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DEPARTMENT OF CHEMISTRY
JOINT M.Sc.-Ph.D PROGRAMME
CHEMISTRY (CY)
CURRICULUM OF 4 SEMESTERS
1st Semester
Subject
Sl. No.
Number
1.
CY41003
2.
3.
CY41007
CY40014
4.
CY40101
5.
6.
7.
CY49001
CY41001
CY49011
2nd Semester
Subject
Sl. No.
Number
1.
CY41002
2.
CY49002
3.
CY40110
4.
5.
6.
7.
8.
CY50015
CY41004
CY40108
CY49004
CY58005
Subject Name
L-T-P
Credit
3-1-0
4
2-0-0
3-1-0
2
4
3-0-0
3
0-0-6
3-1-0
0-0-6
14-3-12
4
4
4
25
Subject Name
L-T-P
Credit
Molecular thermodynamics and Kinetics
Advanced Physical Chemistry Laboratory
Principles of Organometallic & Bio-inorganic
Chemistry
Solid State Chemistry
Analytical & Environmental Chemistry
Structures and Functions of Biomolecules
Biochemical Techniques Laboratory
Viva
Total
3-0-0
0-0-6
3
4
4-0-0
4
3-0-0
3-0-0
3-0-0
0-0-6
3
3
3
4
2
26
Introduction to Quantum Chemistry &
Spectroscopy
Group Theory for chemists
Introduction to Computational Chemistry
Inorganic Chemistry: Structure, Principle, &
Reactivity
Advanced Inorganic Chemistry Laboratory
Principles of Organic Synthesis
Advanced Organic Chemistry Laboratory
Total
16-0-12
2
3rd Semester
Depth/
Subject
Breadth Number
D
D
D
D
CY51001
CY57005
CY58003
4th Semester
Depth/
Subject
Breadth Number
D
D
CY57006
CY58006
Subject Name
L-T-P
Credit
Elective I
Elective II
Elective III
Spectroscopic Methods of Structure
Determination
Project
Seminar
Total
3-0-0
3-0-0
3-0-0
3
3
3
3-1-0
4
0-0-12
0-0-3
12-1-12
8
2
23
Subject Name
L-T-P
Credit
Elective IV
Elective V
Project & Viva
Comprehensive Viva
Total (Depth +Breadth)
3-0-0
3-0-0
0-0-15
3
3
10
2
18
6-0-15
LIST OF ELECTIVE SUBJECTS
Elective I, II, III
Sl.
No
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
Subject
Number
CY60121
CY60103
CY60002
CY60105
CY60004
CY60101
CY60123
CY60013
CY60107
CY60019
CY60109
CY60030
CY60011
CY60111
CY60113
CY60007
CY60005
CY60115
Subject Name
L-T-P
Credit
Chemistry of Materials
Statistical Mechanics for Chemists
Adsorption & Catalysis
Advanced Quantum Chemistry
Biophysical Chemistry
Computational Chemistry
Applications of Computational Chemistry
Advanced Bio-inorganic Chemistry
Chemistry of Nanomaterials
Electroanalysis and sensors
Special Topics in Main Group Chemistry
Inorganic Photochemistry
Environmental Chemistry
Advanced Stereochemistry
Agrochemicals
Chemistry of Natural products
Drug Design and Development
Biotransformation in Organic Chemistry
3-0-0
3-0-0
3-0-0
3-0-0
3-0-0
3-0-0
1-0-3
3-0-0
3-0-0
3-0-0
3-0-0
3-0-0
3-0-0
3-0-0
3-0-0
3-0-0
3-0-0
3-0-0
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
19
20
21
CY60003
CY60117
CY60119
Organic Photochemistry & Pericyclic Reactions
Reagents in Organic synthesis
Physical Organic Chemistry
3-0-0
3-0-0
3-0-0
3
3
3
Subject Name
L-T-P
Credit
3-0-0
3-0-0
3-0-0
4-0-0
3
3
3
4
3-0-0
3
3-0-0
3-0-0
3-0-0
3
3
3
LIST OF ELECTIVE SUBJECTS
Elective IV, V
Sl.
No
1
2
3
4
Subject
Number
CY60104
CY60106
CY60034
CY60102
5
CY60108
6
7
8
CY60110
CY60112
CY60114
Colloids & Drug Delivery
Chemical Bonding & Reactivity
Advanced Chemical Dynamics
Molecular Spectroscopy & Molecular Structure
Applications of Fluorescence Spectroscopy in Chemistry
and Biology
Advanced Polymer Chemistry
Metal Complexes in Catalysis & Materials Science
Physical Methods in Inorganic Chemistry
9
CY60026
Recent Advances in Analytical Chemistry
3-0-0
3
10
CY60012
Synthesis and Processing of Ceramics
3-0-0
3
11
CY60116
Chemistry of Nucleosides and Nucleotides
3-0-0
3
12
CY60118
Chemistry of Lipids, Steroids and Hormones
3-0-0
3
13
CY60014
Medicinal Chemistry
3-0-0
3
14
CY60120
Newer Asymmetric Reactions
3-0-0
3
15
CY60122
Organometallic Strategies in Organic Synthesis
3-0-0
3
16
CY60124
Pharmacological Basis of Therapeutics
3-0-0
3
17
CY60028
Supramolecular Chemistry
3-0-0
3
18
CY60020
Advanced Heterocyclic Chemistry
3-0-0
3
SYLLABII
CHEMISTRY DEPARTMENT
2-Year M.Sc. CHEMISTRY
1st semester
CY41003 Introduction to Quantum Chemistry & Spectroscopy (3-1-0 : 4 Credits)
Prerequisite : Nil
Review of quantum mechanics: Schrödinger wave equation, Eigenfunction, eigenvalues
and operators, Interpretation of wavefunctions, Free particle, Particle-in-a-box, Rigid
rotor, Harmonic oscillator, Hydrogen atom; Introduction to Self Consistent Field
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Theories; Valence Bond and Molecular Orbital theories; Introduction to Molecular
spectroscopy: absorption, emission and resonance.
Books: Methods of Molecular Quantum Mechanics by P.W. Atkins
Physical Chemistry: A Molecular Approach by D.A.McQuarrie and J.D. Simon
Molecular Spectroscopy by I. N. Levine
CY41007 Group Theory for Chemists
(2-0-0 : 2 Credits)
Prerequisite : Nil
Introduction to Linear Algebra required for Group Theory.
Introduction to group theory:
Definitions and theorems; Molecular Symmetry and point groups; Representation of
groups: great orthogonality theorem, character table.
Group Theory and Quantum Mechanics: wave functions as basis of irreducible
representations, the direct product, identification of non-zero matrix elements. Normal
mode analysis.
Books: Mathematical Methods in Physical Sciences, M.L. Boas; Chemical Applications
of Group Theory, F.A. Cotton.
