Download endocrinology and diabetes in schemes and images

Copyright © Emiliano Corpas Cobisa 2012, R.P.I. nº 08/2012/21
ENDOCRINOLOGY AND DIABETES
IN DIAGRAMS AND PICTURES
Author an Editor: Emiliano Corpas, M.D., Ph.D.
and more than 35 contributors
Continuous updating e-book of quick consultation for practicing clinicians and for pre and
postgraduates teaching
46 chapters and a section of diagnostic and therapeutic protocols, which cover the most important knowledge
areas of endocrinology and diabetes. Chapters are made in a systematic and visual manner with variable length
from 30 to 140 pages (slides), an index, and a rating of knowledge and references. The book is composed of
more than 2800 (800 of diabetes) patterns of text schemes, tables, figures, algorithms, clinical guidelines, as well
as many original illustrations and digital images of patients and diagnostic tests. Most contents have been
developed by the author-editor in more than 25 years of clinical and teaching activity. In addition, more than 35
authors are collaborating now in specific areas of endocrinology or other related specialties. Most chapters have
been reviewed by different members of the Spanish Society of Endocrinology or other medical scientific
societies. The annual subscription is individual. Each subscriber will have a key and a password. Downloading
and printing by the subscriber is unlimited in PDF format with "watermarks." In addition, the subscriber may
download images or patterns without "watermarks" for presentations, with a limit of 100 per subscription year .
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ENDOCRINOLOGY AND DIABETES IN DIAGRAMS AND PICTURES
Author and Editor: Emiliano Corpas. MD, PhD
Copyright © Emiliano Corpas Cobisa 2012, R.P.I. nº 08/2012/21
This e-book is the basis of an educational program of clinical endocrinology and diabetes,
now in Spanish that will be published in English in a near future. It is not a conventional
textbook of endocrinology. The main objective is to provide a quick and easy guide for the
clinician practicing in the field.
This publication has its origin in information processed and kept by the author-editor in
more than 25 years of undergraduate teaching in medical school and graduate at different
groups of doctors.
At present, the book consists of 46 chapters, over 2800 slides (over 800 of diabetes) with
a section on diagnostic and therapeutic clinical protocols. Each chapter has a variable length
from 30 to 140 schemes of text and images, an index and is ranked by the level of knowledge to
be transmitted. Although most of the educational material has been developed by the authoreditor, there are over 35 authors collaborating who are contributing their expertise in specific
areas of endocrinology. So, contents have a multidisciplinary character and a clinical practical
orientation with their pathophysiological and pathogenetic basis. Each chapter is written to
review comprehensively each endocrine disorder. Chapters are composed of text schemes,
diagnostic and treatment algorithms, clinical guidelines and numerous original illustrations and
digital images from both patients and diagnostic tests (echo, CT, MRI, nuclear medicine
imaging). Most chapters have been reviewed by several members of the Spanish Society of
Endocrinology or other scientific-medical societies, on request of the author-editor.
The e-book is created with the clear objective of continuous updating and enrichment.
The author-editor, advised by an editorial board, is responsible for updating and directing
contents and reviews. Several authors are being invited to participate in specific clinical issues,
in some cases more specialized, which will be added as new chapters, written using the same
pattern of comprehensive reviews, teaching schemes, algorithms, cartoons and images. Others
4 chapters are programmed to be published in the following year.
The e-book is published on-line in flash-player format in the web site of the Foundation
for Health Research and Training in the Region of Murcia (“Fundación para la Formación e
Investigación Sanitarias de la Región de Murcia”; www.ffis.es), which has considerable
experience in teaching and research in health. The Web site is responsible also for the
management, marketing and distribution of this e-book. Access is on-line, and all subscribers
must respect the current regulations of copyright. They will be able to print and downloading the
chapters, but every slide shall appear with a water-mark. Membership is by individual fee, paid
annually. In future, institutional and biannual subscriptions will be available.
Contents of the book are the basis for courses and training accredited updates in
Endocrinology and Diabetes for doctors, to teach in the near future.
Some contents of the educational program are being published on the author-editor Web
site (www.endocorpas.com) which includes a section for professionals and another for patients.
