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1 DEPARTMENT OF CHEMISTRY JOINT M.Sc.-Ph.D PROGRAMME CHEMISTRY (CY) CURRICULUM OF 4 SEMESTERS 1st Semester Subject Sl. No. Number 1. CY41003 2. 3. CY41007 CY40014 4. CY40101 5. 6. 7. CY49001 CY41001 CY49011 2nd Semester Subject Sl. No. Number 1. CY41002 2. CY49002 3. CY40110 4. 5. 6. 7. 8. CY50015 CY41004 CY40108 CY49004 CY58005 Subject Name L-T-P Credit 3-1-0 4 2-0-0 3-1-0 2 4 3-0-0 3 0-0-6 3-1-0 0-0-6 14-3-12 4 4 4 25 Subject Name L-T-P Credit Molecular thermodynamics and Kinetics Advanced Physical Chemistry Laboratory Principles of Organometallic & Bio-inorganic Chemistry Solid State Chemistry Analytical & Environmental Chemistry Structures and Functions of Biomolecules Biochemical Techniques Laboratory Viva Total 3-0-0 0-0-6 3 4 4-0-0 4 3-0-0 3-0-0 3-0-0 0-0-6 3 3 3 4 2 26 Introduction to Quantum Chemistry & Spectroscopy Group Theory for chemists Introduction to Computational Chemistry Inorganic Chemistry: Structure, Principle, & Reactivity Advanced Inorganic Chemistry Laboratory Principles of Organic Synthesis Advanced Organic Chemistry Laboratory Total 16-0-12 2 3rd Semester Depth/ Subject Breadth Number D D D D CY51001 CY57005 CY58003 4th Semester Depth/ Subject Breadth Number D D CY57006 CY58006 Subject Name L-T-P Credit Elective I Elective II Elective III Spectroscopic Methods of Structure Determination Project Seminar Total 3-0-0 3-0-0 3-0-0 3 3 3 3-1-0 4 0-0-12 0-0-3 12-1-12 8 2 23 Subject Name L-T-P Credit Elective IV Elective V Project & Viva Comprehensive Viva Total (Depth +Breadth) 3-0-0 3-0-0 0-0-15 3 3 10 2 18 6-0-15 LIST OF ELECTIVE SUBJECTS Elective I, II, III Sl. No 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 Subject Number CY60121 CY60103 CY60002 CY60105 CY60004 CY60101 CY60123 CY60013 CY60107 CY60019 CY60109 CY60030 CY60011 CY60111 CY60113 CY60007 CY60005 CY60115 Subject Name L-T-P Credit Chemistry of Materials Statistical Mechanics for Chemists Adsorption & Catalysis Advanced Quantum Chemistry Biophysical Chemistry Computational Chemistry Applications of Computational Chemistry Advanced Bio-inorganic Chemistry Chemistry of Nanomaterials Electroanalysis and sensors Special Topics in Main Group Chemistry Inorganic Photochemistry Environmental Chemistry Advanced Stereochemistry Agrochemicals Chemistry of Natural products Drug Design and Development Biotransformation in Organic Chemistry 3-0-0 3-0-0 3-0-0 3-0-0 3-0-0 3-0-0 1-0-3 3-0-0 3-0-0 3-0-0 3-0-0 3-0-0 3-0-0 3-0-0 3-0-0 3-0-0 3-0-0 3-0-0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 19 20 21 CY60003 CY60117 CY60119 Organic Photochemistry & Pericyclic Reactions Reagents in Organic synthesis Physical Organic Chemistry 3-0-0 3-0-0 3-0-0 3 3 3 Subject Name L-T-P Credit 3-0-0 3-0-0 3-0-0 4-0-0 3 3 3 4 3-0-0 3 3-0-0 3-0-0 3-0-0 3 3 3 LIST OF ELECTIVE SUBJECTS Elective IV, V Sl. No 1 2 3 4 Subject Number CY60104 CY60106 CY60034 CY60102 5 CY60108 6 7 8 CY60110 CY60112 CY60114 Colloids & Drug Delivery Chemical Bonding & Reactivity Advanced Chemical Dynamics Molecular Spectroscopy & Molecular Structure Applications of Fluorescence Spectroscopy in Chemistry and Biology Advanced Polymer Chemistry Metal Complexes in Catalysis & Materials Science Physical Methods in Inorganic Chemistry 9 CY60026 Recent Advances in Analytical Chemistry 3-0-0 3 10 CY60012 Synthesis and Processing of Ceramics 3-0-0 3 11 CY60116 Chemistry of Nucleosides and Nucleotides 3-0-0 3 12 CY60118 Chemistry of Lipids, Steroids and Hormones 3-0-0 3 13 CY60014 Medicinal Chemistry 3-0-0 3 14 CY60120 Newer Asymmetric Reactions 3-0-0 3 15 CY60122 Organometallic Strategies in Organic Synthesis 3-0-0 3 16 CY60124 Pharmacological Basis of Therapeutics 3-0-0 3 17 CY60028 Supramolecular Chemistry 3-0-0 3 18 CY60020 Advanced Heterocyclic Chemistry 3-0-0 3 SYLLABII CHEMISTRY DEPARTMENT 2-Year M.Sc. CHEMISTRY 1st semester CY41003 Introduction to Quantum Chemistry & Spectroscopy (3-1-0 : 4 Credits) Prerequisite : Nil Review of quantum mechanics: Schrödinger wave equation, Eigenfunction, eigenvalues and operators, Interpretation of wavefunctions, Free particle, Particle-in-a-box, Rigid rotor, Harmonic oscillator, Hydrogen atom; Introduction to Self Consistent Field 4 Theories; Valence Bond and Molecular Orbital theories; Introduction to Molecular spectroscopy: absorption, emission and resonance. Books: Methods of Molecular Quantum Mechanics by P.W. Atkins Physical Chemistry: A Molecular Approach by D.A.McQuarrie and J.D. Simon Molecular Spectroscopy by I. N. Levine CY41007 Group Theory for Chemists (2-0-0 : 2 Credits) Prerequisite : Nil Introduction to Linear Algebra required for Group Theory. Introduction to group theory: Definitions and theorems; Molecular Symmetry and point groups; Representation of groups: great orthogonality theorem, character table. Group Theory and Quantum Mechanics: wave functions as basis of irreducible representations, the direct product, identification of non-zero matrix elements. Normal mode analysis. Books: Mathematical Methods in Physical Sciences, M.L. Boas; Chemical Applications of Group Theory, F.A. Cotton. CY40014 Introduction to Computational Chemistry (3-1-0: 4 credits) Prerequisite: Nil Introduction to programming languages; basic numerical analysis: solution of nonlinear equations using Newton-Raphson method, solution of linear systems using Gaussian elimination and pivoting, interpolation and polynomial approximation, numerical solution of differential equations: ODE and PDE: analysis of convergence, stability and consistency; numerical integration; code development and use of commercially available software to perform simple quantum chemical calculations. Book: Computational Chemistry Using the PC, D.W. Rogers. CY40101 Inorganic Chemistry: Structure, Principle, & Reactivity (3-0-0 : 3 Credits) Prerequisite : Nil RS coupling, CFT, Tanabe-Sugano diagram, Ligand field theory, molecular orbital theory. Magnetic and spectral properties of coordination compounds. Inorganic reaction mechanism- substitution, electron transfer, photochemical reactions. Books: B.N. Figgis, J.E Huheey, P.W. Atkins CY49001 Advanced Inorganic Chemistry