CY40014 Introduction to Computational Chemistry (3-1-0: 4 credits)
Prerequisite: Nil
Introduction to programming languages; basic numerical analysis: solution of nonlinear equations
using Newton-Raphson method, solution of linear systems using Gaussian elimination and
pivoting, interpolation and polynomial approximation, numerical solution of differential
equations: ODE and PDE: analysis of convergence, stability and consistency; numerical
integration; code development and use of commercially available software to perform simple
quantum chemical calculations.
Book: Computational Chemistry Using the PC, D.W. Rogers.
CY40101 Inorganic Chemistry: Structure, Principle, & Reactivity (3-0-0 : 3 Credits)
Prerequisite : Nil
RS coupling, CFT, Tanabe-Sugano diagram, Ligand field theory, molecular orbital
theory. Magnetic and spectral properties of coordination compounds. Inorganic reaction
mechanism- substitution, electron transfer, photochemical reactions.
Books: B.N. Figgis, J.E Huheey, P.W. Atkins
CY49001 Advanced Inorganic Chemistry Laboratory (0-0-6 : 4 Credits)
Prerequisite : Nil
Semi-micro Analysis of transition metal and rare earth metal ions in a mixture by using
Spot technique.
Preparation and (Spectroscopic Characterization) of:
Layered Vanadyl Phosphate Dihydrate (Powder XRD, TGA)
Tris(acetylacetonator)managanese(III) (Mag. Susceptibility by Gouy method, and Evans
method, EPR)
Tris(ethylenediamine)cobalt(III) ion & Optical Resolution (UV, specific rotation)
Chlorotribenzyltin(IV) (1H NMR)
Halocobaloxime: a B12 model compound (IR, 1H NMR)
Estimation of phosphoric acid in soft drinks
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Column Chromatographic separation of Chlorophyll from Plant (UV)
Extraction of Fullerene from Soot (13C NMR, and CV)
Book:
Vogel’s Qualitative Inorganic Analysis
General Chemistry Experiment by A.J. Elias
Synthesis & Techniques in Inorganic Chemistry by G.S. Girolami, T.B. Rauchefuss, R.J.
Angelici
CY41001 Principles of Organic Synthesis (3-1-0 : 4 Credits)
Prerequisite:Nil
Ideal synthesis; fundamentals of retrosynthesis, symmetry, stereochemistry, conformation
analysis, molecular mechanics, stereocontrol, ring formation, reactivity, selectivity, catalysis,
organometalic reactions. Functional group transformations, umpolung and protecting groups.
Synthetic strategies and selected total syntheses
Textbook: M. B. Smith, Organic Synthesis. F. A. Carey and R. J Sundberg, Advanced Organic
Chemistry, Part B.
CY49011 Advanced Organic Chemistry Laboratory (0-0-6: 4 credits)
Preparation of o-iodobenzoic acid from anthranilic acid; furoic acid from furfural; thiamine
catalysed benzoin condensation; preparation of benzil from benzoin; benzilic acid from benzil;
and their characterization by UV, IR and NMR; other related experiments.
2nd semester
CY41002 Molecular Thermodynamics and Kinetics (3-0-0 : 3 Credits)
Prerequisite : CY41003
Review of classical thermodynamics; Third law of thermodynamics and residual entropy;
Introduction to Statistical thermodynamics; Thermodynamic quantities from partition
functions; Applications to gases, solids, atomic liquids and polymers. Chemical
equilibrium; Chemical kinetics and molecular reaction dynamics; Theories of chemical
reaction rates.
Book: Physical Chemistry by P.W. Atkins; Physical Chemistry: Statistical mechanics by
H. Metiu; Physical Chemistry: Chemical Kinetics by H. Metiu.
CY49002 Advanced Physical Chemistry Laboratory (0-0-6: 4 credits)
Prerequisite:Nil
Charge transfer complex formation between anthracene and picric acid, To study the formation of
charge transfer complex between 1,2,4,5 Tetramethylbenzene and Tetracyano ethylene in various
solvents, Study of a oscillatory reaction by EMF and absorbance measurement, To study the
mutarotation of D-Glucose at different pH, Determination of partition coefficient of iodine
between water and CCl4 / Equilibrium constant for tri-iodide formation;To study the fluorescence
quenching of Anthracene by CCl4 in n-hexane and ethanol, Determination of Critical micellar
concentration of Sodium Docecyl Sulphate (SDS) in water and in presence of salt by surface
tension, conductance and stokes shift method, Comparative study of Twisted Intramolecular
Charge Transfer (TICT) of 4-N, N-Dimethylamineobenzoinitrile (DMABN) in different solvent
by Fluorescence Spectroscopy, Determination of activation energy and entropy of activation for
acid catalyzed ester hydrolysis, Swelling studies of polyelectrolyte gels in medium of different
6
pH, Synthesis and characterization of copolymer(s) of styrene and methylmethacrylate by radical
polymerization, Determination of activation energy in the bromide-bromate clock reaction,
Kinetics of salt effect and ionic strength (persulfate-iodine reaction), Spectroscopic determination
of the size of CdS-nanoparticles; Determination of unit cell dimensions and density of some
binary compounds of cubic systems by X Ray diffraction; Determination of percent crystallinity,
crystalline melting point, and enthalpy of melting of a crystalline polymer by combined X- Ray
diffraction - differential scanning calorimetry; determination of order of reaction and activation
energy of the solid-state decomposition of CaCO3 by thermogravimetry, determination of pKa of
phenol in the excited state using spectroscopic method.
CY40110 Principles of Organometallic and Bioinorganic Chemistry (4-0-0 : 4
credits)
Prerequisite : CY40101
Organometallic chemistry: Bonding models in sigma and pi-complexes. 18-electron
formalism and isolobal principle. Basic concepts guiding the synthesis and stability of Li,
Mg, B, Si organometallic compounds. Wades/Mingos/Jemmis rule. Basic concepts
guiding the synthesis and stability of transition metal alkyls, carbonyls, alkenes, alkynes,
arenes, allyls, carbenes, and metallocenes. Basic organometallic reactions: oxidativeaddition, reductive elimination, transmetallation, insertion, nucleophilic attach on
coordinated ligand. Typical examples of fluxional organometallics.
Bioinorganic Chemistry: The biochemistry of iron and copper: Dioxygen binding,
transport and utilization in hemoglobin, hemocyanin and hemerythrin. Biological and
synthetic dioxygen carriers. Metal-sulfide proteins: Ferredoxin and nitrogenases.
Metalloporphyrins and Respiration: Cytochromes. Electron transfer reactions.
Metalloenzymes: Carbonic anhydrase, carboxypeptidase and vitamin B12.
