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HMF Probiotics PROFESSIONAL PRODUCT GUIDE NEW New products inside Clinically proven, proprietary, human-sourced strains Visit www.seroyal.com/genestrabrands to view the entire GENESTRA BRANDS line Dedicated to making a difference in peoples’ lives Genestra Brands is a leading-edge line of professional-grade nutraceuticals, helping North American healthcare practitioners restore, rebuild and maintain patient health for over 30 years. A trusted Seroyal brand. 490 Elgin Mills Road East, Richmond Hill, ON L4C 0L8 TEL: 1-800-263-5861 | FAX: 1-800-722-9953 | EMAIL: [email protected] | WEBSITE: www.seroyal.com The aim of this comprehensive product guide is to assist in building more effective and successful patient treatment strategies. The product guide is to be used as an adjunct to Seroyal Continuing Medical Education and is not intended to be utilized as a diagnostic tool nor replace any other required education. The remedies indicated in this product guide are potent medicines that can have profound therapeutic effects on patients. As with any intervention, the dosage may need to be adjusted for those with chronic conditions, very sensitive individuals and those taking multiple medications. Practitioners are solely responsible for the care and treatment provided to their own patients. The information provided by the speaker or speakers in the Seroyal Continuing Medical Education program together with any written material provided do not necessarily represent the views of Seroyal and are not intended as medical advice or an endorsement of any products. This information is for practitioner use only. Copyright © 2015 Seroyal. All rights reserved. No part of this information may be used or reproduced in any form or by any means, or stored in a database or retrieval system, or be distributed or replicated without express permission of Seroyal. Making copies of any part of this information for any purposes other than your own personal use is a violation of copyright law. 2190. Version 45. ii TABLE OF CONTENTS Probiotics 101 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Market leader: Driving probiotic science and innovation for over 30 years. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 HMF Product Overview MAINTENANCE HMF Pre + Probiotic. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 HMF Capsules. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 HMF Forte. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 HMF Super Powder. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 HMF Powder. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 HMF Multi Strain. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 HMF Intensive. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 HMF Intensive Powder. . . . . . . . . . . . . . . . . . . . . . . . . . . 6 HMF Replenish Capsules. . . . . . . . . . . . . . . . . . . . . . . . . 6 HMF Replete. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 IBS SYMPTOMS HMF IBS Relief. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 POST ANTIBIOTIC CARE HMF Antibiotic Care. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 HMF Probiotic Product Comparison Chart. . . 8-9 Probiotics 101 What are probiotics? There are billions of bacteria living in the intestinal tract often referred to as ‘microflora’. Probiotics are live “friendly” bacteria found in the microflora working to keep a healthy intestinal balance, reducing the amount of harmful bacteria while replenishing and maintaining beneficial strains. Maintaining this balance is critical for overall good health. Why supplement with probiotics? Beneficial bacteria may be reduced due to a variety of factors: • Dietary changes or •Age poor diet • Antibiotic or other medication use •Stress • Digestive disorders • Infection or illness • Traveling •Lifestyle Who should take probiotics? Daily probiotic supplementation is considered a necessary component of any healthy diet. It supports health in: • Pre- and post-pregnancy • Infants (1 year+), children and adolescents •Adults •Seniors While probiotics may be added in foods such as yogurt and smoothies, direct probiotic supplementation provides the highest amount of beneficial live and active cultures. Probiotics should be a routine part of a daily lifestyle to help maintain optimal health conditions. An unhealthy balance between the beneficial and harmful bacteria may affect gastrointestinal function. EXPORPHIN DEGRADING (in vitro) HMF Neuro Capsules. . . . . . . . . . . . . . . . . . . . . . . . . . . 10 HMF Neuro Powder. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 URINARY SUPPORT HMF Cystgen . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 YEAST INFECTION SUPPORT HMF Candigen Cream . . . . . . . . . . . . . . . . . . . . . . . . . . 11 HMF Candigen. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 PREGNANCY AND CHILD SUPPORT NEW NEW HMF Maternity. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 HMF Maternity + Pro. . . . . . . . . . . . . . . . . . . . . . . . . . . 12 HMF Child. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 HMF Baby B . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 HMF Baby F. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 HMF Natogen. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 HMF Toddler + Pro. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 Clinical Trials The Swansea Baby Trial. . . . . . . . . . . . . . . . . . . . . . . 15-16 The ProChild Study. . . . . . . . . . . . . . . . . . . . . . . . . . . 17-18 The Sheffield IBS Trial . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 The Cambridge Probiotic / Antibiotic Trial. . . . . . . . . 20 The Swansea ‘Safety in Newborns’ Study. . . . . . . . . . 20 All ages can benefit from probiotic supplementation. 1 Market leader Driving probiotic science and innovation for over 30 years GENESTRA BRANDS Human MicroFlora (HMF) probiotics incorporate safe and effective strains reflecting the latest evidence-based research from human trials, and provide physicians and healthcare professionals a comprehensive range for individualized or condition-specific treatment. Human-sourced strains Natural pH and bile acid resistance: No enteric coatings required Human-sourced microflora bacterial strains have high survival rates through various stomach pH (1.8- 4.2) thus maximizing intestinal tract exposure and eliminating the need for enteric coatings (capsule/tablet barriers that control digestive absorption). Naturally strong adherence: High ratio of intestinal tract carriage CFU (Colony Forming Unit) levels are important but effectiveness is best determined through intestinal tract carriage. Human-sourced microflora bacterial strains have a naturally strong adherence to epithelial cells thus ensuring high ratios of intestinal tract carriage. Clinically proven: Human trials demonstrate safety and efficacy Clinically proven in randomized, double-blind, placebo-controlled human trials 25 billion CFU/day of: • Lactobacillus acidophilus (CUL-60) • Lactobacillus acidophilus (CUL-21) • Bifidobacterium bifidum (CUL-20) • Bifidobacterium animalis subsp. lactis (CUL-34) Clinically proven to: • Improve symptoms of irritable bowel syndrome (IBS) within 6 weeks •Reduce bloating, increase satisfaction with bowel habits, and decrease days with pain • Restore normal micro flora composition following antibiotic therapy Probiotic expertise: Global research and development drive category innovation A collaborative think-tank lead by Dr. Plummer produced over 70 peer reviewed and PubMed listed publications. 10 billion CFU/day of: • Bifidobacterium bifidum (CUL-20) • Bifidobacterium animalis subsp. lactis (CUL-34) • Lactobacillus silvarius (CUL-61) • Lactobacillus paracasei (CUL-08) Clinically proven: • Safe for use during infancy Nigel Plummer PhD: Global authority on probiotics This key probiotic contributor has worked at Pfizer in antibiotic R&D. A continued commitment to research has resulted in collaborations with research institutes and universities within the UK and Europe, developing an extensive knowledge specializing in probiotics, natural antimicrobials and fish oils. Comprehensive range: Convenient formats, age-specific and condition-specific formulas Available in an array of potencies (up to 150 billion CFU), formats (capsules, tablets, powders) and flavours toallow for flexibility in dosing and improved patient compliance. Therapies can be tailored for specific individualized treatments by age (pregnancy support, infants, and children to seniors) or condition-specific probiotics (exorphin degrading, IBS, antibiotic, urinary and yeast infection support). 