Laboratory (0-0-6 : 4 Credits) Prerequisite : Nil Semi-micro Analysis of transition metal and rare earth metal ions in a mixture by using Spot technique. Preparation and (Spectroscopic Characterization) of: Layered Vanadyl Phosphate Dihydrate (Powder XRD, TGA) Tris(acetylacetonator)managanese(III) (Mag. Susceptibility by Gouy method, and Evans method, EPR) Tris(ethylenediamine)cobalt(III) ion & Optical Resolution (UV, specific rotation) Chlorotribenzyltin(IV) (1H NMR) Halocobaloxime: a B12 model compound (IR, 1H NMR) Estimation of phosphoric acid in soft drinks 5 Column Chromatographic separation of Chlorophyll from Plant (UV) Extraction of Fullerene from Soot (13C NMR, and CV) Book: Vogel’s Qualitative Inorganic Analysis General Chemistry Experiment by A.J. Elias Synthesis & Techniques in Inorganic Chemistry by G.S. Girolami, T.B. Rauchefuss, R.J. Angelici CY41001 Principles of Organic Synthesis (3-1-0 : 4 Credits) Prerequisite:Nil Ideal synthesis; fundamentals of retrosynthesis, symmetry, stereochemistry, conformation analysis, molecular mechanics, stereocontrol, ring formation, reactivity, selectivity, catalysis, organometalic reactions. Functional group transformations, umpolung and protecting groups. Synthetic strategies and selected total syntheses Textbook: M. B. Smith, Organic Synthesis. F. A. Carey and R. J Sundberg, Advanced Organic Chemistry, Part B. CY49011 Advanced Organic Chemistry Laboratory (0-0-6: 4 credits) Preparation of o-iodobenzoic acid from anthranilic acid; furoic acid from furfural; thiamine catalysed benzoin condensation; preparation of benzil from benzoin; benzilic acid from benzil; and their characterization by UV, IR and NMR; other related experiments. 2nd semester CY41002 Molecular Thermodynamics and Kinetics (3-0-0 : 3 Credits) Prerequisite : CY41003 Review of classical thermodynamics; Third law of thermodynamics and residual entropy; Introduction to Statistical thermodynamics; Thermodynamic quantities from partition functions; Applications to gases, solids, atomic liquids and polymers. Chemical equilibrium; Chemical kinetics and molecular reaction dynamics; Theories of chemical reaction rates. Book: Physical Chemistry by P.W. Atkins; Physical Chemistry: Statistical mechanics by H. Metiu; Physical Chemistry: Chemical Kinetics by H. Metiu. CY49002 Advanced Physical Chemistry Laboratory (0-0-6: 4 credits) Prerequisite:Nil Charge transfer complex formation between anthracene and picric acid, To study the formation of charge transfer complex between 1,2,4,5 Tetramethylbenzene and Tetracyano ethylene in various solvents, Study of a oscillatory reaction by EMF and absorbance measurement, To study the mutarotation of D-Glucose at different pH, Determination of partition coefficient of iodine between water and CCl4 / Equilibrium constant for tri-iodide formation;To study the fluorescence quenching of Anthracene by CCl4 in n-hexane and ethanol, Determination of Critical micellar concentration of Sodium Docecyl Sulphate (SDS) in water and in presence of salt by surface tension, conductance and stokes shift method, Comparative study of Twisted Intramolecular Charge Transfer (TICT) of 4-N, N-Dimethylamineobenzoinitrile (DMABN) in different solvent by Fluorescence Spectroscopy, Determination of activation energy and entropy of activation for acid catalyzed ester hydrolysis, Swelling studies of polyelectrolyte gels in medium of different 6 pH, Synthesis and characterization of copolymer(s) of styrene and methylmethacrylate by radical polymerization, Determination of activation energy in the bromide-bromate clock reaction, Kinetics of salt effect and ionic strength (persulfate-iodine reaction), Spectroscopic determination of the size of CdS-nanoparticles; Determination of unit cell dimensions and density of some binary compounds of cubic systems by X Ray diffraction; Determination of percent crystallinity, crystalline melting point, and enthalpy of melting of a crystalline polymer by combined X- Ray diffraction - differential scanning calorimetry; determination of order of reaction and activation energy of the solid-state decomposition of CaCO3 by thermogravimetry, determination of pKa of phenol in the excited state using spectroscopic method. CY40110 Principles of Organometallic and Bioinorganic Chemistry (4-0-0 : 4 credits) Prerequisite : CY40101 Organometallic chemistry: Bonding models in sigma and pi-complexes. 18-electron formalism and isolobal principle. Basic concepts guiding the synthesis and stability of Li, Mg, B, Si organometallic compounds. Wades/Mingos/Jemmis rule. Basic concepts guiding the synthesis and stability of transition metal alkyls, carbonyls, alkenes, alkynes, arenes, allyls, carbenes, and metallocenes. Basic organometallic reactions: oxidativeaddition, reductive elimination, transmetallation, insertion, nucleophilic attach on coordinated ligand. Typical examples of fluxional organometallics. Bioinorganic Chemistry: The biochemistry of iron and copper: Dioxygen binding, transport and utilization in hemoglobin, hemocyanin and hemerythrin. Biological and synthetic dioxygen carriers. Metal-sulfide proteins: Ferredoxin and nitrogenases. Metalloporphyrins and Respiration: Cytochromes. Electron transfer reactions. Metalloenzymes: Carbonic anhydrase, carboxypeptidase and vitamin B12. Books: Inorganic Chemistry by J.E. Huheey The Organometallic Chemistry of The Transition Metals, by R.H. Crabtree Principles & Applications of Organo-transition Metal Chemistry, by J.P. Collman, L.S. Hegedus, J.R. Norton, R.G. Finke Bioinorganic Chemistry by Lippard, and Bartini CY50015 Solid State Chemistry (3-0-0: 3 credits) Crystal structure of solids: Fundamental of lattices, unit cell, atomic coordinates, Bravais lattices, crystal direction and planes, types of close packing, packing efficiency, radius ratios; structure types – NaCl, ZnS, Na2O, CdCl2, wurtzite, nickel arsenide, CsCl, CdI2, rutile and Cs2O, perovskite ABO3, K2NiF4, spinels. Crystal diffraction by X-rays, Neutrons and Electrons; Structure determination by X-ray diffraction, Atomic form factor, structure factor and integrated intensity, Concept of reciprocal lattice, Brillouin Zones.Band Theory, Semiconductors (intrinsic & extrinsic), and Devices, Measurement of Band Gaps, Fermi level; Imperfections in Solids: Point, Line, Surface; Thermodynamics of the Defects; Phase Stability: Unary and Binary Phase Diagrams; Ionic Conductivity & Photoconductivity; Colour Centers, Traps, Phosphors; Electrical and Magnetic Properties (Hall Effect); BCS-type superconductivity. 