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Safety Glasses versus Safety Goggles In the research laboratory, properly fitting safety glasses (with eye shields) are the minimum level of eye protection permitted. Every laboratory worker should have his or her own pair of safety glasses, prescription if necessary. They should also have a pair of properly fitting chemical splash goggles as well. Of these safety devices needs to be inspected and cleaned regularly to be effective—dirty glasses or goggles hinder eyesight, badly fitting ones will not protect as well from splash. Safety glasses are appropriate for many laboratory techniques, but certainly not for all. The main criterion for deciding whether safety glasses are sufficient or if the more protective chemical splash goggles are the appropriate eye safety device is: what is the chance that something would be splashed in the eye and what would the consequences of that contact be. If the chance of something being splash or sprayed into the eye is high, or if the reagent is highly corrosive or poisonous, chemical splash goggles are required. As an example of a common laboratory procedure, thin layer chromatography would normally be a good example of a technique where safety glasses are sufficient: ordinary solvents in relatively small quantities, and silica on glass or polyester backing. But if the plates are to be developed by spraying ninhydrin on potassium permanganate solutions onto them, splash goggles must be worn. There is a high chance that the reagent might inadvertently get into the eye (even if done in a hood) and the reagent itself would be highly damaging to ocular tissue. Working with corrosive acids (or bases) is another common procedure. While small quantities of dilute acids can be appropriately used with just safety glasses (10 mL of 1 M HCl for example), any manipulation of concentrated acids (all solutions above 6M in strength at a minimum) require splash goggles. If more than 2.5 L of the full strength acids (18 M sulfuric for example) a face shield in addition to the splash goggles is required. Of course an appropriate lab coat and gloves need to be worn as well, but they are beyond the topic of this discussion. Cleaning glassware is another example where safety glasses are normally sufficient. However once the cleaning agent becomes something more powerful than the ordinary surfactant cleaning solutions, splash goggles are needed. Using potassium hydroxide/ethanol base baths and chromic-sulfuric acid baths are both examples where chemical slash goggles are definitely required.