform discussion. Moderator: National Headache Foundation, 1st Annual Research Symposium, Palm Springs, CA, Feb 2004: Reviewed and selected submissions and prepared questions and led platform discussion. Prevalence and Demographics of Migrainous Headache Adults in a Primary Care Setting: Data from the Landmark Study, National Headache Foundation 1st Annual Research Symposium, Rancho Mirage, CA, Feb 10, 2004. Drug Interactions, The 17th Annual Practicing Physician’s Approach to the Difficult Headache Patient, National Headache Foundation, Rancho Mirage, CA, Feb 12, 2004. Original Syllabus contribution. Diagnostic Challenges in Identifying Migraine, and Acute Treatment of Migraine, Tokyo, Japan, Feb 21, 2004. Preventive Therapy of Migraine. Headache Cooperative of New England, winter course. Stowe, VT. March 2004. Original Syllabus contribution. The New 2004 IHS Classification System: Preliminary Introduction. American Headache Society CME symposium, June 2004. The New 2004 IHS Classification System: Chronic Daily Headache. American Headache Society June 2004. Original Syllabus contribution. Drug Interactions in Headache Management, National Headache Foundation Headache Update 2004, Orlando, Fl, July 15, 2004. Original Syllabus contribution. Preventive Therapy of Migraine, National Headache Foundation Headache Update 2004, July 17, 2004. Original Syllabus contribution. 15 New Thoughts on “Sinus Headache”, 10th Annual Summer Allergy Conference, Albany (NY) Medical College, Saratoga, NY, July 22, 2004. Original Syllabus contribution. Preventive Therapies- Consensus for Guideline Recommendations. Headache Care for Practicing Clinicians. Lisbon, Portugal, Oct 1, 2004. Original Syllabus contribution and invited article, Headache Care. The Migraine Assessment of Current Therapy (Migraine-ACT) questionnaire: further investigation of study methodology and results. Platform presentation, Headache Care for Practicing Clinicians, Lisbon, Portugal, Oct 1-2, 2004. How to Identify and Treat Headache in a Primary Care Setting. Kobe and Kyoto, Japan, Oct 27-28, 2004. Headache Diagnosis in 15 minutes or Less. Headache Cooperative of New England course, Boston, MA, Nov 6, 2004. Original Syllabus contribution. Herbs, Minerals, Vitamins, and Supplements. American Headache Society, Scottsdale, AZ. Nov 13, 2004. Original Syllabus contribution. 5 Papers that will change your clinical practice: The Chronic Daily Headache studies of Dr. Ann Scher. American Headache Society, Scottsdale, AZ. Nov 13, 2004. Original Syllabus contribution. Moderator: American Headache Society, Scottsdale, AZ Nov 2004. Prepared questions and led platform discussion. Pathophysiology of Migraine and Future Targets Beyond Triptans, 24th Annual US Army Medical Department Neurology Education course (AMEDD), Washington, DC. Nov 16, 2004. Original Syllabus contribution. American Headache Society Neurology Ambassador Program Core Faculty, 2000-2004. Chronic Daily Headache. Grand Rounds, Allegheny Medical Center, and Shadyside Hospital, Pittsburgh PA. Feb 2-3,2005. New Options in Migraine Management. Neurological Diseases in 2005: Medical and Surgical Options. Cedars-Sinai Medical Center CME course, San Diego, CA. Feb 18, 2005. Original Syllabus contribution. 16 The Five Best Papers of 2004: Papers that will change your practice. Headache Cooperative of New England Winter Meeting. Stowe, VT. March 5, 2005. Original Syllabus contribution. The Landmark Study: What type of Episodic Headache Really comes into the Primary Care Office Worldwide. 5th National Multidisciplinary Formation Course on Headache, SISC (Italian Headache Society). Capri, Italy. Apr 1, 2005. Original Syllabus contribution. Migraine is Not Usually A Progressive Disorder. Debates in Headache Course, with Dr. Richard Lipton. Joel Saper, MD, Chairman. American Academy of Neurology, Miami, Fl. Apr 12, 2005. Chronic Daily Headache. Medicine Grand Rounds, Borgess Medical Center, Kalamazoo, MI. Apr 15, 2005. New Thoughts in Diagnosis of Migraine. Medicine Grand Rounds, Our Lady of Mercy Medical Center. The Bronx, NY. Apr 20, 2005. Pathophysiology of Migraine. Neurology Grand Rounds, University of Wisconsin. Madison, WI. Apr 29, 2005. Chronic Daily Headache. Neurology Grand Rounds. St Mary’s Hospital, Madison, WI. Apr 29, 2005. The Global Migraine Burden: Socio-economic Impact. Presented at the Migraine Metaforum, European Consensus Conference on Migraine. Migraine: The Forgotten Epidemic: A European Perspective. Sponsored by the European Headache Federation and University of Duisburg/Essen. Rome, Italy. June 10, 2005. Pathophysiology of Migraine. Neurology Grand Rounds. NY Medical College. Valhalla, NY. June 14, 2005. New Thoughts on Diagnosis of Migraine. Family Practice Noon Conference, St Francis Hospital. Indianapolis, IN. Aug 4, 2005. Chronic Daily Headache. Neurology Noon Conference. Albert Einstein Medical Center, Philadelphia, PA. Sept 9, 2005. Case Studies in Headache. NPACE Nurse Practitioners Midwestern CME Course. Chicago, Ill. Sept 13, 2005. Original Syllabus contribution. Findings from the Landmark Study, and the Importance of Targeted Treatment. , in the symposium Is it a Migraine? What Every Woman 17 Needs to Know. Society for Women’s Health Research. NY, NY. Sept 28, 2005. Herbs, Minerals, Vitamins and Supplements in Headache. Headache Care for Practicing Clinicians, London, UK, Oct 29, 2005. Original Syllabus contribution. Controversies in IHS ICHD-II Nomenclature. Headache Care for Practicing Clinicians, London, UK, Oct 29, 2005. Original Syllabus contribution. Case Studies in Headache. NPACE Nurse Practitioners Eastern CME Course. Boston, MA, Nov 2, 2005. Original Syllabus contribution. Multimodal Migraine Therapy, Montefiore-Albert Einstein School of Medicine Neurology CME course, NY, NY, Nov 4, 2005. Original Syllabus contribution. Avoiding Medical and Legal Pitfalls in the Office Diagnosis of Headache. Headache Cooperative of New England Spotlight on New and Emerging Headache Treatments CME course, Nov 12, 2005. Original Syllabus contribution. Herbs, Minerals, Vitamins and Supplements in the Headache Use Today. American Headache Society Scottsdale Symposium, Scottsdale, AZ, Nov 19-20, 2005. Original Syllabus contribution. Navigating the ICHD-II Diagnostic Criteria: Clinical Cases. American Headache Society Scottsdale Symposium, Scottsdale, AZ, Nov 19-20, 2005. Original Syllabus contribution. Work-up of the Headache Patient: What’s Appropriate? American Headache Society Winter Symposium Las Vegas, NV, Jan. 27, 2006. Original Syllabus contribution. Case Discussions and Chronic Daily Headache. American Headache Society Winter Symposium Las Vegas, NV, Jan. 27, 2006. Clinical cases prepared and presented. New Thoughts About Sinus Headache. The 15th Annual [CME] Education Symposium of the Allergy, Asthma, and Immunology Foundation of Northern California. “Controversies in Asthma and Allergies”, San Francisco, CA, Feb 11, 2006. Original Syllabus contribution. Diagnosing Headache: Tools and Strategies for the Busy Clinician. Misdiagnosed, Misunderstood: Effective Strategies for Differentiating Headache. CME Session, The 19th Annual Practicing Physician’s 18 Approach to the Difficult Headache Patient, National Headache Foundation, Rancho Mirage, CA, Feb 16, 2006. Original Syllabus contribution. High and Low Pressure Headaches. CME, The 16th Annual Headache Symposium, Headache Cooperative of New England, Stowe, VT March 4, 2006. Original Syllabus contribution. Debates in Headache: The Case Against Chronic Opioids for Chronic Daily Headache. CME course, 58th Annual Meeting, American Academy of Neurology, Apr 7, 2006. Chronic Daily Headache, CME course. Neuroscience Update for Primary Care Practitioners, Ellis Hospital Neurosciences. Scotia, NY, May 4, 2006. Alternative Treatment: Herbs, Minerals, Vitamins and Supplements. CME course, 21st Century Neurology, Florida Association for the Study of Headache and Neurological Disorders. Palm Beach Gardens, FL, May 11, 2006. Migraine Pathophysiology and Drug Action. CME course, The Changing Face of Migraine Treatment. Diamond Headache Update 2006. Orlando, FL, July 13, 2006. Stopping migraines before they occur. CME course, The Sixth Annural Headache Cooperative of New England Boston Headache Symposium. Boston, MA. Nov 4, 2006. Original Syllabus contribution. Preventive Treatment of Headache. CME course, The 17th Annual Headache Symposium, Headache Cooperative of New England, Stowe, VT March 2, 2007. Original Syllabus contribution. Diagnosis and Treatment Options for Migraine. CME, given in Hamilton and Toronto, Ontario, Canada, March 28-29, 2007. Pathophysiology of Migraine: Link to Acute Treatment. CME, the Wasser Pain Clinic, Toronto, Ontario, Canada, March 28, 2007 and Kingston General Hospital Neurology Grand Rounds, Kingston, Ontario, Canada, March 29, 2007. PFO and Migraine. CME, Ottawa Hospital Neurology Grand Rounds, Ottawa, Canada, March 30, 2007. Current Approach to Menstrual Migraine and Short-term Prevention: Evidence and Evolving Preventive Treatment Models, in Expanding the 19 Boundaries of Migraine Management: A Focus on Menstrual Migriane, CME Symposium, Academy of Managed Care Pharmacies, San Diego, CA, Apr 12, 2007. PFO and Migraine. Focus on Primary Headaches: Recent Advances in Mechanisms and Management, ANIRCEF, Stresa, Italy, May 25, 2007. Original Syllabus contribution and published article. Post-traumatic headaches and headaches attributed to vascular disorders. Headache Medicine Subspecialty CME Examination Review Course, American Headache Society 49th Annual Scientific Meeting, Chicago, Ill, June 6, 2007. Original Syllabus contribution. CGRP Antagonists: Clinical Trials and Potential Implications for Clinical Practice. The Role of CGRP in Migraine Therapy, CME Symposium, American Headache Society 49th Annual Scientific Meeting, Chicago, Ill, June 8, 2007. Original Syllabus contribution. Headache Attributed to Head and/or Neck Injury. Neurology Grand Rounds, Rhode Island Hospital, Brown University School of Medicine, Providence, RI, July 18, 2007. The Future of Acute Treatment of Migraine. Neurology Grand Rounds, Virginia Commonwealth University (Medical College of Virginia), Richmond, VA, Sept 13, 2007. Optimal Acute Treatment of Migraine. Grand Rounds, Mary Washington Hospital, Fredericksberg, VA, Sept 14, 2007. Acute Treatment of Migraine. Grand Rounds, St Lukes Hospital, Boise, Idaho, Oct 10, 2007. Acute Treatment of Migraine. Grand Rounds, Mercy Hospital, Nampa, Idaho, Oct 10, 2007. Acute Treatment of Migraine. Grand Rounds, West Valley Medical Center, Caldwell, Idaho, Oct 11, 2007. Serotonin Syndrome. American Headache Society meeting, Phoenix, AZ, Nov 2, 2007. Original Syllabus contribution. Osteopathic and Chiropractic Treatment of Headache: Evidence-Based Medicine Assessment. American Headache Society meeting, Phoenix, AZ, Nov 2, 2007. Original Syllabus contribution. Pathophysiology of Migraine. Tufts-New England Medical Center Pain Center, Dec 12, 2007. 20 Acute Treatment of Migraine. Neurology Grand Rounds, Walter Reed Army Medical Center, Washington, DC, Jan 16, 2008. Acute Treatment of Migraine. Neurology Grand Rounds, Georgetown University School of Medicine, Washington, DC, Jan 16, 2008. Headache and Migraine: Evaluation, Management, and When to Refer. Cedars Sinai CME Course, Marina Del Rey, CA, Feb 16, 2008. Protocols for Medication Overuse Headache, Headache Cooperative of New England 18th Annual Headache Symposium, Feb 29, 2008. Patent Foramen Ovale and Migraine. Neurology Grand Rounds, Cleveland Clinic, Cleveland, OH, March 17, 2008. PFO and Migraine: Suggested Mechanisms, in Structural Heart Disease: Mechanisms and Mysteries Course, Society for Cardiovascular Angiography and Interventions, American College of Cardiology meeting, Chicago, Apr 1, 2008. Outpatient Headache Therapy, in Headache Therapy, CME course, 60th annual meeting American Academy of Neurology, Chicago, April 18, 2008. Original syllabus contribution. Should Triptans be Available Over-the Counter in the United States? In Debates in Headache, CME course, 60th annual meeting, American Academy of Neurology, Chicago, April 18, 2008. Patent Foramen Ovale and Migraine. Medicine CME Grand Rounds, Allegheny Medical Center, Pittsburgh, PA, Apr 30, 2008. Patent Foramen Ovale and Migraine. Neurology CME Grand Rounds, University of Pittsburgh Medical Center, Pittsburgh, PA, Apr 30, 2008. Chronic Migraine and Medication Overuse Headache. Update in Headache Management, CME course, Cleveland Clinic Center for Headache and Pain and the Ohio Headache Association, Cleveland, OH, May 30, 2008. Original syllabus contribution. CGRP Receptor Antagonists- Targeting Acute Migraine Treatment, in CME Course, New Neuronal Targets In Migraine Therapy: What Does the Future Hold? American Headache Society meeting, Boston, MA, June 28, 2008. Original syllabus contribution. 21 Migraine: Epidemiology and Diagnosis. Cleveland Clinic Neurology Residents Noon Conference, Oct 21, 2008. Migraine: Pathophysiology. Cleveland Clinic Neurology Residents Noon Conference, Oct 22, 2008. Migraine: Acute and Preventive Treatment. Cleveland Clinic Neurology Residents Noon Conference, Oct 27, 2008. Trigeminal Autonomic Cephalalgias and Hemicrania Continua. Cleveland Clinic Neurology Residents Noon Conference, Oct 28, 2008. Herbs, Minerals, Vitamins, and Supplements: Randomized Controlled Trials and Evidence-based Recommendations for Use in Headache. American Headache Society Scottsdale CME Symposium, Scottsdale, AZ, Nov 6, 2008. Original Syllabus Contribution. Preventive Migraine Treatment. American Headache Society Scottsdale CME Symposium, Scottsdale, AZ, Nov 7, 2008. Original Syllabus Contribution. Drug-drug Interactions in Headache. American Headache Society Scottsdale CME Symposium, Scottsdale, AZ, Nov 8, 2008. Original Syllabus Contribution. Epidemiology of Headaches. 1st International Headache CME Summit. Tel Aviv, Israel, November 14, 2008. Debate: Prognosis of Migraine: Is it a potentially serious disorder in some patients? 1st International Headache CME Summit. Tel Aviv, Israel, November 14, 2008. Treatment of Refractory Headache Patients. 