7 Books: Solid State Chemistry and its applications by A. R. West; Solid State Chemistry – An Introduction by L. Smart and E. Moore; Structure and Dynamics – An atomic view of Materials, M. T. Dove; Material Science and Engineering, V. Raghavan. CY41004 Analytical & Environmental Chemistry (3-0-0: 3 Credits) Introductory Topics: Development of Analytical Chemistry, Analytical Terms, Precision and Accuracy, Figures of Merit. Measurement Fundamentals: Signal-to-Noise Ratio, Origin of Instrument Noise, Quantifying Measurements and Extracting Information. Atomic Spectroscopy: Principles, Flame Emission Spectroscopy, Atomic Absorption Spectroscopy, X-Ray Fluorescence. Introduction to Chromatographic Separations: Classification, Chromatographic Parameters, Resolution, Band Broadening. Liquid Chromatography: HPLC Instrumentation, Adsorption Chromatography, Partition Chromatography, Other Types of Liquid Chromatography. Gas Chromatography: Basic Description, Classification of GC Methods, Stationary Phase, Carrier Gas, Detectors, Temperature Programming. Thermal & surface techniques: TG, DTA/DSC, Auger, XPS, SEM/TEM Analysis of Water, Air, and Soil: Significance of various parameters. Environmental sampling. Current trends in the analysis of metal ions and organic pollutants in water, air and soil. Laws, and standards on environmental pollution, and abatement. Book: Skoog and Leary, "Principles of Instrumental Analysis"; Skoog, West, and Holler, “Analytical Chemistry an Introduction”; Bailey, Clark, Ferris, Krause, and Strong, “Chemistry of Environment”;Research and review articles. CY40108 Structure & Functions of Biomolecules (3-0-0 : 3 Credits) Prerequisite : CY41001 Amino acids, structure of proteins; vitamins and coenzymes; the globins; sugars and phosphates; nucleic acids, DNA, RNA; lipids; protein, DNA sequencing; chemical synthesis of peptides, DNA, RNA. Enzyme catalysis; biochemistry of glucose, energy production; citric acid cycle; metabolism of amino acids and nucleotides; catabolism of nucleotides; expression and transmission of genetic information, replication, transcription, translation; cloning and PCR Books: Organic Chemistry: Bruice; Biochemistry: Voet and Voet; Foundations of Chemical Biology: Dobson, Gerrard, Pratt. Bioorganic Chemistry: Dugas. CY49004 Biochemical Techniques Laboratory (0-0-6 : 4 Credits) Prerequisite : Nil Isolation, purification and characterizations of proteins and nucleic acids, gel electrophoresis, estimation of proteins, nucleic acids, cholesterol and sugar, enzyme inhibition studies, microbial growth and antibacterial assay. 3rd semester Elective I, II, III CY60121 Chemistry of Materials (3-0-0 : 3 Credits) Prerequisites: CY50015 8 Introduction to solids with crystal Imperfections: Point defects, dislocations, Interfacial imperfections, Ionic conductivity, Solid electrolyte, Colour centers – reactivity, nonstoichiometric compounds. Phase diagram and phase transformation in solids, application of phase diagram. Diffusion phenomenon in solids: Fick’s Laws of Diffusion, Kirkendall Effect, Atomic Model of Diffusion and other diffusion processes. Mechanical behavior – strength, hardness, deformation, fatigue; Mechanisms of strengthening and toughening of materials; Elastic and Thermal Properties of Materials. Optical properties of Materials: Basic concepts on interaction of light with solids, Optical constants, absorption and emission properties. Books: A. R. West, Solid State Chemistry and its applications; L. Smart and E. Moore, Solid State Chemistry – An Introduction; V. Raghavan, Material Science and Engineering; Nanostructured Materials: Processing, Properties and Potential Applications, Ed by C C Koch; H Singh Nalwa, Handbook of Nanostructured Materials and Nanotechnology; L. Murr, Industrial Materials Science and Engineering; W.G. Moffatt, Structure and Properties of Materials. CY60103 Statistical Mechanics for Chemists (3-0-0 : 3 Credits) Prerequisite : CY41002 Topics in advanced classical and quantum statistical mechanics: equilibrium properties of systems of interacting molecules with applications to ideal Fermi and Bose gases, simple solids, dense fluids and aqueous solutions. Phase Transition: mean field approaches, critical fluctuations and scaling, application to condensation, polymers and liquid crystals. Strong electroytes: Debye-Huckel theory. Time dependent phenomena and statistical mechanics: time correlation functions, introduction to scattering and time-dependent molecular spectroscopy, transport coefficients. Books: Basic Concepts for Simple and Complex Liquids by J.L. Barrat and J.P. Hansen (Cambridge, 2003); Statistical Mechanics by D.A. McQuarrie (Viva, 2003); Introduction to Statistical Mechanics, D. Chandler (Oxford University Press, 1987). CY60002 Adsorption and Catalysis (3-0-0 : 3 Credits) Prerequisite : CY41002 Adsorption Equilibrium. Green technology. Phase transfer and reverse phase transfer catalysis, general principles, physical, dynamic and thermodynamic principles, applications, homogeneous catalysis, energetics, homogeneous active sites, activation and deactivation, selectivity, stereochemistry, orbital symmetry and reactivity of transition metal complexes. Books: Introduction to the principles of Heterogeneous catalysis, by J. M. Thomas and W. J. Thomas; Fine chemicals through heterogeneous catalysis, ed by R. A.Sheldon and H. van Bekkem, Wiley-VCH, Weinheim, 2001; Nanostructured catalysts, ed by S. L. Scott, C. M. Crudden and C. W. Jones, Kluwer Academic, NY, 2003; Theory of Adsorption and Catalysis, A. Clark; Studies in Surface Science and Catalysis volumes, Elsevier. 