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OMB No. 0925-0001/0002 (Rev. 08/12 Approved Through 8/31/2015)
BIOGRAPHICAL SKETCH
Provide the following information for the Senior/key personnel and other significant contributors.
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NAME: Lageman, Sarah Kathryn
eRA COMMONS USER NAME (credential, e.g., agency login): SKLAGEMAN
POSITION TITLE: Assistant Professor of Neurology
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing,
include postdoctoral training and residency training if applicable. Add/delete rows as necessary.)
DEGREE
(if
applicable)
Completion
Date
MM/YYYY
Winthrop University, Rock Hill, SC
B.A.
05/1997
Humboldt University, Berlin, Germany
N/A
University of Florida, Gainesville, FL
M.S.
05/2002
Clinical Psychology
University of Florida, Gainesville, FL
Ph.D.
08/2006
Clinical Psychology
West Virginia University, Morgantown, WV
Internship
06/2006
Clinical Psychology
Mayo Clinic, Rochester, MN
PostDoctoral
Fellowship
07/2008
Clinical
Neuropsychology
INSTITUTION AND LOCATION
FIELD OF STUDY
Psychology
Neuropsychology
A. Personal Statement
I am an early-career clinician-scientist and board-certified clinical neuropsychologist who engages in clinical
practice and research initiatives at the Virginia Commonwealth University’s Parkinson’s and Movement
Disorders Center. I have excellent clinical and research training in neuropsychology and conduct research in
treatment of mild cognitive impairment, emotional disorders, and neurodegenerative illnesses including
Parkinson’s disease and other movement disorders. I focus my research on developing neurocognitive and
behavioral interventions to improve cognition, emotional functioning and quality of life in individuals with
neurodegenerative disorders. Recent publications have focused on the needs of individuals with Parkinson’s
disease and their caregivers and outcomes from multiple clinical trials investigating the effectiveness of
psychosocial interventions in individuals with Parkinson’s disease.
1. Lageman, S. K., Mickens, M., Verkerke, T., & Holloway, K. (2013). Psychological factors in Deep Brain
Stimulation for Parkinson’s Disease. In A. R. Block & D. Sarwer (Eds.), Presurgical Psychological
Screening: Understanding Patients, Improving Outcomes (pp. 127-149). Washington DC: American
Psychological Association.
2. Lageman, S. K., Cash, T. V., & Mickens, M. N. (2014). Patient-reported needs, non-motor symptoms, and
quality of life in Essential Tremor and Parkinson’s Disease. Tremor and Other Hyperkinetic Movements, doi:
10.7916/D8RF5S4J.
3. Lageman, S. K., Mickens, M. N., & Cash, T. V. (2015). Caregiver-Identified Needs and Barriers to Care in
Parkinson’s Disease. Geriatric Nursing, epub ahead of print, doi: 10.1016/j.gerinurse.2015.01.002.
4. Shamaskin-Garroway, A.M., Lageman, S.K., & Rybarczyk, B. (in press). The role of resilience and nonmotor
symptoms in adjustment to Parkinson’s disease. Journal of Health Psychology.