1st International Headache CME Summit. Tel Aviv, Israel, November 16, 2008. Taking the Headache out of Migraine Diagnosis and Treatment. PRIMED CME. Original syllabus contribution. Seattle, WA Sept 26, 2008; New York City, Oct 2, 2008; Tampa, FL Dec 4, 2008. Drug-Drug Interactions in Migraine Treatment. Combined Pain Medicine Grand Rounds. Cleveland Clinic, March 24, 2009. Acute Treatment of Migraine. Headache Therapy course, American Academy of Neurology, May 1, 2009. 22 Pharmacologic Prevention of Migraine. Pain Medicine Grand Rounds, Cleveland Clinic, May 4, 2009. Overview of Migraine. Hospital Grand Rounds, Lakewood Hospital, Lakewood, OH, May 5, 2009. Herbs, minerals, vitamins and supplements in headache. Florida Association for the Study of Headache, West Palm Beach, FL, May 16, 2009. Acute Migraine Treatment – Current and Future. IXth Colombian Congress of Neurology, Santa Marta, Colombia, Aug 15, 2009. Preventive Migraine Treatment- Current and Future. IXth Colombian Congress of Neurology, Santa Marta, Colombia, Aug 15, 2009. Meeting diverse acute migraine treatment needs through novel treatment formulations. CME Satellite Symposium, 14th International Headache Congress, Philadelphia, PA, Sept 12, 2009. Migraine Overview. The 12th National Chinese Conference of Neurology, Beijing, China Oct 16, 2009. Overview of Acute and Preventive Treatments of Migraine and Primary Headaches. The 12th National Chinese Conference of Neurology, Beijing, China Oct 18, 2009. Trigeminal Autonomic Cephalalgias and Other Primary Headaches. With Dr. Lawrence Newman, 2009 Scottsdale Headache Symposium, American Headache Society, Scottsdale, AZ, Nov 6. 2009. Original CME Syllabus submission. Diagnosis of Chronic Daily Headache. 2009 Scottsdale Headache Symposium, American Headache Society, Nov 6. 2009 Scottsdale, AZ. Original CME Syllabus submission. Sphenopalatine (SPG) and Other Stimulation for Headaches. North American Neuromodulation Society Meeting, Las Vegas, NV, Dec 5, 2009. Original CME Syllabus submission. Epidemiology and Diagnosis of Migraine. Cleveland Clinic Neurology Residents Noon Conference, Jan 26, 2010. Pathophysiology of Migraine. Cleveland Clinic Neurology Residents Noon Conference, Feb 3, 2010. 23 Latest Advances in Rescue and Prevention therapy for Migraine. 4th Annual Advances in Neurology and Neurosurgery Symposium, CedarsSinai Medical Center, February 20, 2010, Marina Del Rey, CA. Original CME submission. Acute Treatment of Migraine. Cleveland Clinic Neurology Residents Noon Conference, March 17, 2010. Trigeminal Autonomic Cephalalgias and Hemicrania Continua. Cleveland Clinic Neurology Residents Noon Conference, Apr 6, 2010. What Do I Do Now? In Headache Therapy Course, American Academy of Neurology, Toronto, Ontario, Apr 16, 2009. Original CME submission. Brain Changes and Medication Overuse Headache. In Hot Topics in Headache course, American Academy of Neurology, Toronto, Ontario, Apr 17, 2009. Original CME submission. Medication Overuse Headache. Cleveland Clinic Neurology Residents Noon Conference, May 13, 2010. Pathophysiology and Genesis of Medication Overuse Headache. In Update in Headache Management course, Ohio Headache Association/Cleveland Clinic, Cleveland, Ohio, May 14, 2010. Original CME submission. Pathophysiology of Migraine. In Update in Headache Management course, Ohio Headache Association/Cleveland Clinic, Cleveland, Ohio, May 15, 2010. Original CME submission. Future Treatment of Migraine. In Update in Headache Management course, Ohio Headache Association/Cleveland Clinic, Cleveland, Ohio, May 15, 2010. Original CME submission. The International Classification of Headache Disorders, 2d Edition and Diagnosis of Migraine, its variants, and Tension-type Headache. Cleveland Clinic Neurology Residents Noon Conference, Aug 13, 2010. Trigeminal Autonomic Cephalalgias. Cleveland Clinic Neurology Residents Noon Conference, Aug 18, 2010. Prevention of Migraine. Cleveland Clinic Neurology Residents Noon Conference, Sept 22, 2010. Acute Treatment of Migraine. Cleveland Clinic Neurology Residents Noon Conference, Nov 10, 2010 & March 8, 2011. 24 TACs and Other Primary Headache Syndromes- How We Do it. 2010 Scottsdale Headache Symposium, American Headache Society. Original CME submission, Nov 19, 2010. Chronic Migraine, MOH: Here’s What We Do/Detox. 2010 Scottsdale Headache Symposium, American Headache Society. Original CME submission, Nov 20, 2010. Acute Treatment of Migraine. 24th Annual Practicing Physican’s Approach to the Difficult Headache Patient. Rancho Mirage, CA, Feb 20, 2011. Original CME submission. Overview of Migraine, Acute and Preventive Treatment, Cleveland Clinic Department of Internal Medicine CME course, Cleveland, OH, Feb 25, 2011. Chronic Daily Headache, In Headache In Adults course, American Academy of Neurology Apr 10, 2011. Original CME submission. Utility of LEVADEX (MAP0004) in Situations Where Early Intervention Paradigm Is Impractical. American Academy of Neurology Honolulu, HI, Apr 12, 2011. Acute Treatment of Migraine. In Headache Therapy course, American Academy of Neurology Honolulu, HI, Apr 14, 2011. Migraine. Cleveland Clinic Department of Internal Medicine CME course, Cleveland, OH, May 11, 2011. Non-migrainous Headaches: Secondary Sinister Headaches, Chronic Daily Headache, Trigeminal Autonomic Cephalalgias, and Other Primary Headaches. Cleveland Clinic Department of Internal Medicine CME course, Cleveland, OH, May 11, 2011. Pathophysiology of Medication Overuse Headache. Ohio Headache Association, Columbus, OH, May 13, 2011. The IDE for SPG Stimulation for Episodic Migraine: IRB 10-081: Electrical Stimulation of the Sphenopalatine Ganglion for the Treatment of Migraine Headaches, ATI Scientific Advisory Board, American Headache Society Scientific Meeting, June 1, 2011. Sinister Secondary Headaches, Cleveland Clinic Neurology Residents Noon Conference, July 22, 2011. 25 Thomas H. Mason Memorial Invited Guest CME Lecture: Taking the Headache Out of Migraine Diagnosis and Management. Neuroscience Update for Primary Care Practitioners. EllisMedicine, Scotia, New York October 20, 2011. Expert Opinion: Discuss Your Most Difficult Cases. Challenges in Headache Medicine. Southern Headache Society, Asheville, NC, Oct 22, 2011. The use of opiates in headache: A debate. Southern Headache Society, Asheville, NC, Oct 23, 2011. Advanced Interventions for Headache. Southern Headache Society, Asheville, NC, Oct 23, 2011. TACs and Other Primary Headaches. 2011 Scottsdale Headache Symposium, American Headache Society. Original CME submission, Nov 11, 2011. Chronic Migraine, MOH Pharmaceutical Protocols. 2011 Scottsdale Headache Symposium, American Headache Society. Original CME submission, Nov 12, 2011. Pathophysiology of Migraine. Cleveland Clinic Neurology Residents Noon Conference, Nov 16, 2011. Acute Treatment of Migraine. Cleveland Clinic Neurology Residents Noon Conference, Jan 25, 2012. Trigeminal Autonomic Cephalalgias –Cluster and Paroxysmal Hemicrania. Cleveland Clinic Neurology Residents Noon Conference, Apr 11, 2012. Chronic Migraine and the Role for Botulinum Toxins, in the Cleveland Clinic Second Current and Emerging Uses of Botulinum Toxins in Neurology and Rehabilitation: A Practical Skills Workshop (CME), Birmingham, MI, June 9, 2012 Sinister Secondary Headaches. Cleveland Clinic Neurology Residents Noon Conference, July 25, 2012. Headache Update: Migraines and Beyond, in 2012 Neurology Update- A Comprehensive Review for the Clinician, Cleveland Clinic CME Course, Washington, DC, Aug 3, 2012. 26 Chronic Migraine, Chronic Daily Headache and Medication Overuse Headache, in 2012 Neurology Update- A Comprehensive Review for the Clinician, Cleveland Clinic CME Course, Washington, DC, Aug 3, 2012. Chronic Migraine and Medication Overuse Headache, in The Many Faces of Migraine, Ohio Headache Association CME course, Cincinnati, OH, Sept 7, 2012. Procedural Management of Headaches, in Sixth Annual CME Commonwealth Neurological Society Fall Meeting, Louisville, KY, Sept 15, 2012. Medication Overuse Headache, in Frontiers in Neuromuscular Disease and Neuro-Rehabilitation, Case Western Reserve University and the Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH, Oct 18, 2012. TACS and Other Primary Headaches, American Headache Society Scottsdale Headache Symposium, Scottsdale, AZ, Original CME submission, Nov 16, 2012. Chronic Migraine: Treatment and Protocols, American Headache Society Scottsdale Headache Symposium, Scottsdale, AZ, Original CME submission, Nov 17, 2012. Serotonin Syndrome and Headache Treatment. Maryland Headache Society, Baltimore, MD, Nov 27, 2012. Serotonin Syndrome and Headache Treatment. CME Neurology Grand Rounds, Cleveland Clinic, Dec 10, 2012. Chronic Daily Headache, Chronic Migraine, and Medication Overuse Headache. CME Neurology Grand Rounds, Cleveland Clinic, Feb 4, 2013. Opioids and Migraine. CME 15th Annual Cleveland Clinic Pain Management Symposium, Sarasota, FL, Feb 20, 2013. Medication Overuse Headache. CME 15th Annual Cleveland Clinic Pain Management Symposium, Sarasota, FL, Feb 20, 2013. Treatment of Migraine. Cleveland Clinic Pain Management Didactic Lecture, Cleveland Clinic, Mar 4, 2013 Trigeminal Autonomic Cephalalgias. New York University School of Medicine Neurology Grand Rounds, NY, NY, Mar 12, 2013. 27 Acute Treatment of Migraine. In Therapy of Headache CME course, American Academy of Neurology, San Diego, CA, Mar 16, 2013. Medication Overuse Headache. Cleveland Clinic Pain Management Didactic Lecture, Cleveland Clinic, May 6, 2013 International Classification of the Headaches: What´s new. 50th Dominican Republic Neurological Society Annual Meeting, Punta Cana, Dominican Republic, June 1, 2013. Headaches: New Therapies. 50th Dominican Republic Neurological Society Annual Meeting, Punta Cana, Dominican Republic, June 1, 2013. Migraine Physiopathology. 50th Dominican Republic Neurological Society Annual Meeting, Punta Cana, Dominican Republic, June 1, 2013. Should Randomized Clinical Trials be used in Clinical Practice? In the CME course, Controversies in Headache, International Headache Congress, Boston, MA, June 27, 2013. Migraine Pathophysiology in Practice. In Product Theater, International Headache Congress, Boston, MA, June 29, 2013 Sinister Headaches. Cleveland Clinic Neurology Residents Noon Conference, July 19, 2013. Migraine Update. In 2013 Neurology Update- A Comprehensive Review for the Clinician, Cleveland Clinic CME course, Original syllabus contribution, Washington, DC, August 3, 2013. Chronic Migraine and Medication Overuse Headache. In 2013 Neurology Update- A Comprehensive Review for the Clinician, Cleveland Clinic CME course, Original syllabus contribution, Washington, DC, August 3, 2013. Pathophysiology of Primary Headaches- What is New? In What is New in Headache – 2013, International Headache Society course, Mumbai, India, August 11, 2013. Chronic Migraine- The Evolution, The Diagnostic Challenges. In What is New in Headache – 2013, International Headache Society course, Mumbai, India, August 11, 2013. Migraine Treatment in 2013- Paradigms That Have Changed. In What is New in Headache – 2013, International Headache Society course, Mumbai, India, August 11, 2013. 28 Chronic Migraine and Medication Overuse Headache. South Carolina Neurological Society Annual Meeting, CME, Charleston, SC, Oct 5, 2012. OnabotulinumtoxinA and Chronic Migraine. Morning Conference, Physical Medicine and Rehabilitation and Neurology Residency programs, The Ohio State University Wexner Medical Center, Columbus, Ohio, Oct 7, 2013. Protocols for Medication Overuse Headache and Chronic Migraine. 2013 American Headache Society Scottsdale Headache Symposium. CME, Scottsdale, AZ, Nov 23, 2013. Sphenopalatine Ganglion Stimulation, Deep Brain Stimulation, Hand-held Vagal Nerve Stimulation, Transcranial Magnetic Stimulation. 2013 American Headache Society Scottsdale Headache Symposium. CME, Scottsdale, AZ, Nov 23, 2013. Neuromodulation for Migraine. 17th Annual North American Neuromodulation Society meeting. CME, Las Vegas, NV, Dec 7, 2013. Advances in Cluster Headache Management. 17th Annual North American Neuromodulation Society meeting. CME, Las Vegas, NV, Dec 7, 2013. Chronic Daily Headache, Chronic Migraine, and Medication Overuse Headache. Neurology Grand Rounds, Michigan State University College of Human Medicine, East Lansing, MI, Dec 13, 2013. Chronic Daily Headache, Chronic Migraine, and Medication Overuse Headache. CME Neurosurgery Grand Rounds, Cleveland Clinic, Jan 15, 2014. Trigeminal Autonomic Cephalalgias. Cleveland Clinic Neurology Residents Noon Conference, Jan 17, 2014. Chronic Daily Headache, Chronic Migraine, and Medication Overuse Headache. CME Neurology Grand Rounds, University of Maryland School of Medicine, Baltimore, MD, March 5, 2014. Neuromodulation for Headache: What is the Evidence? CME Headache Cooperative of New England, Stowe, VT, March 8, 2014. Current Treatments Delivered Differently. CME 56th Annual American Headache Scientific Meeting, Los Angeles, CA, June 29, 2014. 29 The Scourge of Frequent Headaches: Practical and Effective Approaches for Diagnosis and Treatment of Chronic Migraine, Chronic Daily Headache, and Medication Overuse Headache. Mercy St Anne Hospital Evening CME Program. Toledo, OH, July 29, 2014. Management of Chronic Daily Headache. 2014 Cleveland Clinic Neurology Update. Washington, DC, August 2, 2014. Migraine Update. 2014 Cleveland Clinic CME Neurology Update. Washington, DC, August 2, 2014. Serotonin Syndrome and Headache Treatment. Stanley Wissman Neuroscience/Brain Injury CME Symposium, Manchester University College of Pharmacy. Fort Wayne, IN, Oct 30, 2014. Diagnosing Migraine. American Headache Society Comprehensive Migraine Education CME Program, San Diego, IN, Nov 8, 2014. Case Studies in Headache. American Headache Society Comprehensive Migraine Education CME Program, San Diego, IN, Nov 8, 2014. Preceptorship in Procedures for Headache (Peripheral Nerve Blocks and Neurotoxin). American Headache Society Comprehensive Migraine Education CME Program, San Diego, IN, Nov 8, 2014. Sphenopalatine Ganglion Neuromodulation and Headache. North Central Headache Society meeting (formerly Ohio Headache Association). New Albany, OH, Dec 6, 2014. Neuromodulation and Headache. Headache Cooperative of the Pacific CME meeting. San Francisco, CA, Jan 16, 2015. Highlights of the AAN, AHS, and EHMTIC Meetings. Headache Cooperative of the Pacific CME meeting. San Francisco, CA, Jan 17, 2015. Chronic Headache: State-of-the-art and Challenging Cases. American Academy of Neurology Breakthroughs in Neurology CME Conference. Phoenix, AZ, Jan 24, 2015. Migraine Therapy: Cutting Edge Innovation. North Carolina Neurological Society 2015 CME Annual Meeting. Charlotte, NC, Feb 21, 2015. Neuromodulation and Headache Disorders. University of Louisville Department of Neurology CME Grand Rounds, Louisville, KY, March 27, 2015. 