2 Get an Early Start on Immune and Digestive Health NEW GENESTRA BRANDS HMF Baby B (for breast fed babies) and HMF Baby F (for formula fed babies) each provide 10 billion CFU of clinically-proven human-sourced strains, to promote an optimal gut flora and support digestive health. Infant microflora composition is an important factor in early immune development, and sub-optimal microflora composition may impact risk of developing atopic disease. In a recent clinical trial, supplementation with the probiotic formula used in HMF Baby B and HMF Baby F reduced atopic eczema incidence by 57% and decreased skin prick reaction to cow’s milk and egg allergens by 44%. HMF Baby B includes additional microflora support from added galactooligosaccharides (GOS), a prebiotic fibre similar to oligosaccharides naturally within breast milk. HMF Baby F contains both GOS and fructooligosaccharides (FOS). 3 MAINTENANCE HMF Pre + Probiotic HMF Capsules HMF Forte PROBIOTIC FORMULA PROBIOTIC FORMULA PROBIOTIC FORMULA Low level maintenance probiotic + prebiotic fibre • 1.25 billion CFU per dose •Includes prebiotic fibre from fructooligosaccharides (FOS) and soluble fibre from psyllium husk •Helps stimulate the growth of intestinal Bifidobacteria •Provides gentle relief of occasional constipation HMF Pre + Probiotic is a low level, long-term maintenance synbiotic formula which provides two strains of proprietary human-sourced Lactobacillus acidophilus, Bifidobacterium bifidum and Bifidobacterium animalis subsp. lactis, along with fructooligosaccharides to specifically assist in maintaining a normal intestinal microflora. EACH SCOOP (5 g) CONTAINS: Probiotic Consortium . . . . . . . . . . . . . . . . . . . . . . . 1.25 billion CFU Lactobacillus acidophilus (CUL-60) Lactobacillus acidophilus (CUL-21) Bifidobacterium bifidum (CUL-20) Bifidobacterium animalis subsp. lactis (CUL-34) Fructooligosaccharides (FOS) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2.5g Psyllium (Plantago ovata) Husk . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2.19 g Recommended Dose: Adults and Adolescents (12 years and older): In a glass, add eight ounces (250 ml) of water or juice to two scoops of HMF Pre + Probiotic and mix. Take two times daily, at least two to three hours before or after taking antibiotics or other medications, or as recommended by your healthcare practitioner. Drink a full glass of liquid with each serving. When used as a gentle laxative, effects are observed twelve to twenty-four hours after first dose, and may take two to three days. 250 g Powder NPN 80041616 4 Product Code: 10423 Low level maintenance probiotic •2.5 billion CFU per capsule •Contributes to a natural healthy gut flora HMF Capsules are a low level, long-term maintenance probiotic formula which provides two strains of proprietary human-sourced Lactobacillus acidophilus, Bifidobacterium bifidum and Bifidobacterium animalis subsp. lactis, to specifically assist in re-establishing and maintaining a normal intestinal microflora. EACH CAPSULE CONTAINS: Probiotic Consortium . . . . . . . . . . . . . . . . . . . . . . 2.5 billionCFU Lactobacillus acidophilus (CUL-60) Lactobacillus acidophilus (CUL-21) Bifidobacterium bifidum (CUL-20) Bifidobacterium animalis subsp. lactis (CUL-34) Non-Medicinal Ingredients: Cellulose, hypromellose, silica, magnesium stearate Recommended Dose: Adults and Children (6 years and older): Take two capsules two times daily with meals, at least two to three hours before or after taking antibiotics, or as recommended by your healthcare practitioner. 60 Vegetable Capsules NPN 80020672 Product Code: 10409 Moderate level maintenance probiotic •10 billion CFU per dose •Includes fructooligosaccharides (FOS) Long-term maintenance •Supporting a healthy normal digestive flora Ideal for vegans • Convenient vegetable capsule format HMF Forte is a moderate level, long-term maintenance probiotic formula which provides two strains of proprietary human-sourced Lactobacillus acidophilus, Bifidobacterium bifidum and Bifidobacterium animalis subsp. lactis, along with fructooligosaccharides (FOS). EACH CAPSULE CONTAINS: Probiotic Consortium . . . . . . . . . . . . . . . . . . . . . . . 10 billion CFU Lactobacillus acidophilus (CUL-60) Lactobacillus acidophilus (CUL-21) Bifidobacterium bifidum (CUL-20) Bifidobacterium animalis subsp. lactis (CUL-34) Non-Medicinal Ingredients: Cellulose, fructooligosaccharides (FOS), hypromellose, silica, magnesium stearate Recommended Dose: Adults and Children (6 years and older): Take one capsule two times daily with meals, at least two to three hours before or after taking antibiotics, or as recommended by your healthcare practitioner. 60 Vegetable Capsules 120 Vegetable Capsules NPN 80020755 Product Code: 10418 Product Code: 10418120 MAINTENANCE HMF Super Powder HMF Powder HMF Multi Strain PROBIOTIC FORMULA PROBIOTIC FORMULA PROBIOTIC FORMULA Moderate level probiotic •10 billion CFU per dose Ideal for vegans •Convenient powder format Moderate level maintenance probiotic •11 billion CFU per dose •Includes fructooligosaccharides Ideal for vegans • Convenient powder format HMF Super Powder is a moderate level maintenance probiotic formula which provides two strains of proprietary humansourced Lactobacillus acidophilus, Bifidobacterium bifidum and Bifidobacterium animalis subsp. lactis, along with fructooligosaccharides, formulated to assist in re-establishing and maintaining normal intestinal microflora. HMF Super Powder is indicated for the promotion and maintenance of intestinal health in adults and children who dislike or have difficulty swallowing capsules. EACH SCOOP (1 g) CONTAINS: Probiotic Consortium . . . . . . . . . . . . . . . . . . . . . . . . 10 billion CFU Lactobacillus acidophilus (CUL-60) Lactobacillus acidophilus (CUL-21) Bifidobacterium bifidum (CUL-20) Bifidobacterium animalis subsp. lactis (CUL-34) Non-Medicinal Ingredient: Fructooligosaccharides (FOS), fructose Recommended Dose: Adults and Children (1 year and older): In a glass, add water or milk to one scoop (¼ teaspoon) of HMF Super Powder and mix. Take two times daily with meals, at least two to three hours before or after taking antibiotics, or as recommended by your healthcare practitioner. 120 g Powder NPN 80020678 Product Code: 10427 HMF Powder is a moderate level maintenance probiotic formula which provides two strains of proprietary human-sourced Lactobacillus acidophilus, Bifidobacterium bifidum and Bifidobacterium animalis subsp. lactis, along with fructooligosaccharides. HMF Powder is indicated for the promotion and maintenance of intestinal health in adults and children alike. EACH SCOOP (1 g) CONTAINS: Probiotic Consortium . . . . . . . . . . . . . . . . . . . . . . . 11 billion.CFU Lactobacillus acidophilus (CUL-60) Lactobacillus acidophilus (CUL-21) Bifidobacterium bifidum (CUL-20) Bifidobacterium animalis subsp. lactis (CUL-34) Fructooligosaccharides (FOS) . . . . . . . . . . . . . . . . . . . . . . . . 880.mg Recommended Dose: Adults and Children (1 year and older): In a glass, add water or milk to one scoop (¼ teaspoon) of HMF Powder and mix. Take two times daily with meals, at least two to three hours before or after taking antibiotics, or as recommended by your healthcare practitioner. 60 g Powder NPN 80041897 Product Code: 10408 Moderate-level maintenance probiotic • 15 billion CFU per dose • No FOS 16 probiotic strains • Includes proprietary human-sourced strains Supports a healthy normal digestive flora •Provides live microorganisms that temporarily modify gut flora HMF Multi Strain is a moderate-level, long-term maintenance probiotic formula which provides sixteen strains including proprietary human-sourced Lactobacillus acidophilus, Bifidobacterium bifidum and Bifidobacterium animalis subsp. lactis. The capsules are 100% pure vegetable-sourced which makes the product ideal for vegans. EACH CAPSULE CONTAINS: Probiotic Consortium . . . . . . . . . . . . . . . . . . . . . . . 