Access to both sections are free. This site contains detailed information on the e-book, some
protocols and clinical guidelines, a demo chapter.
In summary, this endocrinology e-book intends to be a schematic and quick reference
guide for any doctor facing either patients with endocrine disorders or medical teaching in the
field of endocrinology. It is also written to be a reference book for medical students. The work
reviews the more frequent endocrine diseases in a comprehensive but schematic and visual
manner and the practical format permits easy updating and expanding.
ENDORSEMENTS
The e-book is endorsed by Sociedad Española de Endocrinología y Nutrición (SEEN;
Spanish Endocrine and Nutrition Society) and by Sociedad Española de Ginecología y
Obstetricia (SEGO; Spanish Society of Gynaecology and Obstetrics)
The work has been selected as a refererence book for under and postgraduate students
and physicians at Facultad de Medicina de la Universidad de Alcalá (Faculty of Medicine,
Alcala University; Spain).
Others endorsements and recognitions are awaiting.
CHAPTERS
1. Hypopituitarism. Etiology, pathogenesis, diagnosis and treatment (normal and short version).
Emiliano Corpas, Fernando Cordido.
2. Adenohypophysis hormonal hyperfunction. Acromegaly.
Emiliano Corpas, Tomás Lucas, Beatriz Lecumberri.
3. Adenohypophysis hormonal hyperfunction. Hyperprolactinemia.
Emiliano Corpas, José Manuel Gómez.
4. Neurohypophysis. Diabetes insipidus. Syndrome of inappropriate antidiuretic hormone
secretion.
José Manuel Gómez, Emiliano Corpas.
5. Surgical treatment of pituitary adenomas.
José García-Uría, Tomás Lucas, Cristina Lamas, Javier Estrada, Emiliano Corpas.
6. Radiosurgery and pituitary adenomas.
Roberto Martínez.
7. Hypoparathyroidism: Etiology, pathophysiology, diagnosis and treatment. Vitamin D deficiency.
Pseudohypoparathyroidism.
José Manuel Gómez, Emiliano Corpas.
8. Primary hyperparathyroidism: Etiology, pathophysiology, diagnosis and treatment. Hypercalcemia:
Etiology, differential diagnosis and treatment.
Emiliano Corpas, Álvaro Larrad, Eduardo Larrañaga, José Manuel Gómez.
9. Hypothyroidism. Pathogenesis, diagnosis and treatment. Subclinical hypothyroidism.
Emiliano Corpas, Franco Sánchez-Franco.
10. Thyrotoxicosis: Concept and causes. Graves' disease. Thyrotoxic crisis.
Franco Sánchez-Franco, Emiliano Corpas.
11. Graves Orbitopathy.
Natividad Rodríguez, Consuelo Pérez, Román Blanco, Emiliano Corpas.
12. Toxic multinodular goiter. Toxic adenoma. Subclinical hyperthyroidism. Other causes of
hyperthyroidism.
Emiliano Corpas, Franco Sánchez-Franco.
13. Indications and surgical techniques in Graves' disease.
Álvaro Larrad.
14. Goiter. Clinical presentations. Endemic goiter. Simple goiter. Non-toxic multinodular goiter.
Franco Sánchez-Franco, Emiliano Corpas.
15. Thyroiditis. Acute thyroiditis. De Quervain subacute thyroiditis. Chronic autoimmune thyroiditis.
Postpartum thyroiditis. Painless thyroiditis. Fibrous thyroiditis. Amiodarone thyroiditis. Other causes of
thyroiditis.
Emiliano Corpas, Franco Sánchez-Franco.
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16. Thyroid nodules. Management and treatment.
Franco Sánchez-Franco, Emiliano Corpas Cobisa.
17. Malignant thyroid tumors of the follicular epithelium.
Álvaro Larrad, Emiliano Corpas, Franco Sánchez-Franco.
18. Medullary cancer of the thyroid gland.
Franco Sánchez-Franco, Emiliano Corpas, Álvaro Larrad.
19.Cytological more frequent pictures and its thyroid histologic correlation.
Blanca Vicandi, José María Viguer.
