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Protection of the scalp Prof. Dr. med. Ralph M. Trüeb, Dermatologische Praxis und Haarcenter Professor Trüeb, Zentrum Wallisellen, Bahnhofplatz 1A, 8304 Wallisellen www.derma-haarcenter.ch A sensitive scalp is a frequent problem in the physicians practice and quite often it represents a real challenge for the dermatologist. In particular, patients with hair loss and alopecia frequently complain also about scalp problems, and these must be taken into account if a treatment program is to be successful. The main complaint relates to a sensitive scalp, for which various causes can be taken into consideration: an atopic predisposition of the skin, with a tendency to sebostasis, irritation and eczema, a Type IV hypersensitivity to certain shampoo ingredients such as cocamidopropyl betaine and preservatives, age-related dryness of the skin (senile sebostasis), intensive chemical hair treatment, as well as other specific dermatological scalp afflictions such as seborrhoic eczema, psoriasis or treatment sequels, especially those due to the prolonged use of corticosteroid-containing topicals. One condition, characterised by reddening of the scalp, irritation, itching and burning sensations, that does not respond to the usual anti-eczematous or anti-seborrhoic treatment, and for which there is no clear nosocomial attribution to a specific dermatological disease, is often referred to as the Red Scalp Syndrome (Fig. 1a,b). On the one hand, one observes the apparition of the unpleasant symptoms of the sensitive scalp, such as itching, sensations of burning and of tension, as seen after the application of hair-restoring products and due to the drying out and irritating effect of the alcohol and/or of the propylen glycol solvent contained in these preparations. On the other hand, the Red Scalp Syndrome typically occurs in case of a vertex alopecia, in the area maximally exposed to UV radiation and is then considered as a chronic UV-caused lesion of the scalp, a rosacea-like affection from the pathogenic point of view.1 There is also increasing evidence that exposition to UV radiation, apart from the skin lesions also exerts a negative effect on hair growth,2 presumably by generating reactive oxygen radicals and in par- Fig. 1 a allel to an increase of the sensitivity of the hair papilla fibroblasts to oxidative stress.3 In the presence of a specially irritable and sensitive scalp, that seems not to tolerate any external stimuli anymore, the term Burn-Out Syndrome of the scalp is used. A burn-out generally designates a condition of emotional exhaustion and can be considered as the final state of a course that starts with idealistic enthusiasm and ends in disillusonment, depression and agressivity, after going through a whole series of frustrating experiences. Again and again one observes such patient careers in relation to the condition of the scalp and its treatment by various therapeutic approaches. Just as the well-known burn-out syndrome, which is not recognised scientifically as a disease, but rather, according to ICD-10, is a problem of mastering ones life,4 the burn-out of the scalp must not be considered as a distinct entity, but rather as a question of coping with a problem. Fig. 1 b Fig. 1 a, b. Red Scalp Syndrome, before and after 6 months of treatment with a hamamelis-containing shampoo (Erol® Energy Shampoo) It is a matter of protecting the scalp against further negative environmental, medical and cosmetic impacts, of acting towards its appeasement and restoration and at the same time of regaining the trust of the patient. The first step in the treatment and prevention of the irritated scalp consists in an optimisation of the hair-washing frequency. Persons with fatty hair should wash their hair often, sometimes even daily, persons with dry hair less often. This is why a mild shampoo must be chosen, to avoid ingredients with a high irritation potential, or containing known contact allergens. Of particular interest in this context are the anti- and abirritative active principles found in the traditional phytomedicine, such as camomile (Marticaria chamomilla), balloon plant (Cardiospermum halicacabum), peony (Paeonia lactiflora), and the Virginian Witch Hazel (Hamamelis virginiana). When Europeams encountered Native North Amercians for the first time, the groups dwelling in the Northeastern region used about 275 plants for medicinal purposes. Hamamelis virginiana (Fig. 2) was among the most important of those plants, and was used for the treatment of superficial skin wounds and skin inflammations. From the middle of the nineteenth century onwards, hamamelis finally became a constituent of the official European and American medicine. The foliage leaves (Hamamelidis folium) as well as the Fig. 2. Hamamelis twig (usable parts of the plant: bark and leaves) have been specially developed for the care and treatment of the sensitive scalp. The shampoo is composed of extracts of Hamamelis virginiana and a shampoo base of mild tensidic character, free of cocamidopropyl betaine and parabens. Over a period of six months, from October 2009 to March 2010, an observational study was carried out Medicinal drug: Preparation: Ingredients: Application: Hamamelis water (Hamamelidis aqua) Water-vapour distillate of freshly cut or partly dried twigs and leaves. Essential oil Hamamelis water is used for the treatment of wounds and in cometics. Hamamelis bark (Hamamelidis cortex) Water-vapour distillate of the dried, chopped up bark of stems and twigs. Tannins (ca. 8–12 %), such as Hamamelitannin and free gallic acid. Also essential oil, ellagitannin and flavonic glacosides. Used for inflammations of the gum and mucous membrane of the mouth and for light skin lesions, hemorrhoids and varicous- vein complaints. Component of numerous creams, onguents or other medicinal finished products. Hamamelis leaves (Hamamelidis