15 billion CFU Lactobacillus acidophilus (CUL-60) Lactobacillus acidophilus (CUL-21) Bifidobacterium bifidum (CUL-20) Bifidobacterium animalis subsp. lactis (CUL-34) Lactobacillus salivarius (CUL-61) Lactobacillus paracasei (CUL-08) Lactobacillus plantarum (CUL-66) Lactobacillus casei (CUL-06) Lactobacillus fermentum (CUL-67) Lactobacillus gasseri (CUL-09) Bifidobacterium animalis subsp. lactis (CUL-62) Bifidobacterium breve (CUL-74) Streptococcus salivarius subsp. thermophilus (CUL-68) Lactobacillus acidophilus (NCFM™) Bifidobacterium animalis subsp. lactis (HN019) Lactobacillus rhamnosus (HN001) Non-Medicinal Ingredients: Hypromellose, cellulose, silica Recommended Dose: Adults, Adolescents and Children (6 years and older): Take one capsule daily, at least two to three hours before or after taking antibiotics, or as recommended by your healthcare practitioner. 60 Vegetable Capsules Product Code: 10487 NPN 80045939 5 MAINTENANCE HMF Intensive HMF Intensive Powder HMF Replenish Capsules PROBIOTIC FORMULA PROBIOTIC FORMULA PROBIOTIC FORMULA High level probiotic •25 billion CFU per dose Ideal for vegans •Convenient vegetable capsule format HMF Intensive is a highly concentrated probiotic formula which provides two strains of proprietary human-sourced Lactobacillus acidophilus, Bifidobacterium bifidum and Bifidobacterium animalis subsp. lactis in a single daily dose capsule to support the restoration of friendly intestinal flora. HMF Intensive is highly recommended after completion of the HMF Replete program. EACH CAPSULE CONTAINS: Probiotic Consortium . . . . . . . . . . . . . . . . . . . . . . . 25 billion CFU Lactobacillus acidophilus (CUL-60) Lactobacillus acidophilus (CUL-21) Bifidobacterium bifidum (CUL-20) Bifidobacterium animalis subsp. lactis (CUL-34) Non-Medicinal Ingredients: Cellulose, hypromellose Recommended Dose: Adults and Children (6 years and older): Take one capsule daily with a meal, at least two to three hours before or after taking antibiotics, or as recommended by your healthcare practitioner. 30 Vegetable Capsules NPN 80020663 Product Code: 10431 Highly concentrated probiotic formula • 25 billion CFU per dose •Provides live organisms that temporarily modify gut flora Easy-to-use powder formula for long-term maintenance • Includes proprietary human-sourced strains HMF Intensive Powder is a highly concentrated probiotic formula, which provides two strains of proprietary human-sourced Lactobacillus acidophilus, Bifidobacterium bifidum and Bifidobacterium animalis subsp. lactis in a single daily-dose powder to support the restoration of friendly intestinal flora. It is fructooligosaccharide-free and HMF Intensive Powder is highly recommended after completion of the HMF Replete program. HMF Replenish Capsules is a highly concentrated probiotic formula in capsules which provides two strains of proprietary human-sourced Lactobacillus acidophilus, Lactobacillus salivarius, Bifidobacterium bifidum and Bifidobacterium animalis subsp. lactis along with low concentrations of fructooligosaccharides. EACH CAPSULE CONTAINS: Probiotic Consortium . . . . . . . . . . . . . . . . . . . . . . 100 billion CFU Lactobacillus acidophilus (CUL-60) Lactobacillus acidophilus (CUL-21) Bifidobacterium bifidum (CUL-20) Bifidobacterium animalis subsp. lactis (CUL-34) Lactobacillus salivarius (CUL-61) SCOOP (1 g) CONTAINS: EACH Probiotic Consortium . . . . . . . . . . . . . . . . . . . . . . . 25 billion CFU Lactobacillus acidophilus (CUL-60) Lactobacillus acidophilus (CUL-21) Bifidobacterium bifidum (CUL-20) Bifidobacterium animalis subsp. lactis (CUL-34) Non-Medicinal Ingredients: Fructooligosaccharides (FOS), hypromellose, silica, magnesium stearate Non-Medicinal Ingredients: Maltodextrin 14 Vegetable Capsules Recommended Dose: Adults, Adolescents and Children (3 years and older): In a glass, add water or milk to one scoop of HMF Intensive Powder and mix. Take once daily with a meal, at least two to three hours before or after taking antibiotics, or as recommended by your healthcare practitioner. NPN 80023493 30 g Powder 6 High level probiotic • 100 billion CFU per dose • Includes fructooligosaccharides Ideal for vegans • Convenient vegetable capsule format Product Code: 10486 Recommended Dose: Adults and Children (6 years and older): Take one capsule daily with a meal, at least two to three hours before or after taking antibiotics, or as recommended by your healthcare practitioner. Product Code: 10457 MAINTENANCE IBS SYMPTOMS POST ANTIBIOTIC CARE HMF Replete HMF IBS Relief HMF Antibiotic Care PROBIOTIC FORMULA PROBIOTIC FORMULA PROBIOTIC FORMULA High level probiotic •150 billion CFU per sachet Ideal for vegans •Convenient powder sachet format HMF Replete is a highly concentrated probiotic formula in sachets which provides two strains of proprietary humansourced Lactobacillus acidophilus, Lactobacillus salivarius, Bifidobacterium bifidum and Bifidobacterium animalis subsp. lactis along with fructooligosaccharides in high concentrations to ensure rapid establishment and dominance of probiotic cultures in the gastrointestinal tract. EACH SACHET (20 g) CONTAINS: Probiotic Consortium . . . . . . . . . . . . . . . . . . . . . . . . 150 billion CFU Lactobacillus acidophilus (CUL-60) Lactobacillus acidophilus (CUL-21) Bifidobacterium bifidum (CUL-20) Bifidobacterium animalis subsp. lactis (CUL-34) Lactobacillus salivarius (CUL-61) Non-Medicinal Ingredient: Fructooligosaccharides (FOS), apricot powder Recommended Adult Dose: In a glass, add water to ½ sachet of HMF Replete and mix. Take once daily with a meal, at least two to three hours before or after taking antibiotics, or as recommended by your healthcare practitioner. 7 x 20 g Sachets of Powder (140 g) Product Code: 10419 NPN 80020781 Probiotic for IBS support •Clinically proven to improve symptoms of irritable bowel syndrome (IBS) within 6 weeks1 •Reduces bloating, increases satisfaction with bowel habits, and decreases days with pain • 25 billion CFU per dose HMF IBS Relief is clinically proven to significantly reduce the severity of symptoms of intestinal discomfort and days with pain, while improving satisfaction with bowel habits and overall quality of life.1 Human MicroFlora (HMF) probiotic strains are proprietary human-sourced microflora bacterial strains that have strong epithelial adherence and a naturally high tolerance to stomach acid. EACH CAPSULE CONTAINS: Probiotic Consortium . . . . . . . . . . . . . . . . . . . . . . . 25 billion CFU Lactobacillus acidophilus (CUL-60) Lactobacillus acidophilus (CUL-21) Bifidobacterium bifidum (CUL-20) Bifidobacterium animalis subsp. lactis (CUL-34) Non-Medicinal Ingredients: Cellulose, hypromellose Recommended Dose: Adults and Children (11 years and older): Take one capsule daily with a meal, at least two to three hours before or after taking antibiotics, or as recommended by your healthcare practitioner. 30 Vegetable Capsules Product Code: 10437 NPN 80020663 Probiotic for post antibiotic care • Clinically proven to help restore normal micro flora composition following antibiotic therapy1 • 100 billion CFU per dose • Includes fructooligosaccharides HMF Antibiotic Care is clinically proven to supplement the normal intestinal microbiota following antibiotic therapy. The Cambridge Probiotic/Antibiotic Trial concluded that this proprietary blend of Human MicroFlora (HMF) strains was effective in modulating intestinal microflora response to the effects of antibiotic therapy.1 HMF probiotic strains are human-sourced microflora bacterial strains that have strong epithelial adherence and a naturally high tolerance to stomach acid. EACH CAPSULE CONTAINS: Probiotic Consortium . . . . . . . . . . . . . . . . . . . . . . 100 billion CFU Lactobacillus acidophilus (CUL-60) Lactobacillus acidophilus (CUL-21) Bifidobacterium bifidum (CUL-20) Bifidobacterium animalis subsp. lactis (CUL-34) Lactobacillus salivarius (CUL-61) Non-Medicinal Ingredients: Fructooligosaccharides (FOS), hypromellose, silica, magnesium stearate Recommended Dose: Adults and Children (6 years and older): Take one capsule daily with a meal, at least two to three hours before or after taking antibiotics, or as recommended by your healthcare practitioner. 