9 CY60105 Advanced Quantum Chemistry (3-1-0 : 4 Credits) Prerequisite : CY41003 Approximate methods of quantum chemistry: variational principle; LCAO approximation; Huckel Theory; Time-independent perturbation theory. Many electron atoms: Orbital approximation, Slater determinant; Hartree-Fock selfconsistent field theory; Slater type orbitals. Angular momentum of many-particle systems. Spin orbital interaction; LS and JJ coupling. Spectroscopic term symbols for atoms. Molecules and Chemical bonding: Born-Oppenheimer approximation, MO and VB theories illustrated with H2-molecule; Spectroscopic term symbols for diatomics; Directed valence & hybridization in simple polyatomic molecules. Elementary treatments of scattering and density functional theories Books: Methods of Molecular Quantum Mechanics by P.W. Atkins; Quantum Mechanics by I. N. Levine; Density functional theory of atoms and molecules by R.G. Parr and W.Yang; Modern Quantum Chemistry by A. Szabo and N.S. Ostlund. CY60004 Biophysical Chemistry (3-0-0 : 3 Credits) Prerequisite : CY40108 Structures of biological macromolecules (proteins and polynucleic acids); Molecular Mechanics-simulating macromolecular structure; Spectroscopic methods to study structure of proteins and DNA; structural transitions in polypeptides, proteins and polynucleic acids. Interactions between macromolecules; Thermodynamics of protein folding/stability by fluorescence and circular dichroism techniques. Macromolecule-small molecule binding by biophysical methods. Books: Biophysical Chemistry by C.R. Cantor and P.R. Schimmel; Physical Biochemistry by K.E.van Holde, C. Johnson, P. S. Ho; Protein-Ligand Interactions by S. E.Harding and B. Z. Chowdhry. CY60101 Computational Chemistry (3-0-0 : 3 Credits) Prerequisite : CY41003, CY41002 Geometry optimization, Basis set, Frequency analysis, Population analysis, Global and local descriptors. Classical Molecular Dynamics (MD): Lagrangian, Hamiltonian, and Newtonian equations of motions, Various integration algorithms, Periodic boundary conditions and minimum image convention, Potential truncation and shifted-force potentials, Neighbor list, Force calculations, Special methods to handle long range interactions. Classical Monte Carlo (MC): Random numbers, Evaluating integrals using random numbers, Importance sampling, Metropolis algorithm, Smart MC techniques. Analysis of simulated trajectories: Estimation of various distribution functions and transport properties of simulated model systems. Special techniques for simulation of biomolecules and polymers. Ab-initio computing. Books: Computer Simulation of Liquids, by M. P. Allen and D. J. Tildesley; Clarendon Press (Oxford). Understanding Molecular Simulations: From Algorithms to Applications, by D. Frenkel and B. Smit (Academic Press). Quantum Chemistry: (Ref: Hehre, Radom, Schleyer, Pople) CY60123 Applications of Computational Chemistry (1-0-3: 3 Credits) Prerequisite: CY41003, CY41002 Use of random numbers to evaluate area under a curve. 10 Application of numerical methods to solve differential equations. Quantum chemical calculations for simple molecular systems. Code development to evaluate potential energy and force acting on complex molecules in a system. Development of a classical MD code for simple monatomic systems. Development of a classical Metropolis MC code for simple monatomic systems. Use of various commercially available molecular modeling and simulation software. Books: Computer Simulation of Liquids, by M. P. Allen and D. J. Tildesley; Clarendon Press (Oxford). Understanding Molecular Simulations: From Algorithms to Applications, by D. Frenkel and B. Smit (Academic Press); Molecular modeling by A.R. Leach. CY60013 Advanced Bio-inorganic Chemistry (3-0-0 : 3 Credits) Prerequisite : CY40110 Overview of bioinorganic chemistry. Properties of biological molecules. Physical methods in bioinorganic chemistry. Choice,uptake and assembly of metal containing units in biology.Transition metal storage, transport and biomineralization. Electrontransfer proteins: Blue copper proteins, long distance electron transfer. Atom and group transfer chemistry in Fe and Mo:Cytochrome P450, methane monooxygenase, catechol and other dioxygenase, molybdenum oxotransferases. The frontiers of bioinorganic chemistry. Metal/Nucleic-acid interactions. Metals in medicine. CY60107 Chemistry of Nanomaterials (3-0-0 : 3 Credits) Prerequisite : Nil Introduction: Inorganic Materials Chemistry and Nanochemistry; Basics Nanomaterials Synthesis Methods: Bottom-up vs. Top-down Methods; Nanoclusters and Nanowires; Metal, Metal Oxide, semiconductor nanoparticles, quantum confinement, fluorescent properties, and Carbon Nanotubes. Inorganic Materials synthesis by Templating and SelfAssembly; 2-D Nanopatterns and Self-assembled Monolayers on Inorganic Substrates; Mesostructured and Mesoporous Materials; Inorganic-Organic and Inorganic-Polymer Nanocomposite Materials; Opals and Photonic Materials; Layer by layer self-assembly and core-shell Inorganic Nanomaterials; Biomimetics: Bioinspired Synthesis of Inorganic Nanobiomaterials; Catalysis and Photocatalysis (Environmental remediation); Solar Cells and Nanoelectronics/Nanophotonics Applications Studying and working with matter on an ultra-small scale. Delivery of anti-cancer drugs. New ethical, health and safety or social issues. Books: 1. Nanochemistry: A Chemical Approach to Nanomaterials by Andre Arsenault and Geoffrey A. Ozin, RSC, 2005. 2. Nanoscale Materials in Chemistry by Kenneth J. Klabunde, Wiley Interscience, 2001. 