Books:
Inorganic Chemistry by J.E. Huheey
The Organometallic Chemistry of The Transition Metals, by R.H. Crabtree
Principles & Applications of Organo-transition Metal Chemistry, by J.P. Collman, L.S.
Hegedus, J.R. Norton, R.G. Finke
Bioinorganic Chemistry by Lippard, and Bartini
CY50015 Solid State Chemistry (3-0-0: 3 credits)
Crystal structure of solids: Fundamental of lattices, unit cell, atomic coordinates, Bravais
lattices, crystal direction and planes, types of close packing, packing efficiency, radius
ratios; structure types – NaCl, ZnS, Na2O, CdCl2, wurtzite, nickel arsenide, CsCl, CdI2,
rutile and Cs2O, perovskite ABO3, K2NiF4, spinels.
Crystal diffraction by X-rays, Neutrons and Electrons; Structure determination by X-ray
diffraction, Atomic form factor, structure factor and integrated intensity, Concept of
reciprocal lattice, Brillouin Zones.Band Theory, Semiconductors (intrinsic & extrinsic),
and Devices, Measurement of Band Gaps, Fermi level; Imperfections in Solids: Point,
Line, Surface; Thermodynamics of the Defects; Phase Stability: Unary and Binary Phase
Diagrams; Ionic Conductivity & Photoconductivity; Colour Centers, Traps, Phosphors;
Electrical and Magnetic Properties (Hall Effect); BCS-type superconductivity.
7
Books: Solid State Chemistry and its applications by A. R. West; Solid State Chemistry –
An Introduction by L. Smart and E. Moore; Structure and Dynamics – An atomic view of
Materials, M. T. Dove; Material Science and Engineering, V. Raghavan.
CY41004 Analytical & Environmental Chemistry (3-0-0: 3 Credits)
Introductory Topics: Development of Analytical Chemistry, Analytical Terms, Precision
and Accuracy, Figures of Merit.
Measurement Fundamentals: Signal-to-Noise Ratio, Origin of Instrument Noise,
Quantifying Measurements and Extracting Information.
Atomic Spectroscopy: Principles, Flame Emission Spectroscopy, Atomic Absorption
Spectroscopy, X-Ray Fluorescence.
Introduction to Chromatographic Separations: Classification, Chromatographic
Parameters, Resolution, Band Broadening.
Liquid Chromatography: HPLC Instrumentation, Adsorption Chromatography, Partition
Chromatography, Other Types of Liquid Chromatography.
Gas Chromatography: Basic Description, Classification of GC Methods, Stationary
Phase, Carrier Gas, Detectors, Temperature Programming.
Thermal & surface techniques: TG, DTA/DSC, Auger, XPS, SEM/TEM
Analysis of Water, Air, and Soil: Significance of various parameters. Environmental
sampling. Current trends in the analysis of metal ions and organic pollutants in water, air
and soil. Laws, and standards on environmental pollution, and abatement.
Book: Skoog and Leary, "Principles of Instrumental Analysis"; Skoog, West, and Holler,
“Analytical Chemistry an Introduction”; Bailey, Clark, Ferris, Krause, and Strong,
“Chemistry of Environment”;Research and review articles.
CY40108 Structure & Functions of Biomolecules (3-0-0 : 3 Credits)
Prerequisite : CY41001
Amino acids, structure of proteins; vitamins and coenzymes; the globins; sugars and phosphates;
nucleic acids, DNA, RNA; lipids; protein, DNA sequencing; chemical synthesis of peptides,
DNA, RNA. Enzyme catalysis; biochemistry of glucose, energy production; citric acid cycle;
metabolism of amino acids and nucleotides; catabolism of nucleotides; expression and
transmission of genetic information, replication, transcription, translation; cloning and PCR
Books: Organic Chemistry: Bruice; Biochemistry: Voet and Voet; Foundations of Chemical
Biology: Dobson, Gerrard, Pratt. Bioorganic Chemistry: Dugas.
CY49004 Biochemical Techniques Laboratory (0-0-6 : 4 Credits)
Prerequisite : Nil
Isolation, purification and characterizations of proteins and nucleic acids, gel electrophoresis,
estimation of proteins, nucleic acids, cholesterol and sugar, enzyme inhibition studies, microbial
growth and antibacterial assay.
3rd semester
Elective I, II, III
CY60121 Chemistry of Materials (3-0-0 : 3 Credits)
Prerequisites: CY50015
8
Introduction to solids with crystal Imperfections: Point defects, dislocations, Interfacial
imperfections, Ionic conductivity, Solid electrolyte, Colour centers – reactivity,
nonstoichiometric compounds.
Phase diagram and phase transformation in solids, application of phase diagram.
Diffusion phenomenon in solids: Fick’s Laws of Diffusion, Kirkendall Effect, Atomic
Model of Diffusion and other diffusion processes.
Mechanical behavior – strength, hardness, deformation, fatigue; Mechanisms of
strengthening and toughening of materials; Elastic and Thermal Properties of Materials.
Optical properties of Materials: Basic concepts on interaction of light with solids, Optical
constants, absorption and emission properties.
Books: A. R. West, Solid State Chemistry and its applications; L. Smart and E. Moore,
Solid State Chemistry – An Introduction; V. Raghavan, Material Science and
Engineering; Nanostructured Materials: Processing, Properties and Potential
Applications, Ed by C C Koch; H Singh Nalwa, Handbook of Nanostructured Materials
and Nanotechnology; L. Murr, Industrial Materials Science and Engineering; W.G.
Moffatt, Structure and Properties of Materials.
CY60103 Statistical Mechanics for Chemists (3-0-0 : 3 Credits)
Prerequisite : CY41002
Topics in advanced classical and quantum statistical mechanics: equilibrium properties of
systems of interacting molecules with applications to ideal Fermi and Bose gases, simple
solids, dense fluids and aqueous solutions.
Phase Transition: mean field approaches, critical fluctuations and scaling, application to
condensation, polymers and liquid crystals.
Strong electroytes: Debye-Huckel theory.
Time dependent phenomena and statistical mechanics: time correlation functions,
introduction to scattering and time-dependent molecular spectroscopy, transport
coefficients.
Books: Basic Concepts for Simple and Complex Liquids by J.L. Barrat and J.P. Hansen
(Cambridge, 2003); Statistical Mechanics by D.A. McQuarrie (Viva, 2003); Introduction
to Statistical Mechanics, D. Chandler (Oxford University Press, 1987).
CY60002 Adsorption and Catalysis (3-0-0 : 3 Credits)
Prerequisite : CY41002
Adsorption Equilibrium. Green technology. Phase transfer and reverse phase transfer
catalysis, general principles, physical, dynamic and thermodynamic principles,
applications, homogeneous catalysis, energetics, homogeneous active sites, activation and
deactivation, selectivity, stereochemistry, orbital symmetry and reactivity of transition
metal complexes.
