Download Poster Session B

An AACR Special Conference on
THE FUNCTION OF TUMOR MICROENVIRONMENT
IN CANCER PROGRESSION
January 7-10, 2016 • Hard Rock Hotel • San Diego, CA
Poster Session B, Friday, January 8, 4:00 p.m.-6:00 p.m.
Metabolism and Tumor Microenvironment
B01
The metabolic adaptations during cancer-stroma co-evolution: The intracellular pH, NAD(P)H
changes and hydrogen peroxide production in cancer cells. Irina N. Druzhkova, Marina V. Shirmanova,
Maria M. Lukina, Varvara V. Dudenkova, Vsevolod V. Belousov, Sergey A. Lukiyanov, Elena V. Zagaynova.
B02
Oncogene MCT-1 deregulates oxidative metabolism and promotes tumor metastasis via YY1
signaling network. Hong-Yu Tseng, Yen-An Chen, Yi-Rong Chen, Hsin-Ling Hsu.
B03
Control of pancreatic cancer metabolism and histone acetylation by the tumor
microenvironment. Mara H Sherman, Ronald M Evans.
B04
Metabolically activated macrophages: a mechanistic link between obesity and triple-negative
breast cancer? Payal Tiwari, Kelly Schoenfelt, Ariane Blank, Swati Kulkarni, Marsha Rosner, Lev Becker.
B05
N-Myc downstream regulated gene 2 is a novel regulator of lipid metabolism and ubiquitinproteasome system in cancer. Libo Yao, Xia Li, Xiping Liu, Yi Ru, Mei Zhang.
Therapeutic Targeting Tumor Microenvironment
B06
Characterizing the effects of hypoxia and hydrostatic pressure on the expression of
immunotherapeutic targets in prostate cancer cell lines and donor immune cells in culture. Bruce A
Adams, James Lim, Tianna Chow , Susan Bernstein, Charles J Ryan.
B07
Utilizing consomic xenograft models to identify genetic variants in the tumor
microenvironment that determine breast cancer radiation responses. Carmen Bergom, Michael Straza,
Amy Rymaszewski, Anne Frei, Angela Lemke, Shirng-Wern Tsaih, Howard Jacob, Michael J. Flister.
B08, PR09
Antibody mediated blockade of phosphatidylserine synergizes with immune
checkpoint blockade by inhibiting multiple immune suppressive mechanisms. Xianming Huang, Jian
Gong, Michael Gray, Van Nguyen, Ryan Parks, Chris Hughes, Jeff Hutchins, Rolf Brekken, Bruce Freimark.
B09
Ron receptor signaling promotes resistance to androgen ablation therapy in prostate
cancer. Nicholas E Brown, Andrew M Paluch, Susan E Waltz.
B10
Humanized anti-CD29 monoclonal antibody that inhibits multiple cancer hallmarks driven by
the tumor microenvironment. Shawn Carbonell.
B11
Targeting mesenchymal cells in the tumor stroma by GPX4 inhibition. Shrikanta
Chattopadhyay, Cherrie Huang, Ninib Baryawno, Nicolas Severe, Vasanthi Viswanathan, Zarko Boskovic,
Siddhartha Mukherjee, Jeff Gentry, Ben Wittner, Sridhar Ramaswamy, Alykhan Shamji, David Scadden,
Stuart Schreiber.
An AACR Special Conference on
THE FUNCTION OF TUMOR MICROENVIRONMENT
IN CANCER PROGRESSION
January 7-10, 2016 • Hard Rock Hotel • San Diego, CA
Poster Session B, Friday, January 8, 4:00 p.m.-6:00 p.m.
B12
Mast cell-associated macrophage recruitment promotes gastric tumor growth. Moritz
Eissmann, Andrew Jarnicki, Frederic Masson, Michael Buchert, Robert O'Donoghue, Toby Phesse, Christine
Dijkstra, Michele Grimbaldeston, Matthias Ernst.
B13, PR01
Disruption of DDR2-collagen interactions in tumor and stroma with a novel small
molecule inhibitor blunts cancer metastasis. Whitney R Grither, Gregory D Longmore.
B14
Discoidin domain receptor 1 activity drives an aggressive phenotype in gastric
adenocarcinoma. Hoon Hur, In-hye Ham, Da Keun Lee, Hye-Jin Jin, Aguilera Kristina Y. , Hae Jeong Oh,
Sang-Uk Han, Ji-Eun Kwon, Young Bae Kim, Ke Ding, Rolf Brekken.