14 Vegetable Capsules Product Code: 10471 NPN 80023493 1.Plummer et. al. (2008) Clinical trial: a multistrain probiotic preparation significantly reduces symptoms of irritable bowel syndrome in a double-blind placebo-controlled study. Aliment Pharmacol Ther. 29:97-103. 1.Madden JAJ et al. Effect of probiotics on preventing disruption of the intestinal microflora following antibiotic therapy: A double-blind, placebo-controlled pilot study. Int Immunophar 2005: 5: 1091-1097. 7 Condition-specific support Comprehensive range in convenient formats For individualized treatment, HMF probiotics are available in an array of potencies and formulas to allow for flexibility and efficacy. Human MicroFlora (HMF) Probiotics Comparison Chart 8 CFU PER DOSAGE UNIT STRAINS OTHER ACTIVE INGREDIENTS FOS RECOMMENDED DOSE Probiotic and prebiotic to promote a natural healthy gut flora 1.25 billion L. acidophilus (CUL-60) L. acidophilus (CUL-21) B. bifidum (CUL-20) B. animalis subsp. lactis (CUL-34) Psyllium husk Yes HMF Capsules Low level maintenance 2.5 billion No HMF Forte (capsules) Moderate level maintenance 10 billion HMF Super Powder Moderate level maintenance 10 billion L. acidophilus (CUL-60) L. acidophilus (CUL-21) B. bifidum (CUL-20) B. animalis subsp. lactis (CUL-34) L. acidophilus (CUL-60) L. acidophilus (CUL- 21) B. bifidum (CUL-20) B. animalis subsp. lactis (CUL-34) L. acidophilus (CUL-60) L. acidophilus (CUL-21) B. bifidum (CUL-20) B. animalis subsp. lactis (CUL-34) HMF Powder Moderate level maintenance 11 billion L. acidophilus (CUL-60) L. acidophilus (CUL-21) B. bifidum (CUL-20) B. animalis subsp. lactis (CUL-34) Yes HMF Multi Strain (capsules) Moderate level maintenance 15 billion No HMF Intensive (capsules) Intensive use 25 billion HMF Intensive Powder Intensive use 25 billion L. acidophilus (CUL-60) L. acidophilus (CUL-21) B. bifidum (CUL-20) B. animalis subsp. lactis (CUL-34) L. salivarius (CUL-61) L. paracasei (CUL-08) L. plantarum (CUL-66) L. casei (CUL-06) L. fermentum (CUL-67) L. gasseri (CUL-09) B. animalis subsp. lactis(CUL-62) B. breve (CUL-74) S. salivarius subsp. thermophilus (CUL-68) L. acidophilus (NCFM™) B. animalis subsp. lactis (HN019) L. rhamnosus (HN001) L. acidophilus (CUL-60) L. acidophilus (CUL- 21) B. bifidum (CUL-20) B. animalis subsp. lactis (CUL-34) L. acidophilus (CUL-60) L. acidophilus (CUL- 21) B. bifidum (CUL-20) B. animalis subsp. lactis (CUL-34) HMF Replenish Capsules Highest potency probiotic capsule for intensive use 100 billion Yes HMF Replete (powder) Highest potency probiotic powder for intensive use 150 billion per sachet L. acidophilus (CUL-60) L. acidophilus (CUL-21) B. bifidum (CUL-20) B. animalis subsp. lactis (CUL-34) L. salivarius (CUL-61) L. acidophilus (CUL-60) L. acidophilus (CUL-21) B. bifidum (CUL-20) B. animalis subsp. lactis (CUL-34) L. salivarius (CUL-61) PRODUCT PRIMARY INDICATIONS MAINTENANCE HMF Pre + Probiotic (powder) Yes Yes No No Yes Adults and Adolescents (12 years and older): In a glass, add eight ounces (250 ml) of water or juice to two scoops of HMF Pre + Probiotic and mix. Take two times daily, at least two to three hours before or after taking antibiotics or other medications, or as recommended by your healthcare practitioner. Drink a full glass of liquid with each serving. When used as a gentle laxative, effects are observed twelve to twenty-four hours after first dose, and may take two to three days. Adults and Children (6 years and older): Take two capsules two times daily with meals, at least two to three hours before or after taking antibiotics, or as recommended by your healthcare practitioner. Adults and Children (6 years and older): Take one capsule two times daily with meals, at least two to three hours before or after taking antibiotics, or as recommended by your healthcare practitioner. Adults and Children (1 year and older): In a glass, add water or milk to one scoop (¼ teaspoon) of HMF Super Powder and mix. Take two times daily with meals, at least two to three hours before or after taking antibiotics, or as recommended by your healthcare practitioner. Adults and Children (1 year and older): In a glass, add water or milk to one scoop (¼ teaspoon) of HMF Powder and mix. Take two times daily with meals, at least two to three hours before or after taking antibiotics, or as recommended by your healthcare practitioner. Adults, Adolescents and Children (6 years and older): Take one capsule daily, at least two to three hours before or after taking antibiotics, or as recommended by your healthcare practitioner. Adults and Children (6 years and older): Take one capsule daily with a meal, at least two to three hours before or after taking antibiotics, or as recommended by your healthcare practitioner. Adults, Adolescents and Children (3 years and older): In a glass, add water or milk to one scoop of HMF Intensive Powder and mix. Take once daily with a meal, at least two to three hours before or after taking antibiotics, or as recommended by your healthcare practitioner. Adults and Children (6 years and older): Take one capsule daily with a meal, at least two to three hours before or after taking antibiotics, or as recommended by your healthcare practitioner. Adults: In a glass, add water to ½ sachet of HMF Replete and mix. Take once daily with a meal, at least two to three hours before or after taking antibiotics, or as recommended by your healthcare practitioner. PRODUCT PRIMARY INDICATIONS CFU PER DOSAGE UNIT STRAINS IBS SYMPTOMS HMF IBS Relief (capsules) 25 billion Clinically proven to significantly reduce symptoms of Irritable Bowel Syndrome (IBS) POST ANTIBIOTIC CARE 100 billion HMF Antibiotic Care Clinically proven to (capsules) supplement the normal intestinal microbiota following antibiotic therapy EXORPHIN DEGRADING (in vitro) HMF Exorphin degrading capacity 12 billion Neuro Capsules in intestinally-simulated conditions HMF Neuro Powder Exorphin degrading capacity 12 billion in intestinally-simulated conditions OTHER ACTIVE INGREDIENTS FOS RECOMMENDED DOSE L. acidophilus (CUL-60) L. acidophilus (CUL- 21) B. bifidum (CUL-20) B. animalis subsp. lactis (CUL-34) No Adults and Children (11 years and older): Take one capsule daily with a meal, at least two to three hours before or after taking antibiotics, or as recommended by your healthcare practitioner. L. acidophilus (CUL-60) L. acidophilus (CUL-21) B. bifidum (CUL-20) B. animalis subsp. lactis (CUL-34) L. salivarius (CUL-61) Yes Adults and Children (6 years and older): Take one capsule daily with a meal, at least two to three hours before or after taking antibiotics, or as recommended by your healthcare practitioner. Adults, Adolescents and Children (6 years and older): Take one capsule two times daily with meals, at least two to three hours before or after taking antibiotics, or as recommended by your healthcare practitioner. Adults: In a glass, add water to one scoop (¼ teaspoon) of HMF Neuro Powder and mix. Take two times daily with meals, at least two to three hours before or after taking antibiotics, or as recommended by your healthcare practitioner. L. acidophilus (CUL-60) L. acidophilus (CUL-21) B. bifidum (CUL-20) B. animalis subsp. lactis (CUL-34) L. rhamnosus (CUL-63) L. acidophilus (CUL-60) L. acidophilus (CUL-21) B. bifidum (CUL-20) B. animalis subsp. lactis (CUL-34) L. rhamnosus (CUL-63) L-Glutamine No L-Glutamine Yes URINARY SUPPORT HMF Cystgen Helps to prevent recurrent (powder) urinary tract infections (UTIs) 10 billion L. acidophilus (CUL-60) L. acidophilus (CUL-21) Vitamin C, potassium, cranberry fruit juice concentrate No Adults: Take ¼ sachet four times daily or as recommended by your healthcare practitioner. Take with food or immediately after meals. Completely dissolve powderin ¼ glass of cold water or juice. Allow fizzing to stop before drinking. Take at least two to three hours before or after taking antibiotics. For optimal effect, use for a minimum of four weeks. YEAST INFECTION SUPPORT HMF Supports healthy microflora Candigen Cream 100 million