Books: Introduction to the principles of Heterogeneous catalysis, by J. M. Thomas and
W. J. Thomas; Fine chemicals through heterogeneous catalysis, ed by R. A.Sheldon and
H. van Bekkem, Wiley-VCH, Weinheim, 2001; Nanostructured catalysts, ed by S. L.
Scott, C. M. Crudden and C. W. Jones, Kluwer Academic, NY, 2003; Theory of
Adsorption and Catalysis, A. Clark; Studies in Surface Science and Catalysis volumes,
Elsevier.
9
CY60105 Advanced Quantum Chemistry (3-1-0 : 4 Credits)
Prerequisite : CY41003
Approximate methods of quantum chemistry: variational principle; LCAO
approximation; Huckel Theory; Time-independent perturbation theory. Many electron
atoms: Orbital approximation, Slater determinant; Hartree-Fock selfconsistent field
theory; Slater type orbitals. Angular momentum of many-particle systems. Spin orbital
interaction; LS and JJ coupling. Spectroscopic term symbols for atoms. Molecules and
Chemical bonding: Born-Oppenheimer approximation, MO and VB theories illustrated
with H2-molecule; Spectroscopic term symbols for diatomics; Directed valence &
hybridization in simple polyatomic molecules. Elementary treatments of scattering and
density functional theories
Books: Methods of Molecular Quantum Mechanics by P.W. Atkins; Quantum Mechanics
by I. N. Levine; Density functional theory of atoms and molecules by R.G. Parr and
W.Yang; Modern Quantum Chemistry by A. Szabo and N.S. Ostlund.
CY60004 Biophysical Chemistry (3-0-0 : 3 Credits)
Prerequisite : CY40108
Structures of biological macromolecules (proteins and polynucleic acids); Molecular
Mechanics-simulating macromolecular structure; Spectroscopic methods to study
structure of proteins and DNA; structural transitions in polypeptides, proteins and
polynucleic acids. Interactions between macromolecules; Thermodynamics of protein
folding/stability by fluorescence and circular dichroism techniques. Macromolecule-small
molecule binding by biophysical methods.
Books: Biophysical Chemistry by C.R. Cantor and P.R. Schimmel; Physical
Biochemistry by K.E.van Holde, C. Johnson, P. S. Ho; Protein-Ligand Interactions by S.
E.Harding and B. Z. Chowdhry.
CY60101 Computational Chemistry (3-0-0 : 3 Credits)
Prerequisite : CY41003, CY41002
Geometry optimization, Basis set, Frequency analysis, Population analysis, Global and local
descriptors.
Classical Molecular Dynamics (MD): Lagrangian, Hamiltonian, and Newtonian equations of
motions, Various integration algorithms, Periodic boundary conditions and minimum image
convention, Potential truncation and shifted-force potentials, Neighbor list, Force calculations,
Special methods to handle long range interactions.
Classical Monte Carlo (MC): Random numbers, Evaluating integrals using random numbers,
Importance sampling, Metropolis algorithm, Smart MC techniques.
Analysis of simulated trajectories: Estimation of various distribution functions and transport
properties of simulated model systems.
Special techniques for simulation of biomolecules and polymers. Ab-initio computing.
Books: Computer Simulation of Liquids, by M. P. Allen and D. J. Tildesley; Clarendon Press
(Oxford). Understanding Molecular Simulations: From Algorithms to Applications, by D. Frenkel
and B. Smit (Academic Press). Quantum Chemistry: (Ref: Hehre, Radom, Schleyer, Pople)
CY60123 Applications of Computational Chemistry (1-0-3: 3 Credits)
Prerequisite: CY41003, CY41002
Use of random numbers to evaluate area under a curve.
10
Application of numerical methods to solve differential equations.
Quantum chemical calculations for simple molecular systems.
Code development to evaluate potential energy and force acting on complex molecules in a
system.
Development of a classical MD code for simple monatomic systems.
Development of a classical Metropolis MC code for simple monatomic systems. Use of various
commercially available molecular modeling and simulation software.
Books: Computer Simulation of Liquids, by M. P. Allen and D. J. Tildesley; Clarendon Press
(Oxford). Understanding Molecular Simulations: From Algorithms to Applications, by D. Frenkel
and B. Smit (Academic Press); Molecular modeling by A.R. Leach.
CY60013 Advanced Bio-inorganic Chemistry (3-0-0 : 3 Credits)
Prerequisite : CY40110
Overview of bioinorganic chemistry. Properties of biological molecules. Physical
methods in bioinorganic chemistry. Choice,uptake and assembly of metal containing
units in biology.Transition metal storage, transport and biomineralization. Electrontransfer proteins: Blue copper proteins, long distance electron transfer. Atom and group
transfer chemistry in Fe and Mo:Cytochrome P450, methane monooxygenase, catechol
and other dioxygenase, molybdenum oxotransferases. The frontiers of bioinorganic
chemistry. Metal/Nucleic-acid interactions. Metals in medicine.
CY60107 Chemistry of Nanomaterials (3-0-0 : 3 Credits)
Prerequisite : Nil
Introduction: Inorganic Materials Chemistry and Nanochemistry; Basics Nanomaterials
Synthesis Methods: Bottom-up vs. Top-down Methods; Nanoclusters and Nanowires;
Metal, Metal Oxide, semiconductor nanoparticles, quantum confinement, fluorescent
properties, and Carbon Nanotubes. Inorganic Materials synthesis by Templating and SelfAssembly; 2-D Nanopatterns and Self-assembled Monolayers on Inorganic Substrates;
Mesostructured and Mesoporous Materials; Inorganic-Organic and Inorganic-Polymer
Nanocomposite Materials; Opals and Photonic Materials; Layer by layer self-assembly
and core-shell Inorganic Nanomaterials; Biomimetics: Bioinspired Synthesis of Inorganic
Nanobiomaterials; Catalysis and Photocatalysis (Environmental remediation); Solar Cells
and Nanoelectronics/Nanophotonics Applications Studying and working with matter on
an ultra-small scale. Delivery of anti-cancer drugs. New ethical, health and safety or
social issues.
Books:
1. Nanochemistry: A Chemical Approach to Nanomaterials by Andre Arsenault and
Geoffrey A. Ozin, RSC, 2005.
2. Nanoscale Materials in Chemistry by Kenneth J. Klabunde, Wiley Interscience, 2001.
3. Optical Properties of Metal Clusters (Springer) By M. Vollmer and U. Kreibig,1993.
CY60019 Electroanalysis and Sensors (3-0-0 : 3 Credits)
Prerequisite : Nil
Basics of electroanalytical chemistry- modified electrodes and their application.
Fundamentals of electrochemical sensosr. Electroanalytical chemistry in neuroscience.
Electrochemistry of redox proteins. Design of third generation electrochemical sensors.