30 Sphenopalatine Ganglion Stimulation (SPG): Mechanism, Efficacy, and Safety. CME lecture, 17th International Headache Congress, Valencia, Spain, May 13, 2015. Headache Update 2015: New Formulations, Neuromodulation, and Monoclonal Antibodies. 17th Annual Update in Headache and Pain Management, CME Annual Course from the Michigan Headpain and Neurological Institute and Michigan State University, Dearborn, MI, May 29, 2015. Clinical Case Presentations. 17th Annual Update in Headache and Pain Management, CME Annual Course from the Michigan Headpain and Neurological Institute and Michigan State University, Dearborn, MI, May 29, 2015. Prevention of Migraine/Chronic Migraine. Headache Update 2015, Diamond Headache Clinic Research & Educational Foundation CME course, Orlando, FL, July 16, 2015. Neuromodulation. Headache Update 2015, Diamond Headache Clinic Research & Educational Foundation CME course, Orlando, FL, July 16, 2015. Neuromodulation and Headache. 12th Annual Texas Neurological Society Summer Conference and 5th Annual Southern Headache Society Meeting, CME Annual Meeting, Fort Worth, TX, Aug 1, 2015. Headache Update – What is New and What is Approved? Cleveland Clinic 2015 Neurology Update CME Course, Washington, DC, Aug 8, 2015. Trigeminal Autonomic Cephalalgias (TACs) and Other Primary Headaches – Diagnosis and Treatment. Cleveland Clinic 2015 Neurology Update CME Course, Washington, DC, Aug 8, 2015. Challenging Cases: Difficult Headache Cases. Cleveland Clinic 2015 Neurology Update CME Course, Washington, DC, Aug 8, 2015. Neuromodulation and Headache. North Central Headache Society CME course, Toledo, OH Sept 19, 2015. 31 Computer, multimedia, apps, or Internet-based projects Therapeutic Management Issues in the Treatment of Headache and Migraine. Physicians' Teleconference Network, Annenberg Center for Medical Education, 1995. Migraine and the New Triptans. Physicians' Teleconference Network, Annenberg Center for Medical Education, 1998. Tepper SJ. Tolerability and Safety of the Triptans. Continuing Medical Education Monograph and Program at www.virtual-headache.com, 2001. The Landmark Study: Evaluating Diagnosis Patterns in Headache Patients. CD-Rom; Medical Education Resources, Inc, 2004. The Expanding Role of Botulinum Neurotoxins in Clinical Practice. CDRom/ I-Pod, Practice Insights 2005. The Landmark Study. Evaluating Diagnosis Patterns in Headache Patients: A Pharmacy Perspective. Medical Education Resources, Inc. at www.pharmacymigraine.com, 2007. Imitrex RT: The Need for Speed. GSK CD-ROM, 2007. Migraine. Audio-Digest Neurology; June 21, 2010;1(2). Pathophysiology and Genesis of Medication Overuse Headache. AudioDigest Neurology; Nov 21,2010;1(12). Headache and OnabotulinumtoxinA. Presented in Webinar, CCF Comprehensive Neurotoxin Webinar Series (CME), July 25, 2012. Headache and OnabotulinumtoxinA. Presented in Webinar, CCF Comprehensive Neurotoxin Webinar Series (CME), Nov 13, 2013. OnabotulinumA and Headache Disorders. Presented in Webinar, CCF Comprehensive Neurotoxin Webinar Series (CME), Oct 29, 2014. Simple Ways to Help Your Migraine Therapy Work Better. Medscape CME Video, Sept 2, 2015. Bringing Migraine Research to Clinical Practice: Practical Expert Perspectives. Medscape CME Video, Sept 2, 2015. 32 Bibliography Peer-reviewed original research Marks LE, Stevens JC, Tepper, SJ. Interaction of Spatial and Temporal Summation in the Warmth Sense. Sensory Processes. 1976; 1:87-98. Tepper SJ, Cochran A, Hobbs S, Woessner M. Sumatriptan Suppositories for the Acute Treatment of Migraine. Int J Clin Pract. 1998; 52:31-35. Drucker P, Tepper SJ. Daily Sumatriptan for Detoxification from Rebound. Headache. 1998; 38:687-690. Tepper SJ, Donnan GA, Dowson AJ, Bomhof MAM, Elkind A, Meloche J, Tepper S. A long-term study to maximize migraine relief with Zomig. Current Medical Research and Opinion 1999,15: 254-271. Mathew NT, Rapoport A, Saper J, Magnus L, Bernstein P, Klapper J, Ramadan N, Stacey B, Tepper S. Efficacy of Gabapentin in Migraine Prophylaxis. Headache 2001;41:119-128. Sheftell FD, Fox AW, Weeks RE, Tepper SJ. Differentiating the efficacy of 5HT 1B/D Agonists. Headache 2001;41:257-263. Saper JR, Lake AE, Tepper SJ. Nefazodone for Chronic Daily Headache Prophylaxis: An Open Label Study. Headache 2001;41:465-474. Bigal ME, Sheftell FD, Rapoport AM, Tepper SJ, Lipton RB. Chronic Daily Headache: Identification of Factors Associated with Induction and Transformation. Headache 2002;42:575-581. Bigal ME, Rapoport AM, Sheftell FD, Tepper SJ. Long-term follow-up of patients treated for chronic daily headache with analgesic overuse. Cephalalgia 2002;22:327-328. Tepper S, Allen C, Sanders D, Greene A, Boccuzzi S. Co-prescription of triptans with potentially interacting medications: a cohort study involving 240,268 patients. Headache 2003;43:44-48. Bigal ME, Tepper SJ, Rapoport AM, Sheftell FD. Hemicrania Continua: Comparison Between Two Different Classification Systems. Cephalalgia 2002;22:242-245. 33 Bigal ME, Bordini CA, Tepper SJ, Speciali JG. Intravenous magnesium sulfate in the acute treatment of migraine without aura and migraine with aura. A randomized, double blind, placebo controlled study. Cephalalgia 2002;22:345-353. Bigal ME, Rapoport AM, Lipton RB, Tepper SJ, Sheftell RB. Chronic Daily Headache in a Tertiary Care Population. Correlation Between the International Headache Society Diagnostic Criteria and Proposed Revisions of Criteria for Chronic Daily Headache. Cephalalgia 2002;22:432-438. Bigal ME, Bordini CA, Tepper SJ, Speciali JG. Intravenous dipyrone in the acute treatment of migraine without aura and migraine with aura. A randomized, double blind, placebo controlled study. Headache 2002;42:862-871. Bigal ME, Bordini CA, Tepper SJ, Speciali JG. Migraine with Aura vs migraine without Aura: Pain Intensity and Associated Symptoms Intensities following Placebo. Headache 2002;42:872-877. Kosinski M, Bayliss MS, Bjorner JB, Ware JE Jr, Garber WH, Batenhorst A, Cady R, Dahlof CG, Dowson A, Tepper S. A six-item short-form survey for measuring headache impact: the HIT-6. Qual Life Res. 2003;12:963-74. Ware JE Jr, Kosinski M, Bjorner JB, Bayliss MS, Batenhorst A, Dahlof CG, Tepper S, Dowson A. Applications of computerized adaptive testing (CAT) to the assessment of headache impact. Qual Life Res. 2003;12:93552. Antoniazzi AL, Bigal ME, Bordini CA, Tepper SJ, Speciali JG. Headache and Hemodialysis: A Prospective Study. Headache 2003;43:99-102. Bjorner JB, Ware JE, Kosinski M, Tepper S, Dowson A, Bayliss MS, and Batenhorst AS. Validation of the Headache Impact Test using patientreported symptoms and headache severity. In: Olesen J, Steiner TJ, and Lipton RB, Eds. Reducing the Burden of Headache. Oxford: Oxford University Press 2003. Chapter 13, pages 87-92. Bayliss MS, Kosinski M, Diamond M, Tepper S, Garber WH, Ware JE, and Batenhorst AS. HIT-6 scores discriminate among headache sufferers differing in headache-associated workplace productivity loss. In: Olesen J, Steiner TJ, and Lipton RB, Eds. Reducing the Burden of Headache. Oxford: Oxford University Press 2003. Chapter 56, pages 338-342. 34 Bigal ME, Rapoport AM, Lipton RB, Tepper SJ, Sheftell FD. Assessment of Chronic Migraine Disability Using the Migraine Disability Assessment (MIDAS) Questionnaire: A Comparison of Chronic Migraine with Episodic Migraine. Headache 2003;43:336-342. Rapoport AM, Bigal ME, Volcy M, Sheftell FD, Feleppa M, and Tepper SJ. Naratriptan in the Preventive Treatment of Refractory Chronic Migraine: A Review of 27 Cases. Headache 2003;43:482-489. Bigal ME, Rapoport AM, Bordini CA, Tepper SJ, Sheftell FD, Speciali JG. Burden of Migraine in Brazil: Estimate of Cost of Migraine to the Public Health System and an Analytical Study of the Cost-Effectiveness of a Stratified Model of Care. Headache 2003;43:742-754. Bigal ME, Sheftell FD, Rapoport AM, Tepper SJ, Lipton RB, Weeks R, Baskin SM. MMPI personality profiles in patients with primary chronic daily headache. A case-control study. Neurol Sciences 2003;24:103-110. Tepper SJ, Bigal ME, Rapoport AM, Sheftell FD. Botulinum toxin type A in the preventive treatment of refractory headache: a review of 100 consecutive cases. Headache 2004;44:794-800. Prince PB, Rapoport AM, Bigal AM, Sheftell FD, Tepper SJ. The Effect of Weather on Headache. Headache 2004; 44:596-602. Silberstein S, Tepper S, Brandes J, Diamond M, Goldstein J, Winner P, Venkatraman S, Vrigjens F, Malbecq W, Visser WH, Reines S, and Yuen E. Randomized, Double-Blind, Placebo-Controlled Trial of Rofecoxib for the Acute Treatment of Migraine. Neurology 2004; 62: 1552-1557. Dowson AJ, Tepper SJ, Vaos V, Baudet F, D’Amico D, and Kilminster S. Identifying patients who require a change in their current acute migraine treatment: the Migraine Assessment of Current Therapy (Migraine-ACT) questionnaire. Current Medical Research and Opinion 2004;20:1125-35. Sang CN, Ramadan RM, Wallihan RG, Chappell AS, Freitag FG, Smith TR, Silberstein SD, Johnson KW, Phebus LS, Bleakman D, Ornstein PL, Arnold B, Tepper SJ, and Vandenhende F. LY293558, a novel AMPA/GluR5 antagonist, is efficacious and well-tolerated in acute migraine. Cephalalgia 2004;24:596-602. Bigal ME, Rapoport AM, Sheftell FD, Tepper SJ, Lipton RB. Transformed migraine and medication overuse in a tertiary headache center - clinical characteristics and treatment outcomes. Cephalalgia. 2004;24(6):483-90. 35 Sheftell FD, Feleppa M, Tepper SJ, Volcy M, Rapoport AM, Bigal ME. Patterns of use of triptans and reasons for switching them in a tertiary care migraine population. Headache 2004;44:661-8. Bigal ME, Tepper SJ, Sheftell FD, Rapoport AM, Lipton RB. Chronic daily headache: Correlation between the 2004 and the 1988 International Headache Society diagnostic criteria. Headache 2004;44:684-91. Tepper SJ, Dahlof C, Dowson A, Newman L, Mansbach H, Jones M, Pham B, Webster C, Salonen R. Prevalence and Diagnosis of Migraine in Patients Consulting Their Primary Care Physician with a Complaint of Headache: Data from The Landmark Study. Headache 2004;44:856-864. Tepper SJ, D’Amico D, Baos V, Blakeborough P, Dowson AJ. Guidelines for Prescribing Prophylactic Medications for Migraine: A Survey Among Headache Specialists in Different Countries. Headache Care 2004;1:267272. Sheftell FD, Feleppa M, Tepper SJ, Rapoport AM, Ciannella L, Bigal ME. Assessment of Adverse Events Associated with Triptans- Methods of Assessment Influence the Results. Headache 2004;44:978-993. Bigal ME, Lipton RB, Tepper SJ, Rapoport AM, Sheftell FD. Primary Chronic Daily Headache and its Subtypes in Adolescents and Adults. Neurology 2004;63:843-847. Rapoport AM, Bigal ME, Tepper SJ, Sheftell FD. Naratriptan in the preventive treatment of refractory chronic migraine. In: Olesen J, Silberstein SD, Tfelt-Hansen P., Eds. Preventive Pharmacotherapy of Headache Disorders. Oxford: Oxford University Press 2004, pages 205211. Tepper SJ, Baos V, Dowson AJ, Baudet F, D’Amico D, Kilminster S. The Migraine Assessment of Current Therapy (Migraine-ACT) Questionnaire: Further Investigation of Study Results. Headache Care 2005;2:27-31. Dowson AJ, Tepper SJ, Baos V, Baudet F, D’Amico D, Kilminster S. Identifying patients who require a change in their current acute migraine treatment: the Migraine Assessment of Current Therapy (Migraine-ACT) Questionnaire. Headache Care 2005;2:5-10. Dowson AJ, Tepper SJ, Dahlof C. Patients’ preference for triptans and other medications as a tool for assessing the efficacy of acute treatments for migraine. J. Headache and Pain 2005; 6:112–20. 36 Bigal ME, Sheftell FD, Tepper SJ, Rapoport AM, Lipton RB. Migraine days decline with duration of illness in adolescents with transformed migraine. Cephalalgia. 2005;25:482-7. Bigal ME, Rapoport AM, Tepper SJ, Sheftell FD, Lipton RB. The classification of chronic daily headache in adolescents--a comparison between the second edition of the international classification of headache disorders and alternative diagnostic criteria. Headache. 2005;45:582-9. Bigal ME, Rapoport AM, Sheftell FD, Tepper SJ, Lipton RB. Chronic migraine is an earlier stage of transformed migraine in adults. Neurology. 2005;65:1556-61. Sheftell FD, Rapoport AM, Tepper SJ, Bigal ME. Naratriptan in the preventive treatment of refractory transformed migraine: a prospective pilot study. Headache. 2005;45:1400-6. Rapoport AM, Sheftell FD, Tepper SJ, Bigal ME. Levatiracetam in the preventive treatment of transformed migraine: A prospective, open-label, pilot study. Curr Ther Res Clin Exp. 2005:66:212-221. Tepper SJ, Cady R, Dodick D, Freitag FG, Hutchinson SL, Twomey C, Kuhn TA. Oral sumatriptan for the acute treatment of probable migraine: first randomized, controlled study. Headache. 2006 ;46:115-24. Bigal ME, Gironda M, Tepper SJ, Feleppa M, Rapoport AM, Sheftell FD, Lipton RB. Headache prevention outcome and body mass index. Cephalalgia 2006;26:445–450. Tepper SJ, Martin V, Burch SP, Fu AZ, Kwong J, Downs KE. Acute Headache Treatments in Patients With Health Care Coverage: What Prescriptions Are Doctors Writing? Headache and Pain 2006;17:11-17. Bigal ME, Tepper SJ, Sheftell FD, Rapoport AM, Lipton RB. Field Testing Alternative Criteria for Chronic Migraine. Cephalalgia 2006;26:477-482. Kilminster SG, Dowson AJ, Tepper SJ, Baos V, Baudet F, D’Amico D. Reliability, Validity, and Clinical Utility of the Migraine-ACT Questionnaire. Headache 2006;46:553-562. Meskunas CA, Tepper SJ, Rapoport AM, Sheftell FD, Bigal ME. Medications associated with probable medication overuse headache reported in a tertiary care headache center over a 15-year period. Headache. 