20. Thyroid disease in pregnancy and postpartum.
Franco Sánchez-Franco, Emiliano Corpas Cobisa.
21. Adrenocortical insufficiency, acute and chronic. Etiology, pathophysiology, diagnosis and
treatment.
Emiliano Corpas, Javier Salvador.
22. Adrenocortical hyperfunction (Cushing's syndrome). Etiology, pathophysiology, diagnosis and
treatment.
Javier Salvador, Emiliano Corpas.
23. MIneralcorticoid excess. Concepts and etiology. Primary hyperaldosteronism. Secondary
hyperaldosteronism. Emiliano Corpas, Javier Salvador.
24. Pheochromocytoma and paragangliomas. Clinical manifestations, diagnosis and treatment.
Javier Salvador, Emiliano Corpas.
25. Adrenal incidentaloma.
José Manuel Machín Lázaro, Ana Bayo Berzosa, Emiliano Corpas Cobisa, Javier Salvador.
26. Adrenal surgery.
Álvaro Larrad.
27. Laparoscopic surgery of the adrenal gland.
Álvaro Serrano.
28. Hyperandrogenic states in women.
María Jesús Cancelo, Camil Castelo.
29. Diabetes mellitus. Concept, classification and pathogenesis.
Emiliano Corpas, Francisco Javier Escalada.
30. Prediabetes. Prevention of type 2 diabetes.
Francisco Javier Escalada, Emiliano Corpas, Enrique Costilla.
31. Diabetes mellitus. Clinical features. Micro and macroangiopathic chronic complications:
Epidemiology, pathogenesis and prevention. Major interventional studies.
Emiliano Corpas, Francisco Javier Escalada.
32. Diabetic retinopathy.
Esther Lijó, Emiliano Corpas.
33. The kidney in the diabetic patient.
Gabriel de Arriba.
34. Diabetic neuropathy.
José María Vázquez, Emiliano Corpas.
35. Diabetic foot: a multidisciplinary approach.
José Antonio Rubio, José Luis Lázaro, Emiliano Corpas.
36. Cutaneous manifestations of diabetes.
Esther de Eusebio, Jesus Cuevas.
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37. Therapeutic bases of diabetes mellitus. Education, nutrition, exercise and glycemia monitoring.
Treatment of hyperglycemia with oral and incretins agents. Clinical guidelines for therapy of type 2
diabetes.
Francisco Javier Escalada, Emiliano Corpas.
38. Insulin therapy in type 1 and 2 diabetes.
Emiliano Corpas, Francisco Javier Escalada.
39. Diabetic ketoacidosis. Concept, etiology, pathophysiology, clinical features and therapeutic
protocols. Hyperosmolar hyperglycemic state.
Francisco Javier Escalada, Emiliano Corpas.
40. Insulin therapy in the hospitalized patient.
Emiliano Corpas, Antonio Pérez.
41. Hypoglycemia. Pathophysiology, causes, clinical features, diagnosis and treatment. Insulinoma:
Diagnosis, localization, surgical and medical treatment.
Emiliano Corpas, Álvaro Larrad .
42. Obesity. Concept, pathogenesis, diagnosis and therapeutic evaluation.
Emiliano Corpas, Ricardo García-Mayor.
43. Obesity surgery.
Álvaro Larrad.
44. Adult male hypogonadism. Etiology, diagnosis and treatment.
Emiliano Corpas, Juan José Corrales, S. Mitchell Harman.
45. Gynecomastia. Emiliano Corpas, Juan José Corrales.
46. Primary and secondary hyperlipidemia. Hyperlipidemia and atherosclerosis.
Emiliano Corpas, Francisco Javier Tébar.
CHAPTERS IN PREPARATION
- Surgery of benign thyroid and parathyroid pathology. Álvaro Larrad, Antonio Martín-Duce.
- Diabetes and pregnancy. Jose Antonio Rubio-García, Marta Ontañón, Emiliano Corpas.
- Clinical aspects of endocrinology of aging (2 chapters). David Vincent , Emiliano Cobisa,
Ricardo Gomez-Huelgas, Álvaro Larrad, S. Mitchell Harman, Antonio Ruiz-Torres.