L. acidophilus (CUL-60) L. gasseri (CUL-09) Garlic powder No HMF Candigen Supports healthy microflora 200 million (ovules) PREGNANC Y AND CHILD SUPPORT HMF Supports children 2.5 billion Toddler + Pro (powder) L. acidophilus (CUL-60) L. gasseri (CUL-09) Garlic powder No Application: Apply a thin layer of cream to the external vaginal area two to three times daily, or as recommended by your healthcare practitioner. For external use only. Adults: Use one ovule per day at bedtime or as recommended by your healthcare practitioner. B. bifidum (CUL-20) B. animalis subsp. lactis (CUL-34) L. salivarius (CUL-61) L. paracasei (CUL-08) Transgalactooligosaccharides, multivitamin blend Yes HMF Natogen (powder) Probiotic specifically formulated for breast-fed children 3 billion L. acidophilus (CUL-60) L. acidophilus (CUL-21) L. paracasei (CUL-08) B. animalis subsp. lactis (CUL-62) NEW HMF Baby B Probiotic supplement for breast fed babies 10 billion B. bifidum (CUL-20) B. animalis subsp. lactis (CUL-34) L. salivarius (CUL-61) L. paracasei (CUL-08) Galacto-oligosaccharides (GOS) Yes NEW HMF Baby F Probiotic supplement for formula fed babies 10 billion B. bifidum (CUL-20) B. animalis subsp. lactis (CUL-34) L. salivarius (CUL-61) L. paracasei (CUL-08) Transgalacto oligosaccharides (GOS) (from milk) Yes HMF Maternity (capsules) Supports pregnant women 10 billion HMF Maternity + Pro (capsules + softgels) Supports pregnant women 10 billion B. bifidum (CUL-20) B. animalis subsp. lactis (CUL-34) L. salivarius (CUL-61) L. paracasei (CUL-08) B. bifidum (CUL-20) B. animalis subsp. lactis (CUL-34) L. salivarius (CUL-61) L. paracasei (CUL-08) HMF Child (chewable tablets) Child-specific high potency chewable probiotic 12.5 billion L. acidophilus (CUL-60) L. acidophilus (CUL-21) B. bifidum (CUL-20) B. animalis subsp. lactis (CUL-34) L. salivarius (CUL-61) L. paracasei (CUL-08) No No Multivitamin and mineral blend, fish oil with beta carotene and vitamin E No No Children (1-5 years): In a glass, add water or milk to one scoop of HMF Toddler + Pro and mix. Take once daily with a meal, at least two to three hours before or after taking antibiotics, or as recommended by your healthcare practitioner. Children (1-4 years): In a glass, add water or milk to one scoop of powder and mix. Take once daily with a meal, at least two to three hours before or after taking antibiotics, or as recommended by your healthcare practitioner. Children (1-4 years): In a glass, add water or milk to one scoop of HMF Baby B and mix. Take once daily with a meal, at least two to three hours before or after taking antibiotics, or as recommended by your healthcare practitioner. Children (1-4 years): In a glass, add water or milk to one scoop of HMF Baby F and mix. Take once daily with a meal, at least two to three hours before or after taking antibiotics, or as recommended by your healthcare practitioner. Women: Take one capsule daily with a meal, at least two to three hours before or after taking antibiotics, or as recommended by your healthcare practitioner. Women (19 years and older): Take one serrated strip, containing one capsule and one softgel, once daily with a meal or as recommended by your healthcare practitioner. Take a few hours before or after taking other medications, and at least two to three hours before or after taking antibiotics. Children (4 years and older): Chew one tablet two times daily with meals, or as recommended by your healthcare practitioner. 9 EXORPHIN-DEGRADING (in vitro) URINARY SUPPORT HMF Neuro Capsules HMF Neuro Powder HMF Cystgen PROBIOTIC FORMULA PROBIOTIC FORMULA PROBIOTIC FORMULA Moderate level probiotic • 12 billion CFU per dose • Includes L-glutamine Ideal for vegans •Convenient vegetable capsule format Moderate level probiotic • 12 billion CFU per dose • Includes L-glutamine and fructooligosaccharides Ideal for vegans •Convenient powder format HMF Neuro Capsules is a unique preparation containing various strains and species of proprietary human-sourced Lactobacillus and Bifidobacteria to help maintain the integrity and health of the intestinal tract. HMF Neuro Powder is a unique preparation containing various strains and species of proprietary human-sourced Lactobacillus and Bifidobacteria to help maintain the integrity and health of the intestinal tract. EACH CAPSULE CONTAINS: Probiotic Consortium . . . . . . . . . . . . . . . . . . . . . . . 12 billion CFU Lactobacillus acidophilus (CUL-60) Lactobacillus acidophilus (CUL-21) Bifidobacterium bifidum (CUL-20) Bifidobacterium animalis subsp. lactis (CUL-34) Lactobacillus rhamnosus (CUL-63) L-Glutamine. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 250 mg EACH SCOOP (1 g) CONTAINS: Probiotic Consortium . . . . . . . . . . . . . . . . . . . . . . . 12 billion CFU Lactobacillus acidophilus (CUL-60) Lactobacillus acidophilus (CUL-21) Bifidobacterium bifidum (CUL-20) Bifidobacterium animalis subsp. lactis (CUL-34) Lactobacillus rhamnosus (CUL-63) L-Glutamine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 500 mg Fructooligosaccharides (FOS) . . . . . . . . . . . . . . . . . . . . . . . 250 mg Non-Medicinal Ingredients: Hypromellose, silica, magnesium stearate Non-Medicinal Ingredient: Apricot powder Recommended Dose: Adults, Adolescents and Children (6 years and older): Take one capsule two times daily with meals, at least two to three hours before or after taking antibiotics, or as recommended by your healthcare practitioner. Recommended Adult Dose: In a glass, add water to one scoop (¼ teaspoon) of HMF Neuro Powder and mix. Take two times daily with meals, at least two to three hours before or after taking antibiotics, or as recommended by your healthcare practitioner. 60 Vegetable Capsules 60 g Powder NPN 80039135 Product Code: 10442 NPN 80038853 Product Code: 10443 Moderate level probiotic •10 billion CFU per sachet Concentrated cranberry juice extract •Prevents urinary tract infections (UTIs) •Each sachet provides the quivalent to 30 g of fresh cranberry juice HMF Cystgen provides two strains of Lactobacillus formulated for the support and maintenance of a healthy gut microflora. Cranberry juice extracts prevent urinary tract iInfections (UTIs) and are a source of antioxidants. EACH SACHET (7.5 g) CONTAINS: Probiotic Consortium . . . . . . . . . . . . . . . . . . . . . . . 10 billion CFU Lactobacillus acidophilus (CUL-60) Lactobacillus acidophilus (CUL-21) Vitamin C (ascorbic acid) . . . . . . . . . . . . . . . . . . . . . . . . . . . 600 mg Potassium (potassium citrate/ bicarbonate) . . . . . . . . 1515 mg Cranberry (Vaccinium macrocarpon) Fruit Juice Concentrate (36:1). . . . . . . . . . . . . . . . . . . . . . 833 mg 30 g Fresh Equivalent Non-Medicinal Ingredients: Cellulose, citric acid Recommended Adult Dose: Take ¼ sachet four times daily or as recommended by your healthcare practitioner. Take with food or immediately after meals. Completely dissolve powder in ¼ glass of cold water or juice. Allow fizzing to stop before drinking. Take at least two to three hours before or after taking antibiotics. For optimal effect, use for a minimum of four weeks. 6 x 7.5 g Sachets of Powder (45 g) Product Code: 10413 NPN 80037490 10 YEAST INFECTION SUPPORT PREGNANCY & CHILD SUPPORT HMF Candigen Cream HMF Candigen HMF Maternity PROBIOTIC CREAM PROBIOTIC SUPPOSITORIES PROBIOTIC FORMULA Female probiotic cream •100 milllion CFU per gram •Includes garlic powder and Rosa damascena flower oil HMF Candigen Cream provides two strains of Lactobacillus. One gram (1 g) of cream contains 80 million CFU of Lactobacillus acidophilus and 20 million CFU of Lactobacillus gasseri, in combination with 2.47 mg of garlic (Allium sativum) clove powder. For maximum benefit, HMF Candigen Cream should be used along with HMF Candigen probiotic suppositories. Ingredients: PEG-8, PEG-32, Lactobacillus Ferments [Lactobacillus acidophilus (CUL-60); Lactobacillus gasseri (CUL-09)], Allium Sativum (Garlic) Bulb Powder, Rosa Damascena Flower Oil Recommended Application: Apply a thin layer of cream to the external vaginal area two to three times daily, or as recommended by your healthcare practitioner. For external use only. 50 g NPN 80037490 Product Code: 10566 Female probiotic suppositories • 200 million CFU per dose • Includes garlic bulb extract and Rosa damascena flower oil Ideal for vegans • Convenient ovule format HMF Candigen is presented as vaginal ovules which provide two strains of Lactobacillus. For maximum benefits, HMF Candigen should be used along with HMF Candigen Cream. Ingredients: PEG-12, PEG-150, Lactobacillus Ferments [Lactobacillus acidophilus (CUL-60)], Lactobacillus gasseri (CUL-09), Allium Sativum (Garlic) Bulb Extract, Rosa Damascena Flower Oil Recommended Adult Use: Use one ovule per day at bedtime or as recommended by your healthcare practitioner. Remove ovule from blister pack and place into top of applicator. Stand, squat or lie on your back with knees bent. Holding the loaded applicator, gently insert into the vagina as far as it will comfortably go. Holding the barrel of the applicator steady, gently depress the plunger until it stops to release the ovule in the vagina. Remove the applicator. Clean the applicator after each use with soap and warm water and rinse thoroughly. 