B15
Targeting NOX4 in the tumor microenvironment inhibits myofibroblast differentiation and
suppresses tumor progression. Christopher J Hanley, Massimiliano Mellone, Gareth J Thomas.
B16
Lymphatics in triple negative breast cancer: Contribution to chemotherapeutic efficacy in vitro
and in vivo. Alexandra H Harris, Jennifer M Munson.
B17
Disrupting tumor growth through targeting TEM8. Anette M Høye, Sofie Tolstrup, Thomas R Cox,
Jeremy P Mauldin, Arthur E Frankel, Janine T Erler.
B18
CXCL10 suppresses tumor angiogenesis and impedes expression of critical angiogenic factors
in renal cell carcinoma. Hyun A Jin, Jun Hyeok Heo, You Hyun Kang, Ki Hong Kim, Kyung Suk Han, Sung
Joon Hong.
B19
Vascular normalization suppresses tumor progression and potentiates docetaxel
chemotherapy in prostate cancer. You Hyun Kang, Hyun A Jin, Jun Hyeok Heo, Ki Hong Kim, Kyung Seok
Han, Sung Joon Hong.
B20
Obesity-induced Nlrc4 inflammasome promotes angiogenesis in breast cancer. Ryan Kolb,
Liem Phan, Nicholas Borcherding, Yinghong Liu, Fang Yuan, Ann M Janowski, Qing Xie, Kathleen R Markan,
Wei Li, Matthew J Potthoff, Enrique Fuentes-Mattei, Leslie G Ellies, Michael Knudson, Mong-Hong Lee, SaiChing Jim Yeung, Suzanne L Cassel, Fayyaz S Sutterwala, Weizhou Zhang.
B21
Exostosin 1 regulates cancer cell stemness in breast cancer cells. Sarala Manandhar, Chang-gu
Kim, Su Young Oh, Sun-Hee Lee, Jiyoon Seok, Yuk-Dong Jung, Hye-Eun Lee, Young-Sun Choi, You Mie Lee*.
B22
Necuparanib inhibits pancreatic cancer progression and invasion in a 3D tumor and stromal
cell co-culture system. Amanda MacDonald, Michelle Priess, Jennifer Curran, Silva Krause.
B23, PR03
Synthetic peptides suppress M2 macrophages and synergize with chemotherapy in
prostate and breast cancer models. Henry Lopez, George R. Martin, Jesse M. Jaynes, Clayton Yates.
B24
Targeting hyaluronan sensitizes breast cancer associated fibroblasts to lapatinib and
overcomes stromal resistance. Andriy Marusyk, Doris Tabassum, Jennifer Guerriero, Andrew Place, Andrii
Rozhok, Antony Letai, Kornelia Polyak.
An AACR Special Conference on
THE FUNCTION OF TUMOR MICROENVIRONMENT
IN CANCER PROGRESSION
January 7-10, 2016 • Hard Rock Hotel • San Diego, CA
Poster Session B, Friday, January 8, 4:00 p.m.-6:00 p.m.
B25
Characterization, targeting, and modulation of carbonic anhydrase IX activity for the
development of small-molecule inhibitors to treat triple-negative breast cancer. Mam Y Mboge, Zhijuan
Chen, Brian P Mahon, Nicole Lamas, Shingkuang Tu, Fabrizio Carta, Claudiu T Superan, Robert McKenna,
Susan C Frost.
B26
Novel pro-host role for insulin receptor substrate-1 in lung adenocarcinoma. Heather E Metz,
Julia Kargl, Stephanie Busch, Kyoung-Hee Kim, McGarry Houghton.
B27
Blockade of protein kinase A (PKA) localization augments the trafficking and anti-tumor
efficacy of adoptively transferred chimeric antigen receptor-expressing T cells. Kheng Newick, Shaun
O'Brien, Jing Sun, Veena Kapoor, Steve Maceyko, Albert Lo, Ellen Pure, Ed K Moon, Steven M Albelda.
B28
NQO1 stabilizes HIF-1α by inhibiting proteasome-mediated degradation. Eun-Taex Oh, ChanWoo Kim, Heon Joo Park.
B29
Interleukin-4 receptor targeted AP1-ELP-KLAK for enhancing targeted drug delivery and
antitumor effect. Sarangthem Vijaya Devi, Yun Jae Kim, Yong Jin Lee, Bo-yeon Seo, Sun-ha Cheon, ByungHeon Lee, Rang-Woon Park.