2006 May;46(5):766-72. 37 Bigal ME, Rapoport AM, Sheftell FD, Tepper SJ, Lipton RB. The International Classification of Headache Disorders revised criteria for chronic migraine- field testing in a headache specialty clinic. Cephalalgia 2007;27:230-234. Bigal M, Rapoport A, Aurora S, Sheftell F, Tepper S, Dahlof C. Satisfaction with Current Migraine Therapy: Experience from 3 Centers in US and Sweden. Headache 2007;47:475-479. Rapoport AM, Mathew NT, Silberstein SD, Dodick D, Tepper SJ, Sheftell FD, Bigal ME. Zolmitriptan nasal spray in the acute treatment of cluster headache: A double-blind study. Neurology 2007;69:821–826. Bigal M, Sheftell F, Tepper S, Tepper D, Ho TW, Rapoport A. A Randomized Double-Blind Study Comparing Rizatriptan, Dexamethasone, and the Combination of Both in the Acute Treatment of Menstrually Related Migraine. Headache 2008;48(9):1286-1293. Bigal M, Rapoport A, Sheftell F, Tepper D, Tepper S. Memantine in the Preventive Treatment of Refractory Migraine. Headache 2008;48 (9):1337-1342. Tepper SJ, Zatochill M, Szeto M, Sheftell FD, Tepper DE, Bigal ME. A Simple Menstrual Migraine OB/GYN Screener: The Menstrual Migraine Assessment Tool (MMAT). Headache 2008;48:1419-1425. Kung E, Tepper SJ, Rapoport AM, Sheftell FD, Bigal ME. New daily persistent headache in the paediatric population. Cephalalgia. 2009;29(1):17-22. Kowacs PW, Piovesan EJ, Tepper SJ. Rejection and acceptance of possible side-effects of migraine prophylactic drugs. Headache 2009; 49:1022-1027. Tepper SJ, Rezai A, Narouze S, Steiner C, Mohajer P, Ansarinia M. Acute Treatment of Intractable Migraine with Sphenopalatine Ganglion Electrical Stimulation. Headache 2009; 49:983-989. Ansarinia M, Rezai A, Tepper SJ, Steiner CP, Stump J, Stanton-Hicks M, Machado A, Narouze, S. Electrical Stimulation of Sphenopalatine Ganglion (SPG) for Acute Treatment of Cluster Headaches. Headache. 2010 Jul;50(7):1164-74. Blumenfeld A, Ashkenazi A, Grosberg B, Napchan U, Narouze S, Nett B, DePalma T, Rosenthal B, Tepper S, Lipton RB. Patterns of Use of Peripheral Nerve Blocks and Trigger Point Injections among Headache 38 Practitioners in the US: Results of the American Headache Society Interventional Procedure Survey (AHS-IPS). Headache 2010;50:937-942. Whyte CA, Stillman MJ, Tepper SJ. Dihydroergotamine and its use in migraine with posterior fossa symptoms. Headache 2010;50 (9): 14191423. Cleves C, Rothner D, Parikh S, Tepper SJ. Link Between Confusional Migraine, Hemiplegic Migraine and Episodic Ataxia Type 2: Hypothesis, Family Genealogy, Gene typing and Classification. Cephalalgia 2010;30 (6):740-743. Baron EP, Tepper SJ, Mays M, Cherian N. Acute Treatment of BasilarType Migraine with Greater Occipital Nerve Blockade. Headache 2010;50(6):1057-1059. Aurora SK, Silberstein SD, Kori SH, Tepper SJ, Borland SW, Wang M, Dodick DW. MAP0004, orally inhaled DHE: a randomized, controlled study in the acute treatment of migraine. Headache. 2011 Apr;51(4):50717. Tepper SJ, Kori SH, Goadsby PJ, Winner PK, Wang MH, Silberstein SD, Cutrer M. MAP0004, Orally Inhaled DHE for the Acute Treatment of Migraine: Efficacy of Early and Late Treatments. Mayo Clinic Proceedings 2011; 86(10):948-955. Baron EP, Cherian N, Tepper SJ. Role of Greater Occipital Nerve Blocks and Trigger Point Injections for Patients with Dizziness and Headache. The Neurologist 2011;17:312–317. Tepper SJ, Kori SH, Borland SW, Wang MH, Hu B, Mathew NT, Silberstein SD. Efficacy and Safety of MAP0004, Orally Inhaled DHE in Treating Migraines With and Without Allodynia. Headache 2012;52(1): 37-47. Tepper SJ, Lowe MJ, Beall E, Phillips MD, Liu K, Stillman MJ, Horvat M, Jones SE. Iron Deposition in Pain-Regulatory Nuclei in Episodic Migraine and Chronic Daily Headache by MRI. Headache 2012; 52(2): 236-243. Baron EP, Moskowitz SI, Tepper SJ, Gupta R, Novak E, Hussain MS, Stillman MJ. Headache Following Intracranial Neuroendovascular Procedures. Headache 2012 May;52(5):739-48. Landy SH, Tepper SJ, Wein T, Schweizer E, Ramos E. An Open-Label Trial of a Sumatriptan Auto-Injector for Migraine in Patients Currently Treated With Sumatriptan. Headache 2013;53(1):118-25. 39 Peterlin BL, Tietjen GE, Gower BA, Ward TN, Tepper SJ, White LW, Dash PD, Hammond ER, Haythornthwaite JA. Ictal Adiponectin Levels in Episodic Migraineurs: A Randomized Pilot Trial. Headache 2013;53:474490. Almas M, Tepper SJ, Landy S, Schweizer E, Ramos E. Consistency of eletriptan in treating migraine: Results of a randomized, within-patient multiple-dose study. Cephalalgia. 2014;34(2):126-35. Zheng Y, Tepper SJ, Covington EC, Mathews M, Scheman J. Retrospective Outcome Analysis for Headaches in a Pain Rehabilitation Interdisciplinary Program. Headache 2014;54(3):520-7. Tepper SJ, Cady RK, Silberstein S, Messina J, Mahmoud RA, Djupesland PG, Shin P, Siffert J. Breath Powered Nasal Delivery of Sumatriptan Powder (AVP-825) vs Oral Sumatriptan in the Treatment of Acute Migraine (the COMPASS Study): A Randomized Clinical Trial, Headache 2015 May;55(5):621-635. Vij B, Whipple MO, Tepper SJ, Mohabbat AB, Stillman M, Vincent A. Frequency of Migraine Headaches in Patients with Fibromyalgia. Headache 2015 June;55(6):860-865. Case Reports, Technical Notes, Letters Yung W, Tepper SJ, Young DF. Diffuse Bone Marrow Metastasis by Glioblastoma: Postmortem Diagnosis by Peroxidase-antiperoxidase Staining for Glial Fibrillary Acidic Protein. Ann Neurology. 1983: 14:581585. Mullally WJ, Tepper SJ, Walshe TM 3rd, Wang AM, Samuels MA. A misleading cervical bruit in carotid occlusion. N J Med. 1988 Jun;85(6):519-21. Bertino RE, Porter BA, Stimac GK, Tepper SJ. Imaging Spinal Osteomyelitis and Epidural Abscess with Short T1 Inversion Recovery (STIR). Am J Neuroradiology. 1988; 9:563-564. Millson D and Tepper S. Issues related to the assessment of migraine recurrence following triptan therapy. Eur J. Neurology 1999;6(4):525-526. Tepper SJ, Rapoport AM, Nett RB. Eletriptan’s clinical claims questioned. Formulary 2000; 35:612-614 (Letter). 40 Bigal ME, Tepper SJ, Sheftell FD, Rapoport AM. Hemicrania Continua: a report of ten new cases. Arq Neuropsiquiatr 2002;60:695-698. Rapoport AM, Bigal ME, Tepper SJ, Sheftell FD. Treatment of cluster headache with topiramate: Effects and side-effects in five patients. Cephalalgia 2003;23:69-70 (Letter). Volcy M, Tepper SJ, Rapoport AM, Sheftell FD, Bigal MD. Short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms (SUNA)—a case report. Cephalalgia 2005:25:470–472. Volcy M, Sheftell FD, Tepper SJ, Rapoport AM, Bigal ME. Tinnitus in migraine: an allodynic symptom secondary to abnormal cortical functioning? Headache. 2005;45:1083-7. Volcy M, Tepper SJ, Rapoport AM, Sheftell FD, Bigal MD. Botulinum toxin A for the treatment of greater occipital neuralgia and trigeminal neuralgia: a case report with pathophysiological considerations. Cephalalgia,2006;26: 336–340. Volcy M, Rapoport AM, Tepper SJ, Sheftell FD, Bigal ME. Persistent idiopathic facial pain responsive to topiramate. Cephalalgia 2006:26:489491. Bigal ME, Sheftell FD, Tepper SJ, Rapoport AM. Migraine and silent infarcts. Are we making the proper decision? Cephalalgia 2006;26:629630. Sun C, Lay C, Broner S, Silberstein S, Tepper S, Newman L. Reversible Anorgasmia with Topiramate Therapy for Headache: A Report of 7 Patients. Headache 2006; 46:1450-1453. Bigal ME, Sheftell FD, Tepper SJ, Rapoport AM. Discontinuation of medication overuse in headache patients: recovery of therapeutic responsiveness. Cephalalgia. 2007;27:568 (Letter). Tepper SJ, Shapiro, RE, Sun-Edelstein C, Evans RW, Tietjen GE. Triptans and Serotonin Syndrome- A Response. Headache 2012;52(7):1185-1188 (Letter). 41 Editorials, Reviews, Monographs, Journal Features, Chapters Tepper SJ. Tardive Dyskinesia: An Iatrogenic Disorder. McGill Medical Journal. 1979; 45:21-24. Casey DE, Tepper SJ. Cholinergic Aspects of Tardive Dyskinesia. In: Obiols J, Ballus C, Gonzalezmonclus E, Pujol J, eds. Biological Psychiatry Today, Vol. 2. Amsterdam: Elsevier North Holland Biomedical Press; 1979: 647 Tepper SJ, Haas, JF. Prevalence of Tardive Dyskinesia. J Clin Psychiatry. 1979; 39:508-516. Tepper SJ. Neurologic Aspects of Sjogren's Syndrome. Moisture Seekers. Nov 1993; 2:1-6. Cady RK, Rosum RW, Solomon GD, Tepper SJ. Rational Therapy for Headache. 1995; Institute for Contemporary Pharmacy Research (ICPRx). Tepper SJ. A Primary Care Approach to Migraine and Chronic Headache. Primary Care Reports 1996; 2:151-160. Tepper SJ. From Moldy Bread to DHE: The Story of the Ergot Drugs. American Council on Headache Education Newsletter. Spring 1997;8:1. Tepper SJ. Book Review: Frontiers in Headache Research, Vol. 5.Olesen J, Moskowitz M, eds. Neurology. 1997; 48:298. Tepper SJ. Book Review: Office Practice of Neurology. Samuels MA, ed. Neurology. 1997: 49:65A. Tepper SJ. Migraine: Latest Options for Acute Therapy. Consultant. 1998; 38:1163-1175. Tepper SJ. Recent Advances in Antimigraine Therapy: A Clinical Overview of Zolmitriptan's Efficacy and Tolerability. Postgraduate Medicine, Special Report. Jan 1998; 20-26. Tepper SJ. Editorial: Sumatriptan Nasal Spray. Cephalalgia. 1998;18:242. Gawel M, Tepper SJ. The Triptan Revolution. Seminars in Headache Management. 1998; 3:1-10. Tepper SJ. Selection of a New Triptan or Ergot For Your Patient. Seminars in Headache Management.1998; 3:10-14. 42 Tepper SJ, Lucas SL. Highlights of the American Association for the Study of Headache Meeting, San Francisco, California, June26-28, 1998. Seminars in Headache Management.1998; 3:1-7. Tepper SJ. Wolff Award Lecture by Richard Lipton, MD. Seminars in Headache Management.1998; 3:7-8. Lucas SL, Tepper SJ, Sheftell FD. Therapeutic Gain and the Triptans. Seminars in Headache Management.1998; 3:13-14. Tepper SJ, Rapoport AM. The Triptans: A Summary. CNS Drugs 1999(5); 12:403-417. Tepper SJ. The Woman with Right Upper Facial Pain. In: Rapoport AM, Purdy A, Sheftell FD, eds. Advanced Therapy of Headache, 1st Ed. Hamilton, Ontario: B.C. Decker Inc Publisher 1999; Chapter 41, pages 271-276. Sheftell, FD, Rapoport, AM, Purdy A, Tepper SJ. The Woman Who Could Not Decide Which Medicine to Take. In: Rapoport, AM, Purdy A, Sheftell FD, eds. Advanced Therapy of Headache. Hamilton, Ontario: B.C. Decker Inc Publisher 1999; Chapter 5, 31-36. Reprinted in Neurology Reviews 2000; 8:12-16. Tepper SJ. Triptan Update, Almotriptan, and Afterword. Also, editor for Triptan Update section. American Council on Headache Education Newsletter. Spring, 1999, Volume 10, Issue 1:1-6. Tepper SJ. Rizatriptan- A New Agent for the Treatment of Migraine. Today's Therapeutic Trends 1999;17:147-157. Tepper SJ. Migraine update- the triptans: a clinical primer on their use. Primary Care Reports 1999; 5:93-98. Tepper SJ. Triptans: New drugs may provide relief to more migraineurs. National Headache Foundation Headlines May/June 1999:2-4. Tepper SJ. Advances in Headache Medicine: New Advances in Migraine Preventive Medications. American Council on Headache Education Newsletter. Fall, 1999, Volume 10, Issue 3: 9-11. Tepper S. Use of Antidepressants in Headache Therapy. National Headache Foundation Headlines March/April 2000:1-3. 43 Millson DS, Tepper SJ, Rapoport AM. Migraine pharmacotherapy with oral triptans: a rational approach to clinical management. Expert Opin. Pharmacotherapy 2000;1:391-404. Tepper SJ. First-line treatment for migraine: analgesics or triptans; Migraine-specific versus nonspecific treatment. American Council on Headache Education Newsletter 2000;11(issue 2):1,6. Tepper SJ, Sheftell FD, Rapoport AM. Evidence-Based Guidelines for Migraine Headaches. Journal Watch Neurology 2000;2:70. Tepper SJ, Rapoport AM. Book Review: Management of Headache and Headache Medications, Second Edition. Robbins, L. Neurology 2000;55:1425. Tepper SJ. Drug Interactions and the Triptans. CNS News 2001;3:27-29. Tepper SJ. Safety and Rational Use of the Triptans. Medical Clinics of North America July 2001;85:959-971. Rapoport AM and Tepper SJ. Controversies in Neurology: Triptans are all Different. Archives of Neurology 2001;58:1479-1480. Tepper SJ and Gabb MG. Optimizing the Approach to Acute Treatment of Migraine. Am J of Clinical Proceedings 2001;1:7-13. Tepper SJ, Rapoport AM, Sheftell FD. The Pathophysiology of Migraine. The Neurologist 2001;7:279-286. Bigal ME, Rapoport AM, Sheftell FD, Tepper SJ. Novas opções para o tratamento preventivo da migrânea. Atualização com considerações terapêuticas. Migrâneas e Cefaléias 2002;5:13-18. Bigal ME, Rapoport AM, Sheftel FD, Tepper SJ. New Migraine Preventive Options –An Update with Pathophysiological Considerations. Rev Hosp Clin 2002;57:6:293-298. Tepper SJ. Rapoport AM, Sheftell FD. Ethical Considerations in Cluster Headache Research. Current Pain and Headache Reports 2002; 6:47-51. Tepper SJ. Ask the Doctor column, American Council on Headache Education Newsletter 2002;12(issue 4):6. Tepper SJ. Headache Specialist Q&A: Using Antihypertensives in Headache Therapy. NHF Headlines 2002; No. 125:6-7. 44 Sheftell, FD and Tepper SJ. New Paradigms in the Recognition and Acute Treatment of Migraine. Headache 2002;42:58-69. Tepper SJ. Book Review: The Triptans: Novel Drugs for Migraine, in Humphrey P, Ferrari M, and Olesen J, Eds. The Lancet Neurology 2002;1:134. Tepper SJ, Rapoport AM, Sheftell FD. Mechanisms of Action of the 5HT1B/1D Agonists. Archives of Neurology 2002;59:1084-1088. Tepper SJ. Migraine: How to Use Acute Therapy Most Effectively. Consultant 2002;42:977-981. Tepper SJ and Dodick DW. Debate: Analgesic Overuse is a Cause, Not Consequence, of Chronic Daily Headache. Headache 2002;42:543-554. Tepper SJ. Triptans and the Potential for Drug Interactions (Revised edition). CNS News 2002;4:25-28. Tepper SJ. Predicting Effective Migraine Therapy: Response and Recurrence. Headache Quarterly 2002;13:105-110. Tepper SJ, Rapoport AM, Sheftell, FD. Abstract Review-Current Research & Expert Commentary: Botulinum Toxin Type A for Headache, Migraine and Beyond. NY: Rosemont Press, Inc, and Rogers Medical Intelligence Solutions, 2003. Bigal ME, Tepper SJ. Ergotamine and Dihydroergotamine: A Review. Curr Pain Headache Reports 2003;7:55-62. and Curr Headache Reports 2003;2:11-18. Millson DS and Tepper SJ. Abstracts and Citations. Headache 2003;43 (3): 299-308. Tepper SJ, Rapoport AM, Sheftell FS. Strategies of Care for Acute Treatment of Migraine. The Journal of Headache and Pain 2003;3:63-69. Millson DS and Tepper SJ. Abstracts and Citations. Headache 2003;43 (4): 423-429. Tepper SJ and Millson DS. Safety Profile of the Triptans. Expert Opinion on Drug Safety 2003;2:123-132. Millson DS and Tepper SJ. Abstracts and Citations. Headache 2003;43 (6): 686-692. 