6 Vaginal Ovules Product Code: 10568 Probiotic support for pregnant women •Clinically proven to be safe during pregnancy 1 • Source of probiotics that temporarily modify gut flora • 10 billion CFU per dose Expectant mothers may have safety concerns about using probiotics during pregnancy. HMF Maternity’s probiotic formulation is based on recent clinical safety evidence: in a double-blind, placebo-controlled clinical trial conducted on 454 pregnant women, supplementation with HMF Maternity’s probiotic combination did not increase adverse event risk, when compared to placebo treatment.1 EACH CAPSULE CONTAINS: Probiotic Consortium . . . . . . . . . . . . . . . . . . . . . . . 10 billion CFU Bifidobacterium bifidum (CUL-20) Bifidobacterium animalis subsp. lactis (CUL-34) Lactobacillus salivarius (CUL-61) Lactobacillus paracasei (CUL-08) Non-Medicinal Ingredients: Maltodextrin, hypromellose Recommended Dose: Women: Take one capsule daily with a meal, at least two to three hours before or after taking antibiotics, or as recommended by your healthcare practitioner. 30 Vegetable Capsules Product Code: 10492 NPN 80039564 1. Allen SJ et al. Dietary Supplementation with Lactobacilli and Bifidobacteria Is Well Tolerated and Not Associated with Adverse Events during Late Pregnancy and Early Infancy. The Journal of Nutrition. 2010; 140: 483–488 11 PREGNANCY & CHILD SUPPORT HMF Maternity + Pro HMF Child VITAMIN SUPPLEMENT WITH HMF (HUMAN MICROFLORA) PROBIOTICS Nutritional and probiotic supplement for pregnant women •Includes the 4 major foundations of nutrition; vitamins and minerals, antioxidants, clinically proven human-sourced probiotics and omega-3 essential fatty acids • Uses probiotic strains that are clinically proven to be safe during pregnancy1 • 10 billion CFU per dose • Provides folate, to reduce the risk of neural tube defects when taken during early pregnancy Includes high DHA fish oil •Each softgel provides 200 mg of DHA (docosahexaenoic acid) to help support cognitive health and brain function Convenient & cost-effective combination •Each package provides 28 easy-to-use portable strips (containing 1 vegetable capsule and 1 softgel per strip) HMF Maternity + Pro is a nutritional and probiotic supplement for pregnant women. Each dose of HMF Maternity + Pro provides 10 billion CFU of probiotic strains that are clinically proven to be safe during pregnancy,1 plus 20 vitamins and minerals, antioxidants, and 200 mg of DHA. HMF Maternity + Pro supports the development of brain, eyes, and nerves, and helps to the risk of neural tube defects when taken during early pregnancy. PROBIOTIC FORMULA EACH VEGETABLE CAPSULE CONTAINS: Vitamin C (ascorbic acid) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 150 mg Vitamin D (cholecalciferol). . . . . . . . . . . . . . . . . . . . . . . . . 25 mcg / 1000 IU Vitamin K1 (phylloquinone). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 75 mcg Thiamine (thiamine mononitrate). . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2.2 mg Riboflavin. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2.8 mg Niacinamide. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32 mg Vitamin B6 (pyridoxine hydrochloride). . . . . . . . . . . . . . . . . . . . . . . . . 2.8 mg Folate (folic acid). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 800 mcg Vitamin B12 (cyanocobalamin). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 mcg Biotin. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 100 mcg Pantothenic Acid (calcium d-pantothenate). . . . . . . . . . . . . . . . . . . . 12 mg Calcium (calcium carbonate). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 120 mg Iron (ferrous fumarate). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 mg Iodine (potassium iodide). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 150mcg Magnesium (magnesium oxide) . . . . . . . . . . . . . . . . . . . . . . . . . . . . 56.25 mg Zinc (zinc citrate). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 mg Selenium (selenomethionine). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55 mcg Copper [copper (II) citrate]. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1000 mcg Manganese (manganese gluconate) . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 mg Chromium [chromium (III) polynicotinate]. . . . . . . . . . . . . . . . . . . . . . 40 mcg Molybdenum [sodium molybdate (VI)]. . . . . . . . . . . . . . . . . . . . . . . . . 50 mcg N-Acetyl-L-Cysteine. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 mg Probiotic Consortium. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 billion CFU Bifidobacterium bifidum (CUL-20) Bifidobacterium animalis subsp. lactis (CUL-34) Lactobacillus salivarius (CUL-61) Lactobacillus paracasei (CUL-08) Non-Medicinal Ingredients: Hypromellose, silica, magnesium stearate EACH SOFTGEL CAPSULE CONTAINS: Fish Oil (Tuna). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 625 mg Yielding DHA (Docosahexaenoic Acid). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 200 mg EPA (Eicosapentaenoic Acid). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45 mg Beta-carotene. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2400 mcg Vitamin E (d-alpha tocopheryl acetate). . . . . . . . . . . . . 10 mg AT / 15 IU Non-Medicinal Ingredients: Fish gelatin, glycerin Recommended Dose: Women (19 years and older): Take one serrated strip, containing one capsule and one softgel, once daily with a meal or as recommended by your healthcare practitioner. Take a few hours before or after taking other medications, and at least two to three hours before or after taking antibiotics. 28 Vegetable Capsules + 28 Softgel Capsules Product Code: 03168 NPN 80043419 1.Allen SJ et al. Dietary Supplementation with Lactobacilli and Bifidobacteria Is Well Tolerated and Not Associated with Adverse Events during Late Pregnancy and Early Infancy. The Journal of Nutrition. 2010; 140: 483–488 12 Moderate level probiotic ideal for children • Contributes to a natural healthy gut flora • 12.5 billion CFU per dose • Natural blackcurrant-flavoured chewable tablet HMF Child probiotic formula is a moderate level probiotic combination providing Lactobacillus acidophilus, Bifidobacterium bifidum, Lactobacillus paracasei, Lactobacillus salivarius and Bifidobacterium animalis subsp. lactis, which help support a healthy gut flora in children. EACH TABLET CONTAINS: Probiotic Consortium . . . . . . . . . . . . . . . . . . . . . . 12.5 billionCFU Lactobacillus acidophilus (CUL-60) Lactobacillus acidophilus (CUL-21) Bifidobacterium bifidum (CUL-20) Bifidobacterium animalis subsp. lactis (CUL-34) Lactobacillus salivarius (CUL-61) Lactobacillus paracasei (CUL-08) Non-Medicinal Ingredients: Sorbitol, xylitol, natural blackcurrant flavour, silica, magnesium stearate Recommended Dose: Children (4 years and older): Chew one tablet two times daily with meals, at least two to three hours before or after taking antibiotics, or as recommended by your healthcare practitioner. 