3. Optical Properties of Metal Clusters (Springer) By M. Vollmer and U. Kreibig,1993. CY60019 Electroanalysis and Sensors (3-0-0 : 3 Credits) Prerequisite : Nil Basics of electroanalytical chemistry- modified electrodes and their application. Fundamentals of electrochemical sensosr. Electroanalytical chemistry in neuroscience. Electrochemistry of redox proteins. Design of third generation electrochemical sensors. Electrochemical DNA sensors. Electrochemical Impedance spectroscopy and their 11 application . Electrochemical immunoassay: redox and enzyme labeled immunoassay. Electrochemiluminescence and immunoassay; Electrochemical quartz crystal microbalance and its applications. Design of in vivo sensor and measurement of biological molecules like glucose, insulin and cholesterol. Electrochemical sensor for food analysis. Books: F. Scholz, Electroanalytical methods, Springer, 2002. P. Monk, Fundamentals of electroanalytical chemistry, Wiley, 2001. A.P.F. Turner I. Karube, I. G. Wilson, Biosensors- Fundamentals and applications. Oxford University Press, New York, 1987. CY60109 Special Topics in Main Group Chemistry (3-0-0 : 3 Credits) Prerequisite : Nil Structure & Bonding in MG compounds including Hypervalency and Multiple Bond. Recent advances in the coordination, organometallic, and cluster chemistry of MG. C-C bond forming reactions via MG. Bioinorganic chemistry of MG. CY60030 Inorganic Photochemistry (3-0-0 : 3 Credits) Prerequisite : Nil Excited states: excited states, decay, quantum yield, physico chemical laws. Examples of photochemical reactions: photochemical reactions of small molecules: NO, NO2, N2O, CO, O2, O3, SO2 etc.; mechanism and importance; photo redox substitution, isomerization, prompt and delayed reaction, metal bonded systems, solar energy conversion and storage, photo splitting of water by photo galvanic method and semi conductor electrodes. Metal ion catalysis of organic reactions: mechanisms and applications. CY60011 Environmental Chemistry (3-0-0 : 3 Credits) Prerequisite : Nil Essential concepts of environmental chemistry. Air and the atmosphere : Chemistry of the natural atmosphere - Environmental photochemistry in the atmosphere - Chemistry in Troposphere. Photochemical smog. Global Warming- The Greenhouse Effect - Carbon cycle - Carbon sequestration by plants and oceans. Natural waters and the hydrosphere - Water pollution and water quality parameters, CO2/carbonate equilibrium of natural waters - water treatment methods (reverse osmosis, adsorption, ion-exchange, ultra-filtration, membrane treatment etc). Heavy metal toxicity : Tolerance limit of heavy metals in potable water – Mercury and arsenic poisoning – trace metal analysis – AAS, Cold vapour AAS, ICP. Soil Pollution and Bioremediation - Organic Pollution in Soils(DDT – pesticide PCB’s – PAH’s, and Estrogen mimics) and their abatement. Clay minerals as ion exchange media. Energy – Fossil fuels – Alternate energy thoughts – solar – hydrothermal and geothermal - Hydrogen fuel and fuel cells. Concepts of Green Chemistry. Books: 1. Environmental Chemistry, Baird, Colin, 1995, W.H. Freeman and Co., New York. 12 2. Chemistry of Environment, Bailey, Clark , Ferris, Krause, Strong, (2nd edition), Elsevier. 3. Principles of Instrumental Analysis, D.A. Skoog and J.L. Loary, W.B. Saunders CY60111 Advanced Stereochemistry (3-0-0 : 3 Credits) Prerequisite : Nil Molecular Symmetry: Axial, Planar Chirality and Helicity, Topicity and Prostereoisomerism, Conformations of Cyclic Systems: Fused Ring and Bridged Ring Compounds. Dynamic Stereochemistry: Curtin Hammett Principle, Reduction of Cyclic Ketones, Felkin and Cieplak Model; Chiroptical Properties: Applications of ORD and CD; Molecular Recognition: chemical and stereochemical aspects. Book: D. Nasipuri, Stereochemistry of Organic Compounds: Principles, and Applications; E. L. Eliel, Stereochemistry of Organic Compounds. CY60113 Agrochemicals (3-0-0 : 3 Credits) Prerequisite : Nil Plant Growth Regulators: Steroidal and nonsteroidal; synthesis and biological properties of hormones like IAA, Gibberellins, Brassinolides. Role of micronutrients. Food ripening agents. Pesticides: classification, mechanism of action and synthesis. Analysis of pesticide residues and toxicological effects. Pheromones: acyclic, cyclic, chiral and achiral insect sex-attractants, their synthesis and mechanism of action. Book: Industrial Chemistry by Lowenheim and Moran , Wiley - Interscience , New York , 1990. CY60007 Chemistry of Natural products (3-0-0 : 3 Credits) Prerequisite : Nil Isolation, structural characterization, degradation, chemical modifications and biosynthesis of natural products: fatty acids, polyketides, phenylpropanoids, alkaloids, peptides and carbohydrates, prostaglandins, macrolides and polyether antibiotics. Selected topics from the current literature. Books: Chemistry of Natural Products by S. V. Bhat, 2005; Medicinal Natural products by P. M. Dewwick, 2002. CY60006 Drug Design and Development (3-0-0 : 3 Credits) Prerequisite : Nil Drug discovery without a lead; lead discovery; lead modification; combinatorial chemistry; drug receptor interactions; enzyme inhibition and inactivation; drug resistance; drug synergism; different types of inhibitors; DNA-interactive agents; reversible DNA binders; DNA alkylators; DNA strand breakers; Drug metabolism: different pathways for drug deactivation and elimination; Prodrug and drug delivery system: enzyme activation of drugs; mechanisms of drug action; Bioprecursor prodrugs. Books: Organic Chemistry of Drug Design and Drug Action: Silverman; Organic Chemistry: Bruice; Biochemistry: Voet and Voet. CY60115 Biotransformations in Organic Chemistry (3-0-0 : 3 Credits) Prerequisite : Nil 13 General methods for new biocatalyst discovery; Screening and assay methods; Isolation, purification and immobilization techniques; Classification and nomenclature (IUBMB); Catalytic role of enzymes (enzyme kinetics and various kinds of inhibition); Potentials and limitations; Enzymes in functional group transformation; White biotechnology; Few industrial process using enzymes for production of drugs, fine chemicals and chiral intermediates; Combinatorial biocatalysis; Bio-mimetic catalysts (catalytic antibodies, artificial enzymes, molecular imprinted polymeric catalyst) and their applications; DNA and RNA based catalysis; Recombinant DNA technology in enzyme engineering. Books: Enzyme catalysis in organic synthesis (Vol I-III); Eds by K. Drauz and H. Waldmann. Willey-VCH; Biotransformations in organic chemistry. K. Faber . Springer. CY60003 Organic Photochemistry and Pericyclic Reactions (3-0-0 : 3 Credits) Prerequisite : Nil Photochemistry: Principles of photochemical reactions; Excited states and their properties; experimental set up for photochemical reactions; Several useful photochemical