45 Rapoport AM, Tepper SJ, Bigal Marcelo E, Sheftell FD. The Triptan Formulations: How to Match Patients and Products. CNS Drugs 2003;17:431-447. Millson DS and Tepper SJ. Abstracts and Citations. Headache 2003;43 (7): 825-832. Millson DS and Tepper SJ. Abstracts and Citations. Headache 2003;43 (8): 930-938. Tepper SJ. Triptans and The Potential for Drug Interactions (3rd, Revised Edition). CNS News 2003;5:39-42. Millson DS and Tepper SJ. Abstracts and Citations. Headache 2003;43 (9): 1015-1023. Millson DS and Tepper SJ. Abstracts and Citations. Headache 2003;43 (10): 1122-1128. Dowson AJ, Sender J, Lipscombe S, Cady RK, Tepper SJ, Smith R, Smith TR,Taylor FR, Boudreau GP, Van Duijn NP, Poole AC, Baos V, Woeber C. Establishing principles for migraine management in primary care. Int J Clin Pract 2003;57:493-507. Tepper SJ and Rapoport AM. Coital Headache, in Aminoff M and Daroff R, eds, Encyclopedia of the Neurological Science. San Diego: Academic Press, 2003, pp. 510-511. Tepper SJ. An overview of migraine pathophysiology, in Understanding Migraine Headache: Recognition and Intervention, A Special Report. Postgraduate Medicine Nov 2003. Millson DS and Tepper SJ. Abstracts and Citations. Headache 2004;44 (1): 110-117. Millson DS and Tepper SJ. Abstracts and Citations. Headache 2004;44 (2): 194-201. Tepper SJ. New Thoughts on Sinus Headache. Allergy and Asthma Proc 2004; 25:1-2. Millson DS and Tepper SJ. Abstracts and Citations. Headache 2004;44 (3): 295-302. Rapoport AM, Bigal ME, Tepper SJ, and Sheftell FD. Zolmitriptan (Zomig). Exp Review of Neurotherapeutics 2004;4:33-41. 46 Millson DS and Tepper SJ. Abstracts and Citations. Headache 2004;44 (4): 377-383. Sheftell FD, Bigal ME, Tepper SJ, Rapoport AM. Sumatriptan (Imitrex)-A Decade of Use and Experience in the Treatment of Migraine. Exp Review of Neurotherapeutics 2004;4:199-209. Millson DS and Tepper SJ. Abstracts and Citations. Headache 2004;44 (5): 448-455. Tepper SJ. Treatment of Headache Pain with Botulinum Neurotoxins. Pain Practice 2004;4(Issue 1S):S38-S46. Millson DS and Tepper SJ. Abstracts and Citations. Headache 2004;44 (6): 627-634. Rapoport AM, Bigal ME, Tepper SJ, Sheftell FD. Intranasal medications for the treatment of migraine and cluster headache. CNS Drugs, 2004;18:671-85. Millson DS and Tepper SJ. Abstracts and Citations. Headache 2004;44 (7): 734-744. Dowson AJ, Tepper SJ, Cady RK. New Initiatives for the Management of Headache in Primary Care: Reviews of the Second Annual Meeting of the Headache Care for Practising Clinicians (HCPC). Headache Care 2004;1:7-13. Millson DS and Tepper SJ. Abstracts and Citations. Headache 2004;44 (8): 844-852. Tepper SJ, Rapoport AM, Sheftell FD, Bigal ME. Chronic Daily Headache- An Update. Headache Care 2004;1:222-245. Millson DS and Tepper SJ. Abstracts and Citations. Headache 2004;44 (9): 936-943. Tepper SJ. Drug Interactions in Headache: What to Watch for and Why. ACHE Headache Newsletter 2004;15(3):7,11. Millson DS and Tepper SJ. Abstracts and Citations. Headache 2004;44 (10): 1059-1068. 47 Tepper SJ and Reed L. What’s Hot in Headache Research: Potential Therapies for Migraine, Cluster and Chronic Daily Headache. National Headache Foundation NHF Headlines 2005;Jan/Feb 2005:1-4. Millson DS and Tepper SJ. Abstracts and Citations. Headache 2005;45 (1): 91-98. Bigal ME, Rapoport AM, Sheftell FD, Tepper SJ. The Woman with Never-Ending Headaches, in Purdy RA, Tepper SJ, Rapoport AM, Sheftell FD, editors. Advanced Therapy of Headache, 2d Edition. Hamilton, Ontario, London: BC Decker Inc, 2005, pages 109-112. Millson DS and Tepper SJ. Abstracts and Citations. Headache 2005;45 (2): 179-187. Tepper SJ. Herbs, Minerals, Vitamins, and Supplements in Migraine. Primary Care Consultant 2005:45:662-666. Millson DS and Tepper SJ. Abstracts and Citations. Headache 2005;45 (3): 260-267. Tepper SJ. Alternative Medicine in Migraine: Is It Ever a Good Alternative? Headache and Pain 2005;16:69-74. Millson DS and Tepper SJ. Abstracts and Citations. Headache 2005;45 (4): 399-405. Sheftell FD, Tepper SJ, Bigal ME. Migraine: barriers for care. Neurol Sci. 2005;26 Suppl 2:s140-2. Millson DS and Tepper SJ. Abstracts and Citations. Headache 2005;45 (7): 961-968. Krymchantowski A and Tepper SJ. Nonspecific Migraine Acute Treatment. In Lipton RB and Bigal ME, eds. Migraine and Other Headache Disorders. NY: Informa Healthcare, 2005. Pp 273-288. Millson DS and Tepper SJ. Abstracts and Citations. Headache 2005;45 (8): 1092-1100. Rapoport AM, Tepper SJ, Sheftell FD, Kung E, Bigal ME. Which triptan for which patient? Neurol Sci. 2006; 27 Suppl 2:s123-9. Tepper SJ and Millson DS. Abstracts and Citations. Headache 2005;45 (9): 1271-1278. 48 Tepper SJ and Millson DS. Abstracts and Citations. Headache 2005;45 (10): 1421-1428. Pereira Monteiro JMP, Tepper S, Shapiro RE. Headache Associated with Acute Substance Use or Exposure, in Olesen J, Goadsby P, Ramadan N, Tfelt-Hansen P, Welch MA, Editors, The Headaches, 3rd Ed. Philadelphia: Lippincott Williams and Wilkins, 2006, Pp 959-969. Vogler B, Rapoport AM, Tepper SJ, Sheftell F, Bigal ME. Role of melatonin in the pathophysiology of migraine: implications for treatment. CNS Drugs 2006;20:343-350. Millson DS and Tepper SJ. Abstracts and Citations. Headache 2006;46 (1): 183-190. Volcy Gomez M and Tepper SJ. Headaches. in Von Roenn JH, Paice JA, Preodor ME, Editors. Current Diagnosis and Treatment of Pain. New York: Lange Medical Books/McGraw-Hill, 2006, Pp 150-171. Tepper SJ and Millson DS. Abstracts and Citations. Headache 2006;46 (2): 349-355. Tepper SJ. Poor Response to One Triptan No Predictor of Response to Others. Journal Watch Neurology 2006;8:49. Tepper SJ. Abstracts and Citations. Headache 2006;46 (3): 535-543. Tepper SJ. Tailoring Management Strategies for the Patient with Menstrual Migraine: Focus on Prevention and Treatment. Headache 2006; 46 (CME Suppl 2):S61-S68. Tepper SJ, Bigal ME, Dowson AJ. Abstracts and Citations. Headache 2006;46 (4): 695-702. Tepper SJ. Acute Treatment of Migraine. Continuum Lifelong Learning Neurol 2006(6);12:87-105. Tepper SJ, Bigal ME, Dowson AJ. Abstracts and Citations. Headache 2006;46 (5): 821-827. Diener H-C, Steiner TJ, Tepper SJ. Migraine- The Forgotten Epidemic: Development of the EHF/WHA Rome Declaration on Migraine. J Headache and Pain 2006;7:1-5. Tepper SJ, Dowson AJ, Bigal M. Abstracts and Citations. Headache 2006;46 (6): 1024-1034. 49 Kaniecki R, Silberstein S, Tepper SJ. Emerging Concepts in Migraine Therapy: Central Sensitization and Multiple Mechanisms of Migraine. Neurology Reviews 2006;14 (CME Supplement, Dec 2006):1-15. Tepper SJ and Bigal ME. Abstracts and Citations. Headache 2006;46 (7): 1213-1219. Tepper SJ. Chronic Daily Headache, in Levin M and Ward TN, editors. Head, Neck and Facial Pain: A Case-based Handbook of Diagnosis, Management, and Prognosis. Columbus, Ohio: Anadem Publishing 2006. Pp 25-29. Tepper SJ and Bigal ME. Abstracts and Citations. Headache 2006;46 (8): 1311-1320. Volcy M and Tepper SJ. Headaches. in Von Roenn JV, Preodor ME, Paice JA, eds. Current Diagnosis and Treatment of Pain. NY: McGraw-Hill. 2006 Pp 150-171. Taylor FR, Tepper SJ, Bigal ME. Abstracts and Citations. Headache 2006;46(9):1464-1473. Tepper SJ, Bigal, M, Rapoport A, Sheftell F. Alternative Therapies: Evidence Based Evaluation in Migraine. Headache Care 2006, 3:57-64. Tepper SJ. Clinical Insights into Two Replicate Randomized DoubleBlind, Placebo-Controlled Trials of the Time to onset of Pain Relief in the Acute Treatment of Migraine with a Fast-Disintegrating/Rapid-Release Formulation of Sumatriptan Tablets. Clinical Impressions Dec 2006;1:2-4. Tepper SJ, Bigal ME, Taylor FR. Abstracts and Citations. Headache 2007;47(1):140-150. Tepper SJ, Bigal ME, Taylor FR. Abstracts and Citations. Headache 2007;47(2):303-311. Tepper SJ. Trigger Points and Chronic Tension-type Headache. Journal Watch Neurology 2007;9:5. Tepper SJ, Bigal ME, Taylor FR. Abstracts and Citations. Headache 2007;47(3):454-460. Tepper SJ. Treatment of menstrual migraine: evidence-based review. Managed Care 2007;16 (Suppl 7):10-4. 50 Tepper SJ, Bigal ME, Taylor FR. Abstracts and Citations. Headache 2007;47(4):626-633. Tepper SJ, Sheftell FD, Bigal ME. The Patent Foramen Ovale-Migraine Question. Neurol Sci 2007;28:S118–S123. Tepper SJ, Bigal ME, Taylor FR. Abstracts and Citations. Headache 2007;47(6):936-944. Shapiro RE, Tepper SJ. The Serotonin Syndrome, Triptans, and the Potential for Drug-Drug Interactions. Headache 2007;47:266-269. Tepper SJ, Bigal ME, Taylor FR. Abstracts and Citations. Headache 2007;47(7):1103-1110. Sheftell FD, Tepper SJ, Lay CL, Bigal M. Post-traumatic headache: emphasis on chronic types following mild closed head injury. Neurol Sci 2007;28:S203-S207. Tepper SJ, Stillman M, Taylor FR. Abstracts and Citations. Headache 2007;47(8):1234-1244. Peterlin BL, Bigal ME, Tepper SJ, Urakaze M, Sheftell FD, Rapoport AM. Migraine and adiponectin: is there a connection? Cephalalgia 2007; 27:435–446. Taylor FR, Stillman M, Tepper SJ. Abstracts and Citations. Headache 2007;47(9):1354-1364. Tepper SJ. Migraine Prevalence and Disease Burden. Journal Watch Neurology 2007;9:50-51. Tepper DE, Tepper SJ, Sheftell FD, Bigal ME. Headache Attributed to Hypothryoidism. Current Pain and Headache Reports 2007;11:304-309. Rawner E, Tepper SJ. 49th Annual Scientific Meeting of the American Headache Society 2007: 6–10 June, 2007, Chicago, IL, USA. Expert Rev. Neurotherapeutics 2007;7:1093–1095. Tepper SJ. Acute Treatment of Menstrual Migraine. Current Pain and Headache Reports 2007;6:169-173. 51 Newman LC, Cady RK, MacGregor EA, Shulman LP, Hutchinson SL, Martin VT, Silberstein SD, Tepper SJ. A Multidisciplary Approach to Treating Menstrual Migraine: An Algorithm for Short-term Prevention. CME White Paper, University of Cincinnati and IMED Communications. Califon, NY: IMED Communications, November 2007. Stillman MJ, Tepper SJ, Taylor FR. Abstracts and Citations. Headache 2008;48(1):169-179. Tepper SJ and Stillman MJ. Is It Sinus Headache or Migraine? Journal Watch Neurology 2008; 10:36-37. Tepper SJ, Stillman MJ, Taylor FR. Abstracts and Citations. Headache 2008;48(2):301-310. Tepper SJ. A Pivotal Moment in 50 years of Headache History: The First American Migraine Study. Headache 2008; 48:730-1. Taylor FR, Tepper SJ, Stillman MJ. Abstracts and Citations. Headache 2008;48(3):482-490. Tepper SJ and Koch TK. Complementary and Alternative Treatments for Childhood Headaches, in Winner P, ed. Headache in Children and Adolescents, 2d Ed. Hamilton, Ontario: BC Decker, 2008, pages 283-295. Stillman MJ, Taylor FR, Tepper SJ. Abstracts and Citations. Headache 2008;48(4):646-658. Tepper SJ. Evidence-based Basics on Nutraceuticals: Herbs, Minerals, Vitamins, and Supplements in Migraine Management. Information for Health Care Professionals, American Headache Society 2008. Tepper SJ, Stillman MJ, Taylor FR. Abstracts and Citations. Headache 2008;48(6):976-988. Tepper SJ. Preventive Pharmacologic Treatment of Migraine and Tensiontype Headache, in Levin M, ed. The Headache Cooperative of New England Comprehensive Review of Headache Medicine. Oxford: Oxford University Press, 2008, pages 231-254. Taylor FR, Stillman MJ, Tepper SJ. Abstracts and Citations. Headache 2008;48(7):1140-1145. Sun-Edelstein C, Tepper SJ, Shapiro RE. Drug-Induced Serotonin Syndrome: A Review. Expert Opin. Drug Safety 2008: 7(5):1-10. 52 Taylor FR, Tepper SJ, Stillman MJ. Recent Studies on PFO and Migraine: Is There a Future for Closure? Headache 2008;48(7):1083-1086. Tepper SJ. PFO and Migraine: Association and Causation. Cleveland Clinic Neuroscience Pathways Fall/Winter 2008;16-17. Cleves C, Tepper SJ. Sumatriptan Naproxen Sodium Combination for the Acute Treatment of Migraine. Expert Review of Neurotherapeutics 2008; 8(9), 1289–1297. Stillman MJ, Tepper SJ, Taylor FR. Abstracts and Citations. Headache 2008;48:1243-1253. Tepper SJ and Stillman MJ. Clinical and Preclinical Rationale for CGRP Antagonists in the Treatment of Migraine. Headache (Headache Currents) 2008;48:1259-1268. Tepper SJ, Taylor FR, Stillman MJ. Abstracts and Citations. Headache 2008;48(9):1385-1395. Tepper SJ. Complementary and Alternative Treatments for Childhood Headaches. Current Pain and Headache Reports 2008, 12:379–383. Wenzel RG, Tepper S, Korab WE, Freitag F. Serotonin syndrome risks when combining SSRI/SNRI drugs and triptans: literature review and recommendations. Annals of Pharmacotherapy 2008;42(11):1692-6. Tepper SJ and Mays M. Up-to-date pharmacologic options for managing headache pain. Medscape Neurology and Neurosurgery 2008; posted Oct 30, 2008. Dowson AJ and Tepper SJ. Editorial : Migraine: improved outcomes in patients previously poorly responsive to therapy. Int J Clinic Practice 2008;62(12):1822-1824. Kriegler J and Tepper SJ. Facial Pain and Trigeminal Trophic Syndrome. Journal Watch Neurology 2008;10:92-93. Tepper SJ. Perimenstrual Migraines: Are They Different Than Migraines in General? Current Pain and Headache Reports 2008; 12 (6):463-7. D’Amico D and Tepper SJ. Prophylaxis of Migraine: General Principles and Patient Acceptance. Neuropsychiatric Disease and Treatment 2008:4(6) 1–13. 