Electrochemical DNA sensors. Electrochemical Impedance spectroscopy and their
11
application . Electrochemical immunoassay: redox and enzyme labeled immunoassay.
Electrochemiluminescence and immunoassay; Electrochemical quartz crystal
microbalance and its applications. Design of in vivo sensor and measurement of
biological molecules like glucose, insulin and cholesterol. Electrochemical sensor for
food analysis.
Books:
F. Scholz, Electroanalytical methods, Springer, 2002.
P. Monk, Fundamentals of electroanalytical chemistry, Wiley, 2001.
A.P.F. Turner I. Karube, I. G. Wilson, Biosensors- Fundamentals and applications.
Oxford University Press, New York, 1987.
CY60109 Special Topics in Main Group Chemistry (3-0-0 : 3 Credits)
Prerequisite : Nil
Structure & Bonding in MG compounds including Hypervalency and Multiple Bond.
Recent advances in the coordination, organometallic, and cluster chemistry of MG. C-C
bond forming reactions via MG. Bioinorganic chemistry of MG.
CY60030 Inorganic Photochemistry (3-0-0 : 3 Credits)
Prerequisite : Nil
Excited states: excited states, decay, quantum yield, physico chemical laws. Examples of
photochemical reactions: photochemical reactions of small molecules: NO, NO2, N2O,
CO, O2, O3, SO2 etc.; mechanism and importance; photo redox substitution,
isomerization, prompt and delayed reaction, metal bonded systems, solar energy
conversion and storage, photo splitting of water by photo galvanic method and semi
conductor electrodes. Metal ion catalysis of organic reactions: mechanisms and
applications.
CY60011 Environmental Chemistry (3-0-0 : 3 Credits)
Prerequisite : Nil
Essential concepts of environmental chemistry.
Air and the atmosphere : Chemistry of the natural atmosphere - Environmental
photochemistry in the atmosphere - Chemistry in Troposphere. Photochemical smog.
Global Warming- The Greenhouse Effect - Carbon cycle - Carbon sequestration by plants
and oceans.
Natural waters and the hydrosphere - Water pollution and water quality parameters,
CO2/carbonate equilibrium of natural waters - water treatment methods (reverse osmosis,
adsorption, ion-exchange, ultra-filtration, membrane treatment etc). Heavy metal
toxicity : Tolerance limit of heavy metals in potable water – Mercury and arsenic
poisoning – trace metal analysis – AAS, Cold vapour AAS, ICP.
Soil Pollution and Bioremediation - Organic Pollution in Soils(DDT – pesticide PCB’s – PAH’s, and Estrogen mimics) and their abatement. Clay minerals as ion
exchange media.
Energy – Fossil fuels – Alternate energy thoughts – solar – hydrothermal and geothermal
- Hydrogen fuel and fuel cells. Concepts of Green Chemistry.
Books:
1. Environmental Chemistry, Baird, Colin, 1995, W.H. Freeman and Co., New York.
12
2. Chemistry of Environment, Bailey, Clark , Ferris, Krause, Strong, (2nd edition),
Elsevier.
3. Principles of Instrumental Analysis, D.A. Skoog and J.L. Loary, W.B. Saunders
CY60111 Advanced Stereochemistry (3-0-0 : 3 Credits)
Prerequisite : Nil
Molecular Symmetry: Axial, Planar Chirality and Helicity, Topicity and Prostereoisomerism,
Conformations of Cyclic Systems: Fused Ring and Bridged Ring Compounds. Dynamic
Stereochemistry: Curtin Hammett Principle, Reduction of Cyclic Ketones, Felkin and Cieplak
Model; Chiroptical Properties: Applications of ORD and CD; Molecular Recognition: chemical
and stereochemical aspects.
Book: D. Nasipuri, Stereochemistry of Organic Compounds: Principles, and Applications; E. L.
Eliel, Stereochemistry of Organic Compounds.
CY60113 Agrochemicals (3-0-0 : 3 Credits)
Prerequisite : Nil
Plant Growth Regulators: Steroidal and nonsteroidal; synthesis and biological properties of
hormones like IAA, Gibberellins, Brassinolides. Role of micronutrients. Food ripening agents.
Pesticides: classification, mechanism of action and synthesis. Analysis of pesticide residues and
toxicological effects. Pheromones: acyclic, cyclic, chiral and achiral insect sex-attractants, their
synthesis and mechanism of action.
Book: Industrial Chemistry by Lowenheim and Moran , Wiley - Interscience , New York , 1990.
CY60007 Chemistry of Natural products (3-0-0 : 3 Credits)
Prerequisite : Nil
Isolation, structural characterization, degradation, chemical modifications and
biosynthesis of natural products: fatty acids, polyketides, phenylpropanoids, alkaloids,
peptides and carbohydrates, prostaglandins, macrolides and polyether antibiotics.
Selected topics from the current literature.
Books: Chemistry of Natural Products by S. V. Bhat, 2005; Medicinal Natural products by P. M.
Dewwick, 2002.
CY60006 Drug Design and Development (3-0-0 : 3 Credits)
Prerequisite : Nil
Drug discovery without a lead; lead discovery; lead modification; combinatorial chemistry; drug
receptor interactions; enzyme inhibition and inactivation; drug resistance; drug synergism;
different types of inhibitors; DNA-interactive agents; reversible DNA binders; DNA alkylators;
DNA strand breakers; Drug metabolism: different pathways for drug deactivation and
elimination; Prodrug and drug delivery system: enzyme activation of drugs; mechanisms of drug
action; Bioprecursor prodrugs.
Books: Organic Chemistry of Drug Design and Drug Action: Silverman; Organic Chemistry:
Bruice; Biochemistry: Voet and Voet.
CY60115 Biotransformations in Organic Chemistry (3-0-0 : 3 Credits)
Prerequisite : Nil
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General methods for new biocatalyst discovery; Screening and assay methods; Isolation,
purification and immobilization techniques; Classification and nomenclature (IUBMB);
Catalytic role of enzymes (enzyme kinetics and various kinds of inhibition); Potentials
and limitations; Enzymes in functional group transformation; White biotechnology; Few
industrial process using enzymes for production of drugs, fine chemicals and chiral
intermediates; Combinatorial biocatalysis; Bio-mimetic catalysts (catalytic antibodies,
artificial enzymes, molecular imprinted polymeric catalyst) and their applications; DNA
and RNA based catalysis; Recombinant DNA technology in enzyme engineering.
Books: Enzyme catalysis in organic synthesis (Vol I-III); Eds by K. Drauz and H. Waldmann.
Willey-VCH; Biotransformations in organic chemistry. K. Faber . Springer.