reactions and their applications in organic synthesis (isomerization, Patterno-Buchi reaction, Norrish type I and II reaction, Photoreduction, Rearrangements: di-π-methane, oxa di-π- and aza di-π-methane rearrangements, Photocycloaddition, Photochemical aromatic substitution reaction, Reactions with singlet oxygen, Photochemical methods for protection and deprotection). Photochemistry of biological systems (photosensitized reactions of DNA/RNA, DNA damage and repair). Pericyclic reactions: Conservation of molecular orbital symmetry, Symmetry properties of molecular orbitals, Transition state aromaticity, Aromaticity and anti aromaticity (Huckel and Mobius ring), Correlation diagrams and FMO method, Allowed and forbidden reactions, Electrocyclic reactions, Cycloaddition reactions ( 2+2; 4+2; 6+4; 3+2; 4+3 and related reactions, Cheleotropic addition and elimination), Sigmatropic rearrangement, Group transfer reactions (ene reactions). Books: Advanced Organic Chemistry: Structure and Mechanisms (Part A). By Frances A Carey and Richard J Sundberg. Springer; CRC Handbook of Photochemistry and Photobiology. Eds by. William M. Horspool and Pill-Soon Song, CRC Press; Organic Photochemistry (Vol 4) by Albert Padwa (Ed.). Mercel Dekker. Pericyclic reactions by Ian Fleming. Oxford University Press. Cycloaddition reactions in organic synthesis by W. Carruthers. Pergamon. CY60117 Reagents in Organic synthesis (3-0-0 : 3 Credits) Prerequisite : Nil Organosilicon, organotin, organoborane reagents; organocopper, organopalladium and functionalized Grignard reagents; oragnocatalysts; metal carbonyl reagents; Lewis Acids in organic synthesis. Books: Some Modern methods of Organic Synthesis by W. Carruthers, 2004; Advanced Organic Chemistry Pt B: Reaction and Synthesis by F. A. Carey and R. J. Sundberg, 2001. CY60119 Physical Organic Chemistry: Prerequisite: CY41002 14 Acid-base catalysis. General acid and base catalyses. Relationship between the transition state structure and type of acid-base catalysis. Specific acid and base catalyses. Nucleophilic catalysis. Non-covalent binding forces; Electronic organic materials. Overview of orbital symmetry, rearrangements, stereoelectronic effects, the generation and chemistry of carbenium ions, carbanions, carbenes, nitrenes, radicals, excited states, and strained molecules. Methods used to probe the mechanisms of organic reactions and of the chemistry of some important reactive intermediates. Topics will include isotope effects, kinetics, linear fee energy relationships (Hammett equation. Interpretation of σ and ρ constants); BOOK: Eric V. Anslyn and Dennis A. Dougherty, Modern Physical Organic Chemistry. Other texts: i) F. A. Carey and R. J Sundberg, Advanced Organic Chemistry, Parts A; ii) M. B. th Smith and J. March, Advanced Organic Chemistry, Reactions, Mechanisms and Structure, 6 ed.; iii) T. H. Lowry and K. S. Richardson, "Mechanism and Theory in Organic Chemistry," 3rd ed. CY51001 Spectroscopic Methods of Structure Determination (3-1-0: 4 credits) Prerequisite : Nil Nuclear Magnetic Resonance spectroscopy: 1H-, 13C-, 19F-, 15N-, and 31P-NMR, introduction to 2D- NMR techniques, lanthanide shift. Mass spectroscopy: EI, CI, ESI, FAB, GC/MS, LC/MS and MS/MS techniques. Interpretation of spectroscopic (NMR, IR and mass) data, as applied to organic, inorganic and biological systems. Books: Silverstein, R. M.; Webster, F. X. Spectrometric identification of organic compounds; 6th / ed.; Wiley: New York, 1998. Lambert, J. B; Shurvell, H. F, Organic structural spectroscopy, Prentice Hall, 1998. Kemp, W. Organic spectroscopy; 3rd ed.; Macmillan Education: Houndmills, Basingstoke, Hampshire, 1991. 4th semester CY60104 Colloids And Drug Delivery (3-0-0: 3 credits) Prerequisite : Nil Introduction to colloids; size, charge, and morphology of colloids- light scattering, rheology, and microscopic characterization; Biocompatibality and Biodegradability of colloids; Drug delivery systems: Microemulsions/Emulsions, Liposomes, Niosomes, Nanoparticles, microporous materials, microgels, bioconjugate polymers, gels, ointments and creams; their synthesis/preparation methodologies; Drug loading and release techniques; release kinetics; controlled delivery; Microencapsulation for personal care; Nanoencapsulation, Transportation, Transfer, and Targeting; Gene Transfection; Topical, colonic, and parenteral drug delivery; Efficacy and safety considerations; Books: Novel Drug Delivery Systems: Fundamentals, Developmental Concepts, Biomedical Assessments, Yie W. Chien; Techniques of Solubilization of Drugs, Ed. Samuel H. Yalkowsky; Controlled Drug Delivery: Fundamentals and Applications, Ed. J.R. Robinson, and V. H.Lee; Transdermal Drug Delivery: Developmental Issues and Research Initiatives, Ed. J. H. Hadgraft and R. H. Guy; Topical Drug Delivery Formulations, Ed. D. W. Osborne and A. H. Amann. Biodegradable Polymers as Drug Delivery Systems, Ed. M. Chasin and R. Langer. 15 CY60106 Chemical Bonding and Reactivity (3-0-0: 3 credits) Prerequisite : Prerequisite : Nil Valence bond theory; molecular orbital theory; Huckel theory; aromaticity; potential energy surfaces; Hammond postulate, Woodward-Hoffmann rule; crystal and ligand field theories; symmetry and symmetry adapted linear combinations; global reactivity descriptors: electronegativity, hardness, polarizability, electrophilicity index; local reactivity descriptors: local softness, Fukui functions and frontier orbital theory, molecular electrostatic potential and associated electronic structure principles. Books: Density functional theory of atoms and molecules, R G Parr and W Yang; Chemical hardness: Applications from Molecules to Solids, R G Pearson CY60034 Advanced Chemical Dynamics (3-0-0 : 3 Credits) Prerequisite : Nil Transport properties in gases and condensed phases - kinetic theory of transport processes in dilute gases; theory of Brownian motion; transport coefficients from time correlation function formalism; transport in solids and electrolyte solutions. Dynamics of chemical reaction in condensed phases – interactions between reactive molecules; hard sphere collision