53 Tepper SJ and Spears RC. Acute Treatment of Migraine. In Evans, R. Ed. Migraine and other Primary Headaches, Neurologic Clinics 2009; 27 (2):417-427. NY: Elsevier. Tepper SJ, Cleves C, Taylor FR. Patent Foramen Ovale and Migraine: Association, Causation, and Implications of Clinical Trials. Current Pain and Headache Reports 2009;13:221–226. Tepper SJ. Commentary: How different is migraine prevalence among the races? Headache 2009;49: 894. D’Amico D and Tepper SJ. Key Points in Migraine Prophylaxis: Patient Perspective. Neurol Sci 2009; 30 (Suppl 1):S39–S42. Tepper SJ and Cleves C. Telcagepant, a calcitonin gene-related peptide antagonist for the treatment of migraine. Current Opinion in Investigational Drugs 2009; 10(7):711-720. Bamford CC and Tepper SJ. Daily Pharmacologic Prophylaxis of Episodic Migraine. Techniques in Regional Anesthesia and Pain Management 2009;13(1): 20-37. Tepper SJ and Kriegler JS. Update on Menstrual Migraine, The Female Patient, July 2009 ;34 (7):17-24. Whyte C and Tepper SJ. Adverse Effects of Medications Commonly Used in the Treatment of Migraine. Expert Review of Neurotherapeutics 2009;9(9):1379-1391. Hutchinson SL and Tepper SJ. Treatment and management of migraineThe Road Ahead. US Neurology, 2009;5(1):72-74. Tepper SJ. What is CGRP and What Should You Know About It? Answers to Why Everyone is Talking About CGRP Receptor Antagonists. American Headache Society American Council on Headache Education (ACHE) Newsletter 2009;1(3):8-9. Tepper SJ and Tepper DE. How Do I Do It- Acute Treatment of Migraine. American Headache Society CME, at www.AmericanHeadacheSociety.org, 2009, Pp 1-9. Katic´ BJ, Krause SJ, Tepper SJ, Hu HX, Bigal ME. Adherence to Acute Migraine Medication: What Does It Mean, Why Does It Matter? Headache 2010;50(1):117-132. Whyte C, Tepper SJ, Evans R. Rescue Me: Rescue Medication for Migraine, Headache 2010;50(2):307-313. 54 Whyte C and Tepper SJ. Pearls and “Oy-sters”: Trigeminal Autonomic Cephalalgias, Neurology. 2010;74(11):e40-2. Tepper SJ and Tepper DE. Medication Overuse Headache: Breaking the Cycle. Cleveland Clinic Journal of Medicine 2010; 77(4):236-242. Tepper SJ, Gonzalez J, Levin M. Resident and Fellow Section Teaching Case: Migraine Stroke. Headache 2010;50(4):687-691. Baron EP and Tepper SJ. Biofeedback for Migraine and Tension-Type Headache. Journal Watch Neurology 2010;12(5):39. Baron EP, Tepper SJ. Revisiting the Role of Ergots in the Treatment of Migraine and Headache. Headache 2010;50: 1353-1361. Ashkenazi A, Blumenfeld A, Napchan U, Narouze S, Nett B, DePalma T, Rosenthal B, Tepper SJ, Lipton RB. Peripheral Nerve blocks and Trigger Point Injections in Headache Management - A Systematic Review and Suggestions for Future Research, Headache 2010;50(6):943-952. Evans RW, Tepper SJ, Shapiro RE, Sun-Edelstein C, Tietjen GE. The FDA alert on Serotonin Syndrome with Use of Triptans Combined with Selective Serotonin Reuptake Inhibitors or Selective SerotoninNorepinephrine Reuptake Inhibitors: American Headache Society Position Paper. Headache 2010;50(6):1089-1099. Tepper SJ and Tepper DE. Medication Overuse Headache, in Refractory Headache and Its Treatment. In Refractory Migraine, Schulman EA, Levin M, Lake AE and Loder E, eds, NY: Oxford University Press, 2010, Pp 136-159. Tepper SJ. The Role of Prevention. In Handbook of Clinical Neurology, 3rd Series. In Aminoff M, Nappi G and Moskowitz M, eds. NY: Elsevier, 2010, pages 195-205. Kelley NE and Tepper SJ. Defining New Daily-Persistent Headache. Journal Watch Neurology 2010 Nov;12 (11):85. Bamford CC, Mays M, Tepper SJ. Unusual Headaches in the Elderly. Curr Pain Headache Rep. 2011; 15(4):295-301. Baron EP and Tepper SJ. Orally inhaled dihydroergotamine: reviving and improving a classic. Future Neurology. 2011;6(3):327-333. 55 Jenkins B and Tepper SJ. Neurostimulation for primary headache disorders, part 1: pathophysiology and anatomy, history of neuromodulation inheadache treatment, and review of peripheral neuromodulation in primary headaches. Headache 2011;51(8):1254-66. Jenkins B and Tepper SJ. Neurostimulation for Primary Headache Disorders: Part 2, Review of Central Neurostimulators for Primary Headache, Overall Therapeutic Efficacy, Safety, Cost, Patient Selection, and Future Research in Headache Neuromodulation. Headache. 2011;51(9):1408-18. Tepper SJ. Editorial: Serotonin Syndrome: SSRIs, SNRIs, Triptans, and Current Clinical Practice. Headache 2012;52(2): 195-197. Tepper SJ and Stillman MJ. What is the best drug-delivery approach for the acute treatment of migraine? Expert Review of Neurotherapeutics 2012 Mar;12(3):253-5. Tepper SJ. Opioids Should Not Be Used in Migraine. Headache 2012; 52(S1):50-54. Tepper SJ and Rothrock JF. Conclusions on Opioids. Headache 2012; 52(S1):39-39. Tepper SJ. Advanced Interventions for Headache. Headache 2012; 52(S1):30-34. Da Silva AN, Tepper SJ, and Evans RW. Expert Opinion in Headache: Side-Locked and Side Shifting Primary Headaches. Headache 2012;52(7): 1178-1183. Tepper SJ. Medication Overuse Headache. Continuum Lifelong Learning Neurol 2012;18(4):807–822. Da Silva AN and Tepper SJ. Acute Treatment of Migraine. CNS Drugs 2012, CNS Drugs. 2012 Oct 1;26(10):823-39. Stillman MJ, Tepper SJ, Tepper DE, Cho L. QT Prolongation, Torsade de Pointes, Myocardial Ischemia From Coronary Vasospasm, and Headache Medications. Part 1: Review of Serotonergic Cardiac Adverse Events With a Triptan Case. Headache 2013: 2013;53(1):208-216. 56 Stillman MJ, Tepper DE, Tepper SJ, Cho L. QT Prolongation, Torsade de Pointes, Myocardial Ischemia From Coronary Vasospasm, and Headache Medications. Part 2: Review of Headache Medications, Drug–Drug Interactions, QTc Prolongation, and Other Arrhythmias. Headache 2013;53(1):217-24. Tepper SJ. Editorial. Headache 2013;53(1):207. Lakhan SE, Avramut M, Tepper SJ. Structural and Functional Neuroimaging in Migraine: Insights from Three Decades of Research. Headache 2013;53(1):46-66. Estemalik E, Tepper SJ. Preventive Treatment in Migraine and the New US Guidelines. Neuropsychiatric Disease and Treatment 2013;9:709-20. Tepper SJ. Migraine Pathophysiology. Headache Currents Commentary Online Feb 2013; http://www.headachejournal.org/view/0/HCFeb2013.html. Tepper SJ and Stillman MJ. Cluster Headache: Potential Options for Medically Refractory Patients (When All Else Fails). Headache Currents 2013;53(7):1183-1190. Tepper SJ. Orally Inhaled Dihydroergotamine: A Review. Headache 2013;53 (Supplement 2):43-53. Tepper SJ, Chen S, Reidenbach F, Rapoport AM. Intranasal zolmitriptan for the treatment of acute migraine. Headache 2013;53 (Supplement 2): 62-71. Tepper SJ. Clinical Implications for Breath-Powered Powder Sumatriptan Intranasal Treatment. Headache 2013;53(8):1341-1349. Tepper SJ. International Classification of Headache Disorders, 3rd Edition, beta version. Headache Currents 2013; 53(8):1381-1382. Tepper SJ. Traumatic Brain Injury (TBI), Pain, and Headache. Headache Currents 2013; 53(9):1517. Lakhan SE, Tepper SJ, Avramut M. Sphenopalatine Ganglion Stimulation in Primary Headaches. Future Medicine: Novel Approaches in Migraine Treatment Aug 2013:120-132, DOI: 10.1177/0333102412473667. Tepper SJ. Medication Overuse Headache. Headache Currents 2014;54(1):203. 57 Tepper SJ. Idiopathic Intracranial Hypertension and Low CSF Pressure Headaches. Headache Currents 2014;54(2):387-388. Tepper SJ. Vasculitis, Endothelial Disorder, and Headache. Currents 2014;54(3):571. Headache Tepper SJ. Complementary and Alternative Medicine (CAM), Ayurvedic Medicine, and Research into Behavioral and Mind/Body Interventions in Headache. Headache Currents 2014;54(6):1114. Tepper SJ. Chronic Migraine and Medication Overuse Headache. Headache Currents 2014;54(7):1249-50. Messali AJ, Yang M, Gillard JP, Tsai K, Tepper SJ, Bloudek LM, Kori SH. Treatment Persistence and Switching in Triptan Users: A Systematic Literature Review. Headache 2014;54(7):1120-30. Mays M and Tepper SJ. Occipital Nerve Blocks, in Narouze SN. Editor, Interventional Management of Head and Face Pain. NY: Springer, 2014, P. 29-34. Tepper SJ. Nutraceutical and Other Modalities for the Treatment of Headache. Neurology Continuum (Minneap Minn) 2015;21(4):1018–1031. Books Rapoport AM, Sheftell FD, Tepper SJ. Conquering Headache, 3rd Edition. Hamilton, Ontario: B.C. Decker Inc Publisher, 2001. Tepper SJ, Rapoport AM, Sheftell FD, eds. The Spectrum of Migraine, NYC: McMahon Publishing, 2002. Rapoport AM, Sheftell FD, Tepper SJ. Conquering Headache, 4th Edition. Hamilton, Ontario: B.C. Decker Inc Publisher, 2003. Tepper SJ. Understanding Migraine and Other Headaches. Jackson, Miss: University of Mississippi Press, 2004. Rapoport AM, Sheftell FD, Tepper SJ. Conquering Headache, 5th Edition. Hamilton, Ontario, London: Decker DTC, 2004. Purdy RA, Tepper SJ, Rapoport AM, Sheftell FD, editors. Advanced Therapy of Headache, 2d Edition. Hamilton, Ontario, London: BC Decker Inc, 2005. 58 Rapoport AM, Sheftell FD, Blumenfeld A, and Tepper SJ. Conquering Daily Headache. Hamilton, Ontario: B.C. Decker Inc Publisher, 2008. Tepper SJ and Tepper DE, editors. Cleveland Clinic Manual of Headache Therapy. NY: Springer Publishing, 2011. Tepper SJ and Tepper DE, editors. Cleveland Clinic Manual of Headache Therapy, Second Edition. NY: Springer Publishing, 2014. In press or submitted Maasumi K, Thompson NR, Kriegler JS, Tepper SJ. Effect of OnabotulinumtoxinA Injection on Depression in Chronic Migraine, Headache in press, 2015. Abstracts Drucker P, Tepper SJ. Repetitive Outpatient Oral Sumatriptan in Detoxification for Patients with Transformed Migraine with Medication Overuse. Headache. 1997; 37:307308. Winner P, Sheftell F, Ryan R, Tepper SJ. Overview of the Clinical Response to Zolmitriptan in Migraineurs Identified as 'Poor Responders' to Other Migraine Preparations. Headache. 1997:37:336-337. Tepper SJ, Millson DS. Zolmitriptan ('Zomig', 311C90) is Efficacious in Migraine on Awakening. J Neuological Sciences. 1997;150:S106. Solomon GD, Sheftell FD, Tepper SJ. Clinical effectiveness of 'Zomig' (Zolmitriptan, 311C90) in established migraine (>=4hours pretreatment duration). J Am Osteopathic Ass. 1997;97:489. Tepper S, Ward T, Maurer C. Patient-reported Tablet Utilization of Zolmitriptan and Sumatriptan. Headache. 1998; 38: 408-409. Tepper SJ, Millson D. The new triptans (5-HT 1B/1D agonists for acute treatment of migraine: a clinical review using number needed to treat (NNT) analysis. European Journal of Neurology 1998; 5 (Suppl 3):S55. 59 Saper J, Podolnick P, Klapper J, Tepper S, Stacey B, Rapoport A, Ramadan N. Efficacy and safety of gabapentin (Neurontin) in Migraine Prophylaxis. Cephalalgia 1999; 19:380. Millson D and Tepper S. Issues relating to the assessment of migraine recurrence following triptan therapy. European Journal of Neurology 1999; 6:1-2. Tepper SJ, Allen CP, Vandormael K. therapeutic benefit of rizatriptan compared with eletriptan. Cephalalgia 2000;20:355, and Eur J Neurology 2000 7(Suppl 3):86. Sheftell FD, Weeks RE, Tepper SJ, Fox AW. Number Needed to Treat Depends on Placebo Response Rate. Cephalalgia 2000;20:323. Ware, JE, Kosinski M Diamond M, Bayliss MB, Tepper S, Dowson A, Batenhorst AS. Validation of the headache impact test using patient-reported symptoms and headache pain severity. Cephalalgia 2000;20:320. Tepper SJ, Meddis D. Reducing the cost of impairment of Normal Activities due to Migraine: A Stratified-Care Approach. Headache 2000; 40:434-435. Bayliss MS, M Kosinski M, Diamond M, Tepper S , Garber WH, Ware J, Batenhorst A. HIT-6 Scores Discriminate Among Headache Sufferers Differing in HeadacheAssociated Workplace Productivity Loss. Neurology 2001;56 (Suppl 3):A139. Sang CM, Ramadan NM, Chappell AS, Freitag FG, Smith TR, Silberstein SD, Tepper SJ. A double-blind, placebo-controlled study to investigate the efficacy and tolerability of intravenous 1.2 mg/kg LY293558 vs. 6 mg subcutaneous sumatriptan vs. placebo in patients with an acute migraine attack. Neurology 2001;56 (Suppl 3):A219. [Winner of the Best of the Best award]. Tepper SJ. Acute Treatment of Migraine: Issues of Disability and Early Intervention. Proceedings of the 15th Italian Society for the Study of Headache. Florence, Italy, June 10-13, 2001, P.60. Gallai B, Tepper SJ, Rapoport AM. Cefalia Cronica Quotidiana in Eta’Evolutiva: Studio Retrospettivo Presso Il New England Center for Headache (Connecticut, USA). [Adolescent Chronic Daily Headhache, a Retrospective Study from The New England Center for Headache]. Proceedings of the 15th Italian Society for the Study of Headache. July 10-13, 2001, P.53. Kosinski M, Garber WH, Diamond M, Tepper S, Bayliss MS, Bjorner JB, Batenhorst A. HIT-6 Scores Discriminate Among Headache Sufferers. J Neurological Sciences 2001;187(Suppl 1):S13. 60 Garber WH. Kosinski M, Dahlof C, Tepper S, Kujawski SC, Bjorner JB, Batenhorst A. HIT-6 Reliably Measures the Impact of Headache. J Neurological Sciences 2001;187(Suppl 1):S122., also in Cephalalgia 2001;21:333. Ramadan N, Sang C, Chappell A, Vandenhende F, Johnson K, Phebus L, Bleakman D, Ornstein P, Arnold B, Freitag F, Smotih T, Silberstein S, Tepper S. IV LY293558, an AMPA/KA antagonist, is effective in migraine. Cephalalgia 2001;21:267. Tepper S, Dahlof C, Sheftell F, Dewey J, Batenhorst A. Impact of migraine relative to other headache types. Cephalalgia 2001;21:331-332. Bayliss MS, Kosinski M, Diamond M, Tepper S, Garber WH, Ware J, Batenhorst A. HIT-6 scores discriminate among headache sufferers differing in headache-associated workplace productivity loss. Cephalalgia 2001;21:333-334. Dahlof C, Tepper S, Pryse-Phillips W, Dewey J, Batenhorst AS, Davis K, Barhout VE. Comparability of scores on the Headache Impact Test (HIT) and HIT-6. Cephalalgia 2001;21:334-335. Tepper SJ. Almotriptan demonstrated a consistent response across multiple migraine attacks during a 1-year trial. Cephalalgia 2001;21:430. Sheftell FD, Tepper SJ. Hypothesis:trigeminal myofascial system (TGM): hypothesis for the relationship between tension-type headache and migraine. Cephalalgia 2001;21:471. Bigal ME, Rapoport AM, Sheftell, FD, Lipton RB, Tepper SJ. Headache Associated with Medication Overuse: Data from Tertiary Care. Neurology 2002 (Suppl 3);58: A170-171. Bigal ME, Sheftell, FD, Rapoport AM, Lipton RB, Tepper SJ. Evaluation of Chronic Daily Headache: Correlation between the International Headache Society and the Proposed Headache Classification for Chronic Daily Headache Systems. Neurology 2002 (Suppl 3);58: A172. Bigal ME, Sheftell FD, Rapoport AM, Tepper SJ, Lipton RB. Chronic Daily Headache: Identification of Factors Associated with Induction and Transformation. Headache 2002;42:428. Bigal ME, Rapoport AM, Lipton RB, Tepper SJ, Sheftell FD. Burden of Migraine in Brazil I: An Estimate of the costs of Migraine to the Public Health System. Headache 2002;42:419-420. Tepper SJ, Bigal ME, Sheftell FD, Rapoport AM, Lipton RB. Burden of Migraine in Brazil 2: An Analytical Study of the Cost Effectiveness of a Stratified Model of Care. Headache 2002;42:426-427. 