B. Positions and Honors
Positions:
2008
Instructor, Department of Psychiatry, Mayo Clinic, Rochester, MN
2008-2010
Assistant Professor and Director of Neuropsychology Consultation Service to Oncology,
Department of Rehabilitation Medicine, Emory University, Atlanta, GA
2010-present Assistant Professor, Department of Neurology, Virginia Commonwealth University,
Richmond, VA
2011-present Neuropsychology Program Director, VCU Parkinson’s and Movement Disorder Center,
Virginia Commonwealth University, Richmond, VA
Honors:
1993-1997
Winthrop University Trustee’s Scholar, President’s and Dean’s Lists, numerous achievement
awards, and membership in Omicron Delta Kappa National Leadership Society, and the
following national honor societies, Phi Kappa Phi, Psi Chi, and Beta Beta Beta
2002
Third place award in Health and Human Performance paper presentation session for a lecture
titled, “Spatio-Temporal Imaging of Cognitive Deficits Following Traumatic Brain Injury”, at the
University of Florida Graduate and Professional Student Council Forum
2004
Women’s Health Research Center’s Best Overall Graduate Student Poster ($200 award) titled,
“The Role of Neuropsychological Testing in Assessing the Impact of Standard Treatments on
Cognition in Breast Cancer Patients”
2007-2008
Mayo Clinic, Department of Psychiatry and Psychology, William N. Friedrich Award
2007-2008
Mayo Clinic, Department of Psychiatry and Psychology, Howard P. Rome Fellow
Academic Writing Award
2010-present American Board of Professional Psychology, Clinical Neuropsychology member
2014
Tremor Journal Summer 2014 Editor’s Picks, for Lageman, S. K., Cash, T. V., & Mickens, M.
N. (2014). Patient-reported needs, non-motor symptoms, and quality of life in Essential Tremor
and Parkinson’s Disease. Tremor and Other Hyperkinetic Movements, doi: 10.7916/D8RF5S4J.
2015
American Psychological Association Division 40-Society for Clinical Neuropsychology ranked
the Lageman & Cash paper, “Initial results of bio-psychosocial trials in individuals with
Parkinson’s disease” among the best submitted, and selected the paper to receive a Blue
Ribbon Award at the APA Convention in Toronto, Canada, 8/6/2015.
C. Contributions to Science
Exploration of psychosocial interventions effective for managing common cognitive and emotional symptoms of
Parkinson’s disease are lacking despite successful development such interventions for individuals with other
chronic illnesses. Research in this area is critically needed, as Parkinson’s disease is the second most
common neurodegenerative disorder and the non-motor symptoms of Parkinson’s disease, including
neuropsychiatric symptoms, result in disability, reduced quality of life, and greater caregiving needs. The
following sections of my work highlight my focus on developing psychosocial interventions effective for
managing these symptoms in Parkinson’s disease.
1. Needs Assessments. Upon joining the VCU Parkinson’s and Movement Disorders Center, I prioritized
developing relationships with the movement disorders community and learning about patient and
caregiver needs. These needs assessments provided directives from individuals living with the disease
and information about desired resources, including interventions for the non-motor symptoms of
Parkinson’s disease.
a. Lageman, S. K., Cash, T. V., & Mickens, M. N. (2014). Patient-reported needs, non-motor
symptoms, and quality of life in Essential Tremor and Parkinson’s Disease. Tremor and Other
Hyperkinetic Movements, doi: 10.7916/D8RF5S4J.
b. Lageman, S. K., Mickens, M. N., & Cash, T. V. (2015). Caregiver-Identified Needs and Barriers
to Care in Parkinson’s Disease. Geriatric Nursing, epub ahead of print, doi:
10.1016/j.gerinurse.2015.01.002.
2. Psychosocial Interventions. Given the high prevalence of non-motor symptoms in Parkinson’s disease,
there is a need for evidence-based interventions to address these symptoms, including mental health
symptoms such as depression and anxiety, cognitive changes, and declines in quality of life. Prior
research on healthy older adults have revealed promising results and provide a basis for investigation
of psychosocial interventions in Parkinson’s disease. Based on this emerging literature, I have focused
on rigorously evaluating the feasibility, tolerability, and initial efficacy on non-motor outcomes for a
range of psychosocial treatments in samples of individuals with PD. Initial results of these studies have
been promising. High feasibility and tolerability were observed, as well as improvements on select nonmotor outcomes, including mental health symptoms, quality of life, and cognitive performance.
a. Shamaskin-Garroway, A.M., Lageman, S.K., & Rybarczyk, B. (in press). The role of resilience
and nonmotor symptoms in adjustment to Parkinson’s disease. Journal of Health Psychology.
b. Cash, T.V. & Lageman, S.K. (manuscript submitted for publication). Randomized controlled
expressive writing pilot intervention in individuals with Parkinson's disease and their caregivers.
