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Injectable Medications for Blood Sugar Management Types of Insulin Onset Maximum Effect Duration Available Forms Looks Like Storage Humalog (Lispro) 0–15 Minutes 30–90 Minutes 3–5 Hours Lilly: Vial, Disposable Pen, Penfill Cartridge 28 days, once in use NovoLog (Aspart) 0–15 Minutes 60–120 Minutes 3–5 Hours Novo Nordisk: Vial, Disposable Pen (Flexpen), Penfill Cartridge 28 days, once in use Apidra (Glulisine) 0–15 Minutes 1–2 Hours 3–4 Hours Sanofi-Aventis: Vial, Penfill Cartridge (Opticlix) 28 days, once in use Lilly Humulin: Vial 28 days, once in use Novo Nordisk Novolin: Vial, Penfill Cartridge, InnoLet 28 days, once in use Lilly: Vial, Disposable Pen Vial: 28 days, once in use Novo Nordisk: Vial, Penfill Cartridge, InnoLet Pen: 14 days, once in use Regular NPH 1/2–1 Hours 1.5–4 Hours 2–3 Hours 4–12 Hours 3–6 Hours 12–18 Hours Lantus (Glargine) 1–2 Hours Flat 24 Hours Sanofi-Aventis: Vial, Penfill Cartridge (Opticlix) Do not mix Lantus with any other insulin. 28 days, once in use Levemir (Detemir) 0.8–2 Hours 3.2–9.3 Hours (Dose Dependent) Up to 24 Hours Novo Nordisk: Vial, Disposable Pen (Flexpen) Vial: 42 days, once in use Pen: 42 days, once in use Lilly: Vial, Disposable Pen Vial: 28 days, once in use Pen: 10 days, once in use Novo Nordisk: Vial, Penfill Cartridge, InnoLet 28 days, once in use Humulin or Novolin 70/30 70% Isophane Suspension (intermediate acting insulin) 30% Regular Humulin 50/50 50% Isophane Suspension (intermediate acting insulin) 50% Regular Lilly: Vial 28 days, once in use Humalog Mix 50/50 50% Lispro Protamine Suspension (NPL) (intermediate acting) 50% Humalog Lilly: Vial, Disposable Pen Vial: 28 days, once in use Pen: 10 days, once in use Humalog Mix 75/25 75% Lispro Protamine Suspension (NPL) (intermediate acting) 25% Humalog Lilly: Vial, Disposable Pen Vial: 28 days, once in use Pen: 10 days, once in use NovoLog Mix (70/30) 70% Aspart Protamine Suspension (intermediate acting) 30% NovoLog Novo Nordisk: Vial, Disposable Pen (Flexpen), Penfill Cartridge Vial: 28 days, once in use Pen: 14 days, once in use Store unused vials, cartridges and disposable pens in the refrigerator. Humulin and Novolin are brand names, not types of insulin. Insulin Devices Looks Like Novopen 3 (For use with Penfill Cartridge) Novo Nordisk Devices Flexpen (Disposable Pen) Innolet (Disposable Device) Lilly Device Disposable Pen Sanofi-Aventis Device Opticlix (Permanent Pen) Drug What It Is How Given Side Effects Available Forms Synthetic analog of human amylin, for type 1 or 2. Decrease gastric emptying, increases satiety, decreases after meal glucagon, decreases after meal glucose excursion. Subcutaneous injection, 15 –120 micrograms at main part of meal (use conversion chart at right for units needed in U-100 syringe). Inject in abdomen or thigh, not arm, 2 inches from insulin injection, not mixing with insulin. Hypoglycemia (decrease premeal insulin dosages 30-50%, including premixed insulins), anorexia, nausea, vomiting (titrate dose weekly if tolerated). Vial Incretin Mimetic Increases insulin secretion, decreases liver sugar output, decreases rate sugar enters blood, decreases food intake. Pen injection: 5 micrograms first month, 10 micrograms next month if tolerated. Twice daily, within 60 minutes before first meal and evening meal, at least 6 hours apart. Hypoglycemia with sulfonylureas, nausea, vomiting, dizziness, feeling jittery, headache. 5 mcg Pen 10 mcg Pen Symlin (pramlintide) Byetta (exenatide) Action Looks Like Diabetes Educators: Call 1-800-635-2288 for information or patient brochures. Medicare Part B patients: Call 1-877-231-5199 and mention reference code EDO6500 to order your diabetes testing supplies. Website: www.PrescriptionSolutions.com/diabetes The information in this educational tool does not substitute for the medical advice, diagnosis or treatment of your physician. Always seek the help of your physician or qualified health provider for any questions you may have regarding a medical condition. Prescription Solutions is an affiliate of UnitedHealthcare Insurance Company. HCP-MSS07-001-JJ 1/09 Symlin Dose Prescribed Increment Using U-100 Syringes (Units) 15 mcg 30 mcg 45 mcg 60 mcg 120 mcg 2.5 units 5.0 units 7.5 units 10 units 20 units