61 Moore WMM, Kwong WJ, Tepper SJ, Bowers BW, Batenhorst AS Bayliss MS. Sensitivity of Headache Impact Test (HIT) in Distinguishing Headache Impact among Headache Sufferers Receiving Pharmacologic Treatment. Neurology 2002 (Suppl 3);58: A416-417, also in Headache 2002; 42:423-424, also in Cephalalgia 2002 (suppl 1):2526. Tepper S, Ryan R, Rapoport A, Abu-Shakra S. Efficacy of Oral Zolmitriptan 2.5 mg in Mild, Moderate and Severe Migraine: Results of Treating More than 20,000 Attacks. Neurology 2002 (Suppl 3);58: A417. Tepper S, Allen C, Sanders D, Greene A, Boccuzzi S. Co-prescription of triptans with potentially interacting medications: a cohort study involving 240,268 patients. Headache 2002;42:397; also in European Journal of Neurology 2002;9(Supp l2):150. Tepper S, Allen C, Sanders D, Greene A, Boccuzzi S. Co-prescription of triptans with other medications. Cephalalgia 2002;22 (suppl1):6-7. Loder E, Silberstein SD, Smith T, Tepper S, Mueller L, Abu-Shakra S. Oral Zolmitriptan Shows Efficacy as Early as 30 Minutes in the Treatment of Migraine Associated with Menses: Results of a Large Multicenter Placebo-controlled Study. Headache 2002;42:397. Rapoport AM, Bigal M, Lipton RB, Sheftell FD, Tepper SJ. Assessment of Chronic Migraine Disability Using the Migraine Disability Assessment Scale (MIDAS): A Comparison with Episodic Migraine. Headache 2002;42:432. Sheftell FD, Bigal M, Tepper SJ, Rapoport AM, Lipton RB. Clinical Presentation of Chronic Daily Headache Possible Differences Among Its Subtypes. Headache 2002;42:434. Moore WMM, Kwong WJ, Tepper SJ, Diamond ML, Bayliss MS, Batenhorst AS. Profile of Adolescents Headache Sufferers completing the Headache Impact Test via the Internet. Headache 2002; 42:442-443. Bayliss M, Dewey J, Tepper S, Cady R, Diamond M, Batenhorst A, Kwong J. Value of delivering health status assessment via the internet. Cephalalgia 2002;22 (suppl 1):10-11. Dowson A, Dahlof C, Tepper S, Newman L. Prevalence and Diagnosis of Migraine in a Primary Care Setting. Cephalalgia 2002;22:590-591. Dowson A, Dahlof C, Tepper S, Newman L. The Spectrum of Headaches Experienced by Migraineurs in a Primary Care Setting. Cephalalgia 2002;22:591. Tepper SJ, Dowson A, Newman L, Dahlof C, Webster C, Petrie J, Pham B. Landmark Study Group. Expert Panel Review of Patient Diary Data Using IHS Classification. Cephalalgia 2002;22: 611. 62 Tepper S, Dowson A, Dahlof C, Newman L, Kinrade F, Loftus JV. Prevalence and Diagnosis of Migraine in a Primary Care Setting. European Journal of Neurology 2002;9(Supp l2):43. Dahlof C, Tepper S, Dowson A, Newman L, Pham B, Kwong J, Jones M. Reduced headache impact after three months of sumatriptan migraine therapy in the primary care setting. European Journal of Neurology 2002;9(Supp l2):44. Newman L, Tepper S, Dahlof C, Dowson a, Malik F, Loftus JV. The Spectrum of Headaches Experienced by Migraineurs in a Primary Care Setting. European Journal of Neurology 2002;9(Supp l2):186-187. Tepper S, Dahlof C, Newman L, Dowsonon A, Pham B, Kwong J, Scott A. Association of headache impact test (HIT-6) and IHS migraine diagnosis in the primary care setting. European Journal of Neurology 2002;9(Supp l2):187. Silberstein S, Tepper S, Brandes J, Diamond M, Goldstein J, Winner P, Venkatraman S, Vrigjens F, Malbecq W, Visser WH, Reines S, and Yuen E. A Randomized, DoubleBlind, Placebo-Controlled Trial of Rofecoxib for the Acute Treatment of Migraine. Neurology 2003;60 (Supp 1):A337. Sheftell FD, Bigal ME, Rapoport AM, Feleppa M, Tepper SJ. Determinants of Triptan Preference in a Tertiary Care Migraine Population: Patterns of Use. Neurology 2003;60 (Supp 1):A237; also in Cephalalgia 2003;23:714. Tepper SJ, Bigal ME, Sheftell FD, Rapoport AM. Botulinum Toxin A in the Preventive Treatment of Refractory Headache. Neurology 2003;60 (Supp 1):A323. Also in the 2003 APS Database. Bigal ME, Sheftell FD, Rapoport AM, Tepper SJ, Feleppa M. Triptan Use in a Migrainuer Population. Determinants of Preference. Neurology 2003;60 (Supp 1):A170171. Rapoport AM, Bigal ME, Volcy M, Shertell FD, Feleppa M, Tepper SJ. Naratriptan in the Preventive Treatment of Refractory Chronic Migraine. Neurology 2003;60 (Supp 1):A254. Prince PB, Rapoport AM, Bigal AM, Sheftell FD, Tepper SJ. The Effect of Weather on Headache. Neurology 2003;60 (Supp 1):A513. Also Headache 2004;44:513. Bigal ME, Rapoport AM, Sheftell FD, Tepper SJ, and Lipton RB. Correlation Between the 1988 International Headache Society diagnostic Criteria, the 2003 Revised Criteria, and the Proposed Revisions of Criteria for Chronic Daily Headache. Headache 2003;43:509-510. 63 Silberstein S, Tepper S, Brandes J, Diamond M, Goldstein J, Winner P, Venkatraman S, Vrigjens F, Malbecq W, Visser WH, Reines S, and Yuen E. Efficacy and Safety of Rofecoxib for the Acute Treatment of Migraine: Results of a Randomized, Placebocontrolled Trial. Headache 2003;43:524. Sheftell FD, Bigal ME, Tepper SJ, and Rapoport AM. Patterns of Use of Triptans in a Tertiary Care Migraine Population. Headache 2003;43:534-535. Tepper SJ, Bigal ME, Sheftell FD, Rapoport AM. The Effect of Botulinum toxin on the Disability of Refractory Headaches. Headache 2003;43:578-579. Tepper S, and Freitag F. Prophylactic Use of Frovatriptan for Menstrually Associated Migraine is Effective and Does Not Cause Rebound Migraine in the Postdosing Period. Headache 2003;43:585. Rapoport AM, Bigal ME, Tepper SJ, and Sheftell FD. Naratriptan in the Preventive Treatment of Refractory Chronic Migraine. Headache 2003;43:578-579. Dahlof C, Dowson A, Newman L, Tepper S, Pham B. Headache Spectrum: Insight from the Landmark Study, Cephalalgia 2003:23:622. Tepper S, Dahlof C, Dowson A, Newman L, and Kuhn TA. Prevalence and demographics of migrainous headache adults in a primary care setting: data from the Landmark Study. Cephalalgia 2003:23:622. Sheftell F, Bigal M, Volcy M, Tepper S, Weeks R. Tolerability and efficacy are related after triptan use. Cephalalgia 2003;23:697. Bigal M, Tepper S, Rapoport A, Feleppa M, Sheftell F. ‘Switching’ behaviors in longitudinal use of triptans. Cephalalgia 2003;23:705. Rapoport A, Bigal M, Sheftell F, Volcy M, Feleppa M, Tepper S. Naratriptan in the preventive treatment of refractory chronic migraine. Cephalalgia 2003;23:751. Tepper S, Bigal M, Sheftell F, Rapoport A. Botulinum Toxin type A in the preventive treatment of refractory headaches- comparison between medication overusers and nonmedication overusers groups. Cephalalgia 2003;23:715. Sheftell FD, Feleppa M, Tepper SJ, Rapoport SJ, Rapoport AM, Bigal ME. Adverse Events Associated with Triptans- Methods of Assessment Influence the Results. Headache 2004;44:470. Tepper S, Dodick D, Cady R, Lucas S, Hutchinson S, Few C, Kuhn T. Oral Sumatriptan for Probable Migraine Without Aura (2004 IHS 1.6.1): Results of a Randomized, Double-Blind Placebo-Controlled Study. Headache 2004;44:477-478. 64 Lipton R, Dodick D, Cady R, Tepper S, Few C, Kuhn T. Headache Response Sustained Through 4 Hours in Adults with Probable Migraine in a Controlled Clinical Study. Should Response Rates Include Subjects Who Achieve and Then Lose Response within 4 Hours? Headache 2004;44:482-483. Rapoport AM, Tepper SJ, Sheftell FD, Bigal ME. Levetiracetam in the Preventive Treatment of Transformed Migraine. Headache 2004;44:517. Bigal ME, Lipton RB, Rapoport AM, Tepper SJ, Sheftell FD. The Classification of Chronic Daily Headache in Adolescents and Adults. Headache 2004;44:519-520. Bigal ME, Sheftell F, Tepper SJ, Rapoport AM, Lipton RB. Migraine Days Decline with Duration of Illness in Adolescents with Transformed Migraine. Headache 2004;44:520. Sheftell FD, Bigal ME, Rapoport AM, Tepper SJ. Assessment of Adverse Events Asssociated with Triptans. Neurology 2004;62(Suppl 5):A81. Rapoport AM, Tepper SJ, Sheftell FD, Bigal ME. Levetiracetam in the Preventive Treatment of Transformed Migraine. A Prospective Study. Neurology 2004;62(Suppl 5):A147. Bigal ME, Sheftell FD, Rapoport AM, Tepper SJ, Lipton RB. Chronic Daily Headache in Adolescents and Adults. A Comparative Study. Neurology 2004;62(Suppl 5):A337. Bigal MB, Lipton RB, Tepper SJ, Sheftell FD, Rapoport AM. Evolution of Transformed Migraine in Adolescents: Migraine Days Decline with Duration of illness. Neurology 2004;62(Suppl 5):A442. Dowson AJ, Cady RK, Tepper SJ, Smith TR, Shapero G. Pharmacologic management of migraine. Ann Intern Med. 2004;140:W26. Dowson AJ , Tepper SJ, Baos V, D’Amico D, Baudet F, Kilminster S. The Migraine Assessment of Current Therapy (Migraine-ACT) Questionnaire: a new assessment tool to identify patients who require a change in their current acute migraine treatment. Cephalalgia 2004;24:1093. Dahlof C, Aurora S, Rapoport AM, Tepper SJ, Sheftell FD, Bigal ME. Satisfaction with Current Migraine Acute Treatment. A Multicentric Study. Headache 2005;45:781-782. Dahlof C, Aurora S, Rapoport A, Tepper S, Bigal M. Satisfaction with current therapy. Experience from 3 centers in US and Sweden. Neurology 2005;61(suppl 1): 336. Bigal ME, Tepper SJ, Rapoport AM, Sheftell FD, Lipton RB. Chronic Migraine Is an Earlier Stage of Transformed Migraine in Adults. Headache 2005;45:769-770. 65 Bigal M, Feleppa M, Tepper S, Rapoport AM. The prevention outcome and body mass index. Neurology 2005;61(suppl 1):132-133. Lipton R, Rapoport A, Tepper S, Bigal M. The classification of chronic daily headaches in adolescents. Neurology 2005;61(Suppl 1):133 Rapoport AM, Dahlof C, Aurora SK, Tepper SJ, Bigal ME, Sheftell FD. Zolmitriptan Nasal Spray in the Acute Treatment of Migraine. A Preference Study. Headache 2005;45:805-806. Bigal ME, Rapoport AM, Tepper SJ, Sheftell FD, Lipton RB. Headache Prevention Outcome and Body Mass Index. Headache 2005;45:827-828. Sheftell FD, Tepper SJ, Rapoport AM, Bigal ME. Naratriptan in the Preventive Treatment of Refractory Transformed Migraine. A Prospective Pilot Study. Headache 2005;45:818. Meskunas C, Sheftell F, Rapoport A, Tepper S, Bigal M. Medications Associated with Probable Medication Overuse Headache Reported in a Tertiary Care Headache Center over a 15-Year Period. Neurology 2006;66 (Suppl 2):A141. Silberstein SD, Mauskop A, Dodick DW, Frishberg BM, Tepper SJ, McAllister P, Aurora SK, Loder EW, Freitag FG. Program to Assess headache Treatment Strategies: An Observational Study of Botulinum toxin type A in the Preventive treatment of headache. Headache 2006;46:846-847. Rapoport AM, Dahlof CG, Aurora S, Tepper SJ, Sheftell FD, Bigal ME. Consistency of Efficacy of Zolmitriptan Nasal Spray vs. Usual Care in the Acute Treatment of Migraine. Headache 2006;46:864. Bigal ME, Sheftell FD, Tepper SJ, Rapoport AM, Lipton RB. Field Testing Alternative Criteria for Chronic Migraine. Headache 2006;46:836-837. Bigal ME, Meskunas C, Tepper SJ, Rapoport AM, Sheftell FD. Medications Associated with Probable Medication Overuse Headache Reported in a Tertiary Care Headache Center Over a 15-year Period. Headache 2006;46:894. Silberstein SD, Mauskop A, Dodick DW, Frishberg BM, Tepper SJ, McAllister P, Aurora SK, Freitag FG. Predictors of outcomes with botulinum toxin type a in the preventive treatment of headache. Cephalalgia 2006;26:1371. Peterlin BL, Bigal ME, Urakaze MU, Rapoport AM. Migraine and adiponectin: is there a connection? Cephalalgia 2006;26:1385. 66 Rapoport AM, Mathew N, Silberstein S, Dodick D, Sheftell F, Tepper S, Choyce L, Bigal M. Zolmitriptan Nasal Spray in the Acute Treatment of Cluster Headache- A DoubleBlind, Placebo-Controlled, Multicentric Study. Neurology 2007;68 (Suppl 1):A261; also Headache 2007;47:766. Liebenstein M, Bigal M, Sheftell F, Tepper S, Rapoport A, Lipton R. Validation of the Chronic Daily Headache Questionnaire (CDH-Q). Neurology 2007;68 (Suppl 1):A369; also Headache 2007;47:760-761. Tepper SJ, Kruep EJ, Runken MC, Chakravarty S. Treatment Patterns for Migraine Headache: A Managed Care Perspective. Headache 2008; 48:S47-S48. Tepper SJ, Bigal ME, Sheftell FD, Zatochill MK, Szeto M. Development of a Simple Menstrual Migraine Screening Tool for Obstetric and Gynecology Clinics. American College of Obstetrics and Gynecology meeting, May 5, 2008, New Orleans, LA. Tepper SJ, Kruep EJ, Runken MC, Chakravarty S. Treatment Patterns for Migraine Headache: A Managed Care Perspective. Headache 2008;S46-47. Tepper SJ, Bigal ME, Sheftell FD, Zatochill MK, Szeto M. Development of a Simple Menstrual Migraine Screening Tool for Obstetric and Gynecology Clinics. Nurse Practitioners in Womens Health meeting, Oct 16, 2008, Seattle, WA. Ansarinia M, Rezai A, Stanton-Hicks M, Machado A, Tepper S, Steiner C, Stump J, Deogonokar M, Francisoco A, Narouze S. Stimulation of Sphenopalatine Ganglion (SPG) for Treatment of Acute Cluster Headaches. North American Neuromodulation Society meeting, Dec 5, 2008, Las Vegas, NV. Narouze S, Rezai A, Tepper SJ, Mohajer P, Ansarinia M. Sphenopalatine Ganglion Stimulation for the Acute Treatment of Intractable Migraine. American Academy of Pain Medicine meeting, Jan 28-31, 2009, Honolulu, HI. Tepper SJ, Kruep EJ, Runken MC, Chakravarty S. Treatment Patterns for Migraine Headache: A Managed Care Perspective. Diamond Headache Symposium, Phoenix, AZ, Feb 10, 2009 (platform presentation). Cherian N, Stillman MJ, Gargano F, Whalen V, Tepper SJ. Cervicogenic Headache: A possible manifestation of peripheral vestibular dysfunction? Neurology 2009;72 (11, Supplement 3):A176. Kung E, Tepper SJ, Rapoport AM, Sheftell FD, Bigal ME. New Daily Persistent Headache in the Pediatric Population. Neurology 2009;72 (11, Supplement 3):A253. Also presented at the American Academy of Pain Medicine, February 3-6, 2010, San Antonio, TX. 67 Tepper SJ, Rezai AR, Narouze S, Machado A, Steiner C, Stump J, Ansarinia M. Acute Treatment of Medically Refractory Cluster Headache by Electrical Stimulation of the Sphenopalatine Ganglion (SPG). Neurology 2009;72 (11, Supplement 3):A90-91. Rezai AR, Ansarinia M, Narouze S, Steiner C, Machado A, Francisco A, Deogaonkar M, Tepper SJ. Stimulation of Sphenopalatine Ganglion (SPG) for Treatment of Severe Acute Cluster Headaches. World Society for Stereotactic and Functional Neurosurgery, Toronto, May 24-27, 2009. Tepper SJ, Kori SH, Mathew NT, Saper JR, Winner PD, Freitag FG, Borland SW, Wang M, Hu B, Silberstein SD. Efficacy evaluation of LEVADEX™ (previously MAP0004) in treating resistant migraine including migraine with allodynia, morning migraine, disabling migraine and migraine treated late in its cycle. 