- Obesity bariatric surgery: Nutritional aspects in the pre-and postoperatively. Surgical and
metabolic complications. Julia Álvarez, Irene Bretón, Alvaro Larrad.
- Gender identity disorders. Enrique Costilla Martín, Fracisco Javier Tébar Massó.
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EDITORIAL BOARD
1. Dr..Emiliano Corpas. Editor and author. Consultant in Endocrinology, Guadalajara University
Hospital (Spain). Associate Professor, Faculty of Medicine, Alcalá University.
2. Dr. Francisco Javier Escalada. Consultant in Endocrinology. University Clinic Navarra. Associate
Professor Faculty of Medicine, Navarra University.
3. Dr. Jose Garcia-Uría. Chief of Neurosurgery Service, Puerta de Hierro University Hospital. Professor
of Neurosurgery. Faculty of Medicine, Autonomous University of Madrid.
4. Dr. José Manuel Gómez. Endocrinology and Nutrition Specialist. Barcelona, Spain.
5. Dr. S. Mitchell Harman. The Kronos Longevity Research Institute. Chief of Endocrinology Service of
Veterans Administration Hospital, Arizona, USA.
6. Dr. Alvaro Larrad. Endocrine and metabolic surgery. Nuestra Señora del Rosario Hospital. Madrid.
7. Dr. Franco Sánchez-Franco. Endocrinology and Diabetes Center and “Nuestra Señora del
Rosario“ Hospital. Madrid. Former President of the Spanish Endocrinology and Nutrition Society.
8. Dr. Francisco Javier Tébar. Chief of Endocrinology Service, Virgen de la Arrixaca University Hospital.
Full Professor of Medicine, Faculty of Medicine, Murcia University.
CONTRIBUTORS
Julia Álvarez. Section of Endocrinology and Nutrition. Hospital Universitario Príncipe de Asturias.
Faculty of Medicine, Alcalá University. Bariatric surgery: Preoperative, postoperative and complications.
Gabriel de Arriba de la Fuente. Nefrology Section, Hospital Universitario de Guadalajara. Faculty of
Medicine, Alcalá University. The kidney in the diabetic patient.
Ana Bayo. Radiology Service, Hospital Universitario de Guadalajara. Faculty of Medicine, Alcalá
University. Adrenal incidentaloma.
Román Blanco. Ophthalmology Service, Hospital Universitario de Guadalajara . Faculty of Medicine,
Alcalá University. Graves orbitopathy.
Irene Bretón Lesmes. Endocrinology y Nutrition Service. Hospital Universitario Gregorio Marañón.
Faculty of Medicine Complutense, Complutense University of Madrid. Bariatric surgery: Preoperative,
postoperative and complications.
María Jesus Cancelo. Obstetrics and Gynecology Service. Hospital Universitario de Guadalajara.
Faculty of Medicine, Alcalá University. Hyperandrogenic states in women.
Camil Castelo. Gynecology Service, Institut Clínic of Gynecology, Obstetrics and Neonatology, Hospital
Clínic. Barcelona University. IDIBAPS. Hyperandrogenic states in women.
Fernando Cordido. Endocrinology Service. Hospital Universitario Juán Canalejo. Faculty of Medicine,
La Coruña University. Hypopituitarism
Juan José Corrales. Endocrinology Service, Hospital Universitario de Salamanca. Faculty of Medicine,
Salamanca University. Adult male hypogonadism. Gynecomastia.
Enrique Costilla. Endocrinology and Nutrition Unit, Hospital Universitario de Guadalajara. Faculty of
Medicine, Alcalá University. Prevention of type 2 diabetes. Disorders of gender identity.
Jesus Cuevas. Pathology Service, Hospital Universitario de Guadalajara. Faculty of Medicine, Alcalá
University. Cutaneous manifestations of diabetes.
Francisco Javier Escalada. Endocrinology and Nutrition Department, Clínica Universidad de Navarra.