theory; transition state theory; Kramer's theory of reactions in solution; linear free energy relationships; unimolecular reactions; electron transfer reactions; biomolecular reactions; chaos in reaction-diffusion systems and fractal dimensions. Books: Basic Concepts for Simple and Complex Liquids by J.L. Barrat and J.P. Hansen; Statistical Mechanics by D.A. McQuarrie; Non-equilibrium Statistical Mechanics by R. Kubo; Chemical Dynamics in Condensed Phases by A. Nitzan. CY60102 Molecular Spectroscopy and Molecular Structure (3-1-0: 4 credits) Prerequisite : CY41003 Introduction to theory of spectroscopy: Interaction of radiation with matter; Absorption, Emission. Magnetic Resonance spectroscopy and spin chemistry. Introduction to ultrafast spectroscopy and imaging. Books: Methods of molecular quantum mechanics, by P. W. Atkins; Molecular spectroscopy by J. D. Graybeal. Introduction To Magnetic Resonance by H. Günther; Fluorescence Imaging Spectroscopy and Microscopy by X. F. Wang and B. Herman (Eds.). CY60108 Application of Fluorescence Spectroscopy in Chemistry and Biology: (3-00 : 3 Credits) Prerequisite : Prerequisite : Nil Introduction to Fluorescence, Instrumentation for fluorescence spectroscopy, Flurophores, Time-domain lifetime measurements, solvent effects on emission spectra, Dynamics of solvent and spectral relaxation, Quenching of fluorescence, fluorescence resonance energy transfer (FRET), fluorescence anisotropy, energy transfer, time- 16 resolved energy transfer and conformation distributions of biopolymers, protein fluorescence, fluorescence sensing, Nucleic acids fluorescence, Application of fluorescence spectroscopy in cancer detection. Book: Fluorescence spectroscopy, J. R. Lakowicz. CY60110 Advanced Polymer Chemistry (3-0-0 : 3 Credits) Prerequisite : Nil Synthesis and reaction of polymers; thermodynamics and kinetics of polymerization; modern synthetic techniques: living radical polymerization – ATRP, SFRP, RAFT, living ionic polymerization, ring-opening polymerization; modern characterization techniques; water-soluble polymers, gels and hydrogels; properties of polymers, polymer blends, additives for polymers; chemical aspects to polymer processing, polymer surface and its modification; introduction to industrial polymers; application of polymers in medicine, nanotechnology, electronics; eco-friendly polymers: biodegradable, bio-sourced polymers, polymers from renewable resources. Books: Principles of Polymerization, 4th edition, by G. Odian; John Wiley and Sons, Inc. 2004; Introduction to Physical Polymer Science, 4th Edition L. H. Sperling, Wiley, 2006. CY60112 Metal Complexes in Catalysis and Material Science (3-0-0 : 3 Credits) Prerequisite : Nil Catalytic Reactions and the 16/18 VE Rule; Transition metal assisted valence isomerizations; Isomerization of unsaturated molecules; Arylation/vinylation of olefins; Alkene and Alkyne metathesis; Oligomerization and Polymerization; Olefin oxidation; Hydrogenation of alkenes; Fischer-Tropsch reactions; The water- gas shift reactions; Carbonylation Reactions; Hydroformylation; Hydrocyanation; Activation of C-H bonds in alkanes; Hydrosilylation and Hydroboration Reactions; Oxygen transfer reactions. Review of Basic concepts of ligand dissociation, substitution, and elimination reactions. Organometallics in electronic and optoelectronic applications. Chemical Vapor Deposition (MOCVD) leading to metal carbides, metal nitrides, metal borides, metal oxides, metal chalcogenides, semi-conductors, metal films. Organometallic chemistry related molecular material. Books: Homogeneous Catalysis by Sumit Bhaduri CY60114 Physical Methods In Inorganic Chemistry Prerequisite : Nil Infrared and Raman Spectroscopy Review of basics, applications of IR and Raman in inorganic systems – metal coordinated sulphate, dioxygen, carboxylate, aminoacids, perchlorates, nitrites, nitrates, thiocyanate and isocyanate. Mass Spectrometry: Principles and presentation of spectra – molecular fragmentation – ion reactions – Inorganic applications. NMR Spectroscopy Review of basics, applications of multinuclear nmr in inorganic compounds – Examples from 1H, 11B, 13C, 19F, 31P, 51V, 77Se, 95Mo, 119Sn, 199Pt. Study of fluxional behavior of molecules – an elementary treatment of second order spectra – examples – NMR of paramagnetic molecules – Lanthanide shift reagents 17 Magnetic properties Magnetic moments and their applications to the elucidation of the structures of inorganic compounds – temperature independent paramagnetism. Magnetic properties of lanthanides and actinides. Spin crossover in coordination compounds. EPR spectroscopy Theory of EPR spectroscopy - Spin densities and McConnell relationship –Applications of ESR to some simple systems such as CH3, p-benzosemiquinone, Xe+2 -Factors affecting the magnitude of g and A in metal species - Zero field splitting and Kramers degeneracy – Spectra of VO(II), Mn(II), Fe(II), Co(II), Ni(II) and Cu(II) complexes – Applications of EPR to a few biological molecules containing Cu(II) and Fe(III) ions. Mossbauer Spectroscopy Isomer shifts – Magnetic interactions – Mossbauer emission spectroscopy –applications to iron and tin compounds. Textbooks and Reference Books 1. R.S. Drago, “Physical Methods in Inorganic Chemistry”, 3rd Ed., Wiley Eastern Company. 2. F.A. Cotton and G.Wilkinson, “Advanced Inorganic Chemistry”, 3rd ed., WileyEastern Company, New Delhi 1990. 4. Lewis and Wilkins, “Modern Coordination Chemistry”. 5. E.A.V.Ebsworth, “Structural Methods in Inorganic Chemistry”, 3rd ed., ELBS, Great Britain, 1987. CY60026 Recent Advances in Analytical Chemistry (3-0-0 : 3 Credits) Prerequisite : Nil Review of basic concepts. Analytical aspects of sample preparation. Separation techniques and Chromatography. Aalytical Methods and Applications: Small angle X-ray and XRF. Plasma emission spectroscopy, Raman and Surface Enhanced Ramon Spectroscopy (SERS), SEM, TEM, EDAX, EPMA, Mass spectrometry (ICP-MS, ESI, MALDI TOF and TANDEM MS-MS methods). Books: 1. Principles of Analytical Chemistry, F.W. Fifield and D. Kealey, (5th Edition), Blackwell Science. 