14th International Headache Congress, Philadelphia, PA, Sept 10-12, 2009. Silberstein SD, Kori S, Tepper SJ, Borland SW, Wang W, Reppine AE, Amer TA, Dodick DW. LEVADEX, a novel orally inhaled treatment for acute migraine: efficacy and tolerability results of a Phase 3 study. 14th International Headache Congress, Philadelphia, PA, Sept 10-12, 2009 (LBPOR4, PO04). Cephalalgia 2009;29 (Suppl 1):12-13. Ansarinia M, Rezai A, Tepper SJ, Mohajer P, Steiner CP, Stanton-Hicks M, Narouze S. Sphenopalatine Ganglion (SPG) stimulation during Acute Migraine and Cluster Headaches. 14th International Headache Congress, Philadelphia, PA, Sept 10-12, 2009 (PO39). ). Cephalalgia 2009;29 (Suppl 1):27. White C, Tepper SJ, Stillman MJ. Dihydroergotamine and Its Use in Migraine with Posterior Fossa Symptoms. 14th International Headache Congress, Philadelphia, PA, Sept 10-12, 2009 (PO26). ). Cephalalgia 2009;29 (Suppl 1):21. Cherian N, Stillman MJ, Gargano F, Whalen V, Tepper SJ. Cervicogenic Headache: A possible manifestation of peripheral vestibular dysfunction? 14th International Headache Congress, Philadelphia, PA, Sept 10-12, 2009 (PO288). ). Cephalalgia 2009;29 (Suppl 1):123. Tepper SJ, Liu K, Jones SE, Phillips MD, Stillman MJ, Horvat M, Lowe MJ. Functional MRI Suggests Iron Deposition in Pain Regulatory Nuclei in Episodic Migraine and Chronic Daily Headache. (SC02.006) American Academy of Neurology meeting, Toronto, Ontario, April 2010. Neurology 2010;74(Suppl 2):A591. Tepper SJ, Kori SH, Borland SW, Wang M, Hu B, Silberstein SD. Evaluation of Efficacy and Safety of MAP0004 in Reversing Central Sensitization and Treating Migraines in Established Allodynic Patients. (P04.007) American Academy of Neurology meeting, Toronto, Ontario, April 2010. Neurology 2010;74(Suppl 2):A321. 68 Stillman MJ, Foudad-Terazi F, Zhou L, Tepper SJ, Cherian N. The Identification and Characterization of Autonomic Dysfunction in Migraineurs with and without Auras. (P04.248). American Academy of Neurology meeting, Toronto, Ontario, April 2010. Neurology 2010;74 (Suppl 2):A379. Baron EP, Moskowitz S, Tepper SJ. Headache Following Intracranial Endovascular Procedures. American Headache Society meeting, LA, CA June 2010. Headache 2010;50 (June 2010):S7-8; also Headache 2010;50(S1):7-8. Stillman M, Fouad F, Cherian N, Tepper S, Zhou L. The Identifaction and Characterization of Autonomic Dysfunction in Migraineurs with and without Auras: Phase I. American Headache Society Scientific meeting, LA, CA, June 2010. Headache 2010;50 (June 2010): S10, also Headache 2010;50(S1):10. Tepper SJ, Lowe MJ, Liu K, Phillips MD, Stillman MJ, Horvat M, Jones SE. Iron Deposition in Pain Regulatory Nuclei in Episodic Migraine and Chronic Daily Headache as Measured for Functional MRI. Platform presentation at the American Headache Society scientific meeting, LA, June 2010; Headache 2010;50 (June 2010): S59; also Headache 2010;50(S1):60. Tepper SJ, Kori SH, Goadsby PJ, Winner PK, Wang MH, Silberstein SD. Utility of Levadex in Situations Where Early Intervention Paradigm is Impractical. Platform presentation at the American Headache Society scientific meeting, LA, June 2010; Headache 2010;50 (S1):72. ; J. Headache and Pain 2010;11(Supplement 1):462. Kori S, Silberstein S, Aurora S, Tepper S, Borland S, Wang M, Reppine A, Armer T, Dodick D. Levadex, a novel orally inhaled treatment for acute migraine: efficacy and tolerability results of a Phase 3 study. 2d European Headache and Migraine Trust International Congress, Nice France, Oct, 2010. J. Headache and Pain 2010;11(Supplement 1):462. DOI 10.1007/s10194-010-0259-3. Kori S, Tepper S, Mathew N, Saper J, Winner P, Freitag F, Borland S, Wang M, Hu B, Silberstein S. Efficacy evaluation of Levadex in treating resistant migraine including migraine with allodynia, disabling migraine and migraine treated late. 2d European Headache and Migraine Trust International Congress, Nice France, Oct, 2010. J. Headache and Pain 2010;11 (Supplement 1):464. DOI 10.1007/s10194-010-0259-3. Kori S, Tepper S, Boland S, Wang M, Hu B, Silberstein S. Evaluation of efficacy and safety of Levadex (MAP0004) in reversing central sensitization and treating migraine in established allodynic patients. 2d European Headache and Migraine Trust International Congress, Nice France, Oct, 2010. J. Headache and Pain 2010;11(Supplement 1):466. DOI 10.1007/s10194-010-0259-3. 69 Tepper S, Kori S, Goadsby P, Ferrari M, Lipton R, Borland S, Wang M, Kellerman D, Dodick D. Migraine Recurrence Rates: Case for Standardization of the Definition. 2d European Headache and Migraine Trust International Congress, Nice France, Oct, 2010; J. Headache and Pain 2010;11(Supplement 1):471. DOI 10.1007/s10194-0100259-3. Kori SH, Tepper SJ, Goadsby PJ, Winner PK, Wang MH, Silberstein SD. Utility of Levadex in situations where early intervention paradigm is impractical. J. Headache and Pain 2010;11(Supplement 1):322. DOI 10.1007/s10194-010-0259-3. Platform presentation at the 2d European Headache and Migraine Trust International Congress, Nice France, Oct 31, 2010; Neurology 2011;76 (Suppl 4):A266-A267. Kori S, Tepper S, Goadsb PJ, Wommer P, Wang M, Silbestein SD. Utility of OralyInhaled Dihydroergotamine When Early Intervention is Impractical. 136th Meeting of the American Neurological Association, Sept 27, 2011; Poster T1603. Tepper SJ, Kori SH, Goadsby P, Ferrari M, Lipton R, Borland S, Wang M, Kellerman D, Dodick D. Migraine Recurrence Rates: Case for Standardization of the Definition. Neurology 2011;76 (Suppl 4):A444-A445. Also presented at the 136th Meeting of the American Neurological Association, Sept 27, 2011; Poster T1617. Almas M, Tepper S, Landy S, Ramos É. Eletriptan Provides Consistent Migraine Relief: Results of a Within−Patient Multiple−Dose Study, accepted as scientific abstract number 3163 for the American Academy of Neurology meeting, New Orleans, LA, April 24, 2012. Also, American Headache Society 54th Annual Scientific meeting, Los Angeles, CA. Headache 2012;52(5):886; Poster 32. Landy S, Tepper S, Wein T, Schweizer E, Ramos E. An Open-Label Trial of Alsuma Auto-Injector for Migraine. American Headache Society 54th Annual Scientific meeting, Los Angeles, CA. Headache 2012;52 (5):877; Poster 12. Peterlin BL, Tietjen GE , Gower BA , White LW, Hammond E, Dash PD, Ward TN, Tepper SJ, Haythornthwaite JA. Adiponectin (ADP) & ADP Oligomers are Differentially Modulated by Treatment Response in Episodic Migraineurs. American Neurological Association meeting, Boston, MA, Sept 2012. Almas M, Tepper S, Landy S, Ramos É. Eletriptan Provides Consistent Migraine Relief: Results of a Within−Patient Multiple−Dose Study, American Academy of Neurology meeting, New Orleans, LA, April 24, 2013. Zheng Y, Tepper S, Covington E, Mathews M, Scheman J. Pain Rehabilitation: Can It Help Patients with Intractable Headache? Cephalalgia 2013;33(Supplement 8): 80 [International Headache Congress, Poster 96, Boston, MA, June 27-30, 2013]. Tsai K, Tepper SJ, Bloudek LM, Messali A, Kori SH. Adherence and Persistence to Triptans for Acute Migraine: A Systematic Literature Review. Academy of Managed Care Pharmacy, San Antonio, TX, Oct 15-18, 2013. 70 Thorland K, Sun-Edelstein C, Kanters S, Druyts E, Eapen S, Ebrahim S, Bhambri R, Ramos E, Mills EJ, Lantéri-Minet M, Tepper S. Risk of medication overuse headache across classes of treatment for migraine. American Headache Society 56th Annual Scientific Meeting, Los Angeles, California, June 26-29, 2014 (late break). Tepper SJ, Newman L, Holdbrook F, Earl NL, Davar G. Comparable Efficacy and Safety For Exploratory Endpoints Regardless of Pain Severity and Treatment Time After Migraine Onset: Results From a Phase 3 Trial of Orally Inhaled Dihydroergotamine (MAP0004) for the Acute Treatment of Migraine. Headache 2014;54(S1):13-14. American Headache Society 56th Annual Scientific Meeting, Los Angeles, California, June 26-29, 2014. Vij B, Vutien P, Horvat M, Tepper DE, Tepper SJ. OnabotulinumtoxinA in the Treatment of New Daily Persistent Headache (NDPH). Headache 2014;54(S1):57. American Headache Society 56th Annual Scientific Meeting, Los Angeles, California, June 26-29, 2014. Tepper S, Cady R, Silberstein S, Messina J, Mahmoud R, Djupesland PG, Shin P, Siffert J. A randomized, double-blind, double-dummy, active-comparator crossover study of Breath Powered nasal delivery of sumatriptan powder (AVP-825) in the treatment of acute migraine (the COMPASS study). Poster at: 56th Annual Meeting of the American Headache Society; June 26-29, 2014; Los Angeles, CA. Abstract LBP37. Tepper SJ, Mechtler, LL, Kudrow DB, Silberstein SD, Calhoun AH, Lipton RB, Spitzer L, Mullin C, Liebler EJ; on behalf of the ACT Study Group. Clinical Effects of gammaCore for Rescue Treatment of Acute Cluster Headache: Report from the Doubleblind Phase of Acute Cluster Headache Treatment (ACT) Study. 4th European Headache Federation and Migraine Trust International Congress, Copenhagen, Denmark, Sept 1821, 2014. Silberstein SD, Mechtler LL, Kudrow DB, Tepper SJ, Calhoun AH, Lipton RB, Spitzer L, Mullin C, Liebler EJ; on behalf of the ACT Study Group. Efficacy and Safety of Noninvasive Vagus Nerve Stimulation With GammaCore for the Abortive Treatment of Acute Cluster Headache: Report From the Double-blind Stage of the Acute Cluster Headache Treatment (ACT) Study. 4th European Headache Federation and Migraine Trust International Congress, Copenhagen, Denmark, Sept 18-21, 2014. Tepper S, Cady R, Silberstein S, Messina J, Mahmoud R, Djupesland P, Shin P, Siffert J. Primary Efficacy Outcomes from COMPASS: A Comparison of Breath Powered Device Containing 22 mg Sumatriptan Powder (AVP-825) Versus 100 mg Oral Sumatriptan in Acute Treatment of Migraine. Neurology. 2015;84(14 Suppl). American Academy of Neurology, Washington, DC, April 22, 2015. Poster S23.001. Platform presentation. 71 Tepper S, Cady R, Messina J, Mahmoud R, Djupesland P, Shin P, Siffert J. Secondary efficacy outcomes from COMPASS: a comparison of Breath Powered device containing 22 mg sumatriptan powder (AVP-825) versus oral 100 mg sumatriptan in episodic migraine [AAN 2015 abstract P3.059]. Neurology. 2015;84(14 Suppl). Silberstein S, Tepper SJ, Cady RK, Messina J, Mahmoud RA, Djupesland PG, Shin P, Siffert J, Siegert S, Wallick C. Secondary Efficacy Outcomes from COMPASS: Comparison of a Breath Powered Delivery System Containing 22 mg Sumatriptan Powder (AVP-825) Versus Oral 100 mg Sumatriptan in Episodic Migraine. 27th American Academy of Managed Care Pharmacy, San Diego, CA, Apr 7-10, 2015, also American Academy of Neurology, Washington, DC, April 21, 2015. Halker R, Tepper S, Siegert S, Wallick C. Total migraine freedom for Breath Powered intranasal delivery of 22mg sumatriptan powder (AVP-825) versus 100mg oral sumatriptan from the COMPASS study in acute migraine. Oral Presentation at: 17th Biennial Congress of the International Headache Society; May 14-17, 2015; Valencia, Spain. Maasumi K, Thompson NR, Kriegler JS, Tepper SJ. Effect of OnabotulinumtoxinA Injection on Depression in Chronic Migraine. 17th International Headache Congress, Valencia, Spain, May 14-15, 2015. Tariq N, Tepper SJ, Kriegler J. Long term outcomes in hypnic headache syndrome: 32 patient series from a tertiary referral center. 17th International Headache Congress, Valencia, Spain, May 15-16, 2015. Platform presentation, American Headache Society 57th Scientific Meeting, Washington, DC, June 18-21, 2015. Tariq N, Estemalik E, Afzal MR, Mays M, Tepper SJ, Kriegler J. Geographic Distribution and Demographic Characteristics of United Council of Neurologic Subspecialties (UCNS) Certified Headache Specialists Across the United States. American Headache Society 57th Scientific Meeting, Washington, DC, June 18-21, 2015. Halker, R, Tepper, SJ.Siegert S, Wallick C. Total Migraine Freedom for Breath Powered Intranasal Delivery of 22 mg Sumatriptan Powder (AVP-825) Versus 100 mg Oral Sumatriptan from the COMPASS Study of Acute Treatment of Migraine. Headache. 2015;55(Suppl 3):136. American Headache Society 57th Scientific Meeting, Washington, DC, June 18-21, 2015. Halker R, Tepper S, Siegert S, Wallick C. Total migraine freedom for Breath Powered intranasal delivery of 22mg sumatriptan powder (AVP-825) versus 100mg oral sumatriptan from the COMPASS study of acute treatment of migraine [ISPOR-Int 2015 abstract]. Value Health. 2015;18(3):A278. 72 Tepper SJ, Cady R, Messina J, Mahmoud R, Djupesland P, Shin P, Siffert J, Siegert S, Wallick C. Secondary efficacy outcomes from COMPASS: a comparison of Breath Powered device containing 22 mg sumatriptan powder (AVP-825) versus oral 100 mg sumatriptan in episodic migraine. Poster at: 27th Annual Meeting and Expo of the Academy of Managed Care Pharmacy; April 7-10, 2015; San Diego, CA. Tariq N, Estemalik E, Adil M, Tepper SJ. Kriegler J. Safety and Efficacy of OnabotulinumtoxinA for chronic migraines in the elderly. A comparison with PREEMPT-II clinical trial. American Headache Society 57th Scientific Meeting, Washington, DC, June 18-21, 2015. Clinical Studies list provided on request Dr. Tepper has participated and completed more than 300 clinical trials since 1990. He participated in 10-30 trials on an ongoing basis at The New England Research Institute from 1999-2007, and a list can be provided. He was Co-Director of Research at the Center for Neurological Restoration, Neurological Institute, Cleveland Clinic until 2015, and had multiple clinical trials underway, with studies in new formulations, monoclonal antibodies, and devices. Personal Information Home Address: PO Box 355 105 Melody Lane South Chatham, MA 02659 Home Phone: 508-432-7121 Marital Status: Married; two sons 73