CY60003 Organic Photochemistry and Pericyclic Reactions (3-0-0 : 3 Credits)
Prerequisite : Nil
Photochemistry: Principles of photochemical reactions; Excited states and their properties;
experimental set up for photochemical reactions; Several useful photochemical reactions and their
applications in organic synthesis (isomerization, Patterno-Buchi reaction, Norrish type I and II
reaction, Photoreduction, Rearrangements: di-π-methane, oxa di-π- and aza di-π-methane
rearrangements, Photocycloaddition, Photochemical aromatic substitution reaction, Reactions
with singlet oxygen, Photochemical methods for protection and deprotection). Photochemistry of
biological systems (photosensitized reactions of DNA/RNA, DNA damage and repair).
Pericyclic reactions: Conservation of molecular orbital symmetry, Symmetry properties of
molecular orbitals, Transition state aromaticity, Aromaticity and anti aromaticity (Huckel and
Mobius ring), Correlation diagrams and FMO method, Allowed and forbidden reactions,
Electrocyclic reactions, Cycloaddition reactions ( 2+2; 4+2; 6+4; 3+2; 4+3 and related reactions,
Cheleotropic addition and elimination), Sigmatropic rearrangement, Group transfer reactions (ene
reactions).
Books: Advanced Organic Chemistry: Structure and Mechanisms (Part A). By Frances A Carey
and Richard J Sundberg. Springer; CRC Handbook of Photochemistry and Photobiology. Eds by.
William M. Horspool and Pill-Soon Song, CRC Press; Organic Photochemistry (Vol 4) by Albert
Padwa (Ed.). Mercel Dekker. Pericyclic reactions by Ian Fleming. Oxford University Press.
Cycloaddition reactions in organic synthesis by W. Carruthers. Pergamon.
CY60117 Reagents in Organic synthesis (3-0-0 : 3 Credits)
Prerequisite : Nil
Organosilicon, organotin, organoborane reagents; organocopper, organopalladium and
functionalized Grignard reagents; oragnocatalysts; metal carbonyl reagents; Lewis Acids
in organic synthesis.
Books: Some Modern methods of Organic Synthesis by W. Carruthers, 2004; Advanced Organic
Chemistry Pt B: Reaction and Synthesis by F. A. Carey and R. J. Sundberg, 2001.
CY60119 Physical Organic Chemistry:
Prerequisite: CY41002
14
Acid-base catalysis. General acid and base catalyses. Relationship between the transition state
structure and type of acid-base catalysis. Specific acid and base catalyses. Nucleophilic catalysis.
Non-covalent binding forces; Electronic organic materials.
Overview of orbital symmetry, rearrangements, stereoelectronic effects, the generation and
chemistry of carbenium ions, carbanions, carbenes, nitrenes, radicals, excited states, and strained
molecules. Methods used to probe the mechanisms of organic reactions and of the chemistry of
some important reactive intermediates. Topics will include isotope effects, kinetics, linear fee
energy relationships (Hammett equation. Interpretation of σ and ρ constants);
BOOK: Eric V. Anslyn and Dennis A. Dougherty, Modern Physical Organic Chemistry.
Other texts: i) F. A. Carey and R. J Sundberg, Advanced Organic Chemistry, Parts A; ii) M. B.
th
Smith and J. March, Advanced Organic Chemistry, Reactions, Mechanisms and Structure, 6 ed.;
iii) T. H. Lowry and K. S. Richardson, "Mechanism and Theory in Organic Chemistry," 3rd ed.
CY51001 Spectroscopic Methods of Structure Determination (3-1-0: 4 credits)
Prerequisite : Nil
Nuclear Magnetic Resonance spectroscopy: 1H-, 13C-, 19F-, 15N-, and 31P-NMR, introduction to
2D- NMR techniques, lanthanide shift.
Mass spectroscopy: EI, CI, ESI, FAB, GC/MS, LC/MS and MS/MS techniques.
Interpretation of spectroscopic (NMR, IR and mass) data, as applied to organic, inorganic
and biological systems.
Books: Silverstein, R. M.; Webster, F. X. Spectrometric identification of organic compounds;
6th / ed.; Wiley: New York, 1998. Lambert, J. B; Shurvell, H. F, Organic
structural spectroscopy, Prentice Hall, 1998. Kemp, W. Organic spectroscopy; 3rd ed.;
Macmillan Education: Houndmills, Basingstoke, Hampshire, 1991.
4th semester
CY60104 Colloids And Drug Delivery (3-0-0: 3 credits)
Prerequisite : Nil
Introduction to colloids; size, charge, and morphology of colloids- light scattering,
rheology, and microscopic characterization; Biocompatibality and Biodegradability of
colloids; Drug delivery systems: Microemulsions/Emulsions, Liposomes, Niosomes,
Nanoparticles, microporous materials, microgels, bioconjugate polymers, gels, ointments
and creams; their synthesis/preparation methodologies; Drug loading and release
techniques; release kinetics; controlled delivery; Microencapsulation for personal care;
Nanoencapsulation, Transportation, Transfer, and Targeting; Gene Transfection; Topical,
colonic, and parenteral drug delivery; Efficacy and safety considerations;
Books: Novel Drug Delivery Systems: Fundamentals, Developmental Concepts,
Biomedical Assessments, Yie W. Chien; Techniques of Solubilization of Drugs, Ed.
Samuel H. Yalkowsky; Controlled Drug Delivery: Fundamentals and Applications, Ed.
J.R. Robinson, and V. H.Lee; Transdermal Drug Delivery: Developmental Issues and
Research Initiatives, Ed. J. H. Hadgraft and R. H. Guy; Topical Drug Delivery
Formulations, Ed. D. W. Osborne and A. H. Amann. Biodegradable Polymers as Drug
Delivery Systems, Ed. M. Chasin and R. Langer.
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CY60106 Chemical Bonding and Reactivity (3-0-0: 3 credits)
Prerequisite : Prerequisite : Nil
Valence bond theory; molecular orbital theory; Huckel theory; aromaticity; potential energy
surfaces; Hammond postulate, Woodward-Hoffmann rule; crystal and ligand field theories;
symmetry and symmetry adapted linear combinations; global reactivity descriptors:
electronegativity, hardness, polarizability, electrophilicity index; local reactivity descriptors: local
softness, Fukui functions and frontier orbital theory, molecular electrostatic potential and
associated electronic structure principles.
Books:
Density functional theory of atoms and molecules, R G Parr and W Yang;
Chemical hardness: Applications from Molecules to Solids, R G Pearson
CY60034 Advanced Chemical Dynamics (3-0-0 : 3 Credits)
Prerequisite : Nil
Transport properties in gases and condensed phases - kinetic theory of transport processes
in dilute gases; theory of Brownian motion; transport coefficients from time correlation
function formalism; transport in solids and electrolyte solutions.