Faculty of Medicine, Navarra University. Diabetes mellitus. Concept, classification and patogénesis;
Prediabetes; Clinical features, micro and macroangiopathic chronic complications: Epidemiology,
pathogenesis and prevention, major interventional studies; Therapeutic bases of diabetes mellitus;
Insulin therapy in type 1 and 2 diabetes; Diabetic ketoacidosis and hyperosmolar hyperglycemic state.
6
Esther de Eusebio. Dermatology Section, Hospital Universitario de Guadalajara. Faculty of Medicine,
Alcalá University. Cutaneous manifestations of diabetes.
Ricardo García-Mayor. Endocrinology and Nutrition Specialist. Vigo (Spain)
José García-Uría. Service of Neurosurgery, Hospital Universitario Puerta de Hierro. Faculty of Medicine,
Autonomous University of Madrid. Surgical treatment of pituitary adenomas.
José Manuel Gómez -Sáez. Endocrinology and Nutrition Specialist. Barcelona (Spain).
Hyperprolactinemia; Neurohypophysis; Hyperparathyroidism; Hypoparathyroidism.
Ricardo Gómez Huelgas. Internal Medicine Service. Hospital Universitario Carlos Haya. Faculty of
Medicine, Málaga University. Cinical aspects of aging endocrinology (2 chapters; diabetes).
S. Mitchell Harman. The Kronos Longevity Research Institute and Endocrinology Service of Veterans
Administration Hospital, Arizona, USA. Adult male hypogonadism. Etiology, diagnosis and treatment.
Álvaro Larrad. Endocrine Surgery. Medical-Surgical Unit Endocrine-Metabolic.Hospital Nuestra
Señora del Rosario.
Indications and surgical technique for Graves disease. Malignant thyroid tumors of the follicular
epithelium. Medullary cancer of the thyroid. Surgery of benign thyroid and parathyroid pathology.
Primary hyperparathyroidism. Adrenal surgery. Treatment of diabetes type 2. Hypoglycemia and
insulinoma. Obesity surgery. Clinical aspects of endocrinology and aging. Bariatric surgery: Preoperative,
postoperative and complications.
Eduardo Larrañaga. Endocrine and metabolic surgery. Primary hyperparathyroidism.
José Luis Lázaro. Diabetic foot unit, University Clinic of Podiatry, Complutense University of Madrid.
Diabetic Foot: A multidisciplinary approach.
Beatriz Lecumberri. Acromegaly. Hospital Universitario La Paz. Faculty of Medicine, Autonomous
University of Madrid.
Esther Lijó. Ophthalmology Service, Hospital Universitario de Guadalajara. Diabetic retinopathy.
Tomás Lucas. Fundación Sociedad Española de Endocrinología y Nutrición. Endocrinology and
Nutrition Specialist. Acromegaly. Surgical treatment of pituitary adenomas.
Jose Manuel Machín. Internal Medicine Service, Hospital Universitario de Guadalajara. Adrenal
incidentaloma.
Antonio Martín-Duce. Endocrine and metabolic surgery. Hospital NISA and Hospital del Rosario.
School of nursing and physiotherapy, Alcalá University. Madrid. Surgery of benign thyroid and
parathyroid pathology.
Roberto Martínez-Álvarez. Radiosurgery Unit, Hospital Ruber Internacional, Madrid. Radiosurgery and
pituitary adenomas.
Marta Ontañón Nasarre. Gynaecology and obstetrics Service. Hospital Príncipe de Asturias. Faculty of
Medicine, Alcalá University. Diabetes and pregnancy.
Antonio Pérez.. Endocrinology Service. Hospital Universitario de Sant Pau. Faculty of Medicine,
Autonomous University of Barcelona. Insulin therapy in hospitalized patients.
Consuelo Pérez. Ophthalmology Service, Hospital Universitario Príncipe de Asturias. Faculty of
Medicine, Alcalá University. Graves orbitopathy.
José Antonio Rubio. Endocrinology and Nutrition Section, Hospital Universitario Príncipe de Asturias.
Biomedical Sciences Department, Alcalá University. Diabetic Foot: A multidisciplinary approach.
Diabetes and pregnancy.
Natividad Rodríguez . Ophthalmology Service, Hospital Universitario de Guadalajara. Faculty of
Medicine, Alcalá University. Graves orbitopathy.