folium) Water-vapour distillate of dried hamamelis leaves. Tannins (ca. 3–8 %), especially hamamelitannin as well as single and oligomeric proanthocyanidins, essential oil, (Ionon, safrol), flavonoids and caffeic acid derivatives. Used for slight skin lesions, local inflammation of the skin and mucous membranes, hemorrhoids and varicous-vein complaints. bark (Hamamelidis cortex) of the native Northamerican Virginian witch hazel are used. Today, the following commercially used medicinal preparations are obtained from Hamamelis, with the corresponding ingredients and applications, as listed in the table:5 Quality plays an important role. Commonly used hamamelis distillate (HMM-Water) elicits only low peaks for the active-principles. To achieve a rapid regeneration of the scalp and a positive course of the entire therapeutic process, the use of high-grade active principles, from hamamelis obtained from wild stocks and sustainable production, is therefore essential. The Erol® Energy hair care products, based on Virginian witch hazel, with the botanical name Hamamelis virginiana, at the Dermatologic Clinic of the University Hospital Zurich, during which the hamamelis products Erol® Energy Shampoo and Tonic were dispensed to patients complaining about subjective irritation symptoms of the scalp, with or without objectiveyl observable alterations such as reddening, squames, papules and excoriations. Many patients had previously used various medicinal shampoos, mainly against seborrhea and dandruff, as well as corticosteroid-containing topicals, but without success. After a period of application of four weeks, the majority of patients reported an improvement of the subjective manifestations of irritation, and after the end of the application they rated the tolerance of both products as good to excellent. Overall, the majority of the patients were satisfied with the products. The documented efficacy can be attributed chiefly to Hamamelis virginiana. The main active principles are the flavonoids and tannins contained in hamamelis, as a natural source of antioxidants and radical captors.6 Furthermore, the vegetal ingredients additionally contained in Erol® Energy Hair Tonic promote the metabolism and blood flow (rosemary, field horsetail), inhibit the proliferation of propionibacterium (rosemary), are active against dandruff (rosemary), strengthen the connective tissue (field horsetail) and stimulate healthy hair growth (birch, stinging nettle). Since that time, in the period between August 2010 and December 2013, Erol® Energy Shampoo has been applied successfully in 1‘373 patients (1‘233 women and 140 men) at the dermatological practice and Hair Center Professor Trüeb, to treat a irritable scalp conditions or as a concomitant treatment to a minoxidil therapy for androgenetis alocepia. Durin g this period, 369 (26.9%) have received the Erol shampoo more than once. Experience has shown that the local application of topical minoxidil products (2 to 5%) in an alcohol and water base for the treatment of androgenetic alopecia often leads to irritation of the scalp, which can have a negative impact on patience compliance. The complaints of the patients and the reddening of the scalp can be misinterpreted as a seborrheic eczema and treated with irritaton-causing anti-dandruff shampoos or topical corticosteroids in alcoholic bases (scalp applications), and thus only aggravate the problem. As a concomitant therapy for topical minoxidil in androgenetic alopecia, treatment with a mild shampoo with reduced irritative potential, based on Hamamelis, is therefor a much more suitable option. References 1. Oberholzer PA, Nobbe S, Kolm I, Kerl K, Kamarachev J, Trüeb RM. Red scalp disease--a rosacea-like dermatosis of the scalp? Successful therapy with oral tetracycline. Dermatology 2009;219:179-81 2. Trüeb RM. Is androgenetic alopecia a photoaggravated dermatosis? Dermatology 2003;207:343-8 3. Bahta AW, Farjo N, Farjo B, Philpott MP. Premature senescence of balding dermal papilla cells in vitro is associated with p16(INK4a) expression. J Invest Dermatol 2008;128:1088-94 4. ICD-10: Z70-Z76 auf DIMDI 5. Willibald Pschyrembel: Pschyrembel Naturheilkunde und alternative Heilverfahren. 3rd edition. De Gruyter, Berlin 2006, ISBN 3-11-018524-5 6. Reuter J, Wölfle U, Korting HC, Schempp C. Which plant for which skin disease? Part 2: Dermatophytes, chronic venous insufficiency, photoprotection, actinic keratoses, vitiligo, hair loss, cosmetic indications. J Dtsch Dermatol Ges 2010;8:866-73 Detailled information under www.hamamelis.ch Conclusion The choice of suitable hair-care products represents an important aspect in the treatment plan for the sensitive scalp. Hair washing is the most common form of scalp and hair treatment. In this context, a shampoo must accomplish more than just cleanse. It should additionally be adapted to the specific requirements of the different hair types, to age and to washing routines. But most importantly, it should have a positive influence on problematic scalp conditions. With the Erol® Energy hair-care products, the advantages of Hamamelis are now also available for the treatment of the scalp, especially in the context of the problems associated with the Red Scalp Syndrome, the burn-out of the scalp and the topical minoxidil treatment for androgenetic alopecia. Products Pharmacode Main active principle Particulars Erol® energy Hair Shampoo Hamamelis 3589275 200 ml EAN 7640126460109 Hamamelis virginiana as a distillate with increased active-principle content. Hamamelis distillate Apomedica from wild stocks without pesticide residues and additives. Erol® energy Hair Tonic Hamamelis 3589252 200 ml EAN 7640126460116 Hamamelis virginiana as a distillate with increased active-principle content. Hamamelis distillate Apomedica from wild stocks without pesticide residues and additives. In case of dandruff, reddening, and itching; favours hair growth.