2. Principles of Instrumental Analysis, Holler, Skoog, Crouch, 6th Edition,Thomson, 2007. 3. Fundamentals of Analytical Chemistry D.A., Skoog CY60012 Synthesis and Processing of Ceramics (3-0-0 : 3 Credits) Prerequisite : Nil Classification of ceramics and materials: crystal structures and properties. Elementary ceramic phase diagrams. Ceramic powder preparation from naturally occurring raw materials. Synthesis of ceramic powders, fabrication of ceramic bodies from powders: pressing, casting, vapour phase techniques, sintering, finishing, machining. Ceramic coatings CY60116 Chemistry of Nucleosides and Nucleotides (3-0-0 : 3 Credits) 18 Prerequisite :Nil Carbohydrates: Structures; Reactions at the anomeric centre; Reactions at the non-anomeric centre; protection-deprotection; chemical synthesis of oligosaccharides; chiral pool; natural products; Nucleosides: Structures; Modification of carbohydrate moiety; Modification of heterocycle moiety; ring conformation; DNA and RNA; oligonucleotide synthesis; PNA, LNA and other unnatural oligonucleotides. Books: Nucleic acids in chemistry and biology: Blackburn and Gait; Advanced organic chemistry of nucleic acids: Shabarova and Bogdanov. CY60118 Chemistry of Lipids, Steroids and Hormones (3-0-0 : 3 Credits) Prerequisite : Nil Characteristics of different types of lipids, Oxidation of fatty acids, Fatty acid synthesis, Triglyceride synthesis, Cholesterol biosynthesis, Function of hormones, Synthesis of male and female hormones, Leukotrienes and Prostaglandins Books: Organic Chemistry Vol.2 I. L. Finar; Outlines of Biochemistry Conn and Stumpf CY60014 Medicinal Chemistry (3-0-0 : 3 Credits) Prerequisite : Nil Drug discovery without a lead; lead discovery; lead modification; combinatorial chemistry; drug receptor interactions; enzyme inhibition and inactivation; drug resistance; drug synergism; different types of inhibitors; DNA-interactive agents; reversible DNA binders; DNA alkylators; DNA strand breakers; Drug metabolism: different pathways for drug deactivation and elimination; Prodrug and drug delivery system: enzyme activation of drugs; mechanisms of drug action; Bioprecursor prodrugs. Books: Organic Chemistry of Drug Design and Drug Action: Silverman; Organic Chemistry: Bruice; Biochemistry: Voet and Voet CY60120 Newer Asymmetric Reactions (3-0-0 : 3 Credits) Prerequisite : Nil Principles of asymmetric reaction and synthesis; Kinetic resolution, Dynamic kinetic resolution (DKR) and autocatalytic reactions; Chemo-, regio-, diastereo- and enantiocontrolled approaches; Chirality transfer and relay; Asymmetric inductions; Chiral pools, auxiliaries and templates; Asymmetric oxidations: Sharpless asymmetric epoxidation, dihydroxylation, aminohydroxylation, Jacobsen strategy, Sulphoxidation, Shi epoxidation. Asymmetric reduction reactions: Reduction of ketones, imines and olefins. Asymmetric C-C bond forming reaction: Simmon-Smith reaction, aldol reaction and alkylation based on Evans method, Mukayama aldol reaction, Shibasaki bi-metallic catalyst system; RAMP-SAMP based alkylation strategy, Meyers oxazoline and bis-lactam based methods; Michael reaction, Henry reaction (Nitro aldol), BaylisHillman-Morita reactions, Asymmetric allylation, Asymmetric cycloaddition reactions, Asymmetric hydroformylation. Asymmetric C-X bond formimg reaction: Asymmetric aziridination and regioselective ring opening of aziridines; Ring forming reactions. Organocatalysis: α-functionalization of aldehyde and ketones, 1,4-conjugate addition (βfunctionalization and α,β-bifunctionalization of α,β-unsaturated carbonyl compounds). Books: Asymmetric Reactions and Processes in Chemistry: Ernest L. Eliel; Catalytic Asymmetric Synthesis: 2nd Ed., Iwao Ojima; Asymmetric Organocatalysis: From Biomimetic Concept to Applications in Asymmetric Synthesis: David MacMillan CY60122 Organometallic Strategies in Organic Synthesis (3-0-0 : 3 Credits) Prerequisite : Nil 19 Introductory concepts of transition metal organometallics and their reaction patterns including selectivity and atom economy. C-C bond formation by stoichiometric and catalytic organometallic strategies involving alkene, alkyne, diene, allyl, carbene, propargyl, and arene. Lanthanides in organic reactions. Books: Transition metal reagents and catalysts- Innovation in organic synthesis, J. Tsuji, John Wiley & Sons Ltd.; Transition metals for organic synthesis- Building blocks and fine chemicals Vol. 1 and 2, Ed. M. Beller and C. Bolm, Wiley-VCH; Transition metals in the synthesis of complex organic molecules, L. S. Hegedus, University Science Books. CY60124 Pharmacological Basis of Therapeutics (3-0-0 : 3 Credits) Prerequisite : CY40108 Pharmacokinetics: the mechanism of drug absorption, distribution and elimination. Pharmacodynamics: mechanism of action of the following drugs: drugs acting on CNS disorder, inflammation, cardiac and renal dysfunction, G.I. disorders. Chemotherapy of parasitic infection, microbial diseases, neoplasticity. Immunomodulatory drugs: hormones and hormone antagonists. Book: Pharmacological basis of therapeutics: Goodman and Goodman. CY60028 Supramolecular Chemistry (3-0-0 : 3 Credits) Prerequisite : Nil From molecular to supramolecules, factors leading to strong binding, hydrogen bonding and stacking interactions, design, synthesis and binding studies of synthetic receptors, design, properties and applications of crown ethers, siderophores, cyclophanes, cyclodextrins, Catenanes and rotaxanes. Metal guided self-assemblies and applications, Supramolecular reactivity and catalysis, supramolecular devices, transportation of anions and cations across transmembrane channels, Self-assembled monolayers, Crystal engineering of hydrogen bonded and metal-organic framework solids. Books: Jean-Marie Lehn: Supramolecular Chemistry Concepts and Perspectives CY60020 Advanced Heterocyclic Chemistry (3-0-0 : 3 Credits) Prerequisite : Nil Synthesis and reactions: indoles, azines, purines, pteridines,azoles, benzopyrimidines, compounds with oxygen and sulfur hetero atoms and small-ring heterocycles.Role of heterocyclic compounds in biological systems. Books: J.A. Joule and K.Mills, Heterocyclic Chemistry.