30 Chewable Tablets NPN 80020665 Product Code: 10451 PREGNANCY & CHILD SUPPORT HMF Baby B PROBIOTIC FORMULA HMF Baby F PROBIOTIC FORMULA PROBIOTIC FORMULA Probiotic supplement for breast fed babies •Safe for use during infancy •A recent clinical trial found that this probiotic formula safely and effectively reduced atopic eczema incidence and skin prick reaction to common allergens in infants1 •10 billion CFU per dose •Helps support gastrointestinal health •Promotes a favourable gut flora Probiotic supplement for formula fed babies •Safe for use during infancy •A recent clinical trial found that this probiotic formula safely and effectively reduced atopic eczema incidence and skin prick reaction to common allergens in infants1 •10 billion CFU per dose •Helps support gastrointestinal health •Promotes a favourable gut flora HMF Baby B probiotic supplement for breast fed babies provides Lactobacillus salivarius, Lactobacillus paracasei, Bifidobacterium bifidum and Bifidobacterium animalis subsp. lactis, which help to support intestinal/gastrointestinal health. Infant microflora composition also influences early immune development, and may impact risk of developing atopic disease. HMF Baby F probiotic supplement for formula fed babies provides Lactobacillus salivarius, Lactobacillus paracasei, Bifidobacterium bifidum and Bifidobacterium animalis subsp. lactis, which help to support gastrointestinal health. Infant microflora composition also influences early immune development, and may impact risk of developing atopic disease. HMF Baby B powder dissolves easily into milk, breast milk, or water. HMF Baby F contains galactooligosaccharides (GOS), a type of prebiotic fiber found naturally within breast milk that may help to support a healthy gastrointestinal microflora.2 Fructooligosaccharides (FOS) are also included for additional prebiotic fiber content.2 HMF Baby F powder dissolves easily into milk or water. EACH SCOOP (200 mg) CONTAINS: Probiotic Consortium. . . . . . . . . . . . . . . . . . . . . . . 10 billion CFU Bifidobacterium bifidum (CUL-20) Bifidobacterium animalis subsp. lactis (CUL-34) Lactobacillus salivarius (CUL-61) Lactobacillus paracasei (CUL-08) Non-Medicinal Ingredients: Transgalactooligosaccharides (GOS) (from milk) Contains: Milk Recommended Dose: Children (1-4 years): In a glass, add water or milk to one scoop of HMF Baby B and mix. Take once daily with a meal, at least two to three hours before or after taking antibiotics, or as recommended by your healthcare practitioner. Product Size: 6g Powder Product Code: 10491 NPN 80048579 EGETARIAN 1. Allen SJ et al. Probiotics in the prevention of eczema: a randomized controlled trial. Arch. Dis. Child. 2014; 99(11): 1014-1019 HMF Natogen EACH SCOOP (1.1 g) CONTAINS: Probiotic Consortium. . . . . . . . . . . . . . . . . . . . . . . . 10 billion CFU Bifidobacterium bifidum (CUL-20) Bifidobacterium animalis subsp. lactis (CUL-34) Lactobacillus salivarius (CUL-61) Lactobacillus paracasei (CUL-08) Low level probiotic •3 billion CFU per dose Easy-to-use •Add 1 scoop (100 mg) to milk or water HMF Natogen child probiotic formula provides Lactobacillus acidophilus, Lactobacillus paracasei and Bifidobacterium animalis subsp. lactis, which contribute to a healthy intestinal microflora in children (1-4 years). EACH SCOOP (100 mg) CONTAINS: Probiotic Consortium . . . . . . . . . . . . . . . . . . . . . . . . 3 billion CFU Lactobacillus acidophilus (CUL-60) Lactobacillus acidophilus (CUL-21) Lactobacillus paracasei (CUL-08) Bifidobacterium animalis subsp. lactis (CUL-62) Non-Medicinal Ingredient: Lactose monohydrate (milk) Recommended Dose: Children (1-4 years): In a glass, add water or milk to one scoop of HMF Natogen and mix. Take once daily with a meal, at least two to three hours before or after taking antibiotics, or as recommended by your healthcare practitioner. 6 g Powder Product Code: 10424 NPN 80014287 EGETARIAN Non-Medicinal Ingredients: Transgalactooligosaccharides (GOS) (from milk), fructooligosaccharides (FOS) Contains: Milk 30 Vegetable Capsules Product Code: 10493 Recommended Dose: Children (1-4 years): In a glass, add water or milk to one scoop of HMF Baby F and mix. Take once daily with a meal, at least two to three hours before or after taking antibiotics, or as recommended by your healthcare practitioner. NPN 80048547 EGETARIAN 1. Allen SJ et al. Probiotics in the prevention of eczema: a randomized controlled trial. Arch. Dis. Child. 2014; 99: 11 1014-1019 2. Jeurink P, van Esch B, Rijnierse A, Garssen J, and Knippels L. Mechanisms underlying immune effects of dietary oligosaccharides. American Journal of Clinical Nutrition. 2013; 98(suppl.): 572S–577S 13 PREGNANCY & CHILD SUPPORT HMF Toddler + Pro VITAMIN SUPPLEMENT WITH HMF (HUMAN MICROFLORA) PROBIOTICS Vitamin and probiotic combination for toddlers • Includes vitamins, minerals, antioxidants and clinically proven human-sourced probiotics • Supports normal growth and development • Helps to maintain eyesight, skin, membranes and immune function • Provides 2.5 billion CFU of probiotics that promote a favourable microflora composition • Added GOS and FOS prebiotic fibres support gastrointestinal microflora • Great-tasting berry flavour HMF Toddler + Pro supports pediatric nutrition and intestinal health with a unique consortium of human-sourced probiotic strains, plus over 10 vitamins. Vitamins A, C, D, and K support the development and maintenance of bones, cartilage, teeth and gums. Red blood cell formation and macronutrient metabolism are supported with vitamins B1, B2, B3, B5, B6, biotin, folate and B12. EACH SCOOP (1 g) CONTAINS: Vitamin A (vitamin A acetate). . . . . . . 400 mcg RAE / 1333 IU Vitamin C (ascorbic acid) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 40 mg Vitamin D (cholecalciferol). . . . . . . . . . . . . . . . . . 5 mcg / 200 IU Vitamin E (d-alpha tocopheryl acetate). . . . . . . 6 mg AT / 9 IU Vitamin K1 (phylloquinone) . . . . . . . . . . . . . . . . . . . . . . . . . . . 30 mcg Thiamine (thiamine mononitrate). . . . . . . . . . . . . . . . . . . 0.55 mg Riboflavin. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 0.7 mg Niacinamide. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 mg Vitamin B6 (pyridoxine hydrochloride). . . . . . . . . . . . . . . . 0.7 mg Folate (folic acid). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 100 mcg Vitamin B12 (methylcobalamin). . . . . . . . . . . . . . . . . . . . . . 1.25 mcg Biotin. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 mcg Pantothenic Acid (calcium d-pantothenate). . . . . . . . . . . . 3 mg Probiotic Consortium. . . . . . . . . . . . . . . . . . . . . . . 2.5 billion CFU Bifidobacterium bifidum (CUL-20) Bifidobacterium animalis subsp. lactis (CUL-34) Lactobacillus salivarius (CUL-61) Lactobacillus paracasei (CUL-08) Non-Medicinal Ingredients: Fructooligosaccharides (FOS), transgalactooligosaccharides, fruit blend (strawberry, blackberry, blackcurrant, bilberry, elderberry), xylitol, natural strawberry flavour Contains: Milk Recommended Dose: Children (1-5 years): In a glass, add water or milk to one scoop of HMF Toddler + Pro and mix. Take once daily with a meal, at least two to three hours before or after taking antibiotics, or as recommended by your healthcare practitioner. 