Antonio Ruiz-Torres. Instituto Teófilo Hernando. Faculty of Medicine. Autonomous University of Madrid.
Cinical aspects of aging endocrinology.
7
Javier Salvador Rodríguez. Endocrinology y Nutrition Department. Clínica Universidad de Navarra.
Faculty of Medicine, Navarra University. Adrenocortical insufficiency Adrenocortical hyperfunction.
MIneralcorticoid excess. Pheochromocytoma and paragangliomas. Adrenal incidentaloma.
Franco Sánchez-Franco. Endocrinology and Diabetes Center and “Nuestra Señora del
Rosario“ Hospital. Madrid. Hypothyroidism. Hyperthyroidism. Goiter. Tiroiditis. Management of the
thyroid nodule. Malignant thyroid tumors of the follicular epithelium. Medullary cancer of the thyroid.
Thyroid disease in pregnancy.
Álvaro Serrano. Urology Service, Hospital Universitario de Guadalajara. Faculty of Medicine, Alcalá
University. Laparoscopic surgery of the adrenal gland.
Francisco Javier Tébar. Endocrinology Service, Hospital Virgen de la Arrixaca. Faculty of Medicine,
Murcia University. Hyperlipidaemia. Gender identity disorders.
José María Vázquez. Neurology Specialist. Madrid. Diabetic neuropathy.
David Vicent . Endocrinology laboratory. Hospital Carlos III. Madrid. Cinical aspects of aging
endocrinology (2 chapters).
José María Viguer . Pathology Department, Hospital Universitario La Paz. Faculty of Medicine,
Autonomous University of Madrid. Thyroid Cytopathology.
Blanca Vicandi Plaza. Pathology Department, Hospital Universitario La Paz. Faculty of Medicine,
Autonomous University of Madrid. Thyroid Cytopathology.
REVIEWERS FOR THE FIRST EDITION
Carmen Bernal. Endocrinology and Nutrition Specialist, Madrid. Hypoglycemia.
José García-Uría. Service of Neurosurgery, Hospital Universitario Puerta de Hierro. Faculty of Medicine,
Autonomous University of Madrid. Disorders of pituitary gland and hypothalamus.
José Manuel Gómez-Sáez. Endocrinology and Nutrition Specialist, Barcelona. Thyroid cancer.
S. Mitchell Harman, M.D., Ph.D. The Kronos Longevity Research Institute and Endocrinology Service of
Veterans Administration Hospital, Arizona, USA. Adult male hypogonadism.
Federico Hawkins. Endocrinology and Nutrition Service, Hospital 12 de Octubre. Faculty of Medicine,
Complutense University of Madrid. Hyperparathyroidism.
Larrad Álvaro. Endocrine Surgery. Hospital NISA de Aravaca (Madrid). Obesity.
Alfonso Leal. Experimental Endocrinology, Faculty of Medicine, Sevilla University. Disorders of the
adrenal glands.
Tomás Lucas. Fundación Sociedad Española de Endocrinología y Nutrición. Endocrinology and
Nutrition Specialist. Disorders of pituitary gland and hypothalamus.
Javier Tébar. Endocrinology Service, Hospital Virgen de la Arrixaca. Faculty of Medicine, Murcia
University. Diabetes and hyperlipidemia.
Guillermo Martinez. Endocrinology and Nutrition Service, Hospital 12 de Octubre. Faculty of Medicine,
Complutense University of Madrid. Hypoparathyroidism.
Franco Sánchez-Franco. Endocrinology and Diabetes Center and “Nuestra Señora del Rosario
Hospital”. Madrid. Disorders of the thyroid gland.
José María Viguer. Pathology Department, Hospital Universitario La Paz. Faculty of Medicine,
Autonomous University of Madrid. Thyroid nodules: Management and treatment.
8
AUTHOR and EDITOR: Emiliano Corpas Cobisa, MD, PhD.