(NCT02217735).
c. Cash, T.V., Ekouevi, V.S., Kilbourn, C., & Lageman, S.K. (manuscript submitted for publication).
Pilot study of a mindfulness-based group intervention for individuals with Parkinson’s disease
and their caregivers.
3. Neurocognitive Interventions. Focused interventions targeting the cognitive symptoms commonly
experienced in Parkinson’s disease are much needed. Prior research of memory and problem solving
interventions to target Mild Cognitive Impairment have been successful in early Alzheimer’s disease
populations; however, no assessment of their efficacy in Parkinson’s disease has been conducted. I
developed and piloted a memory and problem solving intervention to target these symptoms. The
randomized controlled trial (NCT01646333) is nearing completion and preliminary results revealed
improvements in memory, mental flexibility and depression in individuals who received the memory and
problem solving intervention and improvements in self-reported stigma, social anxiety and everyday
cognitive functions in both groups. Given community need for access to interventions from further
distances, I designed a clinical trial to evaluate computer-based cognitive training programs in
Parkinson’s disease (NCT02225314). This trial is also nearing completion and initial results revealed
participant difficulty in completing the intervention and low tolerability of using computer-based
programs. Outcomes of study measures were inconsistent and potentially spurious; however,
participants did report improvements in cognition on subjective, self-report measures.
Complete List of Published Work in MyBibliography:
http://www.ncbi.nlm.nih.gov/myncbi/collections/bibliography/48204885/?reload=publicURL
D. Research Support
07/01/2015-6/30/2016: “Development of Software for Neurocognitive Interventions for Individuals with
Parkinson’s Disease”
VCU School of Medicine Dean’s Academic Enhancement Fund recipient in Neurology
Goals: This project is designed to develop and pilot software in the form of an App for the iPad to deliver a 2month calendar-based memory and problem-solving intervention to individuals with mild cognitive impairments
related to Parkinson’s disease. Responsibilities include study design, collaboration on development of the App,
pilot testing of the App on a minimum of five participants, including weekly phone-based sessions to facilitate
use of the intervention, monitor progress towards patient-identified goals, and treatment recommendations as
needed, data collection, data analyses, manuscript preparation, and dissemination of results at community and
national presentations.
Role: PI
07/01/2012-06/30/2015: “A Randomized Controlled Trial of Neurocognitive and Supportive Therapy
Interventions for Individuals with Parkinson’s Disease”
The Michael J. Fox Foundation for Parkinson’s Research, PT107964
Goals: This randomized controlled trial is designed to evaluate impact of targeted neurocognitive strategies
versus supportive therapy on cognitive, emotional, and overall quality of life in individuals with Parkinson’s
disease. The neurocognitive strategies include memory support and problem solving skills training that have
previously been demonstrated to benefit individuals with mild cognitive impairment. Responsibilities include
study design, participation recruitment, ongoing collection of participant consent and neuropsychological and
questionnaire data, training and ongoing supervision of graduate students involved in patient contact and data
collection, data analyses, manuscript preparation, and dissemination of results at community and national
presentations.
Role: PI
07/01/2012-06/30/2012: “Computer-based cognitive training for individuals with Parkinson’s disease”
A.D. Williams Committee, Virginia Commonwealth University, ADWilliams2012-647173
Goals: This RCT is a 3-arm randomized controlled trial comparing Brain Fitness, InSight, and an active control
training program to evaluate the feasibility of empirically supported computer-based cognitive training
programs for patients diagnosed with Parkinson’s disease with Mild Cognitive Impairment. Responsibilities
include study design, participation recruitment, ongoing collection of participant consent and
neuropsychological and questionnaire data, training and ongoing supervision of graduate students involved in
patient contact and data collection, data analyses, manuscript preparation, and dissemination of results at
community and national presentations.
Role: PI