Dynamics of chemical reaction in condensed phases – interactions between reactive
molecules; hard sphere collision theory; transition state theory; Kramer's theory of
reactions in solution; linear free energy relationships; unimolecular reactions; electron
transfer reactions; biomolecular reactions; chaos in reaction-diffusion systems and fractal
dimensions.
Books: Basic Concepts for Simple and Complex Liquids by J.L. Barrat and J.P. Hansen;
Statistical Mechanics by D.A. McQuarrie; Non-equilibrium Statistical Mechanics by R.
Kubo; Chemical Dynamics in Condensed Phases by A. Nitzan.
CY60102 Molecular Spectroscopy and Molecular Structure (3-1-0: 4 credits)
Prerequisite : CY41003
Introduction to theory of spectroscopy: Interaction of radiation with matter; Absorption,
Emission. Magnetic Resonance spectroscopy and spin chemistry. Introduction to ultrafast
spectroscopy and imaging.
Books: Methods of molecular quantum mechanics, by P. W. Atkins; Molecular spectroscopy by
J. D. Graybeal. Introduction To Magnetic Resonance by H. Günther; Fluorescence Imaging
Spectroscopy and Microscopy by X. F. Wang and B. Herman (Eds.).
CY60108 Application of Fluorescence Spectroscopy in Chemistry and Biology: (3-00 : 3 Credits)
Prerequisite : Prerequisite : Nil
Introduction to Fluorescence, Instrumentation for fluorescence spectroscopy,
Flurophores, Time-domain lifetime measurements, solvent effects on emission spectra,
Dynamics of solvent and spectral relaxation, Quenching of fluorescence, fluorescence
resonance energy transfer (FRET), fluorescence anisotropy, energy transfer, time-
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resolved energy transfer and conformation distributions of biopolymers, protein
fluorescence, fluorescence sensing, Nucleic acids fluorescence, Application of
fluorescence spectroscopy in cancer detection.
Book: Fluorescence spectroscopy, J. R. Lakowicz.
CY60110 Advanced Polymer Chemistry (3-0-0 : 3 Credits)
Prerequisite : Nil
Synthesis and reaction of polymers; thermodynamics and kinetics of polymerization;
modern synthetic techniques: living radical polymerization – ATRP, SFRP, RAFT, living
ionic polymerization, ring-opening polymerization; modern characterization techniques;
water-soluble polymers, gels and hydrogels; properties of polymers, polymer blends,
additives for polymers; chemical aspects to polymer processing, polymer surface and its
modification; introduction to industrial polymers; application of polymers in medicine,
nanotechnology, electronics; eco-friendly polymers: biodegradable, bio-sourced
polymers, polymers from renewable resources.
Books: Principles of Polymerization, 4th edition, by G. Odian; John Wiley and Sons, Inc.
2004; Introduction to Physical Polymer Science, 4th Edition L. H. Sperling, Wiley, 2006.
CY60112 Metal Complexes in Catalysis and Material Science (3-0-0 : 3 Credits)
Prerequisite : Nil
Catalytic Reactions and the 16/18 VE Rule; Transition metal assisted valence
isomerizations; Isomerization of unsaturated molecules; Arylation/vinylation of olefins;
Alkene and Alkyne metathesis; Oligomerization and Polymerization; Olefin oxidation;
Hydrogenation of alkenes; Fischer-Tropsch reactions; The water- gas shift reactions;
Carbonylation Reactions; Hydroformylation; Hydrocyanation; Activation of C-H bonds
in alkanes; Hydrosilylation and Hydroboration Reactions; Oxygen transfer reactions.
Review of Basic concepts of ligand dissociation, substitution, and elimination reactions.
Organometallics in electronic and optoelectronic applications. Chemical Vapor
Deposition (MOCVD) leading to metal carbides, metal nitrides, metal borides, metal
oxides, metal chalcogenides, semi-conductors, metal films. Organometallic chemistry
related molecular material.
Books: Homogeneous Catalysis by Sumit Bhaduri
CY60114 Physical Methods In Inorganic Chemistry
Prerequisite : Nil
Infrared and Raman Spectroscopy
Review of basics, applications of IR and Raman in inorganic systems – metal coordinated
sulphate, dioxygen, carboxylate, aminoacids, perchlorates, nitrites, nitrates, thiocyanate
and isocyanate.
Mass Spectrometry: Principles and presentation of spectra – molecular fragmentation –
ion reactions – Inorganic applications.
NMR Spectroscopy
Review of basics, applications of multinuclear nmr in inorganic compounds – Examples
from 1H, 11B, 13C, 19F, 31P, 51V, 77Se, 95Mo, 119Sn, 199Pt. Study of fluxional behavior of
molecules – an elementary treatment of second order spectra – examples – NMR of
paramagnetic molecules – Lanthanide shift reagents
17
Magnetic properties
Magnetic moments and their applications to the elucidation of the structures of inorganic
compounds – temperature independent paramagnetism. Magnetic properties of
lanthanides and actinides. Spin crossover in coordination compounds.
EPR spectroscopy
Theory of EPR spectroscopy - Spin densities and McConnell relationship –Applications
of ESR to some simple systems such as CH3, p-benzosemiquinone, Xe+2 -Factors
affecting the magnitude of g and A in metal species - Zero field splitting and Kramers
degeneracy – Spectra of VO(II), Mn(II), Fe(II), Co(II), Ni(II) and Cu(II) complexes –
Applications of EPR to a few biological molecules containing Cu(II) and Fe(III) ions.
Mossbauer Spectroscopy
Isomer shifts – Magnetic interactions – Mossbauer emission spectroscopy –applications
to iron and tin compounds.
Textbooks and Reference Books
1. R.S. Drago, “Physical Methods in Inorganic Chemistry”, 3rd Ed., Wiley Eastern
Company.
2. F.A. Cotton and G.Wilkinson, “Advanced Inorganic Chemistry”, 3rd ed., WileyEastern Company, New Delhi 1990.
4. Lewis and Wilkins, “Modern Coordination Chemistry”.
5. E.A.V.Ebsworth, “Structural Methods in Inorganic Chemistry”, 3rd ed., ELBS, Great
Britain, 1987.
CY60026 Recent Advances in Analytical Chemistry (3-0-0 : 3 Credits)
Prerequisite : Nil
Review of basic concepts. Analytical aspects of sample preparation. Separation
techniques and Chromatography. Aalytical Methods and Applications: Small angle X-ray
and XRF. Plasma emission spectroscopy, Raman and Surface Enhanced Ramon
Spectroscopy (SERS), SEM, TEM, EDAX, EPMA, Mass spectrometry (ICP-MS, ESI,
MALDI TOF and TANDEM MS-MS methods).
Books:
1. Principles of Analytical Chemistry, F.W. Fifield and D. Kealey, (5th Edition),
Blackwell Science.