Dr. Emiliano Corpas is Cobisa is a Specialist in Endocrinology and Nutrition and in Internal Medicine. He
serves as Consultant at the Endocrinology and Nutrition Unit, at the “Hospital Universitario de
Guadalajara” since 1982 and he is Associate Professor of Endocrinology at the “Universidad de Alcalá”
for over 25 years. He graduated from the “Universidad Complutense de Madrid” and completed his
residency in Endocrinology at the “Hospital de la Princesa ” in Madrid. In 1988, he took his doctorate
degree from the “Universidad Autonoma de Madrid” on a cross-sectional study of aging in healthy
population of Guadalajara. He has been a Medical Associate of National Institute of Health of the U.S. in
the Gerontology Research Center, and a Visiting Scientist in the Department of Medicine of Johns
Hopkins Hospital, in Baltimore for 3 years. In that time he was involved in the endocrinology of aging,
particularly in the study of the hypothalamic-pituitary GH axis. He is the author of several original papers
and reviews in national and international journals. He has been medical advisor for some
pharmaceutical corporations. He has been exercising private practice as specialist of endocrinology and
metabolism for about 15 years.
Relevant references of his bibliography

Corpas-Cobisa, E. "Cambios hormonales y metabólicos con la edad. I. Función hipotálamo-hipofisaria, tiroidea, adrenal y
gonadal". Revista Española de Geriatria y Gerontologia 25:158-167, 1990.

Corpas-Cobisa, E. "Cambios hormonales y metabólicos con la edad. II. Metabolismo fosforo-calcio, catecolaminas,
péptido atrial natriurético, pancreas endocrino y lipoproteinas". Revista Española de Geriatria y Gerontologia 25:207-216,
1990.

Corpas, E.; Harman, S.M.; Piñeyro, M.A.; Roberson, R.; Blackman, M.R. GHRH 1-29 twice daily reverses the decreased
GH and IGF-I levels in old men. Journal of Clinical Endocrinolology and Metabolism 75:530-535, 1992.

Corpas E, Blackman MR, Harman SM. Serum IGF-binding protein-3 is related to IGF-I, but not to spontaneous GH release,
in healthy older men. Hormone and Metabolic Research 24:543-545, 1992.

Corpas, E.; Blackman, M.R.; Roberson, R.; Scholfield, D.; Harman, S.M. Oral arginine/lysine does not increase growth
hormone and insulin-like growth facto-I in old men. Journal of Gerontology 48: M128-M133, 1993.

Corpas E, Harman SM, Piñeyro MA, Roberson R, Blackman MR. Continuous subcutaneous infusion of GHRH 1-44 for 14
days increase GH and IGF-I levels in old men. Journal of Clinical Endocrinolology and Metabolism 76:134-138, 1993.

Corpas, E.; Harman, S.M.; Blackman, M.R. Growth hormone and human aging. En Endocrine Reviews. Ed. A. NegroVilar. Edit. The American Endocrine Society. Volumen 14:20-39, 1993.

Ruiz-Torres, A and Corpas, E. Anthropometrical changes in aging: Their relationship with GH secretion and its possible
metabolic consequences. En Growth hormone replacement therapy in adults: pros and cons. Ed. Z. Laron y O. Butenandt.
Edit. Freund Publishing House, 123-136, 1993.

Blackman, M.R.; Vittone, J.; Corpas, E.; Busby-Whitehead, J., Stevens, T.; Bellantoni, M.; Rogers, M.; Stewart, K.; Tobin,
J.; Spencer, R.; Harman, S.M. Effects of Growth Hormone Releasing Hormone (GHRH) Administration in Healthy Aging
Men. In: "GHRH, GH, and IGF-I: Basic and Clinical Advances”, M.R. Blackman, S.M. Harman, J. Roth, and J.R. Shapiro,
(Eds). New York: Springer-Verlag, 257-26, 1995.

Adler, W.H., J.E. Nagel, S.M. Harman, E. Corpas, and M.R. Blackman, Recombinant human growth hormone and immune
function in the elderly, In: “GHRH, GH, and IGF- I: Basic and Clinical Advances”, M.R. Blackman, S.M. Harman, J. Roth,
and J.R. Shapiro, (Eds). Springer-Verlag, New York, NY, Ch. 26, pp 277-290, 1995.
9