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Burke Medical Research Institute
785 Mamaroneck Avenue
White Plains, NY 10605
(914) 597-2551
www.burke.org
WEEKLY COLLOQUIUM
TUESDAY, 11/24/2015, 12:30 PM
ROSEDALE CONFERENCE ROOM
BILLINGS BUILDING
“DEVELOPMENT AND REPAIR OF NEURAL CIRCUITS”
YIMIN ZOU, PH.D.
PROFESSOR AND CHAIR
NEUROBIOLOGY SECTION
DIVISION OF BIOLOGICAL SCIENCES
UNIVERSITY OF CALIFORNIA, SAN DIEGO
In development, axons are guided to their
targets by a large number of directional
cues to form neural circuits. Interesting, we
found the same molecular cues are
reactivated after traumatic injury in the
central nervous system and play similar
roles in regulating axon plasticity. I will talk
about our latest progress in understanding
the growth cone signaling mechanisms in
axon guidance and the characterization of
the role of axon guidance molecules after
spinal cord injury. We found that the highly
conserved cell polarity signaling pathways
mediate asymmetric signaling in growth
cones and that removing repulsive Wnt
signaling
promotes
recovery
of
proprioceptive functions and fine motor
control after spinal cord injury.
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Recent Publications:
Edmund R Hollis II, Nao Ishiko, Maysam Pessian, Kristine Tolentino, Corinne A. Lee-Kubli, Nigel A. Calcutt and Yimin Zou*.
Remodeling of spared proprioceptive circuit of a small number of neurons supports major functional recovery. Nature
Communications. 2015 Jan 19;6:6079. doi: 10.1038/ncomms7079.
Edmund R Hollis II, Nao Ishiko, Kristine Tolentino, Ernest Doherty, Maria J. Rodriguez, Nigel Calcutt and Yimin Zou*. A novel and
robust pre-conditioning lesion induced by ethidium bromide. Experimental Neurology. 2014 Dec 23. pii: S0014-4886(14)00389-6.
Keisuke Onishi, Edmund Hollis and Yimin Zou. Axon guidance and injury-lessons from Wnts and Wnt signaling. Curr Opin
Neurobiol. 2014 Aug;27C:232-240.
FOR MORE INFORMATION ON THE WEEKLY COLLOQUIA, CONTACT [email protected]
BURKE MEDICAL RESEARCH INSTITUTE . 785 MAMARONECK AVE . WHITE PLAINS, NY 10605
THE BURKE MEDICAL RESEARCH INSTITUTE IS AN ACADEMIC AFFILIATE OF
WEILL CORNELL MEDICINE