2. Principles of Instrumental Analysis, Holler, Skoog, Crouch, 6th Edition,Thomson,
2007.
3. Fundamentals of Analytical Chemistry D.A., Skoog
CY60012 Synthesis and Processing of Ceramics (3-0-0 : 3 Credits)
Prerequisite : Nil
Classification of ceramics and materials: crystal structures and properties. Elementary
ceramic phase diagrams. Ceramic powder preparation from naturally occurring raw
materials. Synthesis of ceramic powders, fabrication of ceramic bodies from powders:
pressing, casting, vapour phase techniques, sintering, finishing, machining. Ceramic
coatings
CY60116 Chemistry of Nucleosides and Nucleotides (3-0-0 : 3 Credits)
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Prerequisite :Nil
Carbohydrates: Structures; Reactions at the anomeric centre; Reactions at the non-anomeric
centre; protection-deprotection; chemical synthesis of oligosaccharides; chiral pool; natural
products; Nucleosides: Structures; Modification of carbohydrate moiety; Modification of
heterocycle moiety; ring conformation; DNA and RNA; oligonucleotide synthesis; PNA, LNA
and other unnatural oligonucleotides.
Books: Nucleic acids in chemistry and biology: Blackburn and Gait; Advanced organic chemistry
of nucleic acids: Shabarova and Bogdanov.
CY60118 Chemistry of Lipids, Steroids and Hormones (3-0-0 : 3 Credits)
Prerequisite : Nil
Characteristics of different types of lipids, Oxidation of fatty acids, Fatty acid synthesis,
Triglyceride synthesis, Cholesterol biosynthesis, Function of hormones, Synthesis of male and
female hormones, Leukotrienes and Prostaglandins
Books: Organic Chemistry Vol.2 I. L. Finar; Outlines of Biochemistry Conn and Stumpf
CY60014 Medicinal Chemistry (3-0-0 : 3 Credits)
Prerequisite : Nil
Drug discovery without a lead; lead discovery; lead modification; combinatorial chemistry; drug
receptor interactions; enzyme inhibition and inactivation; drug resistance; drug synergism;
different types of inhibitors; DNA-interactive agents; reversible DNA binders; DNA alkylators;
DNA strand breakers; Drug metabolism: different pathways for drug deactivation and
elimination; Prodrug and drug delivery system: enzyme activation of drugs; mechanisms of drug
action; Bioprecursor prodrugs.
Books: Organic Chemistry of Drug Design and Drug Action: Silverman; Organic Chemistry:
Bruice; Biochemistry: Voet and Voet
CY60120 Newer Asymmetric Reactions (3-0-0 : 3 Credits)
Prerequisite : Nil
Principles of asymmetric reaction and synthesis; Kinetic resolution, Dynamic kinetic
resolution (DKR) and autocatalytic reactions; Chemo-, regio-, diastereo- and enantiocontrolled approaches; Chirality transfer and relay; Asymmetric inductions; Chiral pools,
auxiliaries and templates;
Asymmetric
oxidations:
Sharpless
asymmetric
epoxidation,
dihydroxylation,
aminohydroxylation, Jacobsen strategy, Sulphoxidation, Shi epoxidation. Asymmetric reduction
reactions: Reduction of ketones, imines and olefins. Asymmetric C-C bond forming reaction:
Simmon-Smith reaction, aldol reaction and alkylation based on Evans method, Mukayama aldol
reaction, Shibasaki bi-metallic catalyst system; RAMP-SAMP based alkylation strategy, Meyers
oxazoline and bis-lactam based methods; Michael reaction, Henry reaction (Nitro aldol), BaylisHillman-Morita reactions, Asymmetric allylation, Asymmetric cycloaddition reactions,
Asymmetric hydroformylation. Asymmetric C-X bond formimg reaction: Asymmetric
aziridination and regioselective ring opening of aziridines; Ring forming reactions.
Organocatalysis: α-functionalization of aldehyde and ketones, 1,4-conjugate addition (βfunctionalization and α,β-bifunctionalization of α,β-unsaturated carbonyl compounds).
Books: Asymmetric Reactions and Processes in Chemistry: Ernest L. Eliel; Catalytic Asymmetric
Synthesis: 2nd Ed., Iwao Ojima; Asymmetric Organocatalysis: From Biomimetic Concept to
Applications in Asymmetric Synthesis: David MacMillan
CY60122 Organometallic Strategies in Organic Synthesis (3-0-0 : 3 Credits)
Prerequisite : Nil
19
Introductory concepts of transition metal organometallics and their reaction patterns including
selectivity and atom economy.
C-C bond formation by stoichiometric and catalytic organometallic strategies involving alkene,
alkyne, diene, allyl, carbene, propargyl, and arene.
Lanthanides in organic reactions.
Books: Transition metal reagents and catalysts- Innovation in organic synthesis, J. Tsuji, John
Wiley & Sons Ltd.; Transition metals for organic synthesis- Building blocks and fine chemicals
Vol. 1 and 2, Ed. M. Beller and C. Bolm, Wiley-VCH; Transition metals in the synthesis of
complex organic molecules, L. S. Hegedus, University Science Books.
CY60124 Pharmacological Basis of Therapeutics (3-0-0 : 3 Credits)
Prerequisite : CY40108
Pharmacokinetics: the mechanism of drug absorption, distribution and elimination.
Pharmacodynamics: mechanism of action of the following drugs: drugs acting on CNS disorder,
inflammation, cardiac and renal dysfunction, G.I. disorders. Chemotherapy of parasitic infection,
microbial diseases, neoplasticity. Immunomodulatory drugs: hormones and hormone antagonists.
Book: Pharmacological basis of therapeutics: Goodman and Goodman.
CY60028 Supramolecular Chemistry (3-0-0 : 3 Credits)
Prerequisite : Nil
From molecular to supramolecules, factors leading to strong binding, hydrogen bonding and
stacking interactions, design, synthesis and binding studies of synthetic receptors, design,
properties and applications of crown ethers, siderophores, cyclophanes, cyclodextrins, Catenanes
and rotaxanes. Metal guided self-assemblies and applications, Supramolecular reactivity and
catalysis, supramolecular devices, transportation of anions and cations across transmembrane
channels, Self-assembled monolayers, Crystal engineering of hydrogen bonded and metal-organic
framework solids.
Books: Jean-Marie Lehn: Supramolecular Chemistry Concepts and Perspectives
CY60020 Advanced Heterocyclic Chemistry (3-0-0 : 3 Credits)
Prerequisite : Nil
Synthesis and reactions: indoles, azines, purines, pteridines,azoles, benzopyrimidines, compounds
with oxygen and sulfur hetero atoms and small-ring heterocycles.Role of heterocyclic compounds
in biological systems.
Books: J.A. Joule and K.Mills, Heterocyclic Chemistry.