60 g Powder NPN 80039780 EGETARIAN 14 Product Code: 03169 HMF Probiotic Clinical Trials The Swansea Baby Trial Probiotics in the Prevention of Eczema: A Randomised Controlled Trial (Allen at al. 2014) The probiotic formula that is used in GENESTRA BRANDS HMF Baby B and HMF Baby F was found to safely and effectively reduce atopic eczema incidence and skin prick sensitivity to common allergens in infants. In a randomized, double-blind, placebo-controlled, parallel group trial, 454 pregnant women at 36 weeks of gestation were assigned to either the probiotic capsule treatment group (Lactobacillus salivarius CUL61 6.25×109 colony forming units (CFUs), Lactobacillus paracasei CUL08 1.25×109 CFU, Bifidobacterium animalis subsp. lactis CUL34 1.25×109 CFU and Bifidobacterium bifidum CUL20 1.25×109 CFU) or the placebo capsule treatment group. Participants began daily supplementation with either treatment until giving birth; participants’ infants then began daily supplementation until 6 months of age. At 6 months and 2 Atopic Eczema at 2 Years Percent Placebo Group 12.10% HMF Probiotic Group 5.30% years of age, skin prick testing (SPT) was performed using common food allergens (cow’s milk, hen’s egg). The presence of atopic eczema was determined based upon the presence of one or more positive SPTs. In comparison with the infant participants in the placebo group, participants in the probiotic group experienced a statistically significant 57% decrease in atopic eczema. Participants in the probiotic group also experienced a significant 44% decrease in skin prick sensitivity to common food allergens. •57% decrease in atopic eczema • 44% decrease in skin prick sensitivity to food allergens ReducedAAtopic 22 Years in Probiotic Group Reduced topic EEczema czema atat Years in Probio7c Group 14.00% 12.00% 10.00% * 8.00% 6.00% 4.00% 2.00% 0.00% Placebo Group Placebo Group ProbioticGGroup Probio6c roup * p < 0.05 15 SPT positive at 6 m Total Cow's Milk Protein Egg Protein Placebo Group 10.88% 3.40% 9.50% Probiotic Group 3.97% 0% 3.40% Fewer Prick Text TestScores Scoresatat66Months MonthsininProbiotic Priobiotic Group FewerPositive Positive Skin Skin Prick Group 12.00% 10.00% 8.00% Placebo Group ProbioAc Group 6.00% * * 4.00% 2.00% * 0.00% 16 Total Total Cow’s Milk Protein Cow's Milk Protein EggPProtein Egg rotein * p < 0.05 The ProChild Study Probiotics and Vitamin C for the Prevention of Respiratory Tract Infections in Children Attending Preschool: A Randomised Controlled Pilot Study (Garaiova at al. 2014) The probiotic formula used in several GENESTRA BRANDS HMF products, in combination with vitamin C, was found to significantly reduce incidence of upper respiratory tract infections (URTI) in preschool children. The number of days with URTI symptoms, school absenteeism, and usage of cough medication were also significantly reduced. In a 6 month long, randomized, double-blind, placebo-controlled study, 57 preschool children aged 3-6 were randomized to either the placebo tablet group or the probiotic and vitamin C tablet group (12.5 billion CFU of Lactobacillus acidophilus CUL60 and CUL 21, Bifidobacterium animalis subsp. lactis CUL34, and Bifidobacterium bifidum CUL20). The URTI symptoms evaluated included sneezing, sore throat, cough, runny and blocked nose. Compared with the placebo group, the children in the probiotic group had 33% less incidence of URTI, a significant decrease in the number of days with URTI symptoms, a 30% decrease in school absenteeism incidence rate, and a significant reduction in cough medication usage. • 33% less incidence of upper respiratory tract infections (URTI) •Significantly fewer days with URTI symptoms •30% less school absenteeism •Significant reduction in cough medication usage URTI symptoms Placebo Group HMF Probiotic Group Mean Days with URTI Symptoms 43.1 22.1 Decreased Mean Days With URTI URTI Symptoms in Probiotic Group Group Decreased Mean Days With Symptoms in Probiotic 45 40 35 * 30 25 20 15 10 5 0 Placebo Group Probiotic Group Probiotic Group * p < 0.05 17 Individual URTI Symptoms - Cough Placebo Group HMF Probiotic Group Mean days With Cough Symptoms 23.5 11.9 Decreased Days WithCough Cough Symptoms in Probiotic Group Group Decreased MeanMean Days With Symptoms in Probiotic 25 20 * 15 10 5 0 PlaceboGroup Group Placebo ProbioticGroup Group Probiotic * p < 0.05 Individual URTI Symptoms - Sneezing Placebo Group HMF Probiotic Group Mean Days With Sneezing Symptoms 9.6 2.3 Decreased Mean Days With Sneezing Symptoms in Probiotic Group Group Decreased Mean Days With Sneezing Symptoms in Probiotic 10 9 8 7 6 5 * 4 3 2 1 0 18 Placebo PlaceboGroup Group Probiotic ProbioticGroup Group * p < 0.05 The Sheffield IBS Trial Clinical Trial: A Multistrain Probiotic Preparation Significantly Reduces Symptoms of Irritable Bowel Syndrome in a Double-Blind Placebo-Controlled Study (Williams et al. 2008) The probiotic formula that is used in GENESTRA BRANDS HMF IBS Relief was found to decrease the severity of IBS symptoms and number of days with pain, while improving satisfaction with bowel habits and overall quality of life. This 8-week long, double-blind, randomized, placebo-controlled study was conducted in 52 participants diagnosed with IBS, as defined by the Rome II Criteria. Participants were randomized to either the placebo capsule treatment group or the probiotic capsule group (2.5x1010 CFU from Lactobacillus acidophilus CUL60 and CUL 21, Bifidobacterium animalis subsp. lactis CUL34, and Bifidobacterium bifidum CUL20). Participants scored their IBS symptom severity (including bloating, satisfaction with bowel habits, number of days with pain, quality of life, and abdominal pain) at baseline and every 2 weeks during supplementation. In comparison with the placebo group, a significantly greater improvement in total IBS symptoms was observed in participants in the probiotic treatment group throughout the 8 week supplementation period. In the probiotic group, satisfaction with bowel habits was significantly improved in just 6 weeks, and quality of life scores were improved after 8 weeks of supplementation. • Significantly improved IBS Symptom Severity Scores • 22% decrease in days with pain • 32% improvement in satisfaction with bowel habits IBS Symptom Severity Scores IBS Relief Group Placebo Group Before Supplementation 73.39 252.08 At 8 Weeks of Probiotic Supplementation 39.65 172 % Change at Week 8 133.39 80.66 Probiotic SupplementationReduces ReducesIBS Probiotic Supplementation IBS Symptom SeverityScores Scores Symptom Severity 300 250 * 200 150 100 Before Supplementation Before Supplementation At 8 Weeks of Probiotic At 8 Weeks of Probiotic Supplementation Supplmentation * p < 0.05 19 The Cambridge Probiotic / Antibiotic Trial Effect of Probiotics on Preventing Disruption of the Intestinal Microflora Following Antibiotic Therapy: A Double-Blind, Placebo-Controlled Pilot Study (Plummer et al. 2005) The probiotic formula that is used in GENESTRA BRANDS HMF Antibiotic Care was found to minimize disruption of the intestinal micobiota following antibiotic therapy and prevent the development of antibiotic resistance. This 5-week long, double-blind placebo-controlled study was conducted in 162 participants infected with Helicobacter pylori that were receiving a triple therapy antibiotic treatment regimen. Participants received antibiotic therapy for days 1-7 of the study, and probiotic or placebo therapy for days 1-21. The probiotic capsule contained 2.5×1010 CFU from Lactobacillus acidophilus CUL60 and CUL21, and two strains of Bifidobacterium. Fecal samples were obtained at days 1, 7 and 35, and then analyzed for bacterial composition and bacterial strain antibiotic resistance. Compared with the placebo group, significantly fewer participants in the probiotic treatment group had enterococci bacteria resistant to amoxicillin. Probiotic supplementation helped significantly reduce overgrowth of potentially harmful facultative anaerobic bacteria, including coliforms, enterococci and Staphylococcus aureus. As well, probiotic supplementation helped to minimize the loss of lactobacilli bacteria: the level of lactobacilli was significantly lowered in the placebo group following antibiotic therapy, but not in the probiotic treatment group. • Significant reduction in antibiotic resistance • Decreased overgrowth of coliforms, enterococci and Staphylococcus aureus bacteria •Prevented loss of lactobacilli bacteria The Swansea ‘Safety in Newborns’ Study Dietary Supplementation with Lactobacilli and Bifidobacteria is Well Tolerated and Not Associated with Adverse Events During Late Pregnancy and Early Infancy (Allen at al. 2010) The probiotic formula that is used in GENESTRA BRANDS HMF Baby B and HMF Baby F was found to be safe for use by pregnant mothers at 36+ weeks of gestation and in infants aged 0-6 months. Probiotic supplementation did not impact adverse event incidence, number of visits to the doctor, or mothers’ assessment of infant health. Based on these findings, the authors concluded that usage of the probiotic formula was safe during pregnancy and infancy. • No increase in adverse event incidence in pregnant mothers •No increase in adverse event incidence in infants 20 Notes 21 A trusted Seroyal brand. To order, call: 1-800-263-5861 [email protected] For more information, visit: www.seroyal.com