B30
Discovery and functional characterization of novel anti-PD-1 antibodies using ex vivo cellbased assays, single-cell immunoprofiling, and in vivo studies in humanized mice. Felix Scheuplein,
Sheila Ranganath, Thomas McQuade, Lei Wang, Vikki Spaulding, Sri Vadde, Jennifer Watkins-Yoon, Bin
Feng, Shanu Mehta, Maria Isabel Chiu, Cokey Nguyen.
B31
Cytokine-mediated paracrine communication between pancreatic cancer and stellate cells and
therapeutic applications for pancreatic ductal adenocarcinoma. Yu Shi, Tony Hunter.
B32
A tumor microenvironment specific EGFR targeting antibody-drug conjugate promotes
regression in KRAS or BRAF mutant tumors. Bob Veneziale, Lei Huang, Xiaoming Li, Qiping Zhao,
Chunmei Zhao, Ryan Osgood, Jessica Cowell, Sanna Rosengren, Jason Parise, Ge Wei, Kim Phan, Robert
Connor, Steve Rowe, Gilbert Keller, Gregory Frost, Dan Maneval, Curtis Thompson, Michael Shepard,
Christopher Thanos.
B34
Targeting M2-tumor associated macrophages (M2-TAMs) in prostate cancer. Jelani C Zarif,
James R. Hernandez, Kenneth J Pienta.
Translational Potential of the Microenvironment
B35
Modeling interstitial fluid movement in the tumor microenvironment: A role in fibroblast
activation? Sadhvi Nithiananthan, Aileen Crawford, Daniel W Lambert, Simon Whawell.
An AACR Special Conference on
THE FUNCTION OF TUMOR MICROENVIRONMENT
IN CANCER PROGRESSION
January 7-10, 2016 • Hard Rock Hotel • San Diego, CA
Poster Session B, Friday, January 8, 4:00 p.m.-6:00 p.m.
Tumor Microenvironment and Metabolic Adaptations
B36
Interrogating cellular metabolism to improve therapy for EGFR mutant NSCLC. Chun-Te
Chiang, Chi-Li Chiu, Cosimo Arnesano, Scott E Fraser, David B Agus, Dan L Ruderman, Shannon M
Mumenthaler.
B37
Targeting tumor-stroma metabolic symbiosis for head and neck cancer therapy. Dhruv Kumar,
Vikalp Vishwakarma, Jacob New, Wade Gutierrez, Hemant Chavan, Partha Kasturi, Ossama Tawfik, Douglas
Girod, Bennett Van Houten, George Leef, Radhika Joshi, Shary Shelton, Jeffrey Straub, Yelizaveta Shnayder,
Kiran Kakarala, Terance Tsue, Fangchen Lin, Sumana Dasari, Sufi Thomas.
Tumor and Stromal Cell Impact on Early Events in Carcinogenesis
B38
Myeloid cells mold the microenvironment of nascent tumor and the associated
immunoregulation. Mario Paolo Colombo.
B39
Identifying molecular signatures of tumor dormancy as a basis for the rational design of
precision nanomedicines. Galia Tiram, Shiran Ferber, Ronit Satchi-Fainaro.
B40, PR07
Mechanisms of stromal reprogramming mediated by heat shock factor 1. Ruth ScherzShouval, Marc L Mendillo, Giorgio Gaglia, Irit Ben-Aharon, Andrew H. Beck, Luke Whitesell, Susan Lindquist.
B41
Cell-contact dependent epithelial-stromal cross talk, including a modulation of stromal PDGFR
expression, drives the progression of early stage breast cancer lesions. Carina Strell, Janna Paulsson,
Artur Mezheyeuski, Shao-Bo Jin, Pernilla Roswall, Johanna Andrea, Oliver Frings, Fredrick Warnberg,
Hemming Johansson, Karin Jirstrom, Kristian Pietras, Per Hall, Urban Lendahl, Christer Betsholtz, Derek C
Radisky, Arne Ostman.
B42
Dysregulation of key microRNAs controlling tumor-host interactions triggers escape from
osteosarcoma dormancy. Galia Tiram, Paula Ofek, Taturo Udagawa, Noam Shomron, Maayan Roniger,
Batsheva Kerem, Yuval Shaked, Sarit Aviel-Ronen, Iris Barshack, Marcelo Calderon, Rainer Haag, Ronit
Satchi-Fainaro.